المؤلفون: Zhou X, Liu J, Xiao S, Liang X, Li Y, Mo F, Xin X, Yang Y, Gao C

المصدر: International Journal of Nanomedicine, Vol Volume 19, Pp 7691-7708 (2024)

مصطلحات موضوعية: aav engineering, capsid modification, surface tethering, virus load, rational design, directed evolution, machine learning, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://www.dovepress.com/adeno-associated-virus-engineering-and-load-strategy-for-tropism-modif-peer-reviewed-fulltext-article-IJN; https://doaj.org/toc/1178-2013

URL الوصول: https://doaj.org/article/58c2fe22206644798bb3b5c759c63da4

المؤلفون: Robin Nilson, Olivia Lübbers, Christoph Q. Schmidt, Markus Rojewski, Philip Helge Zeplin, Wolfgang Funk, Hubert Schrezenmeier, Astrid Kritzinger, Stefan Kochanek, Lea Krutzke

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 96-110 (2022)

مصطلحات موضوعية: mesenchymal stromal cells, mesenchymal stem cells, adenovirus, HAdV-5, capsid modification, viral vectors, Genetics, QH426-470, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050122000341; https://doaj.org/toc/2329-0501

URL الوصول: https://doaj.org/article/87a64ed911c04f28ab8c34275b460b7b

المؤلفون: Naidoo, Jerusha, Stanek, Lisa M, Ohno, Kousaku, Trewman, Savanah, Samaranch, Lluis, Hadaczek, Piotr, O'Riordan, Catherine, Sullivan, Jennifer, San Sebastian, Waldy, Bringas, John R, Snieckus, Christopher, Mahmoodi, Amin, Mahmoodi, Amir, Forsayeth, John, Bankiewicz, Krystof S, Shihabuddin, Lamya S

المصدر: Molecular Therapy. 26(10)

مصطلحات موضوعية: Medical Biotechnology, Biomedical and Clinical Sciences, Neurosciences, Neurodegenerative, Gene Therapy, Genetics, Neurological, Animals, Axonal Transport, Brain, Capsid Proteins, Central Nervous System, Dependovirus, Disease Models, Animal, Genetic Therapy, Genetic Vectors, Heparan Sulfate Proteoglycans, Humans, Infusions, Intraventricular, Motor Neurons, Neurons, Parvovirinae, Primates, Spinal Cord, Thalamus, AAV vectors, CNS disorders, brain, capsid modification, gene therapy, nervous system, non-human primate, spinal cord, transduction, viral vector, Biological Sciences, Technology, Medical and Health Sciences, Biotechnology, Clinical sciences, Medical biotechnology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3wm7w7gm

المؤلفون: Sarah B. Erickson, Quan Pham, Xiaofu Cao, Jake Glicksman, Rachel E. Kelemen, Seyed S. Shahraeini, Sebastian Bodkin, Zainab Kiyam, Abhishek Chatterjee

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Ecology, Infectious Diseases, Virology, Space Science, Chemical Sciences not elsewhere classified, particularly attractive strategy, human gene therapy, specific cell types, attachment heavily impacts, minor capsid proteins, using ncaa mutagenesis, associated virus conjugates, associated virus, virus capsid, specific incorporation, capsid modification, capsid labeling, aav conjugates, targeted transduction, systematically alter, selectively incorporating, retargeting ligand, promising approach, precisely control, precise manipulation, mediated retargeting, highly sensitive

Relation: https://figshare.com/articles/journal_contribution/Precise_Manipulation_of_the_Site_and_Stoichiometry_of_Capsid_Modification_Enables_Optimization_of_Functional_Adeno-Associated_Virus_Conjugates/24846144

الاتاحة: https://doi.org/10.1021/acs.bioconjchem.3c00411.s001
https://figshare.com/articles/journal_contribution/Precise_Manipulation_of_the_Site_and_Stoichiometry_of_Capsid_Modification_Enables_Optimization_of_Functional_Adeno-Associated_Virus_Conjugates/24846144

المؤلفون: Juliane Kuklik, Stefan Michelfelder, Felix Schiele, Sebastian Kreuz, Thorsten Lamla, Philipp Müller, John E. Park

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 15; Pages: 8355

مصطلحات موضوعية: adeno-associated viral vectors, AAV, protein engineering, retargeting, bispecific antibody, capsid modification, FAP, PD-L1

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms22158355

الاتاحة: https://doi.org/10.3390/ijms22158355

المؤلفون: Denice Weklak, Daniel Pembaur, Georgia Koukou, Franziska Jönsson, Claudia Hagedorn, Florian Kreppel

المصدر: Viruses; Volume 13; Issue 7; Pages: 1300

مصطلحات موضوعية: adenovirus, capsid modification, chemical modification, PEGylation, HPMA, COVID-19 vaccine

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Viral Immunology, Vaccines, and Antivirals; https://dx.doi.org/10.3390/v13071300

الاتاحة: https://doi.org/10.3390/v13071300

المؤلفون: Bijay Dhungel, Aparna Jayachandran, Christopher J. Layton, Jason C. Steel

المصدر: Drug Delivery, Vol 24, Iss 1, Pp 289-299 (2017)

مصطلحات موضوعية: aav, hcc, targeted gene delivery, gene therapy transcriptional targeting, transductional targeting, capsid modification, tumor specific promoters, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1071-7544; https://doaj.org/toc/1521-0464

URL الوصول: https://doaj.org/article/33294d228d0040988493b32300a7351d

المؤلفون: Nilson, Robin

المساهمون: Kochanek, Stefan, Brunner, Cornelia, Nettelbeck, Dirk

مصطلحات موضوعية: Oncolytic Virotherapy, Genetic therapy, Adenoviruses, Human, Mesenchymal stromal cells, Adenovirus 5, Onkolytische Viren, Oncolytic Virus, Transduction enhancers, Gentherapie, Carrier cells, Gene therapy, Mesenchymal stem cells, ddc:610, DDC 610 / Medicine & health, Capsid modification, Mesenchymzelle

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a420a0f15b94dc6eb57d72685aca16

المؤلفون: B Dhungel, A Jayachandran, Christopher Layton, Jason Steel

مصطلحات موضوعية: Gene and molecular therapy, AAV, Targeted gene delivery, Gene therapy transcriptional targeting, Transductional targeting, Capsid modification, Tumor specific promoters, HCC, Animals, Carcinoma, Hepatocellular, Dependovirus, Gene Transfer Techniques, Humans, Liver Neoplasms

Relation: https://figshare.com/articles/journal_contribution/Seek_and_destroy_Targeted_adeno-associated_viruses_for_gene_delivery_to_hepatocellular_carcinoma/20963704; http://hdl.handle.net/10779/cqu.20963704.v1

الاتاحة: http://hdl.handle.net/10779/cqu.20963704.v1

المؤلفون: Kuklik, Juliane

المساهمون: Kochanek, Stefan, Park, John, Schubert, Maren, Sinzger, Christian

مصطلحات موضوعية: Antibody, Capsid modification, Retargeting, Adeno-associated virus, AAV, Antibodies, Dependovirus, Genetics, Capsid proteins, Antikörper, Capsid, Dependoviren

وصف الملف: application/pdf

الاتاحة: https://doi.org/10.18725/OPARU-45588
http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-45664-9

المؤلفون: Natalie Baum, Kathleen Börner, Friedrich Koch-Nolte, Friedrich Haag, Martin Trepel, Anna Marei Eichhoff, Sahil Adriouch, Ingke Braren, Birte Albrecht, Jakob Körbelin, Dirk Grimm, Waldemar Schäfer

المساهمون: Department of Infectious Diseases/Virology [Heidelberg, Germany] (Cluster of Excellence CellNetworks), Universität Heidelberg [Heidelberg], Institute for Immunology, Hannover Medical School [Hannover] (MHH), Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: Molecular Therapy. Methods & Clinical Development
Molecular Therapy-Methods and Clinical Development
Molecular Therapy-Methods and Clinical Development, Nature Publishing Group, 2019, 15, pp.211-220. ⟨10.1016/j.omtm.2019.09.003⟩
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss, Pp 211-220 (2019)

مصطلحات موضوعية: 0301 basic medicine, vector-targeting, capsid modification, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, lcsh:QH426-470, viruses, VHH, adeno-associated virus, Vectors in gene therapy, medicine.disease_cause, Article, ligand-insertion, 03 medical and health sciences, Transduction (genetics), 0302 clinical medicine, Genetics, medicine, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, lcsh:QH573-671, Molecular Biology, Adeno-associated virus, ComputingMilieux_MISCELLANEOUS, Tropism, single-domain antibody, lcsh:Cytology, Chemistry, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, Fusion protein, Transmembrane protein, 3. Good health, Cell biology, lcsh:Genetics, nanobody, 030104 developmental biology, Single-domain antibody, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Capsid, 030220 oncology & carcinogenesis, [SDV.IMM]Life Sciences [q-bio]/Immunology, Molecular Medicine, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, P2X7, cell-specific vectors, CD38

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d2995b499b8a382e8a9600fa77edb8
https://doi.org/10.1016/j.omtm.2019.09.003

المؤلفون: Philipp Müller, John Edward Park, Stefan Michelfelder, Juliane Kuklik, Felix Schiele, Thorsten Lamla, Sebastian Kreuz

المصدر: International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8355, p 8355 (2021)

مصطلحات موضوعية: PD-L1, capsid modification, QH301-705.5, adeno-associated viral vectors, Genetic Vectors, Biology, Catalysis, Epitope, Article, Inorganic Chemistry, Epitopes, Capsid, Transduction, Genetic, Antibodies, Bispecific, Endopeptidases, Humans, Vector (molecular biology), Biology (General), Physical and Theoretical Chemistry, Receptor, QD1-999, Molecular Biology, Spectroscopy, retargeting, Linear epitope, Organic Chemistry, Gene Transfer Techniques, FAP, Membrane Proteins, AAV, protein engineering, General Medicine, Protein engineering, Genetic Therapy, Dependovirus, Computer Science Applications, Cell biology, Chemistry, bispecific antibody, Retargeting, Kexin, Capsid Proteins, Proprotein Convertase 9

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7492fe6f1126b27cd270f0c0becbc2
http://europepmc.org/articles/PMC8347852

المؤلفون: Lam, Anh Kim, Frabutt, Dylan A., Li, Lei, Xiao, Weidong

المساهمون: Pediatrics, School of Medicine

المصدر: Author

مصطلحات موضوعية: capsid modification, AAV, Adeno-associated virus, chemical modicfication, capsid engineering

وصف الملف: application/pdf

Relation: Human Gene Therapy; Lam, A. K., Frabutt, D. A., Li, L., & Xiao, W. (2021). Chemical Modifications of the Capsid for Redirecting and Improving the Efficacy of Adeno-Associated Virus Vectors. Human Gene Therapy, 32(23–24), 1433–1438. https://doi.org/10.1089/hum.2021.124; 1043-0342, 1557-7422; https://hdl.handle.net/1805/27581

الاتاحة: https://hdl.handle.net/1805/27581

المؤلفون: Prasad R. Konkalmatt, Defeng eDeng, Stephanie eThomas, Michael T. Wu, Craig D. Logsdon, Brent A. French, Kimberly A Kelly

المصدر: Frontiers in Oncology, Vol 3 (2013)

مصطلحات موضوعية: Gene Therapy, Pancreatic Cancer, aav, phage display, targeted gene delivery, capsid modification, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00084/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/bc580d6f5e0549c082577fe778c9bea0

المؤلفون: Gamble, Lena J, Ugai, Hideyo, Wang, Minghui, Borovjagin, Anton V, Matthews, Qiana L

المساهمون: NIH

المصدر: Journal of Molecular Biochemistry; Vol 1, No 1 (2012)

مصطلحات موضوعية: Conditionally replicative adenoviruses (CRAds), Ovarian Cancer, arginine-glycine-aspartate (RGD) motif, capsid-modification, anti-cancer therapy

وصف الملف: application/pdf

Relation: http://www.jmolbiochem.com/index.php/JmolBiochem/article/view/9/7; http://www.jmolbiochem.com/index.php/JmolBiochem/article/view/9

الاتاحة: http://www.jmolbiochem.com/index.php/JmolBiochem/article/view/9

المؤلفون: Kousaku Ohno, John Forsayeth, Amir Mahmoodi, Waldy San Sebastian, Amin Mahmoodi, Krystof S. Bankiewicz, Lamya S. Shihabuddin, Savanah Trewman, Jerusha Naidoo, Catherine R. O'Riordan, Piotr Hadaczek, Lisa M. Stanek, John Bringas, Jennifer Sullivan, Christopher Snieckus, Lluis Samaranch

المصدر: Molecular therapy : the journal of the American Society of Gene Therapy, vol 26, iss 10

مصطلحات موضوعية: Central Nervous System, 0301 basic medicine, Nervous system, Technology, non-human primate, Neurodegenerative, Deep cerebellar nuclei, Medical and Health Sciences, Axonal Transport, Transduction (genetics), Thalamus, Parvovirinae, Drug Discovery, Motor Neurons, Neurons, nervous system, viral vector, Brain, Gene Therapy, Biological Sciences, Dependovirus, transduction, Infusions, Intraventricular, medicine.anatomical_structure, Spinal Cord, Neurological, Molecular Medicine, Original Article, Biotechnology, Primates, Infusions, capsid modification, Intraventricular, brain, Genetic Vectors, Central nervous system, Biology, AAV vectors, Viral vector, 03 medical and health sciences, CNS disorders, Genetics, medicine, Animals, Humans, Molecular Biology, Pharmacology, Animal, Neurosciences, spinal cord, Genetic Therapy, Motor neuron, Spinal cord, Disease Models, Animal, 030104 developmental biology, Disease Models, Capsid Proteins, Neuroscience, Heparan Sulfate Proteoglycans

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43439e3c94e50be5bc9e21e6cd4f7a73
https://doi.org/10.1016/j.ymthe.2018.07.008

المؤلفون: Jason C. Steel, Aparna Jayachandran, Bijay Dhungel, Christopher J. Layton

المصدر: Drug Delivery
article-version (VoR) Version of Record
Drug Delivery, Vol 24, Iss 1, Pp 289-299 (2017)

مصطلحات موضوعية: 0301 basic medicine, capsid modification, Carcinoma, Hepatocellular, Genetic enhancement, Pharmaceutical Science, RM1-950, Review, Review Article, Gene delivery, Biology, targeted gene delivery, medicine.disease_cause, Bioinformatics, Virus, Viral vector, 03 medical and health sciences, medicine, Animals, Humans, Vector (molecular biology), HCC, transductional targeting, gene therapy transcriptional targeting, Liver Neoplasms, tumor specific promoters, Gene Transfer Techniques, AAV, General Medicine, Dependovirus, medicine.disease, digestive system diseases, Clinical trial, 030104 developmental biology, Herpes simplex virus, Hepatocellular carcinoma, Immunology, Therapeutics. Pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530051f44567262d3f0e48061bdfaf36
http://europepmc.org/articles/PMC8241004

المؤلفون: Sujit Pujhari, Satyender Hansra, Alexander N. Zakhartchouk

المصدر: The Open Virology Journal

مصطلحات موضوعية: Serotype, viruses, hexon, Biology, Porcine reproductive and respiratory syndrome virus, biology.organism_classification, Virology, Epitope, Virus, Article, Hypervariable region, Capsid, Antigen, Cell culture, vaccine, Adenovirus, capsid-modification

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb22e4ccf31612f2847e37c08f47460

المؤلفون: Dhungel, Bijay, Jayachandran, Aparna, Layton, Christopher J., Steel, Jason C.

مصطلحات موضوعية: AAV, HCC, Targeted gene delivery, Gene therapy transcriptional targeting, Transductional targeting, Capsid modification, Tumor specific promoters, 3003 Pharmaceutical Science

Relation: orcid:0000-0001-6933-9991; Not set

الاتاحة: https://espace.library.uq.edu.au/view/UQ:453583

المؤلفون: Chi-Yi Yu, Chunping Qiao, Xiao Xiao, Zhongren Cao, Zhenhua Yuan, Bing Wang, Juan Li

المصدر: Gene therapy

مصطلحات موضوعية: capsid modification, viruses, Genetic Vectors, Biology, Tropism, Article, muscle targeting, 03 medical and health sciences, Mice, 0302 clinical medicine, In vivo, Genetics, Myocyte, Animals, Molecular Biology, 030304 developmental biology, Infectivity, 0303 health sciences, Mice, Inbred ICR, Myogenesis, Heparin, Muscles, Myocardium, Gene Transfer Techniques, Gene targeting, AAV, Dependovirus, Molecular biology, systemic delivery, 3. Good health, 030220 oncology & carcinogenesis, Gene Targeting, Injections, Intravenous, Systemic administration, Tissue tropism, Molecular Medicine, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe558b1c7e289a640d5cf7dbe37742fb
http://europepmc.org/articles/PMC2726895