المؤلفون: Dan Zou, Sitong Feng, Bowen Hu, Mengya Guo, Yan Lv, Rong Ma, Yuxin Du, Jifeng Feng

المصدر: Cell & Bioscience, Vol 14, Iss 1, Pp 1-22 (2024)

مصطلحات موضوعية: Bromodomains, B-cell non-Hodgkin lymphoma, Bromodomain and extra-terminal domain, Epigenetics, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-3701

URL الوصول: https://doaj.org/article/ddd556e235734428be405c5096e11b12

المؤلفون: Yu Meng, Hui-Yan Sun, Yi He, Qian Zhou, Yi-Huang Liu, Hui Su, Ming-Zhu Yin, Fu-Rong Zeng, Xiang Chen, Guang-Tong Deng

المصدر: Military Medical Research, Vol 10, Iss 1, Pp 1-5 (2023)

مصطلحات موضوعية: Melanoma, Bromodomain and extra terminal domain (BET) inhibitor, Ferroptosis, Cell death, AKR1C2, Immunotherapy, Medicine (General), R5-920, Military Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2054-9369

URL الوصول: https://doaj.org/article/397467047a774b85b98b57d86241bd49

المؤلفون: Yuki Kotani, Yoshinori Imura, Sho Nakai, Ryota Chijimatsu, Haruna Takami, Akitomo Inoue, Hirokazu Mae, Satoshi Takenaka, Hidetatsu Outani, Seiji Okada

المصدر: Cancers, Vol 16, Iss 6, p 1125 (2024)

مصطلحات موضوعية: synovial sarcoma, BCL2 family, bromodomain and extra-terminal domain protein inhibitor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Relation: https://www.mdpi.com/2072-6694/16/6/1125; https://doaj.org/toc/2072-6694; https://doaj.org/article/3cf699fa8b3c41c6af77eb4afe8a0456

الاتاحة: https://doi.org/10.3390/cancers16061125
https://doaj.org/article/3cf699fa8b3c41c6af77eb4afe8a0456

المؤلفون: Tanimoto, Saki, Sone, Kenbun, Jonouchi, Yuri, Hachijo, Ryuta, Suzuki, Eri, Tsuboyama, Natsumi, Toyohara, Yusuke, Inoue, Futaba, Honjoh, Harunori, Fukuda, Tomohiko, Taguchi, Ayumi, Miyamoto, Yuichiro, Iriyama, Takayuki, Mori, Mayuyo, Asada, Ken, Komatsu, Masaaki, Kaneko, Syuzo, Hamamoto, Ryuji, Wada-Hiraike, Osamu, Oda, Katsutoshi, Hirota, Yasushi, Osuga, Yutaka

المصدر: Oncol Lett ; ISSN:1792-1082 ; Volume:29 ; Issue:3

مصطلحات موضوعية: apoptosis, bromodomain and extra-terminal domain protein, c-Myc, endometrioid endometrial carcinoma, epigenetics, ovarian endometrioid carcinoma

Relation: https://doi.org/10.3892/ol.2024.14852; https://pubmed.ncbi.nlm.nih.gov/39736925; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683525/

الاتاحة: https://doi.org/10.3892/ol.2024.14852
https://pubmed.ncbi.nlm.nih.gov/39736925
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683525/

المؤلفون: Christopher D. Sarsons, Dean Gilham, Laura M. Tsujikawa, Sylwia Wasiak, Li Fu, Brooke D. Rakai, Stephanie C. Stotz, Agostina Carestia, Michael Sweeney, Ewelina Kulikowski

المصدر: Biomedicines, Vol 11, Iss 2683, p 2683 (2023)

مصطلحات موضوعية: facioscapulohumeral muscular dystrophy, FSHD, DUX4, bromodomain and extra-terminal domain, BET inhibitor, transcriptome, Biology (General), QH301-705.5

Relation: https://www.mdpi.com/2227-9059/11/10/2683; https://doaj.org/toc/2227-9059; https://doaj.org/article/51286032f8f3442ebfcdb580ce159e02

الاتاحة: https://doi.org/10.3390/biomedicines11102683
https://doaj.org/article/51286032f8f3442ebfcdb580ce159e02

المؤلفون: Archit Trivedi, Aanchal Mehrotra, Caitlin E. Baum, Brandon Lewis, Tupa Basuroy, Thomas Blomquist, Robert Trumbly, Fabian V. Filipp, Vijayasaradhi Setaluri, Ivana L. de la Serna

المصدر: Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-18 (2020)

مصطلحات موضوعية: Bromodomain and extra-terminal domain, BET, JQ1, BRD4, MITF, ChIP-Seq, Genetics, QH426-470

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s13072-020-00333-z; https://doaj.org/toc/1756-8935

URL الوصول: https://doaj.org/article/3388d5c1150043a58943b8a9ef32ec3a

المؤلفون: Schlichting, Jara Pascale

مصطلحات موضوعية: BET-Inhibition, Hämatopoese, Hämatopoetische Stammzelle, bromodomain and extra-terminal domain (BET) family, JQ1, 610: Medizin, Blutstammzelle, Epigenetik, Knochenmarktransplantation, Hämatologie, ddc:610:

URL الوصول: http://nbn-resolving.de/urn:nbn:de:gbv:18-ediss-107490
https://ediss.sub.uni-hamburg.de/handle/ediss/10125

المؤلفون: Zhirong Lin, Zhenzhen Li, Zhen Guo, Yanjun Cao, Jingyan Li, Peiqing Liu, Zhuoming Li

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: bromodomain containing protein 2 (BRD2), bromodomain and extra-terminal domain (BET) family, cardiac hypertrophy, cardiac metabolism, citrate cycle (TCA cycle), Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.887991/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/941cca8a451148b3b2b03b015afa62d2

المؤلفون: Ka Lung Cheung, Claudia Kim, Ming-Ming Zhou

المصدر: Frontiers in Molecular Biosciences, Vol 8 (2021)

مصطلحات موضوعية: bromodomain, bromodomain and extra-terminal domain proteins, gene transcription, inhibitors, cancer, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2021.728777/full; https://doaj.org/toc/2296-889X

URL الوصول: https://doaj.org/article/621ad4ad96a3463fb3c3cf7f6315c71b

المؤلفون: Jiacheng Lai, Ziqiang Liu, Yulei Zhao, Chengyuan Ma, Haiyan Huang

المصدر: Frontiers in Oncology, Vol 11 (2021)

مصطلحات موضوعية: cancer, bromodomain and extra-terminal domain protein, I-BET151, signal transduction, drug combination, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.716830/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/b313a72a97bc4a68bd1908902c801be1

المؤلفون: Piquereau, Jérôme, Boet, Angèle, Péchoux, Christine, Antigny, Fabrice, Lambert, Mélanie, Gressette, Mélanie, Ranchoux, Benoît, Gambaryan, Natalia, Domergue-Dupont, Valérie, Mumby, Sharon, Montani, David, Adcock, Ian M., Humbert, Marc, Garnier, Anne, Rücker-Martin, Catherine, Perros, Frédéric

المساهمون: Signalisation et physiopathologie cardiovasculaire (CARPAT (UMRS1180)), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique (HPPIT), Université Paris-Sud - Paris 11 (UP11)-Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Saclay, Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), Université Paris-Sud - Paris 11 (UP11), Réanimation des cardiopathies congénitales Le Plessis-Robinson (Centre chirurgical Marie Lannelongue), Centre Chirurgical Marie Lannelongue (CCML), Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, National Heart and Lung Institute London (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Ingénierie et Plateformes au Service de l'Innovation Thérapeutique de Paris Saclay (IPSIT), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), This work was supported by research grants from INSERM, National Funding Agency for Research (ANR) (Grant ANR-13-JSV1-0011-01), Laboratoire d’Excellence (LabEx) en Recherche sur le Médicament et l’Innovation Thérapeutique (LERMIT), Assistance Publique Hôpitaux de Paris (Département Hospitalo-Universitaire Thorax Innovation), Legs Poix (Chancellerie des Universités de Paris). F.A. was supported by a post-doctoral grant from Aviesan and by Lefoulon Delalande Institute. INSERM UMR_S 999 research unit, ANR-13-JSV1-0011,EMIR,Mécanismes épigénétiques dans l'inflammation et le remodelage vasculaire de l'hypertension pulmonaire(2013), ANR-11-IDEX-0003,IPS,Idex Paris-Saclay(2011)

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: heart, bromodomain and extra-terminal domain, bromodomain and extra-terminal domain inhibitor, mitochondria, cardiotoxicity, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system

Relation: info:eu-repo/semantics/altIdentifier/pmid/30934680; PRODINRA: 479925; PUBMED: 30934680; PUBMEDCENTRAL: PMC6480532; WOS: 000464980400012

الاتاحة: https://inserm.hal.science/inserm-02567799
https://inserm.hal.science/inserm-02567799v1/document
https://inserm.hal.science/inserm-02567799v1/file/The%20BET%20Bromodomain%20Inhibitor%20I-BET-151%20Induces%20Structural%20and%20Functional%20Alterations%20of%20the%20Heart%20Mitochondria%20in%20Healthy%20Male%20Mice%20and%20Rats.pdf
https://doi.org/10.3390/ijms20071527

المؤلفون: Gianluca Civenni, Giuseppina M. Carbone, Carlo V. Catapano

المصدر: Molecular & Cellular Oncology, Vol 6, Iss 5 (2019)

مصطلحات موضوعية: prostate cancer, cancer stem cells, bromodomain and extra-terminal domain proteins, brd4, mitochondrial fission, mff, epigenetics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2372-3556

URL الوصول: https://doaj.org/article/f761285377c6439c840deaba4c2a4c43

المؤلفون: Yi He, Wenyong Long, Qing Liu

المصدر: Frontiers in Pharmacology, Vol 10 (2019)

مصطلحات موضوعية: super-enhancer, neoplasms, bromodomain and extra-terminal domain protein, cyclin-dependent kinase 7, enhancer elements, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.00361/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/757a4f33558f4c9b8b10de362ff61b36

المؤلفون: Reyes-Garau, D., Ribeiro, Marcelo L., Roué, Gaël, Universitat Autònoma de Barcelona

مصطلحات موضوعية: BRD2, BRD4, Bromodomain and Extra-Terminal Domain, MYC, NF-κB, Combination therapy, Hematological malignancies, Protein degraders, Super-enhancer

وصف الملف: application/pdf

Relation: Instituto de Salud Carlos III PI15-00102; Instituto de Salud Carlos III PI18-01383; Cancers; Vol. 11 Núm. 10 (october 2019), p. 1483; https://ddd.uab.cat/record/216633; urn:10.3390/cancers11101483; urn:oai:ddd.uab.cat:216633; urn:scopus_id:85073444075; urn:articleid:20726694v11n10p1483; urn:pmid:31581671; urn:pmc-uid:6826405; urn:pmcid:PMC6826405; urn:oai:pubmedcentral.nih.gov:6826405

الاتاحة: https://ddd.uab.cat/record/216633

المؤلفون: Diana Reyes-Garau, Marcelo L. Ribeiro, Gaël Roué

المصدر: Cancers; Volume 11; Issue 10; Pages: 1483

مصطلحات موضوعية: bromodomain and extra-terminal domain, BRD2, BRD4, super-enhancer, NF-κB, MYC, combination therapy, hematological malignancies, protein degraders

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cancers11101483

الاتاحة: https://doi.org/10.3390/cancers11101483

المؤلفون: Yasushi Taniguchi

المصدر: International Journal of Molecular Sciences; Volume 17; Issue 11; Pages: 1849

مصطلحات موضوعية: Bromodomain and Extra-Terminal Domain (BET), bromodomain, histone acetylation, gene transcription, BET inhibitor

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms17111849

الاتاحة: https://doi.org/10.3390/ijms17111849

المؤلفون: Zhirong Lin, Zhenzhen Li, Zhen Guo, Yanjun Cao, Jingyan Li, Peiqing Liu, Zhuoming Li

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, bromodomain containing protein 2 (BRD2), bromodomain and extra-terminal domain (BET) family, cardiac hypertrophy, cardiac metabolism, citrate cycle (TCA cycle)

Relation: https://figshare.com/articles/dataset/DataSheet1_Epigenetic_Reader_Bromodomain_Containing_Protein_2_Facilitates_Pathological_Cardiac_Hypertrophy_via_Regulating_the_Expression_of_Citrate_Cycle_Genes_docx/19860748

الاتاحة: https://doi.org/10.3389/fphar.2022.887991.s001
https://figshare.com/articles/dataset/DataSheet1_Epigenetic_Reader_Bromodomain_Containing_Protein_2_Facilitates_Pathological_Cardiac_Hypertrophy_via_Regulating_the_Expression_of_Citrate_Cycle_Genes_docx/19860748

المؤلفون: Claudia Kim, Ka Lung Cheung, Ming-Ming Zhou

المصدر: Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences

مصطلحات موضوعية: Regulation of gene expression, BRD4, biology, QH301-705.5, bromodomain and extra-terminal domain proteins, RNA polymerase II, hemic and immune systems, Review, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, Chromatin remodeling, Bromodomain, Chromatin, Cell biology, gene transcription, Histone, bromodomain, inhibitors, biology.protein, cancer, Molecular Biosciences, Biology (General), Molecular Biology, Transcription factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b11e3b70e6c2cf6cc460c9c14954fe
https://www.frontiersin.org/articles/10.3389/fmolb.2021.728777/full

المؤلفون: Christine Péchoux, Natalia Gambaryan, Marc Humbert, Fabrice Antigny, Sharon Mumby, Angèle Boet, Ian M. Adcock, Benoit Ranchoux, Mélanie Gressette, Catherine Rucker-Martin, Mélanie Lambert, Valérie Domergue, David Montani, Anne Garnier, Jérôme Piquereau, Frédéric Perros

المساهمون: Perros, Frédéric, Jeunes Chercheuses et Jeunes Chercheurs - Mécanismes épigénétiques dans l'inflammation et le remodelage vasculaire de l'hypertension pulmonaire - - EMIR2013 - ANR-13-JSV1-0011 - JC - VALID, Idex Paris-Saclay - - IPS2011 - ANR-11-IDEX-0003 - IDEX - VALID, Signalisation et physiopathologie cardiovasculaire (UMRS1180), Institut National de la Santé et de la Recherche Médicale (INSERM), Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Saclay, Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), Université Paris-Sud - Paris 11 (UP11), Réanimation des cardiopathies congénitales [Le Plessis-Robinson] (Centre chirurgical Marie Lannelongue), Centre Chirurgical Marie Lannelongue (CCML), Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Institut Paris Saclay d’Innovation Thérapeutique (IPSIT), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), This work was supported by research grants from INSERM, National Funding Agency for Research (ANR) (Grant ANR-13-JSV1-0011-01), Laboratoire d’Excellence (LabEx) en Recherche sur le Médicament et l’Innovation Thérapeutique (LERMIT), Assistance Publique Hôpitaux de Paris (Département Hospitalo-Universitaire Thorax Innovation), Legs Poix (Chancellerie des Universités de Paris). F.A. was supported by a post-doctoral grant from Aviesan and by Lefoulon Delalande Institute. INSERM UMR_S 999 research unit, ANR-13-JSV1-0011,EMIR,Mécanismes épigénétiques dans l'inflammation et le remodelage vasculaire de l'hypertension pulmonaire(2013), ANR-11-IDEX-0003,IPS,Idex Paris-Saclay(2011), Centre chirurgical Marie Lannelongue-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre chirurgical Marie Lannelongue, AgroParisTech-Institut National de la Recherche Agronomique (INRA)

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2019, 20 (7), pp.1527. ⟨10.3390/ijms20071527⟩
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1527 (2019)
Volume 20
Issue 7
International Journal of Molecular Sciences, MDPI, 2019, 20 (7), pp.1527. ⟨10.3390/ijms20071527⟩
International Journal of Molecular Sciences 7 (20), 1-16. (2019)

مصطلحات موضوعية: Male, 0301 basic medicine, Chemistry, Multidisciplinary, Cardiomyopathy, MELANOMA, Mitochondrion, Mitochondria, Heart, lcsh:Chemistry, Electrocardiography, 0302 clinical medicine, Medicine, Citrate synthase, lcsh:QH301-705.5, Spectroscopy, biology, COMBINING BET, General Medicine, 3. Good health, Computer Science Applications, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, mitochondria, Chemistry, medicine.anatomical_structure, Organ Specificity, 030220 oncology & carcinogenesis, Physical Sciences, HDAC INHIBITORS, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, medicine.medical_specialty, PROTEINS, 0699 Other Biological Sciences, bromodomain and extra-terminal domain, cardiotoxicity, heart, Heterocyclic Compounds, 4 or More Rings, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, bromodomain and extra-terminal domain inhibitor, medicine.artery, Internal medicine, 0399 Other Chemical Sciences, C-MYC, Animals, STRATEGY, Rats, Wistar, Physical and Theoretical Chemistry, Molecular Biology, 0604 Genetics, Cardiotoxicity, Aorta, Science & Technology, Chemical Physics, business.industry, Organic Chemistry, Skeletal muscle, medicine.disease, Bromodomain, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, lcsh:Biology (General), lcsh:QD1-999, Pulmonary artery, biology.protein, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0554969c31d9b71746617416aafaf0e4
https://www.hal.inserm.fr/inserm-02567799

المؤلفون: Xiaosa, Chang, Dejuan, Sun, Danfeng, Shi, Guan, Wang, Yanmei, Chen, Kai, Zhang, Huidan, Tan, Jie, Liu, Bo, Liu, Liang, Ouyang

المصدر: Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Synthetic lethality, DSB, DNA double-strand break, ER, estrogen receptor, HRD, homologous recombination deficiency, BC, breast cancer, Dual-target inhibitor, PARP1, TNBC, triple-negative breast cancer, PI, propidium iodide, HE, hematoxylin-eosin, Quinazolin-4(3H)-one derivatives, CDK4/6, cyclin-dependent kinase 4/6, SAR, structure–activity relationship, ELISA, enzyme linked immunosorbent assay, BRD4, bromodomain 4, TCGA, the cancer genome atlas, TGI, tumor growth inhibition, TR-FRET, time-resolved fluorescence resonance energy transfer, FITC, fluorescein isothiocyanate isomer I, BET, bromodomain and extra-terminal domain, TLC, thin-layer chromatography, PPI, protein−protein interaction, ESI-HR-MS, high-resolution mass spectra, EGFR, epidermal growth factor receptor, FDA, U.S. Food and Drug Administration, SOP, standard operation process, HPLC, high-performance liquid chromatography, shRNA, short hairpin RNA, BRD4, PK, pharmacokinetics, Original Article, BRCA1/2, breast cancer susceptibility gene 1/2, NHEJ, nonhomologous end-joining, HR, homologous recombination, PARP1, poly(ADP-ribose) polymerase-1, IHC, immunohistochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::104d38c88984daa177c12922a724ee12
https://pubmed.ncbi.nlm.nih.gov/33532187