المؤلفون: Pin-Yan Kuo, Hsin-Hsi Tsai, Bo-Ching Lee, Pu-Tien Chiang, Chia-Ju Liu, Ya-Fang Chen, Jiann-Shing Jeng, Ruoh-Fang Yen, Li-Kai Tsai

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

مصطلحات موضوعية: Cerebral microbleed, Cerebral amyloid angiopathy, Hypertension, Pittsburgh Compound B, Intracerebral hemorrhage, Small vessel disease, Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/c72d08bd7c4040f4b369cb3c6fb6196f

المؤلفون: Mickeviciute, G. -C, Valiuskyte, M., Platten, Michael, Wszolek, Z. K., Andersen, O., Danylaité Karrenbauer, V., Ineichen, B. V., Granberg, T.

المصدر: Journal of Internal Medicine. 291(3):269-282

مصطلحات موضوعية: CSF1R-related leukoencephalopathy, CT, microgliopathy, MRI, radiology, colony stimulating factor 1, colony stimulating factor receptor, fluorodeoxyglucose, gadolinium, ioflupane i 123, Pittsburgh compound B, adult, brain calcification, clinician, controlled study, diffusion weighted imaging, female, gene mutation, human, leukoencephalopathy, magnetic resonance angiography, male, meta analysis, neuroimaging, neuropathology, nuclear magnetic resonance imaging, phenotype, positron emission tomography, pyramidal tract, Review, single photon emission computed tomography, spinal cord, systematic review, tumor spheroid, white matter, white matter lesion, brain, diagnostic imaging, mutation, pathology, procedures, Humans, Leukoencephalopathies, Magnetic Resonance Imaging

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-313612
https://doi.org/10.1111/joim.13420

المؤلفون: Maxwell C. Y. Choi, Tiffany H. P. Law, Sirong Chen, William S. K. Cheung, Carmen Yim, Oliver K. S. Ng, Lisa W. C. Au, Vincent C. T. Mok, Peter Y. M. Woo

المصدر: Frontiers in Neurology, Vol 15 (2024)

مصطلحات موضوعية: early-onset cerebral amyloid angiopathy, intracerebral hemorrhage, amyloid-beta, 11C-Pittsburgh compound B positron emission tomography, taxifolin, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2024.1360705/full; https://doaj.org/toc/1664-2295

URL الوصول: https://doaj.org/article/42603084166b434c9baa120dbd255e40

المؤلفون: Harrison, Theresa M, Du, Richard, Klencklen, Giuliana, Baker, Suzanne L, Jagust, William J

المصدر: Alzheimer's & Dementia. 17(7)

مصطلحات موضوعية: Biological Psychology, Psychology, Alzheimer's Disease, Acquired Cognitive Impairment, Brain Disorders, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Biomedical Imaging, Dementia, Aging, Neurosciences, Neurodegenerative, Behavioral and Social Science, 2.1 Biological and endogenous factors, Neurological, Aged, Amyloid beta-Peptides, Atrophy, Brain, Cerebral Cortex, Cognition, Female, Healthy Volunteers, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Positron-Emission Tomography, tau Proteins, Alzheimer's disease, atrophy, cortical integrity, flortaucipir, literature review, neurodegeneration, normal aging, PART, Pittsburgh compound B, positron emission tomography, publication bias, structural magnetic resonance imaging, Clinical Sciences, Geriatrics, Clinical sciences, Biological psychology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3hm1v45n
https://escholarship.org/content/qt3hm1v45n/qt3hm1v45n.pdf

المؤلفون: Wen-Li Xie, Zheng-Yang Lu, Jing Xu, Yu Chen, Hong-Li Teng, Guang-Zhong Yang

مصطلحات موضوعية: Biochemistry, Pharmacology, Ecology, Sociology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, “ tiebaojin ”, exciton chirality method, determined using high, benzisochromanquinone dimer berpolydiquinone, quantum chemical calculation, compound (< b, c (< b, berchemia polyphylla var, 2 b, compounds (< b, (< b, polyphylla var, regarding b, chemical structures, chemical constituents, symmetrical structure, study provides, specifically identified, significant reservoir, scientific foundation, potential source, naphthoquinone moiety

Relation: https://figshare.com/articles/journal_contribution/Chemical_Constituents_from_Berchemia_polyphylla_var_Leioclada/24952636

الاتاحة: https://doi.org/10.1021/acsomega.3c08357.s001
https://figshare.com/articles/journal_contribution/Chemical_Constituents_from_Berchemia_polyphylla_var_Leioclada/24952636

المؤلفون: Pivtoraiko, Violetta N, Racic, Tamara, Abrahamson, Eric E, Villemagne, Victor L, Handen, Benjamin L, Lott, Ira T, Head, Elizabeth, Ikonomovic, Milos D

مصطلحات موضوعية: Biological Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Dementia, Cerebrovascular, Neurodegenerative, Brain Disorders, Alzheimer's Disease, Alzheimer's Disease Related Dementias (ADRD), Vascular Cognitive Impairment/Dementia, Intellectual and Developmental Disabilities (IDD), Rare Diseases, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Down Syndrome, Acquired Cognitive Impairment, Aging, 2.1 Biological and endogenous factors, 4.2 Evaluation of markers and technologies, Neurological, Alzheimer’s disease, Down syndrome, Pittsburgh Compound-B, amyloid, cerebral amyloid angiopathy, default mode network, pyroglutamate, Biochemistry and Cell Biology, Cognitive Sciences, Biological psychology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/375279k1
https://escholarship.org/content/qt375279k1/qt375279k1.pdf

المؤلفون: Ya‐Chin Tsai, Hsin‐Hsi Tsai, Chia‐Ju Liu, Sheng‐Sian Lin, Ya‐Fang Chen, Jiann‐Shing Jeng, Li‐Kai Tsai, Ruoh‐Fang Yen

المصدر: Brain and Behavior, Vol 13, Iss 10, Pp n/a-n/a (2023)

مصطلحات موضوعية: cognitive impairment, dementia, intracerebral hemorrhage, Pittsburgh compound B, small vessel disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2162-3279

URL الوصول: https://doaj.org/article/cf83a7303a264011a631bee8f787abe7

المؤلفون: Amado, Filipe Lopes

مصطلحات موضوعية: Doença de Alzheimer (AD), Quantificação, Análise textural, Tomografia por Emissão de Positrões (PET), Composto B de Pittsburgh marcado com carbono-11 (PiB), Alzheimer’s disease (AD), Quantification, Textural analysis, Positron Emission Tomography (PET), carbon-11 labelled Pittsburgh Compound B (PiB)

الاتاحة: https://hdl.handle.net/10316/103049

المؤلفون: VandeVrede, Lawren, Gibbs, Daniel M, Koestler, Mary, La Joie, Renaud, Ljubenkov, Peter A, Provost, Karine, Soleimani‐Meigooni, David, Strom, Amelia, Tsoy, Elena, Rabinovici, Gil D, Boxer, Adam L

المصدر: Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring. 12(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Neurodegenerative, Brain Disorders, Neurosciences, Clinical Research, aducanumab, Alzheimer's disease, amyloid-related imaging abnormalities, apolipoprotein E, flortaucipir, FTP, Pittsburgh compound B, amyloid‐related imaging abnormalities, Genetics, Biological psychology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1ch0m646
https://escholarship.org/content/qt1ch0m646/qt1ch0m646.pdf

المؤلفون: Chen, Charles, D, Mccullough, Austin, Gordon, Brian, Joseph-Mathurin, Nelly, Flores, Shaney, Mckay, Nicole, S, Hobbs, Diana, A, Hornbeck, Russ, Fagan, Anne, M, Cruchaga, Carlos, Goate, Alison, M, Perrin, Richard, J, Wang, Guoqiao, Li, Yan, Shi, Xinyu, Xiong, Chengjie, Pontecorvo, Michael, J, Klein, Gregory, Su, Yi, Klunk, William, E, Jack, Clifford, Koeppe, Robert, Snider, B. Joy, Berman, Sarah, B, Roberson, Erik, D, Brosch, Jared, Surti, Ghulam, Jiménez-Velázquez, Ivonne, Z, Galasko, Douglas, Honig, Lawrence, S, Brooks, William, S, Clarnette, Roger, Wallon, David, Dubois, Bruno, Pariente, Jérémie, Pasquier, Florence, Sanchez-Valle, Raquel, Shcherbinin, Sergey, Higgins, Ixavier, Tunali, Ilke, Masters, Colin, L, van Dyck, Christopher, H, Masellis, Mario, Hsiung, Robin, Gauthier, Serge, Salloway, Steve, Clifford, David, B, Mills, Susan, Supnet-Bell, Charlene, Mcdade, Eric, Bateman, Randall, J, Benzinger, Tammie, L S

المساهمون: Mallinckrodt Institute of Radiology, Neuroradiology, School of Medicine, Washington University in Saint Louis (WUSTL), Washington University School of Medicine in St. Louis, Mount Sinai School of Medicine, Department of Psychiatry-Icahn School of Medicine at Mount Sinai New York (MSSM), Banner Alzheimer's Institute, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), Mayo Clinic Rochester, University of Michigan Ann Arbor, University of Michigan System, University of Alabama at Birmingham Birmingham (UAB), Indiana University School of Medicine, Indiana University System, Warren Alpert Medical School of Brown University, University of Puerto Rico (UPR), University of California San Diego (UC San Diego), University of California (UC), Columbia University New York, University of New South Wales Sydney (UNSW), The University of Western Australia (UWA), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Groupe de recherche clinique Alzheimer Precision Medicine (GRC 21 - APM), Sorbonne Université (SU), Toulouse NeuroImaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Excellence Laboratory LabEx DISTALZ, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Yale School of Medicine New Haven, Connecticut (YSM), Sunnybrook Research Institute Toronto (SRI), Sunnybrook Health Sciences Centre Toronto (Sunnybrook), Djavad Mowafaghian Centre for Brain Health, Douglas Mental Health University Institute Montréal, McGill University = Université McGill Montréal, Canada, ANR-11-LABX-0009,DISTALZ,Développement de stratégies innovantes pour une approche transdisciplinaire de la maladie d'Alzheime(2011)

المصدر: ISSN: 1619-7070.

مصطلحات موضوعية: Pittsburgh compound B 18 F-florbetapir gantenerumab dominantly inherited Alzheimer disease confidence interval), SD (standard deviation), Pittsburgh compound B, 18 F-florbetapir, gantenerumab, dominantly inherited Alzheimer disease confidence interval), [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics

Relation: info:eu-repo/semantics/altIdentifier/pmid/37017737; PUBMED: 37017737; PUBMEDCENTRAL: PMC10330155

الاتاحة: https://hal.science/hal-04504639
https://hal.science/hal-04504639v1/document
https://hal.science/hal-04504639v1/file/nihms-1894746.pdf
https://doi.org/10.1007/s00259-023-06209-0

المؤلفون: Hiroki Tanaka, Natsuko Kondo, Norio Miyoshi, Shigetoshi Okazaki, Yoshinori Sakurai, 三好 憲雄, 岡崎 茂俊, 櫻井 良憲, 田中 浩基, 近藤 夏子

المصدر: 日本レーザー医学会誌 / The Journal of Japan Society for Laser Surgery and Medicine. 2023, 44(1):2

المؤلفون: La Joie, Renaud, Ayakta, Nagehan, Seeley, William W, Borys, Ewa, Boxer, Adam L, DeCarli, Charles, Doré, Vincent, Grinberg, Lea T, Huang, Eric, Hwang, Ji‐Hye, Ikonomovic, Milos D, Jack, Clifford, Jagust, William J, Jin, Lee‐Way, Klunk, William E, Kofler, Julia, Lesman‐Segev, Orit H, Lockhart, Samuel N, Lowe, Val J, Masters, Colin L, Mathis, Chester A, McLean, Catriona L, Miller, Bruce L, Mungas, Daniel, O'Neil, James P, Olichney, John M, Parisi, Joseph E, Petersen, Ronald C, Rosen, Howard J, Rowe, Christopher C, Spina, Salvatore, Vemuri, Prashanthi, Villemagne, Victor L, Murray, Melissa E, Rabinovici, Gil D

المصدر: Alzheimer's & Dementia. 15(2)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Alzheimer's Disease, Acquired Cognitive Impairment, Brain Disorders, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Biomedical Imaging, Dementia, Aging, Neurosciences, Neurodegenerative, Aged, Alzheimer Disease, Aniline Compounds, Autopsy, Female, Humans, Male, Neuropathology, Plaque, Amyloid, Positron-Emission Tomography, Retrospective Studies, Thiazoles, beta-amyloid, Positron emission tomography, Centiloid, CERAD, Thal, Alzheimer's disease neuropathologic changes, Harmonization, Threshold, Pittsburgh compound-B, β-amyloid, Geriatrics, Clinical sciences, Biological psychology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1k07k1r9
https://escholarship.org/content/qt1k07k1r9/qt1k07k1r9.pdf

المؤلفون: Farzaneh Rahmani, Marina Nguyen, Charles D. Chen, Nicole McKay, Aylin Dincer, Nelly Joseph-Mathurin, Gengsheng Chen, Jingxia Liu, Hilary L. P. Orlowski, John C. Morris, Tammie L. S. Benzinger

المصدر: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2022)

مصطلحات موضوعية: Internal carotid artery, Calcification, Clinical Dementia Rating, White matter hyperintensities, Mini-Mental State Exam, 11C-Pittsburgh compound B, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1758-9193

URL الوصول: https://doaj.org/article/ac6f31e20dd14a2786f8a2f9768845cd

المؤلفون: Rischel, Elise Brøchner, Gejl, Michael, Brock, Birgitte, Rungby, Jørgen, Gjedde, Albert

المصدر: Rischel , E B , Gejl , M , Brock , B , Rungby , J & Gjedde , A 2023 , ' In Alzheimer's disease, amyloid beta accumulation is a protective mechanism that ultimately fails ' , Alzheimer's and Dementia , vol. 19 , no. 3 , pp. 771-783 . https://doi.org/10.1002/alz.12701

مصطلحات موضوعية: Alzheimer's disease, amyloid beta, blood–brain barrier, cerebral blood flow, cerebral glucose metabolism, positron emission tomography, [C]Pittsburgh compound B, [F]fluorodeoxyglucose

Relation: https://pure.au.dk/portal/en/publications/189c118b-3f90-49e6-8bd3-da553eb0d09e

الاتاحة: https://pure.au.dk/portal/en/publications/189c118b-3f90-49e6-8bd3-da553eb0d09e
https://doi.org/10.1002/alz.12701
http://www.scopus.com/inward/record.url?scp=85131333087&partnerID=8YFLogxK

المؤلفون: Bilgel, Murat, An, Yang, Walker, Keenan A, Moghekar, Abhay R, Ashton, Nicholas J, Kac, Przemysław R, Karikari, Thomas K, Blennow, Kaj, Zetterberg, Henrik, Jedynak, Bruno M, Thambisetty, Madhav, Ferrucci, Luigi, Resnick, Susan M

المصدر: Alzheimer's and Dementia , 19 (10) pp. 4335-4345. (2023)

مصطلحات موضوعية: Biomarkers, longitudinal, Pittsburgh compound B, plasma, positron emission tomography

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10175067/3/Zetterberg_Longitudinal%20changes%20in%20Alzheimer%27s-related%20plasma%20biomarkers%20and%20brain%20amyloid.pdf; https://discovery.ucl.ac.uk/id/eprint/10175067/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10175067/3/Zetterberg_Longitudinal%20changes%20in%20Alzheimer%27s-related%20plasma%20biomarkers%20and%20brain%20amyloid.pdf
https://discovery.ucl.ac.uk/id/eprint/10175067/

المؤلفون: Head, Elizabeth, Helman, Alex M, Powell, David, Schmitt, Frederick A

مصطلحات موضوعية: Medical Biochemistry and Metabolomics, Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Neurosciences, Neurodegenerative, Biomedical Imaging, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Intellectual and Developmental Disabilities (IDD), Aging, Acquired Cognitive Impairment, Dementia, Down Syndrome, Aetiology, 2.1 Biological and endogenous factors, Neurological, Amyloid beta-Peptides, Animals, Humans, Neuroimaging, Cerebrovascular pathology, Partial trisomy 21, Pittsburgh Compound B, Trisomy 21, Medicinal and Biomolecular Chemistry, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medical biochemistry and metabolomics

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4347k1t8

المؤلفون: Motonobu Fujishima, Hiroshi Matsuda

المصدر: Neuroimage: Reports, Vol 2, Iss 3, Pp 100101- (2022)

مصطلحات موضوعية: Centiloid, Pittsburgh compound B, Florbetapir, Flutemetamol, Florbetaben, NAV4694, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666956022000253; https://doaj.org/toc/2666-9560

URL الوصول: https://doaj.org/article/fae8913f579a48529abebd7adcaac0f0

المؤلفون: Balzano, Federica, Uccello-Barretta, Gloria, Sicoli, Giuseppe, Vanni, Letizia, Recchimurzo, Alessandra, Aiello, Federica

المساهمون: Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie - CNRS Chimie (INC-CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), CNR Istituto per i Processi Chimico-Fisici (IPCF), Consiglio Nazionale delle Ricerche Messina (CNR)

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: Balzano, F. Uccello-Barretta, G. Sicoli, G. Vanni, L. Recchimurzo, A. Aiello, F. Chiral Discrimination Mechanisms by Silylated-Acetylated Cyclodextrins: Superficial Interactions vs. Inclusion NMR diffusion coefficient ROESY association constant chiral solvating agent compound B methyl 2-chloropropionate Lipodex E, Uccello-Barretta, Sicoli, Vanni, Recchimurzo, Aiello, F. Chiral Discrimination Mechanisms by Silylated-Acetylated Cyclodextrins: Superficial Interactions vs. Inclusion NMR, diffusion coefficient, ROESY, association constant, chiral solvating agent, compound B, methyl 2-chloropropionate, Lipodex E, [CHIM]Chemical Sciences

Relation: hal-03872374; https://hal.science/hal-03872374; https://hal.science/hal-03872374/document; https://hal.science/hal-03872374/file/ijms-23-13169-with-cover.pdf

الاتاحة: https://hal.science/hal-03872374
https://hal.science/hal-03872374/document
https://hal.science/hal-03872374/file/ijms-23-13169-with-cover.pdf
https://doi.org/10.3390/ijms232113169

المؤلفون: Masahiko Takaya, Kazunari Ishii, Kazumasa Saigoh, Osamu Shirakawa

المصدر: Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-6 (2021)

مصطلحات موضوعية: Alzheimer’s disease, Nonfluent/agrammatic variant, Primary progressive aphasia, 11C-Pittsburgh compound-B, 18F-THK5351, Positron emission tomography, Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1752-1947

URL الوصول: https://doaj.org/article/73ef97fe37cc436fb38cd5e59741919d

المؤلفون: Camila de Godoi Carneiro, Daniele de Paula Faria, Artur Martins Coutinho, Carla Rachel Ono, Fábio Luís de Souza Duran, Naomi Antunes da Costa, Alexandre Teles Garcez, Paula Squarzoni da Silveira, Orestes Vicente Forlenza, Sonia Maria Dozzi Brucki, Ricardo Nitrini, Geraldo Busatto Filho, Carlos Alberto Buchpiguel

المصدر: Brazilian Journal of Psychiatry (2022)

مصطلحات موضوعية: Positron emission tomography, amyloid, [11C]-labeled Pittsburgh compound B, perfusion, cerebral glucose metabolism, [18F]fluoro-2-deoxy-d-glucose, aging, neuroimaging, Psychiatry, RC435-571

وصف الملف: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022005008202&tlng=en; https://doaj.org/toc/1809-452X

URL الوصول: https://doaj.org/article/f446d990bf9d4af3b620ff9ef4c1de83