المؤلفون: Kristalle G. Cruz, Maureen Hill Eron, Sparsh Makhaik, Sergey Savinov, Jeanne A. Hardy

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Molecular Biology, Pharmacology, Cancer, Infectious Diseases, Virology, Computational Biology, Chemical Sciences not elsewhere classified, take several months, dengue virus protease, viral cytopathic effect, unique dynamic properties, stabilize zvp synergistically, ns3 protease domain, effectively blocks cleavage, 50 , zika virus ns2b, hybrid proteases composed, mh1 inhibits zvp, active site inhibitor, ns3 protease, unique inhibitor, zika seem, viral family, mh1 inhibits, flaviviral proteases, site inhibitor

Relation: https://figshare.com/articles/journal_contribution/A_Non-Active-Site_Inhibitor_with_Selectivity_for_Zika_Virus_NS2B-NS3_Protease/25054681

الاتاحة: https://doi.org/10.1021/acsinfecdis.3c00330.s001
https://figshare.com/articles/journal_contribution/A_Non-Active-Site_Inhibitor_with_Selectivity_for_Zika_Virus_NS2B-NS3_Protease/25054681

المؤلفون: Ely, Lauren K, Lolicato, Marco, David, Tovo, Lowe, Kate, Kim, Yun Cheol, Samuel, Dharmaraj, Bessette, Paul, Garcia, Jorge L, Mikita, Thomas, Minor, Daniel L, Coughlin, Shaun R

المصدر: Structure. 26(2)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Hematology, Biotechnology, 5.1 Pharmaceuticals, Cardiovascular, Animals, Antibodies, Monoclonal, Anticoagulants, Binding Sites, Antibody, Factor XIa, Humans, Protein Conformation, Thrombosis, IgG, active-site inhibitor, anticoagulant, coagulation, crystal structure, factor XI, hemostasis, intrinsic pathway, protease inhibitor, protease-blocking antibody, thrombosis, Chemical Sciences, Information and Computing Sciences, Biophysics, Biological sciences, Chemical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7mk8c84v
https://escholarship.org/content/qt7mk8c84v/qt7mk8c84v.pdf

المؤلفون: Billy J. Williams-Noonan (10225652), Nevena Todorova (379761), Ketav Kulkarni (1514530), Marie-Isabel Aguilar (1763173), Irene Yarovsky (379764)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, syndrome coronavirus II, Active Site Inhibitor Induces Confo., SARS-CoV -2 s-protein receptor bind., binding enthalpy calculations, modulating ACE 2 conformation, ACE 2 Recognition, novel RNA virus, site inhibitor-bound ACE 2 protein, s-protein binding strength, s-protein binding, SARS-CoV -2 virion, ACE 2, SARS-CoV -2 s-protein, SARS-CoV -2 adhesion, ACE 2 motifs, MLN, RBD, anti-SARS-CoV -2 therapeutics, ACE 2 interactions

Relation: https://figshare.com/articles/journal_contribution/An_Active_Site_Inhibitor_Induces_Conformational_Penalties_for_ACE2_Recognition_by_the_Spike_Protein_of_SARS-CoV_2/14156822

الاتاحة: https://doi.org/10.1021/acs.jpcb.0c11321.s001

المؤلفون: Laco, Gary S

المصدر: Journal of Molecular Biochemistry; Vol 6, No 2 (2017)

مصطلحات موضوعية: active-site inhibitor, cross-species transmission, native resistance, retroviral protease, selected resistance, substrate-grooves, anti-parallel beta-sheet

وصف الملف: application/pdf

Relation: http://www.jmolbiochem.com/index.php/JmolBiochem/article/view/214/134; http://www.jmolbiochem.com/index.php/JmolBiochem/article/view/214

الاتاحة: http://www.jmolbiochem.com/index.php/JmolBiochem/article/view/214

المؤلفون: EVANGELISTI, CAMILLA, Ricci F., Tazzari P., Tabellini G., Battistelli M., Falcieri E., CHIARINI, FRANCESCA, Bortul R., Melchionda F., Pagliaro P., PESSION, ANDREA, McCubrey J. A., MARTELLI, ALBERTO MARIA

المساهمون: Evangelisti, Camilla, Ricci, F., Tazzari, P., Tabellini, G., Battistelli, M., Falcieri, E., Chiarini, Francesca, Bortul, R., Melchionda, F., Pagliaro, P., Pession, Andrea, Mccubrey, J. A., Martelli, ALBERTO MARIA

مصطلحات موضوعية: ACUTE LYMPHOBLASTIC LEUKEMIA (ALL), MTOR, active site inhibitor, TARGETED THERAPY, TRANSLATION

Relation: info:eu-repo/semantics/altIdentifier/pmid/21331075; info:eu-repo/semantics/altIdentifier/wos/WOS:000290471100005; volume:25; issue:5; firstpage:781; lastpage:791; numberofpages:11; journal:LEUKEMIA; http://hdl.handle.net/11380/1288355; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79955818156

الاتاحة: http://hdl.handle.net/11380/1288355
https://doi.org/10.1038/leu.2011.20

المؤلفون: Fraia Melchionda, James A. McCubrey, P. L. Tazzari, Andrea Pession, Roberta Bortul, Elisabetta Falcieri, Michela Battistelli, Francesca Chiarini, Am Martelli, Giovanna Tabellini, Pasqualepaolo Pagliaro, Camilla Evangelisti, Francesca Ricci

المساهمون: Evangelisti C., Ricci F., Tazzari P., Tabellini G., Battistelli M., Falcieri E., Chiarini F., Bortul R., Melchionda F., Pagliaro P., Pession A., McCubrey J.A., Martelli A.M.

مصطلحات موضوعية: Cancer Research, ACUTE LYMPHOBLASTIC LEUKEMIA (ALL), MTOR, active site inhibitors, TARGETED THERAPY, TRANSLATION, active site inhibitor, Blotting, Western, Apoptosis, mTORC1, Biology, Mechanistic Target of Rapamycin Complex 1, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, mTORC2, Mice, Catalytic Domain, Cell Line, Tumor, Autophagy, Animals, Humans, RNA, Messenger, Phosphorylation, Protein kinase B, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Sirolimus, Kinase, Reverse Transcriptase Polymerase Chain Reaction, TOR Serine-Threonine Kinases, RPTOR, Cell Cycle, Proteins, Hematology, Flow Cytometry, Genetic translation, Oncology, Multiprotein Complexes, Cancer research, Immunosuppressive Agents, Transcription Factors

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d639006901e81a370c637100b141a7d
http://hdl.handle.net/11379/155627