المؤلفون: Jack A. Terrett (1318581), Huifen Chen (1551313), Daniel G. Shore (1970782), Elisia Villemure (1833463), Robin Larouche-Gauthier (2095915), Martin Déry (1643473), Francis Beaumier (2097292), Léa Constantineau-Forget (4011557), Chantal Grand-Maître (1957834), Luce Lépissier (10340111), Stéphane Ciblat (10340114), Claudio Sturino (1912390), Yong Chen (109188), Baihua Hu (1600627), Aijun Lu (2312614), Yunli Wang (3091296), Andrew P. Cridland (2343910), Stuart I. Ward (2065105), David H. Hackos (10270058), Rebecca M. Reese (5094347), Shannon D. Shields (10270049), Jun Chen (4238), Alessia Balestrini (10340117), Lorena Riol-Blanco (1343064), Wyne P. Lee (3709543), John Liu (542229), Eric Suto (5550128), Xiumin Wu (3709537), Juan Zhang (48597), Justin Q. Ly (5094341), Hank La (438084), Kevin Johnson (684369), Matt Baumgardner (2069512), Kang-Jye Chou (2820169), Alexis Rohou (10340120), Lionel Rougé (4672339), Brian S. Safina (1429774), Steven Magnuson (1698004), Matthew Volgraf (1845592)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Physiology, Pharmacology, Biotechnology, Ecology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, rat AITC-induced pain assay, Ankyrin 1, novel tetrahydrofuran-based linker, Tetrahydrofuran-Based Transient Rec., nonselective calcium-permeable ion ., polymodal sensor, Rodent Asthma Model, Cryogenic Electron Microscopy Trans., TRPA 1 channel, molecule antagonists, compound 20, compound 21, neuropathic pain, vivo target engagement, physicochemical properties, binding site, bioavailable TRPA 1, dose-dependent reduction

Relation: https://figshare.com/articles/journal_contribution/Tetrahydrofuran-Based_Transient_Receptor_Potential_Ankyrin_1_TRPA1_Antagonists_Ligand-Based_Discovery_Activity_in_a_Rodent_Asthma_Model_and_Mechanism-of-Action_via_Cryogenic_Electron_Microscopy/14258939

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02023.s001

المؤلفون: Daseul Kim (11530083), Ki-young Kim (11530086)

مصطلحات موضوعية: Microbiology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, without directly reducing, crystal violet assay, associated genes (<, 5 &# 956, 25 &# 956, extract completely blocked, dose dependently reduce, hedera rhombea <, dimorphic transition assay, >, thereby increases, dose dependent reduction, tropicalis var <, parapsilosis var <, fungal infections worldwide, fungal growth assay, fungal biofilm formation, biofilm formation inhibition, extract showed inhibition

Relation: https://figshare.com/articles/figure/Inhibition_of_i_Canddia_i_spp_biofilm_formation_by_i_H_i_i_rhombea_i_extract_/16754214

الاتاحة: https://doi.org/10.1371/journal.pone.0258108.g001

المؤلفون: Daseul Kim (11530083), Ki-young Kim (11530086)

مصطلحات موضوعية: Microbiology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, without directly reducing, crystal violet assay, associated genes (<, 5 &# 956, 25 &# 956, extract completely blocked, dose dependently reduce, hedera rhombea <, dimorphic transition assay, >, thereby increases, dose dependent reduction, tropicalis var <, parapsilosis var <, fungal infections worldwide, fungal growth assay, fungal biofilm formation, biofilm formation inhibition, extract showed inhibition

Relation: https://figshare.com/articles/dataset/S1_Data_-/16754211

الاتاحة: https://doi.org/10.1371/journal.pone.0258108.s001

المؤلفون: Daseul Kim (11530083), Ki-young Kim (11530086)

مصطلحات موضوعية: Microbiology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, without directly reducing, crystal violet assay, associated genes (<, 5 &# 956, 25 &# 956, extract completely blocked, dose dependently reduce, hedera rhombea <, dimorphic transition assay, >, thereby increases, dose dependent reduction, tropicalis var <, parapsilosis var <, fungal infections worldwide, fungal growth assay, fungal biofilm formation, biofilm formation inhibition, extract showed inhibition

Relation: https://figshare.com/articles/figure/_i_H_i_i_rhombea_i_extracts_increased_the_susceptibility_of_i_C_i_i_albicans_i_to_miconazole_etc_/16754217

الاتاحة: https://doi.org/10.1371/journal.pone.0258108.g002

المؤلفون: Daseul Kim (11530083), Ki-young Kim (11530086)

مصطلحات موضوعية: Microbiology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, without directly reducing, crystal violet assay, associated genes (<, 5 &# 956, 25 &# 956, extract completely blocked, dose dependently reduce, hedera rhombea <, dimorphic transition assay, >, thereby increases, dose dependent reduction, tropicalis var <, parapsilosis var <, fungal infections worldwide, fungal growth assay, fungal biofilm formation, biofilm formation inhibition, extract showed inhibition

Relation: https://figshare.com/articles/figure/_i_H_i_i_rhombea_i_extract_inhibited_adhesion_of_C_albicans_to_HaCaT_cells_/16754223

الاتاحة: https://doi.org/10.1371/journal.pone.0258108.g004

المؤلفون: Daseul Kim (11530083), Ki-young Kim (11530086)

مصطلحات موضوعية: Microbiology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, without directly reducing, crystal violet assay, associated genes (<, 5 &# 956, 25 &# 956, extract completely blocked, dose dependently reduce, hedera rhombea <, dimorphic transition assay, >, thereby increases, dose dependent reduction, tropicalis var <, parapsilosis var <, fungal infections worldwide, fungal growth assay, fungal biofilm formation, biofilm formation inhibition, extract showed inhibition

Relation: https://figshare.com/articles/figure/Inhibition_of_i_C_i_i_albicans_i_dimorphic_transition_by_i_H_i_i_rhombea_i_extract_in_different_hyphal-inducing_media_/16754220

الاتاحة: https://doi.org/10.1371/journal.pone.0258108.g003

المؤلفون: Daseul Kim (11530083), Ki-young Kim (11530086)

مصطلحات موضوعية: Microbiology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, without directly reducing, crystal violet assay, associated genes (<, 5 &# 956, 25 &# 956, extract completely blocked, dose dependently reduce, hedera rhombea <, dimorphic transition assay, >, thereby increases, dose dependent reduction, tropicalis var <, parapsilosis var <, fungal infections worldwide, fungal growth assay, fungal biofilm formation, biofilm formation inhibition, extract showed inhibition

Relation: https://figshare.com/articles/figure/_i_H_i_i_rhombea_i_extract_inhibited_the_expression_of_genes_related_to_biofilm_formation_and_virulence_of_i_C_i_i_albicans_i_/16754226

الاتاحة: https://doi.org/10.1371/journal.pone.0258108.g005

المؤلفون: Daseul Kim (11530083), Ki-young Kim (11530086)

مصطلحات موضوعية: Microbiology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, without directly reducing, crystal violet assay, associated genes (<, 5 &# 956, 25 &# 956, extract completely blocked, dose dependently reduce, hedera rhombea <, dimorphic transition assay, >, thereby increases, dose dependent reduction, tropicalis var <, parapsilosis var <, fungal infections worldwide, fungal growth assay, fungal biofilm formation, biofilm formation inhibition, extract showed inhibition

Relation: https://figshare.com/articles/figure/_i_H_i_i_rhombea_i_extract_did_not_show_any_toxicity_against_the_human_skin_cells_/16754229

الاتاحة: https://doi.org/10.1371/journal.pone.0258108.g006

المؤلفون: Daseul Kim (11530083), Ki-young Kim (11530086)

مصطلحات موضوعية: Microbiology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, without directly reducing, crystal violet assay, associated genes (<, 5 &# 956, 25 &# 956, extract completely blocked, dose dependently reduce, hedera rhombea <, dimorphic transition assay, >, thereby increases, dose dependent reduction, tropicalis var <, parapsilosis var <, fungal infections worldwide, fungal growth assay, fungal biofilm formation, biofilm formation inhibition, extract showed inhibition

Relation: https://figshare.com/articles/figure/_i_H_i_i_rhombea_i_extract_did_not_inhibit_the_growth_of_i_C_i_i_albicans_i_/16754232

الاتاحة: https://doi.org/10.1371/journal.pone.0258108.g007

المؤلفون: Daseul Kim (11530083), Ki-young Kim (11530086)

مصطلحات موضوعية: Microbiology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, without directly reducing, crystal violet assay, associated genes (<, 5 &# 956, 25 &# 956, extract completely blocked, dose dependently reduce, hedera rhombea <, dimorphic transition assay, >, thereby increases, dose dependent reduction, tropicalis var <, parapsilosis var <, fungal infections worldwide, fungal growth assay, fungal biofilm formation, biofilm formation inhibition, extract showed inhibition

Relation: https://figshare.com/articles/dataset/Strains_used_in_this_study_/16754238

الاتاحة: https://doi.org/10.1371/journal.pone.0258108.t001

المؤلفون: Daseul Kim (11530083), Ki-young Kim (11530086)

مصطلحات موضوعية: Microbiology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, without directly reducing, crystal violet assay, associated genes (<, 5 &# 956, 25 &# 956, extract completely blocked, dose dependently reduce, hedera rhombea <, dimorphic transition assay, >, thereby increases, dose dependent reduction, tropicalis var <, parapsilosis var <, fungal infections worldwide, fungal growth assay, fungal biofilm formation, biofilm formation inhibition, extract showed inhibition

Relation: https://figshare.com/articles/dataset/Primers_for_i_C_i_i_albicans_i_genes_used_in_this_study_/16754241

الاتاحة: https://doi.org/10.1371/journal.pone.0258108.t002

المؤلفون: Jack A. Terrett (1318581), Huifen Chen (1551313), Daniel G. Shore (1970782), Elisia Villemure (1833463), Robin Larouche-Gauthier (2095915), Martin Déry (1643473), Francis Beaumier (2097292), Léa Constantineau-Forget (4011557), Chantal Grand-Maître (1957834), Luce Lépissier (10340111), Stéphane Ciblat (10340114), Claudio Sturino (1912390), Yong Chen (109188), Baihua Hu (1600627), Aijun Lu (2312614), Yunli Wang (3091296), Andrew P. Cridland (2343910), Stuart I. Ward (2065105), David H. Hackos (10270058), Rebecca M. Reese (5094347), Shannon D. Shields (10270049), Jun Chen (4238), Alessia Balestrini (10340117), Lorena Riol-Blanco (1343064), Wyne P. Lee (3709543), John Liu (542229), Eric Suto (5550128), Xiumin Wu (3709537), Juan Zhang (48597), Justin Q. Ly (5094341), Hank La (438084), Kevin Johnson (684369), Matt Baumgardner (2069512), Kang-Jye Chou (2820169), Alexis Rohou (10340120), Lionel Rougé (4672339), Brian S. Safina (1429774), Steven Magnuson (1698004), Matthew Volgraf (1845592)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Physiology, Pharmacology, Biotechnology, Ecology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, rat AITC-induced pain assay, Ankyrin 1, novel tetrahydrofuran-based linker, Tetrahydrofuran-Based Transient Rec., nonselective calcium-permeable ion ., polymodal sensor, Rodent Asthma Model, Cryogenic Electron Microscopy Trans., TRPA 1 channel, molecule antagonists, compound 20, compound 21, neuropathic pain, vivo target engagement, physicochemical properties, binding site, bioavailable TRPA 1, dose-dependent reduction

Relation: https://figshare.com/articles/dataset/Tetrahydrofuran-Based_Transient_Receptor_Potential_Ankyrin_1_TRPA1_Antagonists_Ligand-Based_Discovery_Activity_in_a_Rodent_Asthma_Model_and_Mechanism-of-Action_via_Cryogenic_Electron_Microscopy/14258942

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02023.s002