المؤلفون: Hong-Ju Yang, Hai-Ying Zhang, Guo-Hua Bi, Yi He, Jun-Tao Gao, Zheng-Xiong Xi

المصدر: Cell Reports, Vol 20, Iss 2, Pp 319-332 (2017)

مصطلحات موضوعية: etiology of addiction, cocaine reward, glutamate, dopamine, autoreceptor, mGluR2, NMDA receptor, self-administration, relapse, addiction, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124717308604; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/1e7306157bac48da9f54d55088e03436

المؤلفون: Tiziana Romanazzi, Daniele Zanella, Angela Di Iacovo, Manan Bhatt, Aurelio Galli, Elena Bossi

المساهمون: Romanazzi, Tiziana, Zanella, Daniele, DI IACOVO, Angela, Bhatt, MANAN JUGGNU, Galli, Aurelio, Bossi, Elena

مصطلحات موضوعية: Bile diversion surgery, used for treating obesity, increases the circulating bile acids (BAs) and reduces food and cocaine reward-related behavior in mice. Feeding mice addicted to cocaine with obeticholic acid (OCA), a BA analog, induced the same effect of the surgery. The interactions of OCA with DAT heterologously expressed in X. laevis oocytes showed that OCA promotes a transient Na+-inward current, without affecting dopamine (DA) affinity and kinetic parameters. Docking simulations suggest that OCA could stabilize DAT in an occluded conformation (Romanazzi et al., 2021). The second treatment with OCA does not elicit any current. To fully recover the current elicited by OCA, it is necessary to activate the maximal transport current with substrate at saturating concentration. Reducing DA concentration to a value proximal to the K0.5, induces a smaller OCA current. The same happens with the transport of norepinephrine or serotonin, which are also DAT substrates with a lower affinity than DA. These experiments confirm the model obtained by molecular docking, suggesting that OCA binds, opens a transient conductance, and then freezes DAT in an occluded conformation that makes it resistant to other BA-mediated alterations of the membrane potential. DAT occluded state can be recovered only in the presence of the physiological substrates. Testing the BAs on other SLC6 will shed a light on the specificity of the interaction.

Relation: ispartofbook:72° Congresso Nazionale SIF; 72° Congresso Nazionale SIF; https://hdl.handle.net/11383/2146212

الاتاحة: https://hdl.handle.net/11383/2146212

المؤلفون: Ballestín Hinojosa, Raúl, Ferrer Pérez, Carmen, Rodríguez Arias, Marta

المصدر: RODERIC: Repositorio Institucional de la Universitat de Valéncia
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RODERIC. Repositorio Institucional de la Universitat de Valéncia

مصطلحات موضوعية: cocaine reward, social stress, depression, PSICOLOGÍA [UNESCO], UNESCO::PSICOLOGÍA, resilience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3a62e586148845744ed0ce8efa2b3842
https://hdl.handle.net/10550/78233

المؤلفون: Blum, K., Febo, M., Badgaiyan, R. D., Demetrovics, Z., Simpatico, T., Fahlke, Claudia, 1964, Oscar-Berman, M., Li, M., Dushaj, K., Gold, M. S.

المصدر: Current Neuropharmacology. 15(1):184-194

مصطلحات موضوعية: Psychiatry, Psykiatri, Dopamine homeostasis, genetics, reward deficiency solution system, Reward Deficiency Syndrome (RDS), alcohol-dependent individuals, reduced striatal response, dopamine-receptor gene, drug-addiction, induced reinstatement, ethanol, withdrawal, cocaine reward, d2, micrornas, brain, Neurosciences & Neurology, Pharmacology & Pharmacy

URL الوصول: https://gup.ub.gu.se/publication/250378

المؤلفون: Jamie Byrne, G Murray

مصطلحات موضوعية: Biology, BRAIN, Circadian rhythms, CIRCADIAN SYSTEM, COCAINE REWARD, diurnal rhythms, FMRI, INCENTIVE SALIENCE, IOWA GAMBLING TASK, Life Sciences & Biomedicine, Life Sciences & Biomedicine - Other Topics, MOOD, Physiology, PREFRONTAL CORTEX, reward, RISK-TAKING, Science & Technology, TIME, wanting, 3209 Neurosciences

Relation: http://hdl.handle.net/10536/DRO/DU:30155939; https://figshare.com/articles/journal_contribution/Diurnal_rhythms_in_psychological_reward_functioning_in_healthy_young_men_Wanting_liking_and_learning/20645598

الاتاحة: http://hdl.handle.net/10536/DRO/DU:30155939
https://figshare.com/articles/journal_contribution/Diurnal_rhythms_in_psychological_reward_functioning_in_healthy_young_men_Wanting_liking_and_learning/20645598

المؤلفون: Zheng-Xiong Xi, Hai Ying Zhang, Yi He, Jun Tao Gao, Hong Ju Yang, Guo Hua Bi

المصدر: Cell Reports, Vol 20, Iss 2, Pp 319-332 (2017)

مصطلحات موضوعية: 0301 basic medicine, Male, media_common.quotation_subject, Dopamine, Glutamic Acid, glutamate, Nucleus accumbens, Pharmacology, Receptors, Metabotropic Glutamate, Receptors, N-Methyl-D-Aspartate, General Biochemistry, Genetics and Molecular Biology, Nucleus Accumbens, Article, 03 medical and health sciences, Cocaine-Related Disorders, Mice, 0302 clinical medicine, Cocaine, Risk Factors, Medicine, Animals, Rats, Wistar, lcsh:QH301-705.5, autoreceptor, mGluR2, media_common, relapse, Mice, Knockout, business.industry, Addiction, Glutamate receptor, etiology of addiction, NMDA receptor, Rats, 030104 developmental biology, lcsh:Biology (General), Metabotropic glutamate receptor, cocaine reward, addiction, Metabotropic glutamate receptor 2, Self-administration, business, self-administration, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3483c0c42d3e0389d6aeae644b369778
https://pubmed.ncbi.nlm.nih.gov/28700935

المؤلفون: Kokane, Saurabh Sanjeev

المساهمون: Perrotti, Linda I

مصطلحات موضوعية: Cocaine reward, Estradiol, Sex-differences, ERK, mTOR, Conditioned place preference, SL327, Rapamycin, Cocaine-conditioned reward

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10106/30184

الاتاحة: http://hdl.handle.net/10106/30184

المؤلفون: Jeong, J, Park, YU, Kim, DK, Lee, S, Kwak, Y, Lee, SA, Lee, H, Suh, YH, Gho, YS, Hwang, D, PARK, SANG KI

المساهمون: 생명과학과, 10149637, Gho, YS, PARK, SANG KI

مصطلحات موضوعية: CYCLIN-DEPENDENT KINASE-5, NUCLEUS-ACCUMBENS, CORTICAL-NEURONS, DENDRITIC SPINES, COCAINE REWARD, NMDA RECEPTORS, BETA-CATENIN, BINDING, MORPHOLOGY, BRAIN

Relation: PLoS One; 12; E84482; SCI급, SCOPUS 등재논문; SCI; Multidisciplinary Sciences; Science & Technology - Other Topics; 2013-OAK-0000028978; https://oasis.postech.ac.kr/handle/2014.oak/14951; 15750; PLoS One, v.8, no.12, pp.E84482; 000329323900103; 2-s2.0-84896698780

الاتاحة: https://oasis.postech.ac.kr/handle/2014.oak/14951
https://doi.org/10.1371/JOURNAL.PONE.0084482

المؤلفون: Jun-Xu Li, Yanan Zhang, David A. Thorn, Jian-Feng Liu

المصدر: International Journal of Neuropsychopharmacology

مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, medicine.drug_class, TAAR1, Drug-Seeking Behavior, Self Administration, Partial agonist, cocaine reward memory, Extinction, Psychological, Receptors, G-Protein-Coupled, 03 medical and health sciences, 0302 clinical medicine, Cocaine, Reward, Memory, expression, reconsolidation, Phenethylamines, medicine, Animals, Pharmacology (medical), Regular Research Article, Oxazoles, Pharmacology, extinction, Dopaminergic, Extinction (psychology), RO5166017, Conditioned place preference, Rats, Psychiatry and Mental health, 030104 developmental biology, Anesthesia, Memory consolidation, Psychology, Neuroscience, Locomotion, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24457bd0fb49d87daf351c0a78a6227
https://doi.org/10.1093/ijnp/pyw009