المؤلفون: Debora Obergfäll, Markus Wild, Mona Sommerer, Malena Barillas Dahm, Jintawee Kicuntod, Julia Tillmanns, Melanie Kögler, Josephine Lösing, Kishore Dhotre, Regina Müller, Christina Wangen, Sabrina Wagner, Quang V. Phan, Lüder Wiebusch, Katarína Briestenská, Jela Mistríková, Lauren Kerr-Jones, Richard J. Stanton, Sebastian Voigt, Friedrich Hahn, Manfred Marschall

المصدر: Pharmaceutics, Vol 16, Iss 9, p 1238 (2024)

مصطلحات موضوعية: human pathogenic herpesviruses, virus-supportive cellular protein kinases, cyclin-dependent kinase 8 (CDK8), human cytomegalovirus (HCMV), regulation of viral replication, negative impact of CDK8 inhibitors, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/9/1238; https://doaj.org/toc/1999-4923

URL الوصول: https://doaj.org/article/50f7819660bd402ab81087a6f158cee0

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/journal_contribution/One-hundred_ns_all-atom_molecular_dynamics_simulations_show_that_stabilization_of_R77_side_chain_provided_by_the_R-clamp_in_the_wild-type_complex_could_be_reproduced_by_Met_Ile_and_Trp_in_the_A83M_Y120I_double_mutant_/17017374

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.s004

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/journal_contribution/Contour_plots_illustrating_cell_surface_CD4_expression_and_HIV-1_Nef_transduction_GFP_levels_/17017362

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.s001

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/journal_contribution/Contour_plots_illustrating_cell_surface_CD4_expression_and_SIVcpz_Nef_transduction_GFP_levels_/17017371

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.s003

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/journal_contribution/Role_of_the_R-clamp_in_Nef-mediated_enhancement_of_virion_infectivity_/17017383

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.s006

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/journal_contribution/Role_of_R-clamp_residues_83_120_in_intracellular_Hck-Nef_complex_formation_/17017377

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.s005

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/figure/Hck-activating_potential_of_selected_HIV-1_Nefs_/17017392

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.g001

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/figure/Fig_2_-/17017398

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.g002

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/figure/The_arginine_clamp_/17017404

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.g003

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/figure/Role_of_residue_83_120_pairing_in_the_HIV-1_N_Nef_R-clamp_/17017410

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.g004

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/figure/Comprehensive_testing_of_R-clamp_residue_pairing_rules_by_mutagenesis_of_SF2-Nef_/17017425

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.g006

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/figure/Putative_cross-species_transmission_and_evolution_of_R-clamp_categories_/17017443

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.g009

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/figure/R-clamp_architecture_of_SIVcpz_Nef_proteins_/17017416

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.g005

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/figure/Role_of_the_R-clamp_in_activation_of_in_vitro_differentiated_macrophages_by_Nef_/17017437

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.g008

المؤلفون: Zhe Zhao (157204), Riku Fagerlund (11707983), Helena Tossavainen (198209), Kristina Hopfensperger (824159), Rishikesh Lotke (9549926), Smitha Srinivasachar Badarinarayan (11707986), Frank Kirchhoff (94157), Perttu Permi (150487), Kei Sato (493447), Daniel Sauter (109619), Kalle Saksela (153572)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Infectious Diseases, Virology, simian immunodeficiency viruses, side chain compositions, highly conserved arginine, eastern chimpanzee subspecies, cellular protein kinases, aforementioned two classes, tyrosine kinase hck, combining structural analyses, nef residues 83, accessory protein nef, several distinct r, functional evolutionary intermediate, div >< p, ), clamp design principles, 1 nef activates, sh3 domain binding, sh3 domain, sh3 binding, structural basis, kinase deregulation

Relation: https://figshare.com/articles/dataset/R-clamp_residue_combinations_in_the_HIV-1-like_superfamily_of_Nef_proteins_/17017446

الاتاحة: https://doi.org/10.1371/journal.ppat.1009728.t001