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1Academic Journal
المؤلفون: Hiroaki Mitsuya, Arun K. Ghosh, Sergei V. Gulnik, John W. Erickson, Victor Maroun, Kenji Maeda, Khaja A. Hussain, Kazuhisa Yoshimura, Ryohei Kato, Mark F. Kavlick, A Potent, Human Immunodeficiency Virus
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.539.4162; http://jvi.asm.org/content/76/3/1349.full.pdf
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2
المؤلفون: Abelardo Silva, John W. Erickson, Betty Yu, Sergei V. Gulnik, Elena Afonina, Michael Eissenstat, Hiroko Yokoe, Tanya Guerassina, Douglas Ludtke
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:5078-5083
مصطلحات موضوعية: Indoles, medicine.medical_treatment, Clinical Biochemistry, Human immunodeficiency virus (HIV), Pharmaceutical Science, Crystallography, X-Ray, medicine.disease_cause, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, HIV Protease, Drug Resistance, Viral, Drug Discovery, medicine, Humans, HIV Protease Inhibitor, Oxindole, Molecular Biology, IC50, Darunavir, Hydrolase inhibitor, Sulfonamides, Binding Sites, Protease, Protease binding, Organic Chemistry, virus diseases, HIV Protease Inhibitors, Virology, Oxindoles, Protein Structure, Tertiary, chemistry, HIV-1, Molecular Medicine
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3
المؤلفون: John W. Erickson, Dong Xie, Leonid I. Suvorov, Sergei V. Gulnik
المصدر: Protein Science. 8:2460-2464
مصطلحات موضوعية: Stereochemistry, medicine.medical_treatment, Optical property, Cleavage (embryo), Biochemistry, Catalysis, Substrate Specificity, HIV Protease, medicine, Amino Acid Sequence, Enzyme kinetics, Molecular Biology, chemistry.chemical_classification, Protease, Substrate (chemistry), Drug resistant mutants, Models, Theoretical, Combinatorial chemistry, Enzymes, Kinetics, Enzyme, Amino Acid Substitution, chemistry, Mutagenesis, Site-Directed, Regression Analysis, Oligopeptides, Research Article
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4
المؤلفون: Sergei V. Gulnik, Michael A. Eissenstat
المصدر: Current Opinion in HIV and AIDS. 3:633-641
مصطلحات موضوعية: Infectious Diseases, Protease, Oncology, Oncology (nursing), Chemistry, Virology, medicine.medical_treatment, Immunology, medicine, HIV Protease Inhibitor, Hematology
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5
المؤلفون: Elena Afonina, Ramnarayan S. Randad, Djamel Medjahed, John W. Erickson, Oluwatoyin A. Asojo, Sergei V. Gulnik, Abelardo M. Silva, Betty Yu
المصدر: Acta Crystallographica Section D Biological Crystallography. 58:2001-2008
مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, biology, Protein Conformation, Stereochemistry, Plasmodium falciparum, Mutant, Protozoan Proteins, Plasmepsin, General Medicine, Cleavage (embryo), biology.organism_classification, Crystallography, Protein structure, Plasmepsin II, Enzyme, chemistry, Structural Biology, Hydrolase, Serine, Animals, Aspartic Acid Endopeptidases, Protease Inhibitors
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6
المؤلفون: Elena Afonina, Betty Yu, Elena Gustchina, Young Ho Kim, Abelardo M. Silva, John W. Erickson, Sergei V. Gulnik
المصدر: Protein Expression and Purification. 24:412-419
مصطلحات موضوعية: Enzyme Precursors, chemistry.chemical_classification, Plasmodium, Protein Folding, Mutant, Biology, Cleavage (embryo), medicine.disease_cause, Enzyme Activation, Enzyme activator, Enzyme, chemistry, Biochemistry, Mutation, medicine, Animals, Aspartic Acid Endopeptidases, Electrophoresis, Polyacrylamide Gel, Histidine, Protein folding, Protein Processing, Post-Translational, Escherichia coli, Biotechnology
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7
المؤلفون: Sergei V. Gulnik, Leonid I. Suvorov, Pavel Majer, John W. Erickson
المصدر: Protein & Peptide Letters. 7:219-223
مصطلحات موضوعية: Structural Biology, General Medicine, Biochemistry
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8
المؤلفون: Dorien de Jong, Pauline J. Schipper, Sergei V. Gulnik, John W. Erickson, Rob Schuurman, Monique Nijhuis, Jan Albert, Charles A. Boucher, Elena Gustchina
المصدر: AIDS. 13:2349-2359
مصطلحات موضوعية: Time Factors, medicine.medical_treatment, Immunology, Population, HIV Infections, Drug resistance, Biology, Virus Replication, HIV Protease, HIV-1 protease, medicine, Humans, Immunology and Allergy, Protease inhibitor (pharmacology), Amino Acid Sequence, education, Phylogeny, DNA Primers, Genetics, education.field_of_study, Ritonavir, Protease, Base Sequence, Virulence, Genetic Variation, Drug Resistance, Microbial, HIV Protease Inhibitors, Virology, Infectious Diseases, Viral replication, Mutation, HIV-1, biology.protein, Viral disease, medicine.drug
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9
المؤلفون: Sherman F. Stinson, David J. Clanton, Tyra House, Betty Yu, T. Narayana Bhat, John W. Erickson, Ramnarayan S. Randad, Michael A. Eissenstat, Lucyna Lubkowska, Sergei V. Gulnik
المصدر: Bioorganic & Medicinal Chemistry Letters. 8:3537-3542
مصطلحات موضوعية: Carbamate, Anti-HIV Agents, Stereochemistry, medicine.drug_class, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Ligands, Biochemistry, Chemical synthesis, Cell Line, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, HIV Protease Inhibitor, Molecular Biology, chemistry.chemical_classification, biology, Ligand, Organic Chemistry, HIV Protease Inhibitors, Amides, Rats, Enzyme, chemistry, Enzyme inhibitor, Lipophilicity, biology.protein, Molecular Medicine, Half-Life
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10
المؤلفون: Sergei V. Gulnik, Leonid I. Suvorov, Elena Gustchina, Laura Collins, Dong Xie, John W. Erickson
المصدر: Biochemistry. 36:16166-16172
مصطلحات موضوعية: Models, Molecular, Circular dichroism, Protein Conformation, Stereochemistry, Plasmodium falciparum, Protozoan Proteins, Protonation, Calorimetry, Cathepsin D, Biochemistry, Protein Structure, Secondary, Acid dissociation constant, chemistry.chemical_compound, Plasmepsin II, Pepstatins, Aspartic acid, Animals, Aspartic Acid Endopeptidases, Protease Inhibitors, chemistry.chemical_classification, Chemistry, Circular Dichroism, Isothermal titration calorimetry, Hydrogen-Ion Concentration, Crystallography, Enzyme, Thermodynamics, Protons, Pepstatin, Protein Binding
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11
المؤلفون: John W. Erickson, Donald Hupe, Eric T. Baldwin, J. R. Rubin, and Sergei V. Gulnik, Christine Humblet, Susan Elizabeth Hagen, Christopher Gajda, Harriet W. Hamilton, Carolyn Nouhan, Beishan Liu, J. V. N. Vara Prasad, Neil Graham, Edmund L. Ellsworth, Peter J. Tummino, John M. Domagala, Alexander Pavlovsky, Donna Ferguson, Elizabeth A. Lunney, T. N. Bhat, Bradley Dean Tait, Stephen J. Gracheck
المصدر: Journal of Medicinal Chemistry. 40:3781-3792
مصطلحات موضوعية: Anti-HIV Agents, Stereochemistry, medicine.medical_treatment, Thio, Crystallography, X-Ray, Chemical synthesis, Structure-Activity Relationship, HIV Protease, Coumarins, Drug Discovery, medicine, Structure–activity relationship, chemistry.chemical_classification, Binding Sites, Protease, biology, Active site, Stereoisomerism, HIV Protease Inhibitors, Amino acid, Enzyme, chemistry, Pyrones, Enzyme inhibitor, Drug Design, HIV-1, biology.protein, Molecular Medicine
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12
المؤلفون: Jack R. Collins, John W. Erickson, Sergei V. Gulnik, Pavel Majer
المصدر: Protein Science. 6:1458-1466
مصطلحات موضوعية: Models, Molecular, Cathepsin, Binding Sites, Molecular model, Peptidomimetic, Stereochemistry, Cathepsin D, Biology, Biochemistry, Cathepsin A, Structure-Activity Relationship, Cathepsin O, Drug Design, Humans, Thermodynamics, Structure–activity relationship, Computer Simulation, Protease Inhibitors, Amino Acids, Binding site, Molecular Biology, Research Article
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13
المؤلفون: David D. Ho, Stanley K. Burt, Leonard I. Suvorov, Martin Markowitz, Hongmei Mo, Pavel Majer, Sergei V. Gulnik, John W. Erickson
المصدر: AIDS Research and Human Retroviruses. 12:55-61
مصطلحات موضوعية: Pyridines, medicine.medical_treatment, Molecular Sequence Data, Immunology, Drug resistance, Virus, Cell Line, Structure-Activity Relationship, HIV Protease, Virology, medicine, Humans, Structure–activity relationship, Protease inhibitor (pharmacology), Amino Acid Sequence, chemistry.chemical_classification, Methylurea Compounds, Protease, Molecular Structure, Sequence Homology, Amino Acid, biology, Drug Resistance, Microbial, Valine, Biological activity, HIV Protease Inhibitors, Infectious Diseases, Enzyme, Biochemistry, chemistry, Enzyme inhibitor, Drug Design, HIV-1, biology.protein
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14
المؤلفون: Betty Yu, Tracy M. Lynch, Rajan H. Naik, Sergei V. Gulnik, Ramnarayan S. Randad, Abelardo Silva, Anna Bujacz, Sanjeev Munshi, Lucyna Lubkowska, John W. Erickson, T. Narayana Bhat, David J. Clanton
المصدر: Bioorganic & Medicinal Chemistry Letters. 5:2557-2562
مصطلحات موضوعية: chemistry.chemical_classification, Protease, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Ligand (biochemistry), Biochemistry, Hydrophobic effect, Enzyme inhibition, Enzyme, Design synthesis, chemistry, Drug Discovery, medicine, Molecular Medicine, HIV Protease Inhibitor, Structure based, Molecular Biology
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15
المؤلفون: T. Narayana Bhat, Ramnarayan S. Randad, Sanjeev Munshi, John W. Erickson, Betty Yu, Sergei V. Gulnik, Lucyna Lubkowska
المصدر: Bioorganic & Medicinal Chemistry Letters. 5:1707-1712
مصطلحات موضوعية: Protease, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Clinical Biochemistry, Substituent, Rational design, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Molecular Medicine, HIV Protease Inhibitor, Symmetry (geometry), Molecular Biology
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16
المؤلفون: Igor A. Topol, T. Narayana Bhat, Beishan Liu, Sergei V. Gulnik, Hiroaki Mitsuya, Eric T. Baldwin, John W. Erickson, Tsutomu Mimoto, Yoshiaki Kiso
المصدر: Structure. 3:581-590
مصطلحات موضوعية: Proline, Protein Conformation, Stereochemistry, medicine.medical_treatment, Molecular Sequence Data, Substituent, Peptide, Crystallography, X-Ray, Antiviral Agents, Structure-Activity Relationship, chemistry.chemical_compound, HIV Protease, HIV-1 protease, Structural Biology, Transition state analog, medicine, Amino Acid Sequence, Molecular Biology, chemistry.chemical_classification, Binding Sites, Protease, biology, Hydrogen bond, Water, Drug Resistance, Microbial, HIV Protease Inhibitors, Phenylbutyrates, Protease inhibitor (biology), Enzyme, chemistry, biology.protein, Oligopeptides, Hydrogen, medicine.drug
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17
المصدر: Bioorganic & Medicinal Chemistry Letters. 4:2343-2346
مصطلحات موضوعية: Isostere, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Urea, Molecular Medicine, HIV Protease Inhibitor, Symmetry (geometry), Molecular Biology
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18
المصدر: Bioorganic & Medicinal Chemistry Letters. 4:1247-1252
مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biological activity, Biochemistry, Structural water, HIV-1 protease, Enzyme inhibitor, Drug Discovery, biology.protein, Molecular Medicine, Molecular Biology
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19
المصدر: ChemInform. 26
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Isostere, Stereochemistry, Urea, HIV Protease Inhibitor, General Medicine, Symmetry (geometry)
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20
المؤلفون: Sherman F. Stinson, David J. Clanton, Lucyna Lubkowska, T. Narayana Bhat, Betty Yu, Sergei V. Gulnik, Michael A. Eissenstat, Ramnarayan S. Randad, Tyra House, John W. Erickson
المصدر: ChemInform. 30
مصطلحات موضوعية: Carbamate, Stereochemistry, Chemistry, Ligand, medicine.medical_treatment, Lipophilicity, medicine, HIV Protease Inhibitor, General Medicine, In vitro, EC50