المؤلفون: Shengting Deng, Weiguang Yang, Chengkun Fang, Haosheng He, Jiamin Liu, Rejun Fang

المصدر: Animal Nutrition, Vol 19, Iss , Pp 25-40 (2024)

مصطلحات موضوعية: Iron dextran, Weaned piglet, Divalent metal transporter 1, Glucose transporter 5, Intestinal iron absorption, Animal culture, SF1-1100

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405654524001008; https://doaj.org/toc/2405-6545

URL الوصول: https://doaj.org/article/d3ce1d4701014cfbac5fe7f9ff815773

المؤلفون: Francesca Fenaroli, Alessandra Valerio, Rosaria Ingrassia

المصدر: Biomolecules, Vol 14, Iss 7, p 856 (2024)

مصطلحات موضوعية: in vitro ischemia, insulin neuroprotection, oxygen glucose deprivation (OGD), divalent metal transporter 1 (DMT1), ferroptosis, neurodegeneration, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/7/856; https://doaj.org/toc/2218-273X

URL الوصول: https://doaj.org/article/8b6cb05bb1e844b48839f23042e4e8d1

المؤلفون: Yasumasa Okazaki

المصدر: Journal of Clinical Biochemistry and Nutrition. 2024, 74(1):1

المؤلفون: Sahar Youssef Al-Okbi, Hoda Bakr Mabrok, Enas Sabry K Al-Siedy, Rasha Salah Mohamed, Asmaa Abdelmohsen Ramadan

المصدر: Journal of HerbMed Pharmacology, Vol 11, Iss 1, Pp 63-74 (2022)

مصطلحات موضوعية: parkinson′s disease, iron status, immune system, divalent metal transporter 1‎, dopamine receptors d1‎, nutraceuticals, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://herbmedpharmacol.com/PDF/jhp-11-63.pdf; https://doaj.org/toc/2345-5004

URL الوصول: https://doaj.org/article/8a09ad9465be4418a8bbf5d5c21d4466

المؤلفون: Hounjet, Judith, Groot, Arjan J., Piepers, Jolanda P., Kranenburg, Onno, Zwijnenburg, Danny A., Rapino, Francesca A., Koster, Jan B., Kampen, Kim R., Vooijs, Marc A.

المساهمون: Lab Translational Oncology, Cancer, Regenerative Medicine and Stem Cells

مصطلحات موضوعية: divalent metal transporter 1 (Dmt1, Slc11A2, NRAMP2), iron, notch, stem cell fate and differentiation, vesicles, Biochemistry, Molecular Biology, Cell Biology

وصف الملف: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/450840

الاتاحة: https://dspace.library.uu.nl/handle/1874/450840

المؤلفون: Peng, Wilson, Chung, Kaitlin B, Lawrence, B Paige, O'Banion, M Kerry, Dirksen, Robert T, Wojtovich, Andrew P, Onukwufor, John O

المصدر: Free Radic Biol Med ; ISSN:1873-4596 ; Volume:224

مصطلحات موضوعية: Aβ proteotoxicity, Bioenergetics, Divalent metal transporter 1, Ferroptosis, Oxidative stress

Relation: https://doi.org/10.1016/j.freeradbiomed.2024.09.034; https://pubmed.ncbi.nlm.nih.gov/39317269; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568904/

الاتاحة: https://doi.org/10.1016/j.freeradbiomed.2024.09.034
https://pubmed.ncbi.nlm.nih.gov/39317269
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568904/

المؤلفون: Frank Thévenod, Wing-Kee Lee, Michael D. Garrick

المصدر: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

مصطلحات موضوعية: reactive oxygen species, divalent metal transporter 1, ionic mimicry, manganese, copper, nephrotoxicity, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.687810/full; https://doaj.org/toc/2296-634X

URL الوصول: https://doaj.org/article/b78868c5b27343eeba5d800f096b8d55

المؤلفون: Xingzhi Jing, Jiamin Lin, Ting Du, Zhensong Jiang, Tao Li, Guodong Wang, Xiaoyang Liu, Xingang Cui, Kai Sun

المصدر: Frontiers in Cell and Developmental Biology, Vol 8 (2021)

مصطلحات موضوعية: iron overload, osteoarthritis, divalent metal transporter 1 (DMT1), inflammation, chondrocyte, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2020.594509/full; https://doaj.org/toc/2296-634X

URL الوصول: https://doaj.org/article/7d4c893e2901437897cce58eb9fc900a

المؤلفون: Chenyi Yang, Zhengyuan Xia, Tang Li, Yimeng Chen, Mingshu Zhao, Yi Sun, Ji Ma, Yi Wu, Xinyue Wang, Peng Wang, Haiyun Wang

المصدر: Frontiers in Oncology, Vol 10 (2020)

مصطلحات موضوعية: glioma, propofol, divalent metal transporter 1, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor, oxidative stress, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2020.590931/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/798ba67eb99e4ae5bf5c8cb840304773

المؤلفون: Frank Thévenod, Wing-Kee Lee, Michael D. Garrick

المصدر: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

مصطلحات موضوعية: reactive oxygen species, divalent metal transporter 1, ionic mimicry, manganese, copper, nephrotoxicity, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2020.00848/full; https://doaj.org/toc/2296-634X

URL الوصول: https://doaj.org/article/cd6f762e09be4ecfa56e0b8a1aba102d

المؤلفون: Yasumasa Okazaki, Jonathan Glass

المصدر: Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 26-31 (2017)

مصطلحات موضوعية: Peripheral-type benzodiazepine receptor (PBR)-associated protein 7 (PAP7), Divalent metal transporter 1 (DMT1), Peripheral-type benzodiazepine receptor (PBR), Protoporphyrin IX, Iron metabolism, Biology (General), QH301-705.5, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405580816303041; https://doaj.org/toc/2405-5808

URL الوصول: https://doaj.org/article/90d6feb217fd42ca913e63a51594da15

المؤلفون: Katarzyna Skrypnik, Paweł Bogdański, Magdalena Sobieska, Joanna Suliburska

المصدر: Molecules; Volume 25; Issue 7; Pages: 1674

مصطلحات موضوعية: probiotic supplementation, iron, hepcidin, erythroferrone, divalent metal transporter 1, transferrin receptor

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/molecules25071674

الاتاحة: https://doi.org/10.3390/molecules25071674

المؤلفون: Rosaria Ingrassia, Barbara Garavaglia, Maurizio Memo

المصدر: Frontiers in Neuroscience, Vol 13 (2019)

مصطلحات موضوعية: iron homoeostasis, neurodegenerative diseases, aging, transport of iron and heavy metals, divalent metal transporter 1 up-regulation, non-transferrin bound iron transport, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2019.00575/full; https://doaj.org/toc/1662-453X

URL الوصول: https://doaj.org/article/f5556176483b4e799699363dd7206385

المؤلفون: Wuyun, Gerile, Hu, Yang, He, Zihong, Li, Yanchun, Yan, Xu

مصطلحات موضوعية: 0604 Genetics, Institute for Health and Sport, divalent metal transporter 1, DMT1, runners, restriction fragment length polymorphism, PCR-RFLP, molecular marker

وصف الملف: text

Relation: https://vuir.vu.edu.au/40310/; https://vuir.vu.edu.au/40310/1/7064703.pdf; Wuyun, Gerile, Hu, Yang, He, Zihong, Li, Yanchun and Yan, Xu orcid:0000-0001-8547-4210 (2019) The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners. International Journal of Genomics, 2019. ISSN 2314-436X

الاتاحة: https://vuir.vu.edu.au/40310/
https://www.hindawi.com/journals/ijg/2019/7064703/
https://doi.org/10.1155/2019/7064703
https://vuir.vu.edu.au/40310/1/7064703.pdf

المؤلفون: Juan Tian, Wei Zheng, Xin-Lu Li, Yuan-Hong Cui, Zhan-You Wang

المصدر: Frontiers in Aging Neuroscience, Vol 10 (2018)

مصطلحات موضوعية: Alzheimer’s disease, β-amyloid, Nedd4 family interacting protein 1 (Ndfip1), divalent metal transporter 1 (DMT1), iron metabolism, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnagi.2018.00165/full; https://doaj.org/toc/1663-4365

URL الوصول: https://doaj.org/article/89ec2c79aecd4b0aa20c5acd30d0c2fc

المؤلفون: Tian Liu, Wooseok Im, Inhee Mook-Jung, Manho Kim

المصدر: Neural Regeneration Research, Vol 10, Iss 5, Pp 786-791 (2015)

مصطلحات موضوعية: active zone stability, Drosophila, neuromuscular junction, dephosphorylation, Liprin-α, Syd-1, PP2A, GSK-3ß, living scaffolds, neural tissue engineering, cell transplant, biomaterials, regeneration, neurotrauma, neurodegeneration, axon pathfinding, cell migration, injury, plasticity, neurodegenerative disease, brain, therapy, neuron, microglia, neural progenitor, tissue engineering, neuroregeneration, repair, central nervous system, biomaterial, regenerative medicine, nanotechnology, spinal cord injury, axonal regeneration, exosome, extracellular vesicle, microRNA, microvesicle, nerve gap, neurite outgrowth, peripheral nerve injury, Schwann cell, stem cell, hemodynamic phases, cerebral subarachnoid hemorrhage, metabolic crises, nerve regeneration, hypoxic-ischemic brain damage, ginsenoside Rg1, neural stem cells, cell transplantation, cell differentiation, cognition, nerve reconstruction, neural regeneration, brain injury, neuroimaging, functional magnetic resonance imaging, regional homogeneity, apoplexy, subacute, ischemia, participants, healthy, volunteers, brain activity, NSFC grants, neuroprotection, cerebral ischemia/reperfusion injury, lateral intracerebroventricular injection, Apelin-13, nerve apoptosis, Bcl-2, caspase-3, fractalkine, CX3 chemokine receptor 1, neuronal maturation, dendrites, doublecortin, synaptic maturation, newborn neurons, neurodegenerative diseases, Alzheimer′s disease, transgenic animal models, mice, epimedium herb, milkvetch root, kudzuvine root, divalent metal transporter 1, ferroportin 1, microRNA-124, neurogenesis, neuronal survival, Huntington′s disease, SRY-related HMG box transcription factor 9, brain-derived neurotrophic factor, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, mutant huntingtin, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=786;epage=791;aulast=Liu; https://doaj.org/toc/1673-5374

URL الوصول: https://doaj.org/article/0448ee1d67a1402ebda3d3d425a90617

المؤلفون: Hai-jun Gao, Peng-fei Liu, Pei-wen Li, Zhuo-yan Huang, Feng-bo Yu, Ting Lei, Yong Chen, Ye Cheng, Qing-chun Mu, Hai-yan Huang

المصدر: Neural Regeneration Research, Vol 10, Iss 5, Pp 832-840 (2015)

مصطلحات موضوعية: active zone stability, Drosophila, neuromuscular junction, dephosphorylation, Liprin-α, Syd-1, PP2A, GSK-3ß, living scaffolds, neural tissue engineering, cell transplant, biomaterials, regeneration, neurotrauma, neurodegeneration, axon pathfinding, cell migration, injury, plasticity, neurodegenerative disease, brain, therapy, neuron, microglia, neural progenitor, tissue engineering, neuroregeneration, repair, central nervous system, biomaterial, regenerative medicine, nanotechnology, spinal cord injury, axonal regeneration, exosome, extracellular vesicle, microRNA, microvesicle, nerve gap, neurite outgrowth, peripheral nerve injury, Schwann cell, stem cell, hemodynamic phases, cerebral subarachnoid hemorrhage, metabolic crises, nerve regeneration, hypoxic-ischemic brain damage, ginsenoside Rg1, neural stem cells, cell transplantation, cell differentiation, cognition, nerve reconstruction, neural regeneration, brain injury, neuroimaging, functional magnetic resonance imaging, regional homogeneity, apoplexy, subacute, ischemia, participants, healthy, volunteers, brain activity, NSFC grants, neuroprotection, cerebral ischemia/reperfusion injury, lateral intracerebroventricular injection, Apelin-13, nerve apoptosis, Bcl-2, caspase-3, fractalkine, CX3 chemokine receptor 1, neuronal maturation, dendrites, doublecortin, synaptic maturation, newborn neurons, neurodegenerative diseases, Alzheimer′s disease, transgenic animal models, mice, epimedium herb, milkvetch root, kudzuvine root, divalent metal transporter 1, ferroportin 1, microRNA-124, neurogenesis, neuronal survival, Huntington′s disease, SRY-related HMG box transcription factor 9, brain-derived neurotrophic factor, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, mutant huntingtin, Ras/Raf/Erk1/2 signaling pathway, apoptosis, regulation, inhibition, neurogenic bladder, bibliometric analysis, Web of Science database, visualization analysis, CiteSpace III, citation analysis, sciatic nerve injury, autologous nerve grafting, epineurial suturing, three-dimensional finite element models, load, stress, displacement, facial palsy, Bell′s palsy, comparison, methodological quality, fixed effect model, acupuncture, incomplete recovery, randomized controlled trials, electroacupuncture, thalidomide, ankylosing spondylitis, adverse reactions, peripheral neuropathy, prospective study, treatment, dose, treatment time, age, sex, neurological diseases, nerve growth factor, meta-analysis, adverse effects, nerve conduction velocity, ligustrazine, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=832;epage=840;aulast=Gao; https://doaj.org/toc/1673-5374

URL الوصول: https://doaj.org/article/885011d2acd947929edb6238cceaaabb

المؤلفون: Cheng-dong Piao, Kun Yang, Peng Li, Min Luo

المصدر: Neural Regeneration Research, Vol 10, Iss 5, Pp 804-807 (2015)

مصطلحات موضوعية: active zone stability, Drosophila, neuromuscular junction, dephosphorylation, Liprin-α, Syd-1, PP2A, GSK-3ß, living scaffolds, neural tissue engineering, cell transplant, biomaterials, regeneration, neurotrauma, neurodegeneration, axon pathfinding, cell migration, injury, plasticity, neurodegenerative disease, brain, therapy, neuron, microglia, neural progenitor, tissue engineering, neuroregeneration, repair, central nervous system, biomaterial, regenerative medicine, nanotechnology, spinal cord injury, axonal regeneration, exosome, extracellular vesicle, microRNA, microvesicle, nerve gap, neurite outgrowth, peripheral nerve injury, Schwann cell, stem cell, hemodynamic phases, cerebral subarachnoid hemorrhage, metabolic crises, nerve regeneration, hypoxic-ischemic brain damage, ginsenoside Rg1, neural stem cells, cell transplantation, cell differentiation, cognition, nerve reconstruction, neural regeneration, brain injury, neuroimaging, functional magnetic resonance imaging, regional homogeneity, apoplexy, subacute, ischemia, participants, healthy, volunteers, brain activity, NSFC grants, neuroprotection, cerebral ischemia/reperfusion injury, lateral intracerebroventricular injection, Apelin-13, nerve apoptosis, Bcl-2, caspase-3, fractalkine, CX3 chemokine receptor 1, neuronal maturation, dendrites, doublecortin, synaptic maturation, newborn neurons, neurodegenerative diseases, Alzheimer′s disease, transgenic animal models, mice, epimedium herb, milkvetch root, kudzuvine root, divalent metal transporter 1, ferroportin 1, microRNA-124, neurogenesis, neuronal survival, Huntington′s disease, SRY-related HMG box transcription factor 9, brain-derived neurotrophic factor, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, mutant huntingtin, Ras/Raf/Erk1/2 signaling pathway, apoptosis, regulation, inhibition, neurogenic bladder, bibliometric analysis, Web of Science database, visualization analysis, CiteSpace III, citation analysis, sciatic nerve injury, autologous nerve grafting, epineurial suturing, three-dimensional finite element models, load, stress, displacement, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=804;epage=807;aulast=Piao; https://doaj.org/toc/1673-5374

URL الوصول: https://doaj.org/article/70c06e4525af48b6b9e05336113336fd

المؤلفون: Meng Zhao, Xiao-yan Li, Chun-ying Xu, Li-ping Zou

المصدر: Neural Regeneration Research, Vol 10, Iss 5, Pp 819-828 (2015)

مصطلحات موضوعية: active zone stability, Drosophila, neuromuscular junction, dephosphorylation, Liprin-α, Syd-1, PP2A, GSK-3ß, living scaffolds, neural tissue engineering, cell transplant, biomaterials, regeneration, neurotrauma, neurodegeneration, axon pathfinding, cell migration, injury, plasticity, neurodegenerative disease, brain, therapy, neuron, microglia, neural progenitor, tissue engineering, neuroregeneration, repair, central nervous system, biomaterial, regenerative medicine, nanotechnology, spinal cord injury, axonal regeneration, exosome, extracellular vesicle, microRNA, microvesicle, nerve gap, neurite outgrowth, peripheral nerve injury, Schwann cell, stem cell, hemodynamic phases, cerebral subarachnoid hemorrhage, metabolic crises, nerve regeneration, hypoxic-ischemic brain damage, ginsenoside Rg1, neural stem cells, cell transplantation, cell differentiation, cognition, nerve reconstruction, neural regeneration, brain injury, neuroimaging, functional magnetic resonance imaging, regional homogeneity, apoplexy, subacute, ischemia, participants, healthy, volunteers, brain activity, NSFC grants, neuroprotection, cerebral ischemia/reperfusion injury, lateral intracerebroventricular injection, Apelin-13, nerve apoptosis, Bcl-2, caspase-3, fractalkine, CX3 chemokine receptor 1, neuronal maturation, dendrites, doublecortin, synaptic maturation, newborn neurons, neurodegenerative diseases, Alzheimer′s disease, transgenic animal models, mice, epimedium herb, milkvetch root, kudzuvine root, divalent metal transporter 1, ferroportin 1, microRNA-124, neurogenesis, neuronal survival, Huntington′s disease, SRY-related HMG box transcription factor 9, brain-derived neurotrophic factor, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, mutant huntingtin, Ras/Raf/Erk1/2 signaling pathway, apoptosis, regulation, inhibition, neurogenic bladder, bibliometric analysis, Web of Science database, visualization analysis, CiteSpace III, citation analysis, sciatic nerve injury, autologous nerve grafting, epineurial suturing, three-dimensional finite element models, load, stress, displacement, facial palsy, Bell′s palsy, comparison, methodological quality, fixed effect model, acupuncture, incomplete recovery, randomized controlled trials, electroacupuncture, thalidomide, ankylosing spondylitis, adverse reactions, peripheral neuropathy, prospective study, treatment, dose, treatment time, age, sex, neurological diseases, nerve growth factor, meta-analysis, adverse effects, nerve conduction velocity, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=819;epage=828;aulast=Zhao; https://doaj.org/toc/1673-5374

URL الوصول: https://doaj.org/article/82b5243f394d43438676bb882b32723b

المؤلفون: Hong-xia Xue, Wen-yi Fu, Hua-dong Cui, Li-li Yang, Ning Zhang, Li-juan Zhao

المصدر: Neural Regeneration Research, Vol 10, Iss 5, Pp 814-818 (2015)

مصطلحات موضوعية: active zone stability, Drosophila, neuromuscular junction, dephosphorylation, Liprin-α, Syd-1, PP2A, GSK-3ß, living scaffolds, neural tissue engineering, cell transplant, biomaterials, regeneration, neurotrauma, neurodegeneration, axon pathfinding, cell migration, injury, plasticity, neurodegenerative disease, brain, therapy, neuron, microglia, neural progenitor, tissue engineering, neuroregeneration, repair, central nervous system, biomaterial, regenerative medicine, nanotechnology, spinal cord injury, axonal regeneration, exosome, extracellular vesicle, microRNA, microvesicle, nerve gap, neurite outgrowth, peripheral nerve injury, Schwann cell, stem cell, hemodynamic phases, cerebral subarachnoid hemorrhage, metabolic crises, nerve regeneration, hypoxic-ischemic brain damage, ginsenoside Rg1, neural stem cells, cell transplantation, cell differentiation, cognition, nerve reconstruction, neural regeneration, brain injury, neuroimaging, functional magnetic resonance imaging, regional homogeneity, apoplexy, subacute, ischemia, participants, healthy, volunteers, brain activity, NSFC grants, neuroprotection, cerebral ischemia/reperfusion injury, lateral intracerebroventricular injection, Apelin-13, nerve apoptosis, Bcl-2, caspase-3, fractalkine, CX3 chemokine receptor 1, neuronal maturation, dendrites, doublecortin, synaptic maturation, newborn neurons, neurodegenerative diseases, Alzheimer′s disease, transgenic animal models, mice, epimedium herb, milkvetch root, kudzuvine root, divalent metal transporter 1, ferroportin 1, microRNA-124, neurogenesis, neuronal survival, Huntington′s disease, SRY-related HMG box transcription factor 9, brain-derived neurotrophic factor, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, mutant huntingtin, Ras/Raf/Erk1/2 signaling pathway, apoptosis, regulation, inhibition, neurogenic bladder, bibliometric analysis, Web of Science database, visualization analysis, CiteSpace III, citation analysis, sciatic nerve injury, autologous nerve grafting, epineurial suturing, three-dimensional finite element models, load, stress, displacement, facial palsy, Bell′s palsy, comparison, methodological quality, fixed effect model, acupuncture, incomplete recovery, randomized controlled trials, electroacupuncture, thalidomide, ankylosing spondylitis, adverse reactions, peripheral neuropathy, prospective study, treatment, dose, treatment time, age, sex, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=814;epage=818;aulast=Xue; https://doaj.org/toc/1673-5374

URL الوصول: https://doaj.org/article/9ddcd1a07bf649fab9565c8fe840397e