المؤلفون: Christian Nilewski, Sharada Labadie, Binqing Wei, Sushant Malhotra, Steven Do, Lewis Gazzard, Li Liu, Cheng Shao, Jeremy Murray, Yevgeniy Izrayelit, Amy Gustafson, Nicholas F. Endres, Fang Ma, Xin Ye, Jun Zou, Marie Evangelista

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, targeting certain p, switch ii pocket, loop mutant proteins, identified decades ago, gdp state via, clinically validated strategy, selective reversible inhibitors, particular kras g12c, kras mutant proteins, d13 side chain, d13 residue relative, wt kras, kras g13d, kras <, selective inhibition, target selectively, subnanomolar binding, solvent exposure, salt bridge, recent progress, ongoing challenge, conformational flexibility

Relation: https://figshare.com/articles/journal_contribution/Structure-Based_Design_and_Evaluation_of_Reversible_KRAS_G13D_Inhibitors/24755604

الاتاحة: https://doi.org/10.1021/acsmedchemlett.3c00478.s001
https://figshare.com/articles/journal_contribution/Structure-Based_Design_and_Evaluation_of_Reversible_KRAS_G13D_Inhibitors/24755604