المؤلفون: Francois J.F. Jacobs, John R. Helliwell, Alice Brink

المصدر: IUCrJ, Vol 11, Iss 3, Pp 359-373 (2024)

مصطلحات موضوعية: fragment-based covalent drug design, covalent drug discovery, time series, macromolecular crystallography, anomalous difference density, induced fit docking, artificial metalloproteins, infra-red spectroscopy, Crystallography, QD901-999

وصف الملف: electronic resource

Relation: http://scripts.iucr.org/cgi-bin/paper?S2052252524002598; https://doaj.org/toc/2052-2525

URL الوصول: https://doaj.org/article/6ac3ff9824fa41b3a12ec6d842afa58f

المؤلفون: Kristopher W. Hoyt, Daniel A. Urul, Blessing C. Ogboo, Florian Wittlinger, Stefan A. Laufer, Erik M. Schaefer, Earl W. May, David E. Heppner

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, reported kinetic values, provide general guidance, inform best practices, highlight appropriate steps, form covalent bonds, methods commonly employed, covalent drug design, biochemical activity relies, biochemical activity, explored methods, drug development, overview seeks, mutant selectivity, liquid handling, infrequently consistent, increasingly pursued, experimental factors, dependent assays, complex compared, address gaps

Relation: https://figshare.com/articles/journal_contribution/Pitfalls_and_Considerations_in_Determining_the_Potency_and_Mutant_Selectivity_of_Covalent_Epidermal_Growth_Factor_Receptor_Inhibitors/24898013

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01502.s001
https://figshare.com/articles/journal_contribution/Pitfalls_and_Considerations_in_Determining_the_Potency_and_Mutant_Selectivity_of_Covalent_Epidermal_Growth_Factor_Receptor_Inhibitors/24898013