المؤلفون: Ambritha Balasundaram, George Priya C Doss

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Hematology, Plant Biology, Chemical Sciences not elsewhere classified, unstable structures compared, several additional genes, principal component analysis, free energy landscape, comparative atomistic insights, consequent downstream activation, cause constitutive activation, mutation binding energy, structural mechanism study, i1171n strongly promotes, form stable bonds, apo remained inactive, alk fusion proteins, constitutively active kinase, alk inhibitors first, alk kinase domain, activation mechanism, alk kinase, alk inhibitors, study shows

Relation: https://figshare.com/articles/journal_contribution/Comparative_Atomistic_Insights_on_Apo_and_ATP-I1171N_S_T_in_Nonsmall-Cell_Lung_Cancer/24514200

الاتاحة: https://doi.org/10.1021/acsomega.3c05785.s001
https://figshare.com/articles/journal_contribution/Comparative_Atomistic_Insights_on_Apo_and_ATP-I1171N_S_T_in_Nonsmall-Cell_Lung_Cancer/24514200

المؤلفون: Brianna L. Viering, Halie Balogh, Chloe F. Cox, Owee K. Kirpekar, A. Luke Akers, Victoria A. Federico, Gabriel Z. Valenzano, Robin Stempel, Hannah L. Pickett, Pamela M. Lundin, Meghan S. Blackledge, Heather B. Miller

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Pharmacology, Infectious Diseases, Virology, Computational Biology, sigma factors ), quantify transcript levels, oxacillin combined repressed, limited effective lifespan, intracellular atp levels, infected caenorhabditis elegans, cellular pathways would, additional genes involved, biofilm genes methicillin, resistant staphylococcus aureus, potentiates multiple cell, loratadine combats methicillin, investigating loratadine treatment, found significant effects, potentiate existing antibiotics, disrupts biofilm formation, wall active antibiotics, biofilm formation, multiple classes, become resistant, active ingredient, transcriptional effects, pleiotropic effects

Relation: https://figshare.com/articles/journal_contribution/Loratadine_Combats_Methicillin-Resistant_Staphylococcus_aureus_by_Modulating_Virulence_Antibiotic_Resistance_and_Biofilm_Genes/24913797

الاتاحة: https://doi.org/10.1021/acsinfecdis.3c00616.s001
https://figshare.com/articles/journal_contribution/Loratadine_Combats_Methicillin-Resistant_Staphylococcus_aureus_by_Modulating_Virulence_Antibiotic_Resistance_and_Biofilm_Genes/24913797

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/journal_contribution/Real-time_qPCR_and_ChIP_primer_sequences_/17301897

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s010

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/journal_contribution/Glossary_of_mutant_mouse_lines_/17301900

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s011

المؤلفون: Brianna L. Viering, Halie Balogh, Chloe F. Cox, Owee K. Kirpekar, A. Luke Akers, Victoria A. Federico, Gabriel Z. Valenzano, Robin Stempel, Hannah L. Pickett, Pamela M. Lundin, Meghan S. Blackledge, Heather B. Miller

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Pharmacology, Infectious Diseases, Virology, Computational Biology, sigma factors ), quantify transcript levels, oxacillin combined repressed, limited effective lifespan, intracellular atp levels, infected caenorhabditis elegans, cellular pathways would, additional genes involved, biofilm genes methicillin, resistant staphylococcus aureus, potentiates multiple cell, loratadine combats methicillin, investigating loratadine treatment, found significant effects, potentiate existing antibiotics, disrupts biofilm formation, wall active antibiotics, biofilm formation, multiple classes, become resistant, active ingredient, transcriptional effects, pleiotropic effects

Relation: https://figshare.com/articles/dataset/Loratadine_Combats_Methicillin-Resistant_Staphylococcus_aureus_by_Modulating_Virulence_Antibiotic_Resistance_and_Biofilm_Genes/24913803

الاتاحة: https://doi.org/10.1021/acsinfecdis.3c00616.s003
https://figshare.com/articles/dataset/Loratadine_Combats_Methicillin-Resistant_Staphylococcus_aureus_by_Modulating_Virulence_Antibiotic_Resistance_and_Biofilm_Genes/24913803

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_mesenchyme_induces_phospho-histone_H3_/17301873

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s003

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_the_posterior_limb_bud_mesenchyme_does_not_induce_PPD_/17301870

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s002

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/Removal_of_i_Hes1_i_in_a_Gli3_sup_xt_sup_background_rescues_anterior_i_Pax9_i_limb_bud_expression_without_altering_elevated_levels_of_i_Ptch1_i_/17301891

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s008

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_mesenchyme_results_in_defects_in_carpal_joint_formation_/17301867

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s001

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_posterior_mesenchyme_does_not_affect_cell_cycle_regulators_and_SHH_GLI_target_genes_/17301876

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s004

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/HES1_binding_sites_within_the_i_Cdkn1b_i_i_Col2a1_i_i_Pax9_i_i_and_Hes1_i_promoter_enhancer_regions_/17301879

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s005

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/HES1_over-expression_within_limb_bud_mesenchyme_restores_normal_levels_of_i_Bcl2_i_expression_in_SHH_LOF_background_and_HES1_over-expression_does_not_affect_limb_bud_mesenchyme_apoptosis_/17301885

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s006

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/GLI3_binds_specific_regions_of_the_i_Hes1_i_promoter_/17301894

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s009

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_mesenchyme_promotes_cell_proliferation_/17301909

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g002

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/dataset/Raw_Data_and_Statistics_/17301903

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s012

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_mesenchyme_alters_the_expression_of_digit_patterning_factors_/17301915

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g004

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_mesenchyme_induces_preaxial_polydactyly_/17301906

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g001

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/Proposed_model_for_SHH_GLI3_HES1_regulation_of_digit_number_/17301930

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g009

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/HES1_is_a_critical_effector_of_SHH-induced_PPD_/17301927

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g008

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/HES1_and_SHH_GLI3_signaling_cooperatively_regulate_digit_number_/17301924

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g007