المؤلفون: Chunmei Chen, Lingxiang Xiao, Xiaowei Luo, Jian Cai, Lishan Huang, Huaming Tao, Xuefeng Zhou, Yanhui Tan, Yonghong Liu

مصطلحات موضوعية: Biochemistry, Molecular Biology, Neuroscience, Physiology, Pharmacology, Biotechnology, Ecology, Immunology, Hematology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, targeting antiosteoporosis leads, surface plasmon resonance, relevant mrna expression, potential molecular target, new derivatives showing, induced iκbα degradation, novel potential inhibitor, discover novel osteoclast, potent antiosteoporosis agents, κb p65 could, κb inhibitory activity, osteoporosis via downregulation, 2 , novel inhibitors, vitro <, reduced rankl, potent nf, ovariectomized mice

Relation: https://figshare.com/articles/journal_contribution/Identifying_Marine-Derived_Tanzawaic_Acid_Derivatives_as_Novel_Inhibitors_against_Osteoclastogenesis_and_Osteoporosis_via_Downregulation_of_NF-_B_and_NFATc1_Activation/25130224

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01748.s001
https://figshare.com/articles/journal_contribution/Identifying_Marine-Derived_Tanzawaic_Acid_Derivatives_as_Novel_Inhibitors_against_Osteoclastogenesis_and_Osteoporosis_via_Downregulation_of_NF-_B_and_NFATc1_Activation/25130224

المؤلفون: Ping Li, Han Ju, Yihong Xing, Fabao Zhao, Varada Anirudhan, Ruikun Du, Qinghua Cui, Xinyong Liu, Lijun Rong, Peng Zhan

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, phenotypic screening strategy, molecular docking simulations, moderate inhibitory effects, low acute toxicity, gradually developed resistance, discover novel antivirals, >] pyrazine derivative, identify effective drugs, a4 , 2 , approved drugs, 2 ‑<, 2 -<, viral nucleoprotein, spectrum anti, resistant h1n1, pdm09 strain, nuclear accumulation, new mechanisms

Relation: https://figshare.com/articles/journal_contribution/Identification_of_the_Imidazo_1_2_i_a_i_pyrazine_Derivative_b_A4_b_as_a_Potential_Influenza_Virus_Nucleoprotein_Inhibitor/24585060

الاتاحة: https://doi.org/10.1021/acsptsci.3c00174.s001
https://figshare.com/articles/journal_contribution/Identification_of_the_Imidazo_1_2_i_a_i_pyrazine_Derivative_b_A4_b_as_a_Potential_Influenza_Virus_Nucleoprotein_Inhibitor/24585060

المؤلفون: Ruirui Feng, Bo Sun, Shengkai Zhang, Erzheng Su, Andrey Kovalevsky, Feng Zhang, Brad C. Bennett, Qirong Shen, Qun Wan

مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, 6 mg l, 2 mg l, rhizoctonia solani <, discovered eight compounds, higher antifungal activity, discover novel inhibitors, 50 , solani <, antifungal activity, vitro <, 2 μm, antifungal drugs, dhfr inhibitors, study exemplifies, results suggest, potential fungicide, known target, fungal pathogen, folate pathway, essential enzyme, documented fungicide, aided method, 7 μm

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Novel_i_Rhizoctonia_solani_i_DHFR_Inhibitors_as_Fungicides_Using_Virtual_Screening/24711645

الاتاحة: https://doi.org/10.1021/acs.jafc.3c05216.s001
https://figshare.com/articles/journal_contribution/Discovery_of_Novel_i_Rhizoctonia_solani_i_DHFR_Inhibitors_as_Fungicides_Using_Virtual_Screening/24711645

المؤلفون: Neng Jiang, Di Su, De Chen, Shutong Huang, Chunli Tang, Lin Jing, Caiyan Yang, Zhongbo Zhou, Zhiming Yan, Jing Han

مصطلحات موضوعية: Biochemistry, Genetics, Neuroscience, Physiology, Pharmacology, Biotechnology, Science Policy, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, exhibited superior effects, glucagon receptor agonists, glucagon receptor agonist, 4b , 3o , 2f , selected dual glp, discovering potent glp, potent analogue called, designing multiagonists presents, body weight compared, 1 receptor agonists, utilizing natural glp, discover novel glp, novel glucagon, body weight, designing glp, natural sources, based multiagonists, triple glp

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_a_Novel_Glucagon-like_Peptide_1_GLP-1_Analogue_from_Bullfrog_and_Investigation_of_Its_Potential_for_Designing_GLP-1-Based_Multiagonists/24878499

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01049.s001
https://figshare.com/articles/journal_contribution/Discovery_of_a_Novel_Glucagon-like_Peptide_1_GLP-1_Analogue_from_Bullfrog_and_Investigation_of_Its_Potential_for_Designing_GLP-1-Based_Multiagonists/24878499

المؤلفون: Suhyeorn Park, Jiayi Fan, Srinivas Chamakuri, Murugesan Palaniappan, Kiran Sharma, Xuan Qin, Jian Wang, Zhi Tan, Allison Judge, Liya Hu, Banumathi Sankaran, Feng Li, B. V. Venkataram Prasad, Martin M. Matzuk, Timothy Palzkill

مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, enzyme recognition element, substrate binding information, binding pocket present, lactamases cause resistance, encoded chemical library, 6 , lactamase enzymes hydrolyze, discover novel β, binding pocket, novel non, lactamase inhibitors, work demonstrates, utilized dna, resort β, nanomolar potency, mechanistic classes, lactam pharmacophores, lactam class, inhibitor identification, increased potencies, important β, focused dna, different structural

Relation: https://figshare.com/articles/journal_contribution/Exploiting_the_Carboxylate-Binding_Pocket_of_Lactamase_Enzymes_Using_a_Focused_DNA-Encoded_Chemical_Library/24879129

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01834.s001
https://figshare.com/articles/journal_contribution/Exploiting_the_Carboxylate-Binding_Pocket_of_Lactamase_Enzymes_Using_a_Focused_DNA-Encoded_Chemical_Library/24879129

المؤلفون: Ruige Yang (5860649), Zhiyan Liu (6323807), Meiyue Han (11331612), Liping Cui (6285278), Yong Guo (169213)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Ecology, Infectious Diseases, Chemical Sciences not elsewhere classified, three insect pests, possessed good selectivity, myzus persicae sulzer, mythimna separata walker, control efficacy assay, 3 ′ position, insecticidal assay showed, botanical insecticide toosendanin, discover novel natural, b25 , b24 , b23 , b19 , promising aphicidal effect, potent larvicidal activity, potent growth inhibitory, based insecticide candidates, >- benzoylthioureas could, spectrum insecticidal effect, plutella xylostella linnaeus, 50 , >- benzoylthioureas displayed, insecticide candidates, >- benzoylthioureas

Relation: https://figshare.com/articles/journal_contribution/Preparation_and_Biological_Evaluation_of_Novel_Osthole-Derived_i_N_i_Benzoylthioureas_as_Insecticide_Candidates/21713914

الاتاحة: https://doi.org/10.1021/acs.jafc.2c06558.s001

المؤلفون: Yatao Shi (6443357), Zihui Li (1494571), Bin Wang (30851), Xudong Shi (526101), Hui Ye (164331), Daniel G. Delafield (7339400), Langlang Lv (9930291), Zhengqing Ye (9981076), Zhengwei Chen (1572697), Fengfei Ma (5124818), Lingjun Li (548329)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Physiology, Biotechnology, Developmental Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, various biological processes, perform global mapping, largest data set, enabling global analysis, discover novel distribution, biotin thiol tag, affects protein structures, protein citrullination, translational modification, study depicts, pathological roles, mouse tissues, key post, enables derivatization, effective tools, disease pathogenesis, confident identification, citrullination proteome, 432 proteins

Relation: https://figshare.com/articles/journal_contribution/Enabling_Global_Analysis_of_Protein_Citrullination_via_Biotin_Thiol_Tag-Assisted_Mass_Spectrometry/21717997

الاتاحة: https://doi.org/10.1021/acs.analchem.2c03844.s001

المؤلفون: Tingjunhong Ni (9044270), Fei Xie (437662), Yumeng Hao (13196933), Liping Li (120326), Shuo Zhu (452284), Hao Wu (65943), Xiaochen Chi (13196930), Lan Yan (358053), Yuanying Jiang (2470117), Dazhi Zhang (702709)

مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Science Policy, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, triazole side chains, mice systematically infected, discover novel triazoles, cryptococcus neoformans h99, click reaction based, aspergillus fumigatus 7544, acceptable safety profile, 1 month induction, spectrum antifungal activity, improved antifungal activity, resistant fungal ability, displayed excellent antifungal, compounds showed moderate, candida albicans sc5314, 80 , induce drug resistance, biofilm activity, resistance assay, showed powerful, showed better, synthesized via

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Novel_Orally_Bioavailable_Triazoles_with_Potent_and_Broad-Spectrum_Antifungal_Activity_In_Vitro_and_In_Vivo/21720128

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01497.s002

المؤلفون: Patrick C. Barko (10668358), David A. Williams (7167674)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Biotechnology, Ecology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tandem mass spectroscopy, promising analytic methodology, polyunsaturated fatty acids, peripheral adipose stores, performance liquid chromatography, discover novel aspects, clinical disease syndromes, chain fatty acids, amino acid derivatives, enteric microbial dysbiosis, amino acid metabolites, microbial metabolites indicate, mevalonate pathway intermediates, 8 healthy controls, use untargeted analysis, microbial metabolites, mevalonate pathway, healthy controls, untargeted analysis, untargeted quantification

Relation: https://figshare.com/articles/journal_contribution/Comparison_of_imputation_methods_for_missing_values_/16711151

الاتاحة: https://doi.org/10.1371/journal.pone.0257856.s001

المؤلفون: Patrick C. Barko (10668358), David A. Williams (7167674)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Biotechnology, Ecology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tandem mass spectroscopy, promising analytic methodology, polyunsaturated fatty acids, peripheral adipose stores, performance liquid chromatography, discover novel aspects, clinical disease syndromes, chain fatty acids, amino acid derivatives, enteric microbial dysbiosis, amino acid metabolites, microbial metabolites indicate, mevalonate pathway intermediates, 8 healthy controls, use untargeted analysis, microbial metabolites, mevalonate pathway, healthy controls, untargeted analysis, untargeted quantification

Relation: https://figshare.com/articles/journal_contribution/Tables_of_significantly_altered_lipid_and_amino_acid_metabolites_/16711160

الاتاحة: https://doi.org/10.1371/journal.pone.0257856.s004

المؤلفون: Ayumi Ikenaga (11494127), Yuichi Akiyama (11494130), Tatsuya Ishiyama (1289658), Masayuki Gon (1838797), Kazuo Tanaka (1633378), Yoshiki Chujo (1584643), Kyosuke Isoda (6470681)

مصطلحات موضوعية: Biophysics, Genetics, Pharmacology, Biotechnology, Evolutionary Biology, Immunology, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, various spatiotemporal scales, theoretical studies opens, molecular dynamics simulations, circularly polarized luminescence, chiral alkyl chain, assembled structures led, discover novel phenomena, developed novel room, assembled solid states, novel class, solid state, upon heating, thereby rendering, supramolecular chirality, state change, situ <, responsive n, precursor liquid, new avenue, liquid material

Relation: https://figshare.com/articles/journal_contribution/Stimuli-Responsive_Self-Assembly_of_Conjugated_Liquids_Triggers_Circularly_Polarized_Luminescence/16691786

الاتاحة: https://doi.org/10.1021/acsami.1c13119.s001

المؤلفون: Flavia Marinelli

المساهمون: V. Spiwok, O. Mat’átková, M. Rollová, A. Miškovská, M. Kulišová, L. Paulová, J. Káš, Marinelli, Flavia

مصطلحات موضوعية: Discovery of novel antibiotics has dramatically slowed down. After the ‘golden era’ peaked around 1950s, the number of antibiotics marketed each decade has declined. Conversely, the rapid spread of antibiotic resistance among pathogenic bacteria makes the development of novel drugs compulsory. Notably, ESKAPE pathogens (six multidrug-resistant, nosocomial pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), were recently included by the World Health Organization in the list of the life-threatening disease agents which need to be tackle using new drugs. Many are the factors, which exert a negative impact on the antibiotic discovery rate: from the unease to identify new essential susceptible targets and to discover novel active chemical entities, to the regulatory challenges and the limited economic returns that often discourage pharmaceutical companies from investing into the field. In this post-antibiotic era, the best hope for developing a new generation of antibiotics is to discover novel microbial natural products by combining the classical successful biological activity-guided screening (so called Waksman platform) with the perspectives opened by the new genomic tools for genome mining and for the rational engineering of homologous and heterologous hosts. In this presentation, we focus on the exploitation of these tools for discovering and developing novel and old glycopeptide antibiotics (GPAs) facing the spread of multi-drug resistant gram positives. Genome sequencing has in fact recently revealed the organization of GPA biosynthetic gene clusters in pharmaceutically valuable actinobacteria, including long known GPA-producers, as well as in novel producing strains and metagenomic DNA. In addition, although the global regulation of GPA biosynthesis is still largely unexplored, the pathway specific regulation controlling the expression of BGCs is being elucidated in model systems, paving the way to better understand how to effectively produce GPAs for clinical practice.

Relation: info:eu-repo/semantics/altIdentifier/isbn/978-80-7592-092-8; ispartofbook:Book of abstract of BioTech 2020 & 8th Czech-Swiss Symposium with Exhibition; BioTech 2020 & 8th Czech-Swiss Symposium with Exhibition; firstpage:28; lastpage:28; numberofpages:1; http://hdl.handle.net/11383/2113290

الاتاحة: http://hdl.handle.net/11383/2113290

المؤلفون: Marinelli, Flavia

مصطلحات موضوعية: Acinetobacter baumannii, Staphylococcus aureus, paving the way to better understand how to effectively produce GPAs for clinical practice, the pathway specific regulation controlling the expression of BGCs is being elucidated in model systems, to the regulatory challenges and the limited economic returns that often discourage pharmaceutical companies from investing into the field. In this post-antibiotic era, Discovery of novel antibiotics has dramatically slowed down. After the ‘golden era’ peaked around 1950s, and Enterobacter spp.), nosocomial pathogens: Enterococcus faecium, ESKAPE pathogens (six multidrug-resistant, the best hope for developing a new generation of antibiotics is to discover novel microbial natural products by combining the classical successful biological activity-guided screening (so called Waksman platform) with the perspectives opened by the new genomic tools for genome mining and for the rational engineering of homologous and heterologous hosts. In this presentation, Klebsiella pneumoniae, were recently included by the World Health Organization in the list of the life-threatening disease agents which need to be tackle using new drugs. Many are the factors, as well as in novel producing strains and metagenomic DNA. In addition, which exert a negative impact on the antibiotic discovery rate: from the unease to identify new essential susceptible targets and to discover novel active chemical entities, including long known GPA-producers, Discovery of novel antibiotics has dramatically slowed down. After the ‘golden era’ peaked around 1950s, the number of antibiotics marketed each decade has declined. Conversely, the rapid spread of antibiotic resistance among pathogenic bacteria makes the development of novel drugs compulsory. Notably, ESKAPE pathogens (six multidrug-resistant, nosocomial pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), were recently included by the World Health Organization in the list of the life-threatening disease agents which need to be tackle using new drugs. Many are the factors, which exert a negative impact on the antibiotic discovery rate: from the unease to identify new essential susceptible targets and to discover novel active chemical entities, to the regulatory challenges and the limited economic returns that often discourage pharmaceutical companies from investing into the field. In this post-antibiotic era, the best hope for developing a new generation of antibiotics is to discover novel microbial natural products by combining the classical successful biological activity-guided screening (so called Waksman platform) with the perspectives opened by the new genomic tools for genome mining and for the rational engineering of homologous and heterologous hosts. In this presentation, we focus on the exploitation of these tools for discovering and developing novel and old glycopeptide antibiotics (GPAs) facing the spread of multi-drug resistant gram positives. Genome sequencing has in fact recently revealed the organization of GPA biosynthetic gene clusters in pharmaceutically valuable actinobacteria, including long known GPA-producers, as well as in novel producing strains and metagenomic DNA. In addition, although the global regulation of GPA biosynthesis is still largely unexplored, the pathway specific regulation controlling the expression of BGCs is being elucidated in model systems, paving the way to better understand how to effectively produce GPAs for clinical practice, Pseudomonas aeruginosa, we focus on the exploitation of these tools for discovering and developing novel and old glycopeptide antibiotics (GPAs) facing the spread of multi-drug resistant gram positives. Genome sequencing has in fact recently revealed the organization of GPA biosynthetic gene clusters in pharmaceutically valuable actinobacteria, the number of antibiotics marketed each decade has declined. Conversely, although the global regulation of GPA biosynthesis is still largely unexplored, the rapid spread of antibiotic resistance among pathogenic bacteria makes the development of novel drugs compulsory. Notably

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3660::69e3625ab335f4f5d702897cb03c87fc
http://hdl.handle.net/11383/2113290

المؤلفون: Patrick C. Barko (10668358), David A. Williams (7167674)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Biotechnology, Ecology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tandem mass spectroscopy, promising analytic methodology, polyunsaturated fatty acids, peripheral adipose stores, performance liquid chromatography, discover novel aspects, clinical disease syndromes, chain fatty acids, amino acid derivatives, enteric microbial dysbiosis, amino acid metabolites, microbial metabolites indicate, mevalonate pathway intermediates, 8 healthy controls, use untargeted analysis, microbial metabolites, mevalonate pathway, healthy controls, untargeted analysis, untargeted quantification

Relation: https://figshare.com/articles/dataset/Complete_results_of_Welch_s_test_for_differences_in_metabolite_abundance_/16711154

الاتاحة: https://doi.org/10.1371/journal.pone.0257856.s002

المؤلفون: Patrick C. Barko (10668358), David A. Williams (7167674)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Biotechnology, Ecology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tandem mass spectroscopy, promising analytic methodology, polyunsaturated fatty acids, peripheral adipose stores, performance liquid chromatography, discover novel aspects, clinical disease syndromes, chain fatty acids, amino acid derivatives, enteric microbial dysbiosis, amino acid metabolites, microbial metabolites indicate, mevalonate pathway intermediates, 8 healthy controls, use untargeted analysis, microbial metabolites, mevalonate pathway, healthy controls, untargeted analysis, untargeted quantification

Relation: https://figshare.com/articles/dataset/Complete_results_of_metabolite_set_enrichment_analysis_/16711157

الاتاحة: https://doi.org/10.1371/journal.pone.0257856.s003

المؤلفون: Patrick C. Barko (10668358), David A. Williams (7167674)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Biotechnology, Ecology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tandem mass spectroscopy, promising analytic methodology, polyunsaturated fatty acids, peripheral adipose stores, performance liquid chromatography, discover novel aspects, clinical disease syndromes, chain fatty acids, amino acid derivatives, enteric microbial dysbiosis, amino acid metabolites, microbial metabolites indicate, mevalonate pathway intermediates, 8 healthy controls, use untargeted analysis, microbial metabolites, mevalonate pathway, healthy controls, untargeted analysis, untargeted quantification

Relation: https://figshare.com/articles/dataset/Complete_results_of_correlation_analysis_/16711163

الاتاحة: https://doi.org/10.1371/journal.pone.0257856.s005

المؤلفون: Patrick C. Barko (10668358), David A. Williams (7167674)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Biotechnology, Ecology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tandem mass spectroscopy, promising analytic methodology, polyunsaturated fatty acids, peripheral adipose stores, performance liquid chromatography, discover novel aspects, clinical disease syndromes, chain fatty acids, amino acid derivatives, enteric microbial dysbiosis, amino acid metabolites, microbial metabolites indicate, mevalonate pathway intermediates, 8 healthy controls, use untargeted analysis, microbial metabolites, mevalonate pathway, healthy controls, untargeted analysis, untargeted quantification

Relation: https://figshare.com/articles/figure/Comparison_of_serum_mevalonolactone_concentrations_in_dogs_with_EPI_vs_healthy_controls_/16711166

الاتاحة: https://doi.org/10.1371/journal.pone.0257856.s006

المؤلفون: Patrick C. Barko (10668358), David A. Williams (7167674)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Biotechnology, Ecology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tandem mass spectroscopy, promising analytic methodology, polyunsaturated fatty acids, peripheral adipose stores, performance liquid chromatography, discover novel aspects, clinical disease syndromes, chain fatty acids, amino acid derivatives, enteric microbial dysbiosis, amino acid metabolites, microbial metabolites indicate, mevalonate pathway intermediates, 8 healthy controls, use untargeted analysis, microbial metabolites, mevalonate pathway, healthy controls, untargeted analysis, untargeted quantification

Relation: https://figshare.com/articles/figure/Unsupervised_analysis_of_serum_metabolite_profiles_/16711169

الاتاحة: https://doi.org/10.1371/journal.pone.0257856.g001

المؤلفون: Patrick C. Barko (10668358), David A. Williams (7167674)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Biotechnology, Ecology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tandem mass spectroscopy, promising analytic methodology, polyunsaturated fatty acids, peripheral adipose stores, performance liquid chromatography, discover novel aspects, clinical disease syndromes, chain fatty acids, amino acid derivatives, enteric microbial dysbiosis, amino acid metabolites, microbial metabolites indicate, mevalonate pathway intermediates, 8 healthy controls, use untargeted analysis, microbial metabolites, mevalonate pathway, healthy controls, untargeted analysis, untargeted quantification

Relation: https://figshare.com/articles/figure/Metabolite_set_enrichment_analysis_/16711172

الاتاحة: https://doi.org/10.1371/journal.pone.0257856.g002

المؤلفون: Patrick C. Barko (10668358), David A. Williams (7167674)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Biotechnology, Ecology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tandem mass spectroscopy, promising analytic methodology, polyunsaturated fatty acids, peripheral adipose stores, performance liquid chromatography, discover novel aspects, clinical disease syndromes, chain fatty acids, amino acid derivatives, enteric microbial dysbiosis, amino acid metabolites, microbial metabolites indicate, mevalonate pathway intermediates, 8 healthy controls, use untargeted analysis, microbial metabolites, mevalonate pathway, healthy controls, untargeted analysis, untargeted quantification

Relation: https://figshare.com/articles/figure/Comparison_of_serum_microbial_metabolites_between_cats_with_EPI_and_healthy_controls_/16711178

الاتاحة: https://doi.org/10.1371/journal.pone.0257856.g004