المؤلفون: Mohamed Ibrahim, Xinyuanyuan Sun, Vinicius Martins de Oliveira, Ruibin Liu, Joseph Clayton, Haifa El Kilani, Jana Shen, Rolf Hilgenfeld

المصدر: hLife, Vol 2, Iss 8, Pp 419-433 (2024)

مصطلحات موضوعية: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), main protease, Omicron, molecular dynamics, Pro>His mutant, double mutant, Medicine

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S294992832400049X; https://doaj.org/toc/2949-9283

URL الوصول: https://doaj.org/article/267a1214c0c245738d97eb6061005e8c

المؤلفون: Ou, Sai-Hong Ignatius, Nagasaka, Misako, Brazel, Danielle, Hou, Yujie, Zhu, Viola W

المصدر: Translational Oncology. 14(11)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Cancer, Genetics, Lung Cancer, Lung, Clinical Trials and Supportive Activities, TPX-0131, NVL-655, "Single mutant active", "Double mutant active", ALK plus NSCLC, Anaplastic lymphoma kinase tyrosine kinase, inhibitors 4th-generation ALK TKI, 4th-generation ALK TKI, ALK+ NSCLC, Anaplastic lymphoma kinase tyrosine kinase inhibitors, “Double mutant active”, “Single mutant active”, Biochemistry and Cell Biology, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7rk5x7pc

المؤلفون: Di Felice, Mariana, Pagano, Livia, Pennacchietti, Valeria, Diop, Awa, Pietrangeli, Paola, Marcocci, Lucia, Di Matteo, Sara, Malagrinò, Francesca, Toto, Angelo, Gianni, Stefano

المساهمون: Di Felice, Mariana, Pagano, Livia, Pennacchietti, Valeria, Diop, Awa, Pietrangeli, Paola, Marcocci, Lucia, Di Matteo, Sara, Malagrinò, Francesca, Toto, Angelo, Gianni, Stefano

مصطلحات موضوعية: double-mutant cycle, kinetic, multidomain protein, mutagenesi, protein‐protein interaction

Relation: info:eu-repo/semantics/altIdentifier/pmid/38432639; volume:300; issue:4; journal:THE JOURNAL OF BIOLOGICAL CHEMISTRY; https://hdl.handle.net/11573/1706810; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85188713900

الاتاحة: https://hdl.handle.net/11573/1706810
https://doi.org/10.1016/j.jbc.2024.107129

المؤلفون: Clair Chaigne, Dora Sapède, Xavier Cousin, Laurent Sanchou, Patrick Blader, Elise Cau

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Evolutionary Biology, Developmental Biology, Cancer, Mental Health, Biological Sciences not elsewhere classified, div >< p, phase delay following, phase advance upon, photosensitive projection neurons, controlling circadian rhythms, zebrafish melanopsin genes, functional eye contributes, double mutant larvae, projection neurons, circadian rhythms, phase shifts, melanopsin photopigments, circadian system, sole mediator, reveal redundancy, results support, opn4xa <, nocturnal mammals, mutant larvae, locomotor activity

Relation: https://figshare.com/articles/journal_contribution/S4_Table_-/25292212

الاتاحة: https://doi.org/10.1371/journal.pgen.1011172.s009
https://figshare.com/articles/journal_contribution/S4_Table_-/25292212

المؤلفون: Clair Chaigne, Dora Sapède, Xavier Cousin, Laurent Sanchou, Patrick Blader, Elise Cau

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Evolutionary Biology, Developmental Biology, Cancer, Mental Health, Biological Sciences not elsewhere classified, div >< p, phase delay following, phase advance upon, photosensitive projection neurons, controlling circadian rhythms, zebrafish melanopsin genes, functional eye contributes, double mutant larvae, projection neurons, circadian rhythms, phase shifts, melanopsin photopigments, circadian system, sole mediator, reveal redundancy, results support, opn4xa <, nocturnal mammals, mutant larvae, locomotor activity

Relation: https://figshare.com/articles/journal_contribution/Percent_of_rhythmic_i_lak_i_and_sib_larvae_in_DD_and_LL_/25292206

الاتاحة: https://doi.org/10.1371/journal.pgen.1011172.s007
https://figshare.com/articles/journal_contribution/Percent_of_rhythmic_i_lak_i_and_sib_larvae_in_DD_and_LL_/25292206

المؤلفون: Clair Chaigne, Dora Sapède, Xavier Cousin, Laurent Sanchou, Patrick Blader, Elise Cau

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Evolutionary Biology, Developmental Biology, Cancer, Mental Health, Biological Sciences not elsewhere classified, div >< p, phase delay following, phase advance upon, photosensitive projection neurons, controlling circadian rhythms, zebrafish melanopsin genes, functional eye contributes, double mutant larvae, projection neurons, circadian rhythms, phase shifts, melanopsin photopigments, circadian system, sole mediator, reveal redundancy, results support, opn4xa <, nocturnal mammals, mutant larvae, locomotor activity

Relation: https://figshare.com/articles/journal_contribution/Percent_of_rhythmic_i_opn4xa_-_-_i_and_ctl_larvae_in_DD_and_LL_/25292218

الاتاحة: https://doi.org/10.1371/journal.pgen.1011172.s011
https://figshare.com/articles/journal_contribution/Percent_of_rhythmic_i_opn4xa_-_-_i_and_ctl_larvae_in_DD_and_LL_/25292218

المؤلفون: Clair Chaigne, Dora Sapède, Xavier Cousin, Laurent Sanchou, Patrick Blader, Elise Cau

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Evolutionary Biology, Developmental Biology, Cancer, Mental Health, Biological Sciences not elsewhere classified, div >< p, phase delay following, phase advance upon, photosensitive projection neurons, controlling circadian rhythms, zebrafish melanopsin genes, functional eye contributes, double mutant larvae, projection neurons, circadian rhythms, phase shifts, melanopsin photopigments, circadian system, sole mediator, reveal redundancy, results support, opn4xa <, nocturnal mammals, mutant larvae, locomotor activity

Relation: https://figshare.com/articles/journal_contribution/qRTPCR_primer_sequences_used_in_the_study_/25292227

الاتاحة: https://doi.org/10.1371/journal.pgen.1011172.s014
https://figshare.com/articles/journal_contribution/qRTPCR_primer_sequences_used_in_the_study_/25292227

المؤلفون: Yixun Jiang, Mingdong Yao, Haoran Niu, Wenrui Wang, Jiale He, Bin Qiao, Bingzhi Li, Min Dong, Wenhai Xiao, Yingjin Yuan

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, type may contribute, sup >–, shorter nucleophilic distance, residue tyr70 plays, lower energy barriers, also sheds light, y70t single mutant, double mutant y70t, 5 ′- fda, 5 ′- clda, fluorinase organofluorine compounds, exhibit fluorination activity, fluoride versus chloride, g131s mutant, use chloride, wide application, unique enzyme, similar mechanism, quantum mechanics, organic molecule, key role, incorporate fluorine, highly important, halide ions

Relation: https://figshare.com/articles/journal_contribution/Enzyme_Engineering_Renders_Chlorinase_the_Activity_of_Fluorinase/24948378

الاتاحة: https://doi.org/10.1021/acs.jafc.3c08185.s001
https://figshare.com/articles/journal_contribution/Enzyme_Engineering_Renders_Chlorinase_the_Activity_of_Fluorinase/24948378

المؤلفون: Elena Sapède, Neal Sugawara, Randall G. Tyers, Yuko Nakajima, Mosammat Faria Afreen, Jesselin Romero Escobar, James E. Haber

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Biological Sciences not elsewhere classified, unequally spaced heterologies, div >< p, double strand break, dna sequencing analysis, 3 ’ end, saccharomyces cerevisiae <, δ double mutant, strand annealing activity, fa tailless strains, strand annealing, spacer dna, natural 3, annealed strand, tailless strains, tailless construct, ura3 <, uniform repair, top3 helicase, stranded tails, spectrum seen, significant reduction, sequences separated, sequence opposite

Relation: https://figshare.com/articles/journal_contribution/Genomic_sequences_of_the_repeated_fragments_/25148004

الاتاحة: https://doi.org/10.1371/journal.pgen.1010527.s001
https://figshare.com/articles/journal_contribution/Genomic_sequences_of_the_repeated_fragments_/25148004

المؤلفون: Elena Sapède, Neal Sugawara, Randall G. Tyers, Yuko Nakajima, Mosammat Faria Afreen, Jesselin Romero Escobar, James E. Haber

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Biological Sciences not elsewhere classified, unequally spaced heterologies, div >< p, double strand break, dna sequencing analysis, 3 ’ end, saccharomyces cerevisiae <, δ double mutant, strand annealing activity, fa tailless strains, strand annealing, spacer dna, natural 3, annealed strand, tailless strains, tailless construct, ura3 <, uniform repair, top3 helicase, stranded tails, spectrum seen, significant reduction, sequences separated, sequence opposite

Relation: https://figshare.com/articles/journal_contribution/Comparison_of_inducible_and_constitutive_DSBs_/25148007

الاتاحة: https://doi.org/10.1371/journal.pgen.1010527.s002
https://figshare.com/articles/journal_contribution/Comparison_of_inducible_and_constitutive_DSBs_/25148007

المؤلفون: Elena Sapède, Neal Sugawara, Randall G. Tyers, Yuko Nakajima, Mosammat Faria Afreen, Jesselin Romero Escobar, James E. Haber

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Biological Sciences not elsewhere classified, unequally spaced heterologies, div >< p, double strand break, dna sequencing analysis, 3 ’ end, saccharomyces cerevisiae <, δ double mutant, strand annealing activity, fa tailless strains, strand annealing, spacer dna, natural 3, annealed strand, tailless strains, tailless construct, ura3 <, uniform repair, top3 helicase, stranded tails, spectrum seen, significant reduction, sequences separated, sequence opposite

Relation: https://figshare.com/articles/journal_contribution/Primers_to_assembly_gRNAs_/25148022

الاتاحة: https://doi.org/10.1371/journal.pgen.1010527.s007
https://figshare.com/articles/journal_contribution/Primers_to_assembly_gRNAs_/25148022

المؤلفون: Elena Sapède, Neal Sugawara, Randall G. Tyers, Yuko Nakajima, Mosammat Faria Afreen, Jesselin Romero Escobar, James E. Haber

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Biological Sciences not elsewhere classified, unequally spaced heterologies, div >< p, double strand break, dna sequencing analysis, 3 ’ end, saccharomyces cerevisiae <, δ double mutant, strand annealing activity, fa tailless strains, strand annealing, spacer dna, natural 3, annealed strand, tailless strains, tailless construct, ura3 <, uniform repair, top3 helicase, stranded tails, spectrum seen, significant reduction, sequences separated, sequence opposite

Relation: https://figshare.com/articles/journal_contribution/PCR_assay_of_colonies_to_assess_completion_of_SSA_/25148010

الاتاحة: https://doi.org/10.1371/journal.pgen.1010527.s003
https://figshare.com/articles/journal_contribution/PCR_assay_of_colonies_to_assess_completion_of_SSA_/25148010

المؤلفون: Elena Sapède, Neal Sugawara, Randall G. Tyers, Yuko Nakajima, Mosammat Faria Afreen, Jesselin Romero Escobar, James E. Haber

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Biological Sciences not elsewhere classified, unequally spaced heterologies, div >< p, double strand break, dna sequencing analysis, 3 ’ end, saccharomyces cerevisiae <, δ double mutant, strand annealing activity, fa tailless strains, strand annealing, spacer dna, natural 3, annealed strand, tailless strains, tailless construct, ura3 <, uniform repair, top3 helicase, stranded tails, spectrum seen, significant reduction, sequences separated, sequence opposite

Relation: https://figshare.com/articles/journal_contribution/Oligos_and_primers_/25148019

الاتاحة: https://doi.org/10.1371/journal.pgen.1010527.s006
https://figshare.com/articles/journal_contribution/Oligos_and_primers_/25148019

المؤلفون: Elena Sapède, Neal Sugawara, Randall G. Tyers, Yuko Nakajima, Mosammat Faria Afreen, Jesselin Romero Escobar, James E. Haber

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Biological Sciences not elsewhere classified, unequally spaced heterologies, div >< p, double strand break, dna sequencing analysis, 3 ’ end, saccharomyces cerevisiae <, δ double mutant, strand annealing activity, fa tailless strains, strand annealing, spacer dna, natural 3, annealed strand, tailless strains, tailless construct, ura3 <, uniform repair, top3 helicase, stranded tails, spectrum seen, significant reduction, sequences separated, sequence opposite

Relation: https://figshare.com/articles/journal_contribution/Plasmids_/25148016

الاتاحة: https://doi.org/10.1371/journal.pgen.1010527.s005
https://figshare.com/articles/journal_contribution/Plasmids_/25148016

المؤلفون: Elena Sapède, Neal Sugawara, Randall G. Tyers, Yuko Nakajima, Mosammat Faria Afreen, Jesselin Romero Escobar, James E. Haber

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Molecular Biology, Evolutionary Biology, Biological Sciences not elsewhere classified, unequally spaced heterologies, div >< p, double strand break, dna sequencing analysis, 3 ’ end, saccharomyces cerevisiae <, δ double mutant, strand annealing activity, fa tailless strains, strand annealing, spacer dna, natural 3, annealed strand, tailless strains, tailless construct, ura3 <, uniform repair, top3 helicase, stranded tails, spectrum seen, significant reduction, sequences separated, sequence opposite

Relation: https://figshare.com/articles/journal_contribution/Yeast_strains_/25148013

الاتاحة: https://doi.org/10.1371/journal.pgen.1010527.s004
https://figshare.com/articles/journal_contribution/Yeast_strains_/25148013

المؤلفون: Laursen, Louise, Kliche, Johanna, Gianni, Stefano, Jemth, Per

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 117(39):24294-24304

مصطلحات موضوعية: allostery, protein interactions, double-mutant cycle, kinetics, supertertiary structure

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-424583
https://doi.org/10.1073/pnas.2007201117
https://uu.diva-portal.org/smash/get/diva2:1501844/FULLTEXT01.pdf

المؤلفون: Zhijie Chen, Yu Fu, Shimeng Liu, Xinyu Huang, Xiaoting Kong, Zhaojie Mao, Ning Hu, Fengxiang Zhang, Caijing Han

المصدر: Heliyon, Vol 9, Iss 2, Pp e13133- (2023)

مصطلحات موضوعية: Aspartokinase, Double mutant, Site-directed mutation, MST, MD, Mechanism, Science (General), Q1-390, Social sciences (General), H1-99

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844023003407; https://doaj.org/toc/2405-8440

URL الوصول: https://doaj.org/article/75565499114344beb99c251af9bc5c29

المؤلفون: Pavia-Collado, Rubén, Cóppola-Segovia, Valentín, Miquel-Rio, Lluis, Alarcón-Arís, Diana, Rodríguez-Aller, Raquel, Torres López, María, Bortolozzi, Analia

المساهمون: Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica

مصطلحات موضوعية: α-synuclein, Antisense oligonucleotide, Dopamine neurotransmission, Double mutant A30P*A53T, Motor deficits, Parkinson’s disease, Transgenic mouse model

Relation: International Journal of Molecular Sciences, 22 (6), 1-20.; https://idus.us.es/handle//11441/149281

الاتاحة: https://idus.us.es/handle//11441/149281

المؤلفون: Nardella, Caterina, Pagano, Livia, Pennacchietti, Valeria, Felice, Mariana Di, Matteo, Sara Di, Diop, Awa, Malagrinò, Francesca, Marcocci, Lucia, Pietrangeli, Paola, Gianni, Stefano, Toto, Angelo

المساهمون: Nardella, Caterina, Pagano, Livia, Pennacchietti, Valeria, Felice, Mariana Di, Matteo, Sara Di, Diop, Awa, Malagrinò, Francesca, Marcocci, Lucia, Pietrangeli, Paola, Gianni, Stefano, Toto, Angelo

مصطلحات موضوعية: Gab2, SHP2, binding, double mutant cycle, kinetic, protein-protein interaction

Relation: info:eu-repo/semantics/altIdentifier/pmid/37468946; info:eu-repo/semantics/altIdentifier/wos/WOS:001040354200001; volume:32; issue:8; journal:PROTEIN SCIENCE; https://hdl.handle.net/11573/1685968; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85166371265

الاتاحة: https://hdl.handle.net/11573/1685968
https://doi.org/10.1002/pro.4729

المؤلفون: Sami Ben Aoun, Sheikh Muhammad Ibrahim

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Ecology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequent double mutant, possesses remarkable stability, original prosthetic group, functionalizations upon substitution, distinctive overall structure, creating smart biomaterials, corresponding cd spectra, coordinating alanine residue, artificial prosthetic group, 98 ° c, less protoporphyrin derivative, thermus thermophilus <, engineered cytochrome proteins, div >< p, >< sub xmlns, ultimately encouraged reconstitution, cytochrome c (<, natural heme species, axial ligands followed, artificial c

Relation: https://figshare.com/articles/journal_contribution/Supplementary_material_/24536445

الاتاحة: https://doi.org/10.1371/journal.pone.0293972.s001
https://figshare.com/articles/journal_contribution/Supplementary_material_/24536445