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1
المؤلفون: Tingting Chen, Ancheng Shen, Ao Zhang, Chunyong Ding, Zilan Song
المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: PD-L1, programmed death ligand 1, TBK1, medicine.medical_treatment, ICI, immune checkpoint inhibitor, DC50, concentration for 50% degradation, Review, ACMA, 9-amino-6-chloro-2-methoxyacridine, PD-1, programmed death receptor 1, ULD, ubiquitin-like domain, Anti-tumor, ABZI, amidobenzimidazole, 0302 clinical medicine, GMP, guanosine monophosphate, LBD, ligand-binding domain, GTP, guanosine triphosphate, PRRs, pattern recognition receptors, Interferon, cAIMP, cyclic adenosine-inosine monophosphate, Medicine, CMA, 10-carboxymethyl-9-acridanone, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, ISG, interferon stimulated gene, MinEC5×, minimum effective concentration for inducing 5-fold luciferase activity, 0303 health sciences, KD, kinase domain, dsDNA, double-stranded DNA, MG, Mangostin, ITC, isothermal titration calorimetry, Immunogenicity, PBMCs, peripheral-blood mononuclear cells, MDCK, Madin–Darby canine kidney, PROTACs, proteolysis targeting chimeras, FAA, flavone-8-acetic acid, CTD, C-terminal domain, DMXAA, 5,6-dimethylxanthenone-4-acetic acid, DSDP, dispiro diketopiperzine, STAT, signal transducer and activator of transcription, medicine.anatomical_structure, 030220 oncology & carcinogenesis, CDN, cyclic dinucleotide, QC, quinacrine, FP, fluorescence polarization, PDK1, 3-phosphoinositide-dependent protein kinase 1, Immunotherapy, Signal transduction, DCs, dendritic cells, CDA, cyclic diadenosine monophosphate (c-di-AMP), medicine.drug, Ntase, nucleotidyl transferase, ATP, adenosine triphosphate, CDG, cyclic diguanosine monophosphate (c-di-GMP), T cell, SDD, scaffold and dimerization domain, NF-κB, nuclear factor-κB, STING, stimulator of interferon genes, TNFRSF, tumor necrosis factor receptor superfamily, EM, cryo-electron microscopy, ER, endoplasmic reticulum, 03 medical and health sciences, MLK, mixed lineage kinase, Immune system, CBD, cyclic dinucleotide-binding domain, THIQCs, tetrahydroisoquinolone acetic acids, SAR, structure–activity relationship, HCQ, hydrochloroquine, ENPP1, ecto-nucleotide pyrophosphatase/phosphodiesterase, HTS, high throughput screening, 030304 developmental biology, MI, maximum induction, CXCL, chemokine (C-X-C motif) ligand, Innate immune system, PDE, phosphodiesterases, IO, immune-oncology, business.industry, IRF3, interferon regulatory factor 3, i.t., intratumoral, CTT, C-terminal tail, lcsh:RM1-950, BNBC, 6-bromo-N-(naphthalen-1-yl)benzo[d][1,3]dioxole-5-carboxamide, Chimeric antigen receptor, PPi, pyrophosphoric acid, Small molecule modulators, FDA, U.S. Food and Drug Administration, VHL, von Hippel–Lindau, lcsh:Therapeutics. Pharmacology, AMP, adenosine monophosphate, TBK1, TANK-binding kinase 1, Cancer research, cGAMP, cyclic guanosine monophosphate-adenosine monophosphate, business, cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthase, CTLA-4, cytotoxic T lymphocyte associated protein 4, cGAS, STING
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2
المؤلفون: Jiamin Du, Ruihan Chen, Qi Ling, Hong Zhu
المصدر: JHEP Reports
مصطلحات موضوعية: nonalcoholic fatty liver disease, cGAS-STING signalling, ssRNA, single-stranded RNA, Review, SAVI, STING-associated vasculopathy with onset in infancy, PD-L1, programmed cell death protein ligand-1, GVHD, graft-versus-host disease, IFN-I, type I interferon, TNF, tumour necrosis factor, chemistry.chemical_compound, NK cells, natural killer cells, Immunology and Allergy, ALD, alcohol-related liver disease, dsDNA, double-strand DNA, Toll-like receptor, PD-1, programmed cell death protein-1, XRCC, X-ray repair cross complementing, Gastroenterology, Pattern recognition receptor, hepatocellular carcinoma, Cell biology, TGF-β1, transforming growth factor-β1, Stimulator of interferon genes, IRI, ischaemia refusion injury, APCs, antigen-presenting cells, DCs, dendritic cells, HSCs, hepatic stellate cells, liver injury, TLR, Toll-like receptor, AIM2, absent in melanoma 2, NAFLD, non-alcoholic fatty liver disease, aHSCT, allogeneic haematopoietic stem cell transplantation, viral hepatitis, mTOR, mammalian target of rapamycin, STING, stimulator of interferon genes, Biology, CDNs, cyclic dinucleotides, ER, endoplasmic reticulum, AIM2, Cyclic guanosine monophosphate–adenosine monophosphate, PAMPs, pathogen-associated molecular patterns, Internal Medicine, MHC, major histocompatibility complex, NPCs, non-parenchymal cells, Innate immune system, Hepatology, IRF3, interferon regulatory factor 3, Pathogen-associated molecular pattern, LSECs, liver sinusoidal endothelial cells, PPRs, pattern recognition receptors, eye diseases, IL, interleukin, mtDNA, mitochondrial DNA, chemistry, siRNA, small interfering RNA, DAMPs, damage-associated molecular patterns, TBK1, TANK-binding kinase 1, innate immune response, KCs, Kupffer cells, cGAMP, cyclic guanosine monophosphate-adenosine monophosphate, cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthase, HCC, hepatocellular carcinoma, IRF3