نتائج البحث - "antiviral nucleosides"

1

Academic Journal

2′-Fluorinated nucleoside chemistry for new drug discovery: achievements and prospects.

المؤلفون: Meng, Yonggang^1,2 (AUTHOR), Sun, Nannan² (AUTHOR), Liang, Lan³ (AUTHOR), Yu, Bin¹ (AUTHOR) yubin@zzu.edu.cn, Chang, Junbiao^1,2,3 (AUTHOR) changjunbiao@zzu.edu.cn

المصدر: National Science Review. Oct2024, Vol. 11 Issue 10, p1-18. 18p.

مصطلحات موضوعية: *CORONAVIRUS disease treatment, *ANTIVIRAL nucleosides, *DRUG discovery, *COVID-19, *PHARMACEUTICAL chemistry

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2

Academic Journal

Recent advances in drug substance development - prodrug strategies for enhancing the bioavailability and potency of antiviral nucleosides.

المؤلفون: Kutner, Andrzej¹ andrzej.kutner@wum.edu.pl

المصدر: Journal of Medical Science. 2023, Vol. 92 Issue 3, p44-49. 6p.

مصطلحات موضوعية: *ANTIVIRAL nucleosides, *BILAYER lipid membranes, *DRUG development, *BIOAVAILABILITY, *DRUG solubility

3

Academic Journal

Synthesis and Behavior of DNA Oligomers Containing the Ambiguous Z-Nucleobase 5-Aminoimidazole-4-carboxamide.

المؤلفون: Nogi, Yuhei¹ (AUTHOR) karanjit@tokushima-u.ac.jp, Saito-Tarashima, Noriko¹ (AUTHOR) noriko.tarashima@tokushima-u.ac.jp, Karanjit, Sangita¹ (AUTHOR), Minakawa, Noriaki¹ (AUTHOR) noriko.tarashima@tokushima-u.ac.jp

المصدر: Molecules. Apr2023, Vol. 28 Issue 7, p3265. 13p.

مصطلحات موضوعية: *ANTIVIRAL nucleosides, *OLIGOMERS, *DNA polymerases, *BASE pairs, *OLIGOMERIZATION, *RING-opening reactions, *DNA synthesis, *RIBAVIRIN

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4

Academic Journal

Urinary phenotyping of SARS-CoV-2 infection connects clinical diagnostics with metabolomics and uncovers impaired NAD⁺ pathway and SIRT1 activation.

المؤلفون: Lonati, Caterina, Berezhnoy, Georgy, Lawler, Nathan, Masuda, Reika, Kulkarni, Aditi, Sala, Samuele, Nitschke, Philipp, Zizmare, Laimdota, Bucci, Daniele, Cannet, Claire, Schäfer, Hartmut, Singh, Yogesh, Gray, Nicola, Lodge, Samantha, Nicholson, Jeremy, Merle, Uta, Wist, Julien, Trautwein, Christoph

المصدر: Clinical Chemistry & Laboratory Medicine; Mar2024, Vol. 62 Issue 4, p770-788, 19p

مصطلحات موضوعية: NAD (Coenzyme), LIQUID chromatography-mass spectrometry, NICOTINAMIDE, ANTIVIRAL nucleosides, METABOLOMICS, SIRTUINS, SARS-CoV-2

5

Academic Journal

Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic β -Cyclodextrin Carrier for Nucleosides and Nucleotides.

المؤلفون: Ryu, Jang-Ha, Zheng, Weizhong, Yang, Xiao-Hong, Elsaidi, Hassan, Diakur, Jim, Wiebe, Leonard I.

المصدر: Pharmaceutics; Mar2024, Vol. 16 Issue 3, p323, 16p

مصطلحات موضوعية: NUCLEOTIDES, NUCLEOSIDES, ANTIVIRAL nucleosides, MORPHOLOGY, MOLECULAR docking, CYCLODEXTRIN derivatives

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6

Academic Journal

Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic β -Cyclodextrin Carrier for Nucleosides and Nucleotides

المؤلفون: Jang-Ha Ryu, Weizhong Zheng, Xiao-Hong Yang, Hassan Elsaidi, Jim Diakur, Leonard I. Wiebe

المصدر: Pharmaceutics, Vol 16, Iss 3, p 323 (2024)

مصطلحات موضوعية: antiviral nucleosides, arabinosyl adenine (araA, vidarabine), arabinosyl adenine 5′-monophosphate (araAMP), asialoglycoprotein receptor (ASGPr), beta-cyclodextrin (CyD), endocytic receptors, Pharmacy and materia medica, RS1-441

Relation: https://www.mdpi.com/1999-4923/16/3/323; https://doaj.org/toc/1999-4923; https://doaj.org/article/4b6943cd81af4df299dfbf4056fbdc1b

الاتاحة: https://doi.org/10.3390/pharmaceutics16030323
https://doaj.org/article/4b6943cd81af4df299dfbf4056fbdc1b

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7

Academic Journal

Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials.

المؤلفون: Pertusati, Fabrizio¹ (AUTHOR), Pileggi, Elisa¹ (AUTHOR), Richards, Jennifer² (AUTHOR), Wootton, Mandy² (AUTHOR), Leemputte, Thijs Van³ (AUTHOR), Persoons, Leentje⁴ (AUTHOR), Coster, David De³ (AUTHOR), Villanueva, Xabier³ (AUTHOR), Daelemans, Dirk⁴ (AUTHOR), Steenackers, Hans³ (AUTHOR), McGuigan, Christopher¹ (AUTHOR), Serpi, Michaela¹ (AUTHOR) serpim5@cf.ac.uk, Van Leemputte, Thijs⁵ (AUTHOR), De Coster, David⁵ (AUTHOR)

المصدر: Journal of Antimicrobial Chemotherapy (JAC). Oct2020, Vol. 75 Issue 10, p2864-2878. 15p.

8

Academic Journal

Urinary phenotyping of SARS-CoV-2 infection connects clinical diagnostics with metabolomics and uncovers impaired NAD + pathway and SIRT1 activation

المؤلفون: Lonati, Caterina, Berezhnoy, Georgy, Lawler, Nathan, Masuda, Reika, Kulkarni, Aditi, Sala, Samuele, Nitschke, Philipp, Zizmare, Laimdota, Schäfer, Hartmut, Singh, Yogesh, Gray, Nicola, Lodge, Samantha, Nicholson, Jeremy, Merle, Uta, Wist, Julien, Trautwein, Christoph

مصطلحات موضوعية: COVID-19, antiviral nucleosides, kynurenine pathway, sirtuins, precision diagnostics

وصف الملف: pdf

Relation: ispartof: Clinical Chemistry and Laboratory Medicine spage 770 epage 788 issue 4 vol 62; 991005616670307891; https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Urinary-phenotyping-of-SARS-CoV-2-infection-connects/991005616670307891; https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12154387860007891/13167503720007891; alma:61MUN_INST/bibs/991005616670307891

الاتاحة: https://doi.org/10.1515/cclm-2023-1017
https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Urinary-phenotyping-of-SARS-CoV-2-infection-connects/991005616670307891
https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12154387860007891/13167503720007891

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9

Academic Journal

The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold.

المؤلفون: Yates, Mary K.¹, Seley-Radtke, Katherine L.¹ kseley@umbc.edu

المصدر: Antiviral Research. Feb2019, Vol. 162, p5-21. 17p.

مصطلحات موضوعية: *ANTIVIRAL nucleosides, *NUCLEOSIDES, *ANTINEOPLASTIC agents, *ANTIVIRAL agents, *VIROLOGY

10

Academic Journal

Synthesis and antiviral activity of 2′‐deoxy‐6′‐substituted carbocyclic nucleosides.

المؤلفون: Xue, Haitao, Guo, Shuang, Hu, Tianwen, Wei, Daibao, Xie, Yuanchao, Shen, Jingshan

المصدر: Chemical Biology & Drug Design; Apr2022, Vol. 99 Issue 4, p561-572, 12p

مصطلحات موضوعية: RIBAVIRIN, NUCLEOSIDES, ANTIVIRAL nucleosides, HEPATITIS C virus, HEPATITIS B virus, INFLUENZA viruses, METHYL groups, INFLUENZA A virus

11

Academic Journal

Outcome of adefovir add-on lamivudine rescue therapy of up to 5 years in patients with lamivudine-resistant chronic hepatitis B.

المؤلفون: Kim, Sung Bae¹, Kim, Seung Up^1,2,3, Kim, Beom Kyung^1,2,3, Park, Jun Yong^1,2,3, Kim, Do Young^1,2,3, Ahn, Sang Hoon^1,2,3, Han, Kwang‐Hyub^1,2,3

المصدر: Journal of Gastroenterology & Hepatology. Jan2016, Vol. 31 Issue 1, p241-247. 7p. 1 Diagram, 4 Charts.

مصطلحات موضوعية: *ANTIVIRAL nucleosides, *REVERSE transcriptase, *LAMIVUDINE, *NUCLEOSIDE reverse transcriptase inhibitors, *PROTEASE inhibitors, *VIRAL hepatitis, *HEPATITIS B

12

Academic Journal

Long-Term Outcome of Sequential Therapy with Lamivudine Followed by Interferon-β in Nucleoside-Naive, Hepatitis B e-Antigen-Positive Patients with Chronic Hepatitis B Virus Genotype C Infection.

المؤلفون: Enomoto, Masaru¹, Nishiguchi, Shuhei², Tamori, Akihiro¹, Kozuka, Ritsuzo¹, Hayashi, Takehiro¹, Kohmoto, Madoka Toyama¹, Jomura, Hisato³, Morikawa, Hiroyasu¹, Murakami, Yoshiki¹, Shiomi, Susumu⁴, Kawada, Norifumi¹

المصدر: Journal of Interferon & Cytokine Research. Aug2015, Vol. 35 Issue 8, p613-620. 8p.

مصطلحات موضوعية: *LAMIVUDINE, *ANTIVIRAL nucleosides, *INTERFERONS, *ANTINEOPLASTIC agents, *NUCLEOSIDES

13

Academic Journal

Overcoming the delivery barrier of oligonucleotide drugs and enhancing nucleoside drug efficiency: The use of nucleolipids.

المؤلفون: Zhou, Xinyang, Wang, Shuhe, Zhu, Yuejie, Pan, Yufei, Zhang, Lihe, Yang, Zhenjun

المصدر: Medicinal Research Reviews; Jul2020, Vol. 40 Issue 4, p1178-1199, 22p

مصطلحات موضوعية: CATIONIC lipids, DRUG abuse, ANTIVIRAL nucleosides, NUCLEIC acids, CELL membranes

14

Academic Journal

Individual prediction model for lamivudine treatment response in hepatitis B virus e antigen-positive chronic hepatitis B patients.

المؤلفون: Lee, Hyun Woong^1,2, Kang, Wonseok^2,3, Ahn, Sang Hoon^2,3, Lee, Heon Ju^2,4, Hwang, Jae Seok^2,5, Sohn, Joo Hyun^2,6, Jang, Jae Young^2,7, Han, Ki Jun^2,8, Kim, Ja Kyung^2,3, Kim, Do Young^2,3, Paik, Yong Han^2,3, Lee, Chun Kyon^2,9, Choi, Ik‐Seong^2,10, Lee, Kwan Sik^2,3, Han, Kwang‐Hyub^2,3

المصدر: Journal of Gastroenterology & Hepatology. May2014, Vol. 29 Issue 5, p1049-1055. 7p.

مصطلحات موضوعية: *LAMIVUDINE, *ANTIVIRAL nucleosides, *HEPATITIS B virus, *CHRONIC hepatitis B, *GENETIC mutation

15

Academic Journal

A Novel Synthesis of Antiviral Nucleoside Phosphoramidate and Thiophosphoramidate Prodrugs via Nucleoside H -Phosphonamidates.

المؤلفون: Sun, Qi¹ (AUTHOR) sunqi96@tsinghua.org.cn, Li, Xingjian¹ (AUTHOR), Gong, Shanshan¹ (AUTHOR), Liu, Gang¹ (AUTHOR), Shen, Liang¹ (AUTHOR), Peng, Liang² (AUTHOR)

المصدر: Nucleosides, Nucleotides & Nucleic Acids. Nov2013, Vol. 32 Issue 11, p617-638. 22p.

مصطلحات موضوعية: *ANTIVIRAL nucleosides, *PHOSPHORAMIDATES, *NUCLEOSIDE synthesis, *PRODRUGS, *PHOSPHONATES, *CHEMICAL reactions

16

Academic Journal

Suboptimal response to lamivudine therapy in nucleoside analogues (NUCs)-naïve patients with chronic hepatitis B - single-center data from clinical practice in Poland.

المؤلفون: Olszok, Joanna¹, Olszok, Iwona¹ wonaolszok@wp.pl, Bluszcz-Rożnowska, Anita¹

المصدر: Experimental & Clinical Hepatology. 2012, Vol. 8 Issue 3/4, p4-7. 4p.

مصطلحات موضوعية: *LAMIVUDINE, *ANTIVIRAL nucleosides, *HEPATITIS B treatment

17

Academic Journal

Ten Paths to the Discovery of Antivirally Active Nucleoside and Nucleotide Analogues*.

المؤلفون: De Clercq, Erik¹ (AUTHOR) erik.declercq@rega.kuleuven.be

المصدر: Nucleosides, Nucleotides & Nucleic Acids. Apr2012, Vol. 31 Issue 4, p339-352. 14p. 6 Color Photographs, 4 Diagrams.

مصطلحات موضوعية: *ANTIVIRAL nucleosides, *NUCLEOTIDES, *ANTINEOPLASTIC agents, *ADENOSINES, *DRUG development, *LIGANDS (Biochemistry), *TENOFOVIR

18

Academic Journal

Presteady State KineticInvestigation of the Incorporationof Anti-Hepatitis B Nucleotide Analogues Catalyzed by NoncanonicalHuman DNA Polymerases.

المؤلفون: JessicaA. Brown¹, Lindsey R. Pack¹, JasonD. Fowler¹, Zucai Suo¹

المصدر: Chemical Research in Toxicology. Jan2012, Vol. 25 Issue 1, p225-233. 9p.

مصطلحات موضوعية: *ENZYME kinetics, *ANTIVIRAL nucleosides, *HEPATITIS B virus, *ENZYME activation, *CATALYSIS, *DNA polymerases, *DRUG toxicity, *NUCLEOSIDES

19

Academic Journal

3-Trifluoromethylpyrazolones derived nucleosides: Synthesis and antiviral evaluation.

المؤلفون: Ahmed, Ayman M. S., Abou-Elkhair, Reham A. I., El-Torky, Alaa M., Hassan, Abdalla E. A.

المصدر: Nucleosides, Nucleotides & Nucleic Acids; 2019, Vol. 38 Issue 8, p590-603, 14p

مصطلحات موضوعية: MIDDLE East respiratory syndrome, NUCLEOSIDE synthesis, ANTIVIRAL nucleosides, MERS coronavirus, DENGUE hemorrhagic fever, HEMORRHAGIC fever

مصطلحات جغرافية: MIDDLE East

20

Academic Journal

Synthesis of purine modified 2′-C-methyl nucleosides as potential anti-HCV agents

المؤلفون: Zhang, Hong-wang^1,2, Zhou, Longhu^1,2, Coats, Steven J.³, McBrayer, Tamara R.^2,3, Tharnish, Phillip M.^2,3, Bondada, Lavanya^1,2, Detorio, Mervi^1,2, Amichai, Sarah A.^1,2, Johns, Melissa D.^1,2, Whitaker, Tony³, Schinazi, Raymond F.^1,2 rschina@emory.edu

المصدر: Bioorganic & Medicinal Chemistry Letters. Nov2011, Vol. 21 Issue 22, p6788-6792. 5p.

مصطلحات موضوعية: *HEPATITIS C virus, *ANTIVIRAL nucleosides, *ADENOSINES, *VIRAL replication, *CELL-mediated cytotoxicity, *PURINE synthesis

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