المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/journal_contribution/Sequence_read_coverage_depth_for_sequences_derived_from_neutralization_assay_/25063279

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.s001
https://figshare.com/articles/journal_contribution/Sequence_read_coverage_depth_for_sequences_derived_from_neutralization_assay_/25063279

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/journal_contribution/Frequency_of_mutations_detected_in_samples_passaged_in_different_cell_lines_and_with_and_without_antiserum_selection_pressure_see_Antiserum_Pressure_section_Table_3_/25063291

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.s005
https://figshare.com/articles/journal_contribution/Frequency_of_mutations_detected_in_samples_passaged_in_different_cell_lines_and_with_and_without_antiserum_selection_pressure_see_Antiserum_Pressure_section_Table_3_/25063291

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/journal_contribution/Number_of_mutations_per_sample_/25063288

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.s004
https://figshare.com/articles/journal_contribution/Number_of_mutations_per_sample_/25063288

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/journal_contribution/Comparison_of_epitope_regions_for_three_SARS-CoV-2_neutralizing_antibodies_and_the_hACE2_receptor_binding_motif_RBM_/25063285

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.s003
https://figshare.com/articles/journal_contribution/Comparison_of_epitope_regions_for_three_SARS-CoV-2_neutralizing_antibodies_and_the_hACE2_receptor_binding_motif_RBM_/25063285

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/journal_contribution/Mutation_distribution_among_samples_passaged_with_or_without_antibody_selection_pressure_/25063294

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.s006
https://figshare.com/articles/journal_contribution/Mutation_distribution_among_samples_passaged_with_or_without_antibody_selection_pressure_/25063294

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/journal_contribution/Neutralization_assay_GFP_expression_results_/25063282

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.s002
https://figshare.com/articles/journal_contribution/Neutralization_assay_GFP_expression_results_/25063282

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/figure/Molecular_surfaces_for_the_epitope_regions_for_neutralizing_antibodies_and_amino_acids_that_are_prevalent_in_genotypes_that_escaped_antibody_neutralization_/25063300

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.g002
https://figshare.com/articles/figure/Molecular_surfaces_for_the_epitope_regions_for_neutralizing_antibodies_and_amino_acids_that_are_prevalent_in_genotypes_that_escaped_antibody_neutralization_/25063300

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/dataset/Mutations_detected_after_passage_in_cell_lines_/25063309

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.t002
https://figshare.com/articles/dataset/Mutations_detected_after_passage_in_cell_lines_/25063309

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/dataset/Antiserum_dilutions_used_and_collected_per_passage_for_selection_pressure_/25063306

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.t001
https://figshare.com/articles/dataset/Antiserum_dilutions_used_and_collected_per_passage_for_selection_pressure_/25063306

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/dataset/Comparison_of_variant_frequencies_associated_with_cell_culture_passage_passage_under_antiserum_selection_and_mAb_selection_/25063312

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.t003
https://figshare.com/articles/dataset/Comparison_of_variant_frequencies_associated_with_cell_culture_passage_passage_under_antiserum_selection_and_mAb_selection_/25063312

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/figure/Trimer_assembly_of_the_Spike_protein_with_select_mutations_/25063303

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.g003
https://figshare.com/articles/figure/Trimer_assembly_of_the_Spike_protein_with_select_mutations_/25063303

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/figure/Virus_passage_and_assay_workflow_/25063297

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.g001
https://figshare.com/articles/figure/Virus_passage_and_assay_workflow_/25063297

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/dataset/Comparison_of_VA-P6_mutation_frequencies_associated_with_passage_under_mAb_selection_with_predicted_binding_affinity_changes_G_induced_by_observed_mutations_/25063318

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.t005
https://figshare.com/articles/dataset/Comparison_of_VA-P6_mutation_frequencies_associated_with_passage_under_mAb_selection_with_predicted_binding_affinity_changes_G_induced_by_observed_mutations_/25063318

المؤلفون: Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Ecology, Immunology, Statistics, Hematology, Infectious Diseases, Virology, multiple mutations associated, deep sequencing revealed, viral population present, viral inoculum derived, viral phenotype assays, four times concurrently, escaping monoclonal antibody, differential laboratory passaging, circulating viral genotypes, three cell lines, pseudotyped virus stocks, biologically relevant outcomes, mab assessment assays, antibody neutralization assays, laboratory virus, circulating virus, viral stock, phenotypic assays, stocks could, six times

Relation: https://figshare.com/articles/dataset/Neutralization_assay_comparison_of_mAb_escape_by_unpassaged_and_passaged_virus_/25063315

الاتاحة: https://doi.org/10.1371/journal.pone.0289198.t004
https://figshare.com/articles/dataset/Neutralization_assay_comparison_of_mAb_escape_by_unpassaged_and_passaged_virus_/25063315