المؤلفون: Rimmy Nandal, Davinder Kumar, Navidha Aggarwal, Virender Kumar, Balasubramanian Narasimhan, Rakesh Kumar Marwaha, Prabodh Chander Sharma, Surender Kumar, Nitin Bansal, Hitesh Chopra, Aakash Deep

المصدر: EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 672-713 (2024)

مصطلحات موضوعية: antimalarials, clinical trials, malaria, tafenoquine, cipargamin, artefenomel, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.excli.de/excli/article/view/6856; https://doaj.org/toc/1611-2156

URL الوصول: https://doaj.org/article/202fcb5419494dc49082aaec1efb65a6

المؤلفون: Nandal, Rimmy, Kumar, Davinder, Aggarwal, Navidha, Kumar, Virender, Narasimhan, Balasubramanian, Marwaha, Rakesh Kumar, Sharma, Prabodh Chander, Kumar, Surender, Bansal, Nitin, Chopra, Hitesh, Deep, Aakash

المصدر: EXCLI Journal; Bd. 23 (2024); 672-713 ; EXCLI Journal; Vol. 23 (2024); 672-713 ; 1611-2156

مصطلحات موضوعية: antimalarials, clinical trials, malaria, tafenoquine, cipargamin, artefenomel

وصف الملف: application/pdf

Relation: https://www.excli.de/excli/article/view/6856/4933; https://www.excli.de/excli/article/view/6856/4979; https://www.excli.de/excli/article/view/6856/4980; https://www.excli.de/excli/article/view/6856

الاتاحة: https://www.excli.de/excli/article/view/6856

المؤلفون: Gilles Ndayisaba, Adoke Yeka, Kwaku Poku Asante, Martin P. Grobusch, Etienne Karita, Henry Mugerwa, Stephen Asiimwe, Abraham Oduro, Bakary Fofana, Seydou Doumbia, Jay Prakash Jain, Sarita Barsainya, Gerd A. Kullak-Ublick, Guoqin Su, Esther K. Schmitt, Katalin Csermak, Preetam Gandhi, David Hughes

المصدر: Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)

مصطلحات موضوعية: Cipargamin, Malaria, KAE609, Hepatic safety, Phase II randomized controlled trial, Plasmodium falciparum, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-2875

URL الوصول: https://doaj.org/article/890ef9801b434e61bb32253a0c40d2ec

المؤلفون: Gilles Ndayisaba (11860569), Adoke Yeka (18017), Kwaku Poku Asante (8943890), Martin P. Grobusch (10048320), Etienne Karita (62290), Henry Mugerwa (301399), Stephen Asiimwe (819912), Abraham Oduro (391468), Bakary Fofana (3539657), Seydou Doumbia (65941), Jay Prakash Jain (2233621), Sarita Barsainya (11860572), Gerd A. Kullak-Ublick (7413455), Guoqin Su (11860575), Esther K. Schmitt (2283112), Katalin Csermak (11860578), Preetam Gandhi (11860581), David Hughes (47111)

مصطلحات موضوعية: Medicine, Cell Biology, Immunology, Cancer, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Cipargamin, Malaria, KAE609, Hepatic safety, Phase II randomized controlled trial, Plasmodium falciparum

Relation: https://figshare.com/articles/journal_contribution/Additional_file_1_of_Hepatic_safety_and_tolerability_of_cipargamin_KAE609_in_adult_patients_with_Plasmodium_falciparum_malaria_a_randomized_phase_II_controlled_dose-escalation_trial_in_sub-Saharan_Africa/17304822

الاتاحة: https://doi.org/10.6084/m9.figshare.17304822.v1

المؤلفون: Natalie Jane Spillman, Kiaran Kirk

المصدر: International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 149-162 (2015)

مصطلحات موضوعية: Plasmodium, Antimalarial, PfATP4, Resistance selection, Drug discovery, Cipargamin, Infectious and parasitic diseases, RC109-216

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320715300051; https://doaj.org/toc/2211-3207

URL الوصول: https://doaj.org/article/37128bbed9c94bd4844e6fd5a083f365

المؤلفون: Melese Legesse Mitku, Solomon Assefa Huluka, Kaleab Asres, Abdrrahman Shemsu Surur

المصدر: Drug Design, Development and Therapy. 14:4855-4867

مصطلحات موضوعية: Pharmacology, Indole test, biology, Hemozoin, Pharmaceutical Science, biology.organism_classification, Cipargamin, Plasmodium, chemistry.chemical_compound, chemistry, Mechanism of action, Biochemistry, Cryptolepine, Chloroquine, parasitic diseases, Drug Discovery, medicine, Antimalarial Agent, medicine.symptom, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cdb787131b92322d7b006657abc72ed4
https://doi.org/10.2147/dddt.s278588

المؤلفون: Ndayisaba, Gilles, Yeka, Adoke, Asante, Kwaku Poku, Grobusch, Martin P., Karita, Etienne, Mugerwa, Henry, Asiimwe, Stephen, Oduro, Abraham, Fofana, Bakary, Doumbia, Seydou, Jain, Jay Prakash, Barsainya, Sarita, Kullak-Ublick, Gerd A., Su, Guoqin, Schmitt, Esther K., Csermak, Katalin, Gandhi, Preetam, Hughes, David

المساهمون: Infectious diseases, AII - Infectious diseases, APH - Global Health, APH - Aging & Later Life

المصدر: Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Malaria journal, 20(1):478. BioMed Central
Malaria Journal

مصطلحات موضوعية: Adult, Male, Indoles, Hepatic safety, Plasmodium falciparum, RC955-962, 030231 tropical medicine, Infectious and parasitic diseases, RC109-216, Mali, Ghana, Young Adult, Antimalarials, 03 medical and health sciences, 0302 clinical medicine, Arctic medicine. Tropical medicine, parasitic diseases, Humans, Spiro Compounds, Uganda, Gabon, Malaria, Falciparum, Cipargamin, 0303 health sciences, Dose-Response Relationship, Drug, 030306 microbiology, Research, Rwanda, Middle Aged, Phase II randomized controlled trial, Malaria, 3. Good health, Infectious Diseases, Liver, Female, Parasitology, KAE609

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce5ef5bc8b576448c02972253df2cd3
https://researchonline.lshtm.ac.uk/id/eprint/4666148/1/s12936-021-04009-1.pdf

المؤلفون: Colin J. Sutherland, Robert W. Moon, Didier Leroy, Maëlle Duffey, Donelly A. van Schalkwyk

المصدر: International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 5-11 (2021)
International Journal for Parasitology: Drugs and Drug Resistance

مصطلحات موضوعية: Regular article, Plasmodium, Plasmodium falciparum, Infectious and parasitic diseases, RC109-216, chemistry.chemical_compound, Antimalarials, parasitic diseases, medicine, Malaria, Vivax, Humans, Pharmacology (medical), Plasmodium knowlesi, Antimalarial Agent, Malaria, Falciparum, Hypoxanthine, Pharmacology, Drug susceptibility, biology, medicine.disease, biology.organism_classification, Virology, Cipargamin, Infectious Diseases, chemistry, Drug development, ex vivo, Parasitology, Plasmodium vivax, Malaria, Ex vivo

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73f0e893ca920841137d4d6340bae1e

المؤلفون: Adoke Yeka, Judith Straimer, Guoqin Su, Martin P. Grobusch, Kwaku Poku Asante, Vinay Kumar Venishetty, Sarfaraz Sayyed, Stephen Asiimwe, Gilles F. Ndayisaba, Sarita Barsainya, Abraham Oduro, Caroline Boulton, Henry Mugerwa, Esther K. Schmitt, Etienne Karita, Katalin Csermak Renner, Seydou Doumbia, P. Gandhi, Ivan Demin, Bakary Fofana

المساهمون: Infectious diseases, AII - Infectious diseases, APH - Global Health

المصدر: Clinical infectious diseases. Oxford University Press

مصطلحات موضوعية: Microbiology (medical), Adult, medicine.medical_specialty, Sub saharan, Indoles, Plasmodium falciparum, Drug resistance, chemistry.chemical_compound, Antimalarials, Pharmacokinetics, Internal medicine, parasitic diseases, medicine, Dose escalation, Humans, Spiro Compounds, Malaria, Falciparum, Africa South of the Sahara, Fluorenes, biology, business.industry, Artemether, Lumefantrine Drug Combination, biology.organism_classification, medicine.disease, Cipargamin, Clinical trial, Drug Combinations, Infectious Diseases, Treatment Outcome, chemistry, Ethanolamines, Artemether, business, Malaria

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976d24df7b3925eb85fe952adea3a862
https://pubmed.ncbi.nlm.nih.gov/34410358

المؤلفون: Judith Straimer, Esther K. Schmitt, Katalin Csermak Renner, P. Gandhi

المصدر: The Journal of infectious diseases. 225(8)

مصطلحات موضوعية: medicine.medical_specialty, Artemether/lumefantrine, Plasmodium falciparum, Drug Resistance, Protozoan Proteins, Clinical study, chemistry.chemical_compound, Antimalarials, Internal medicine, parasitic diseases, medicine, Prevalence, Immunology and Allergy, Parasite hosting, Animals, Humans, Parasites, Gabon, Artemisinin, Malaria, Falciparum, Allele frequency, biology, business.industry, Artemether, Lumefantrine Drug Combination, Rwanda, biology.organism_classification, medicine.disease, Cipargamin, Infectious Diseases, chemistry, Mutation, Artemether, business, Malaria, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb53b00f9a1635add9e1d40ec215cdb3
https://pubmed.ncbi.nlm.nih.gov/34216470

المؤلفون: Leong, F.J, Li, R, Jain, J.P, Lefèvre, G, Magnusson, B, Diagana, T.T, Partel, P

المساهمون: MICROBIOLOGY AND IMMUNOLOGY

المصدر: Unpaywall 20201031

مصطلحات موضوعية: alanine aminotransferase, amylase, aspartate aminotransferase, bilirubin, cipargamin, creatine kinase, fat, lactate dehydrogenase, liver enzyme, paracetamol, placebo, triacylglycerol lipase, antimalarial agent, indole derivative, spiro compound, abdominal discomfort, adult, alanine aminotransferase blood level, amylase blood level, area under the curve, Article, aspartate aminotransferase blood level, bilirubin blood level, cohort analysis, controlled study, diarrhea, dizziness, double blind procedure, drug absorption, drug blood level

Relation: Leong, F.J, Li, R, Jain, J.P, Lefèvre, G, Magnusson, B, Diagana, T.T, Partel, P (2014). A first-in-human randomized, double-blind, placebo-controlled, single- And multiple-ascending oral dose study of novel antimalarial spiroindolone KAE609 (cipargamin) to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers. Antimicrobial Agents and Chemotherapy 58 (10) : 6209-6214. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.03393-14; https://scholarbank.nus.edu.sg/handle/10635/180137

الاتاحة: https://scholarbank.nus.edu.sg/handle/10635/180137

المؤلفون: Martin P. Grobusch, Suzan A. M. Bouwman, Rella Zoleko-Manego, Ghyslain Mombo-Ngoma, Esther K. Schmitt, Katalin Csermak Renner

المساهمون: Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, APH - Global Health

المصدر: Travel medicine and infectious disease, 36:101765. Elsevier USA

مصطلحات موضوعية: Drug, NITD609, Indoles, media_common.quotation_subject, 030231 tropical medicine, Plasmodium falciparum, Phases of clinical research, Antimalarial, English language, Bioinformatics, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, 0302 clinical medicine, Pre-clinical development, Spiroindolone, Gametocyte, Medicine, Humans, Spiro Compounds, 030212 general & internal medicine, media_common, Cipargamin, business.industry, Public Health, Environmental and Occupational Health, medicine.disease, Clinical development, Malaria, Clinical trial, Infectious Diseases, chemistry, business, KAE609

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f85e5d58dbc4654f82000783cea9f2a
https://pubmed.ncbi.nlm.nih.gov/32561392

المؤلفون: Radka Snajdrova, Thomas Ruch, Elina Siirola

المصدر: Pharmaceutical Biocatalysis ISBN: 9780429353116

مصطلحات موضوعية: Drug, Engineering, chemistry.chemical_compound, chemistry, Biocatalysis, business.industry, media_common.quotation_subject, Computational biology, business, Cipargamin, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::30dd4a2fe5e4a26938b7cbd8c637a046
https://doi.org/10.1201/9780429353116-15

المؤلفون: John P. Holleran, Adele M. Lehane, Melanie C. Ridgway, Kiaran Kirk, Adelaide S. M. Dennis

المصدر: Antimicrobial Agents and Chemotherapy. 62

مصطلحات موضوعية: 0301 basic medicine, Erythrocytes, Indoles, Plasmodium falciparum, Biological Transport, Active, Pharmacology, Antimalarials, 03 medical and health sciences, chemistry.chemical_compound, Extracellular, medicine, Humans, Spiro Compounds, Pharmacology (medical), Antimalarial Agent, Malaria, Falciparum, Mechanisms of Action: Physiological Effects, Cell Size, Osmotic concentration, biology, Chemistry, Erythrocyte fragility, Membrane Transport Proteins, biology.organism_classification, Cipargamin, 3. Good health, Osmotic Fragility, 030104 developmental biology, Infectious Diseases, Efflux, Swelling, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be98607b4f96735597f1236974cc703
https://doi.org/10.1128/aac.00087-18

المؤلفون: McCulloch J

مصطلحات موضوعية: biology, Plasmodium falciparum, Drug resistance, Resistance mutation, Southeast asian, biology.organism_classification, Cipargamin, Virology, chemistry.chemical_compound, chemistry, parasitic diseases, Spiroindolone, Mutation (genetic algorithm), Genotype

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d29cc2cfa6f69b4fef1c1bb4a2cf84
https://doi.org/10.1101/293035

المؤلفون: Helen Turner

المصدر: Future Medicinal Chemistry. 8:227-238

مصطلحات موضوعية: 0301 basic medicine, Drug, Indoles, media_common.quotation_subject, Phenotypic screening, Plasmodium falciparum, 030106 microbiology, Protozoan Proteins, Drug resistance, Biology, Pharmacology, Antimalarials, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, Spiroindolone, medicine, Animals, Humans, Potency, Spiro Compounds, Cation Transport Proteins, media_common, Adenosine Triphosphatases, medicine.disease, Cipargamin, Malaria, 030104 developmental biology, chemistry, Microsomes, Liver, Molecular Medicine, Half-Life

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b78d473162d51eeef8b0acafa8d48f
https://doi.org/10.4155/fmc.15.177

المؤلفون: Kiaran Kirk, Natalie J. Spillman

المصدر: International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 149-162 (2015)

مصطلحات موضوعية: Plasmodium, Erythrocytes, Plasmodium falciparum, Antimalarial, Calcium-Transporting ATPases, Pharmacology, Gene Expression Regulation, Enzymologic, lcsh:Infectious and parasitic diseases, chemistry.chemical_compound, Antimalarials, Spiroindolone, medicine, Humans, lcsh:RC109-216, Pharmacology (medical), Antimalarial Agent, Malaria, Falciparum, PfATP4, Cipargamin, Invited Review, biology, Drug discovery, biology.organism_classification, medicine.disease, 3. Good health, Infectious Diseases, Resistance selection, Mechanism of action, chemistry, Parasitology, medicine.symptom, Malaria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf7d8d277d417f0a5ae31f022bf72ce
http://europepmc.org/articles/PMC4559606

المؤلفون: Kevin S. W. Tan, Chwee Teck Lim, Benoit Malleret, Rossarin Suwanarusk, Bruce Russell, François Nosten, Ming Dao, Laurent Rénia, Rou Zhang, Yee Ling Lau, Brian M. Cooke

المصدر: The Journal of Infectious Diseases

مصطلحات موضوعية: 0301 basic medicine, Erythrocytes, Indoles, Plasmodium vivax, Plasmodium falciparum, malaria, Spleen, red blood cell, Plasmodium, Microbiology, 03 medical and health sciences, chemistry.chemical_compound, Major Articles and Brief Reports, Antimalarials, Spiroindolone, parasitic diseases, medicine, Immunology and Allergy, Humans, Parasites, Spiro Compounds, Malaria, Falciparum, biology, biology.organism_classification, medicine.disease, Cipargamin, spiroindolones, 3. Good health, Red blood cell, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, chemistry, Immunology, Malaria, KAE609

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fd7e60c7dc638cee7d6e470a6b66dd
http://europepmc.org/articles/PMC4676544

المؤلفون: François Nosten, Tran Tinh Hien, Kamal Hamed, Jay Prakash Jain, Phung Duc Thuan, Nhu Thi Hoa, Nicholas J. White, Joel Tarning, Baldur Magnusson, Nguyen Thuy-Nhien

المصدر: Antimicrobial Agents and Chemotherapy

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Indoles, Combination therapy, 030106 microbiology, malaria, Microbial Sensitivity Tests, Parasitemia, Clinical Therapeutics, Pharmacology, resistance, Antimalarials, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, Asian People, Pharmacokinetics, parasitic diseases, medicine, Humans, Spiro Compounds, Pharmacology (medical), Malaria, Falciparum, Artemisinin, biology, business.industry, clinical trial, Plasmodium falciparum, Middle Aged, medicine.disease, biology.organism_classification, Cipargamin, 3. Good health, Infectious Diseases, cipargamin, chemistry, Pharmacodynamics, pharmacokinetic-pharmacodynamic model, business, Malaria, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1eebd774af27a9f70c2a142e9567898
https://doi.org/10.1128/aac.01940-16

المؤلفون: B.K.S Yeung

مصطلحات موضوعية: Drug candidate, Drug discovery, Phenotypic screening, Phases of clinical research, Plasmodium falciparum, Biology, Pharmacology, biology.organism_classification, medicine.disease, Cipargamin, chemistry.chemical_compound, chemistry, parasitic diseases, Spiroindolone, medicine, Malaria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c50a3cde7c63cd67f7f4d04eef3e93c9
https://doi.org/10.1016/b978-0-12-409547-2.12469-2