المؤلفون: Chunlong Ma, Michael Dominic Sacco, Zilei Xia, George Lambrinidis, Julia Alma Townsend, Yanmei Hu, Xiangzhi Meng, Tommy Szeto, Mandy Ba, Xiujun Zhang, Maura Gongora, Fushun Zhang, Michael Thomas Marty, Yan Xiang, Antonios Kolocouris, Yu Chen, Jun Wang

المصدر: ACS Central Science, Vol 7, Iss 7, Pp 1245-1260 (2021)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2374-7951

URL الوصول: https://doaj.org/article/bef2a55234da40e48cbb89c0d1d8e87c

المؤلفون: Zilei Xia (1447603), Michael Sacco (10946846), Yanmei Hu (481598), Chunlong Ma (278995), Xiangzhi Meng (310468), Fushun Zhang (158697), Tommy Szeto (10213100), Yan Xiang (50965), Yu Chen (29959), Jun Wang (5906)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Evolutionary Biology, Immunology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, UAWJ 9-36-3, UAWJ 9-36-1, X-ray crystal structures, broad-spectrum coronavirus antivirals, intracellular protease activity, Boceprevir SARS-CoV -2, inhibitors UAWJ 9-36-1, HCoV-HKU 1. Cell-based Flip-GFP M, SARS-CoV -2 M, Superimposed Cocrystal Structures, SARS-CoV -2. Selectivity, GC -376, 229E, assay results show, host cysteine proteases calpain

Relation: https://figshare.com/articles/journal_contribution/Rational_Design_of_Hybrid_SARS-CoV_2_Main_Protease_Inhibitors_Guided_by_the_Superimposed_Cocrystal_Structures_with_the_Peptidomimetic_Inhibitors_GC-376_Telaprevir_and_Boceprevir/14755073

الاتاحة: https://doi.org/10.1021/acsptsci.1c00099.s001

المؤلفون: Haozhou Tan, Xiangzhi Meng, Maura V Gongora, Michael Dominic Sacco, Fushun Zhang, Yanmei Hu, Yan Xiang, Zilei Xia, Yu Chen, Juliana Choza, Janice Jang, Michael T. Marty, Chunlong Ma, Jun Wang, Julia Alma Townsend, Xiujun Zhang

المصدر: Journal of the American Chemical Society

مصطلحات موضوعية: Models, Molecular, Proteases, medicine.drug_class, Cathepsin L, medicine.medical_treatment, Molecular Dynamics Simulation, Antiviral Agents, Biochemistry, Article, Catalysis, Cathepsin B, Substrate Specificity, Structure-Activity Relationship, Colloid and Surface Chemistry, Acetamides, Drug Discovery, medicine, Cathepsin K, Animals, Humans, Protease Inhibitors, Enzyme Inhibitors, Coronavirus 3C Proteases, Cathepsin, Protease, biology, SARS-CoV-2, Chemistry, Rational design, Calpain, General Chemistry, Drug Design, biology.protein, Antiviral drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a776c964c1436b50a7e439fc31eef452
https://doi.org/10.1021/jacs.1c08060

المؤلفون: Julia Alma Townsend, George Lambrinidis, Michael T. Marty, Yu Chen, Chunlong Ma, Maura V Gongora, Antonios Kolocouris, Jun Wang, Fushun Zhang, Yan Xiang, Zilei Xia, Xiujun Zhang, Xiangzhi Meng, Mandy Ba, Tommy Szeto, Michael Dominic Sacco, Yanmei Hu

المصدر: ACS Central Science, Vol 7, Iss 7, Pp 1245-1260 (2021)
ACS Central Science
bioRxiv
article-version (status) pre
article-version (number) 1

مصطلحات موضوعية: Conformational change, medicine.drug_class, General Chemical Engineering, High-throughput screening, medicine.medical_treatment, Cell, papain-like protease, Article, chemistry.chemical_compound, medicine, QD1-999, chemistry.chemical_classification, Reporter gene, Protease, SARS-CoV-2, Chemistry, COVID-19, General Chemistry, antiviral, PLpro, Papain, medicine.anatomical_structure, Förster resonance energy transfer, Enzyme, Biochemistry, FlipGFP, Antiviral drug, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5a0b6ce5c12197d5b781e2a4e81951
https://doaj.org/article/bef2a55234da40e48cbb89c0d1d8e87c

المؤلفون: Tommy Szeto, Michael Dominic Sacco, Xiangzhi Meng, Yu Chen, Yanmei Hu, Jun Wang, Fushun Zhang, Yan Xiang, Chunlong Ma, Zilei Xia

المصدر: ACS Pharmacology & Translational Science

مصطلحات موضوعية: Proteases, Peptidomimetic, medicine.drug_class, medicine.medical_treatment, viruses, Article, Telaprevir, Cathepsin L, 3CL protease, medicine, Pharmacology (medical), Pharmacology, Protease, biology, Chemistry, SARS-CoV-2, Rational design, virus diseases, COVID-19, Cysteine protease, antiviral, Biochemistry, main protease, biology.protein, Antiviral drug, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a57e2df2732a7cc41c5b1d96ddde395
http://europepmc.org/articles/PMC8204911

المؤلفون: William L. Robinson, Hiroaki Mitsuya, Yuki Takamatsu, Irene T. Weber, Daniel W. Kneller, Arun K. Ghosh, Megan E. Johnson, Satish Kovela, Zilei Xia, Manabu Aoki, Yuan-Fang Wang

المصدر: ChemMedChem

مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Anti-HIV Agents, Carboxylic acid, medicine.medical_treatment, Carboxylic Acids, Molecular Conformation, Carboxamide, Crystallography, X-Ray, Ligands, 01 natural sciences, Biochemistry, Article, Cell Line, chemistry.chemical_compound, HIV-1 protease, HIV Protease, Drug Discovery, medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Phenylboronic acid, Darunavir, Pharmacology, chemistry.chemical_classification, Protease, biology, 010405 organic chemistry, Organic Chemistry, HIV Protease Inhibitors, Boronic Acids, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, biology.protein, HIV-1, Molecular Medicine, Boronic acid, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427b9b7b3e07717dedb775e5a9ea966d
https://pubmed.ncbi.nlm.nih.gov/31549492

المؤلفون: Qizheng Yao, Zilei Xia, Jiadong Hu, Weiqing Xie, Yu-Qi Gao

المصدر: Chemical Communications. 53:7485-7488

مصطلحات موضوعية: Reaction conditions, 010405 organic chemistry, Aryl, Metals and Alloys, General Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, Carroll rearrangement, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Claisen rearrangement, chemistry.chemical_compound, chemistry, Cascade, Materials Chemistry, Ceramics and Composites, Organic chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affd6b79cb1db8025df32ee333ad033a
https://doi.org/10.1039/c7cc03754f

المؤلفون: Zilei Xia, Qizheng Yao, Weiqing Xie, Zhigao Shen, Jiadong Hu

المصدر: RSC Advances. 5:38499-38502

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, General Chemical Engineering, Phenol, Organic chemistry, General Chemistry, Phenols, Carroll rearrangement, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4d1c70600bae5f48e0ec6d8ffd8753f3
https://doi.org/10.1039/c5ra04931h

المؤلفون: Hui Zhang, Xin Yu, Xixian Pan, Zilei Xia, Zhigao Shen, Zheng Liu, Weiqing Xie

المصدر: RSC Adv.. 4:53397-53401

مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Chemistry, Hydride, General Chemical Engineering, Carboxylic acid, Substrate (chemistry), General Chemistry, Oxidative phosphorylation, Photochemistry, Malondialdehyde, Bond cleavage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b3fbe539e7618f797cde3d7c211080a6
https://doi.org/10.1039/c4ra11237g

المؤلفون: Qizheng Yao, Xiaolong Wan, Jiadong Hu, Weiqing Xie, Zhigao Shen, Zilei Xia, Yisheng Lai, Jin-Ming Gao

المصدر: ChemInform. 47

مصطلحات موضوعية: Silanol, chemistry.chemical_compound, Enantiopure drug, Nucleophile, chemistry, Enantioselective synthesis, Reactivity (chemistry), General Medicine, Combinatorial chemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4df7b225fea70402649a83db62901000
https://doi.org/10.1002/chin.201621213

المؤلفون: Shuai Fu, Ziheng An, Liangliang Wu, Zilei Xiang, Zixin Deng, Ran Liu, Tiangang Liu

المصدر: Synthetic and Systems Biotechnology, Vol 7, Iss 3, Pp 949-957 (2022)

مصطلحات موضوعية: Metabolomics, Streptomyces, Spinosad, Hydrophilic interaction liquid chromatography, High resolution mass spectrometry, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405805X22000515; https://doaj.org/toc/2405-805X

URL الوصول: https://doaj.org/article/074c361f0c594840bb3aea002f6d74a2

المؤلفون: Guangde Jiang, Yisheng Lai, Zilei Xia, Weiqing Xie, Xiangyang Feng, Jiadong Hu, Xiaolong Wan, Jin-Ming Gao

المصدر: ChemInform. 47

مصطلحات موضوعية: Tryptamine, chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Alkene, Stereochemistry, Enantioselective synthesis, Absolute configuration, Moiety, Total synthesis, Alcohol, General Medicine, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::500510aa27176382cfc0165839773e11
https://doi.org/10.1002/chin.201604182

المؤلفون: Jiadong Hu, Yisheng Lai, Zhigao Shen, Qizheng Yao, Xiaolong Wan, Zilei Xia, Jin-Ming Gao, Weiqing Xie

المصدر: Organic letters. 18(1)

مصطلحات موضوعية: Silicon, Stereoisomerism, Alkenes, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, chemistry.chemical_compound, Nucleophile, Organic chemistry, Reactivity (chemistry), Physical and Theoretical Chemistry, Silanes, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Enantioselective synthesis, 0104 chemical sciences, Hydrocarbons, Brominated, Silanol, Enantiopure drug, Cyclization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7e3e5f273c1894a794a13c087613e0
https://pubmed.ncbi.nlm.nih.gov/26654658

المؤلفون: Xiangyang Feng, Xiaolong Wan, Zilei Xia, Yisheng Lai, Jin-Ming Gao, Jiadong Hu, Guangde Jiang, Weiqing Xie

المصدر: Organic letters. 17(18)

مصطلحات موضوعية: chemistry.chemical_classification, Molecular Structure, Stereochemistry, Alkene, Organic Chemistry, Enantioselective synthesis, Absolute configuration, Malaysia, Total synthesis, Alcohol, Stereoisomerism, Alkenes, Biochemistry, Catalysis, Tryptamines, Hydrocarbons, Brominated, Indole Alkaloids, chemistry.chemical_compound, chemistry, Cyclization, Moiety, Physical and Theoretical Chemistry, Nuclear Magnetic Resonance, Biomolecular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcba77961ee92f1c85ddf767f1fc4002
https://pubmed.ncbi.nlm.nih.gov/26315849

المؤلفون: Weiqing Xie, Huijun Zhao, Zhigao Shen, Xiaolong Wan, Zilei Xia, Chen Zhu, Jiadong Hu, Yisheng Lai

المصدر: ChemInform. 46

مصطلحات موضوعية: Tryptamine, chemistry.chemical_compound, Hydroxylamine, chemistry, Tryptophan, Organic chemistry, chemical and pharmacologic phenomena, General Medicine, Nitrogen source, human activities

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1db30275eaf19dc6069f62bf1bda5a3d
https://doi.org/10.1002/chin.201537151

المؤلفون: Zhigao Shen, Jiadong Hu, Zilei Xia, Weiqing Xie, Qizheng Yao

المصدر: ChemInform. 46

مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Organic chemistry, Phenol, General Medicine, Phenols, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7f02b22200fd206c93cb6ea687869394
https://doi.org/10.1002/chin.201535083

المؤلفون: Chen Zhu, Yisheng Lai, Jiadong Hu, Xiaolong Wan, Weiqing Xie, Huijun Zhao, Zilei Xia, Zhigao Shen

المصدر: Organicbiomolecular chemistry. 13(19)

مصطلحات موضوعية: Tryptamine, Indoles, Organic Chemistry, Tryptophan, Biochemistry, Tryptamines, Catalysis, chemistry.chemical_compound, Hydroxylamine, Alkaloids, chemistry, Cyclization, Organic chemistry, Pyrroles, Physical and Theoretical Chemistry, Amines, Nitrogen source

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857cb96a54fb1c9544f33481a46a3d0c
https://pubmed.ncbi.nlm.nih.gov/25881571

المؤلفون: Ziling Ye, Bin Shi, Yanglei Huang, Tian Ma, Zilei Xiang, Ben Hu, Zhaolin Kuang, Man Huang, Xiaoying Lin, Zhu Tian, Zixin Deng, Kun Shen, Tiangang Liu

المصدر: The Innovation, Vol 3, Iss 3, Pp 100228- (2022)

مصطلحات موضوعية: vitamin E, farnesene, Saccharomyces cerevisiae, metabolic engineering, chemical synthesis, Science (General), Q1-390

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666675822000248; https://doaj.org/toc/2666-6758

URL الوصول: https://doaj.org/article/fc1f0a6ae980432abb001ec0a66a340e

المؤلفون: Chunlong Ma (278995), Michael Dominic Sacco (10693136), Zilei Xia (1447603), George Lambrinidis (148996), Julia Alma Townsend (10693139), Yanmei Hu (481598), Xiangzhi Meng (310468), Tommy Szeto (10213100), Mandy Ba (10693142), Xiujun Zhang (390551), Maura Gongora (10994951), Fushun Zhang (158697), Michael Thomas Marty (10693148), Yan Xiang (50965), Antonios Kolocouris (1322580), Yu Chen (29959), Jun Wang (5906)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, cell-based FlipGFP assay, SARS-CoV -2, GRL 0617, BL 2 loop, fluorescence resonance energy trans., Jun 9-75-4, Jun 9-72-2, PL, X-ray crystal structure, FlipGFP-Based Reporter Assay, Molecular dynamics simulations, SARS-CoV -2 antivirals, BSL -2, inhibitor

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_SARS-CoV_2_Papain-like_Protease_Inhibitors_through_a_Combination_of_High-Throughput_Screening_and_a_FlipGFP-Based_Reporter_Assay/14810492

الاتاحة: https://doi.org/10.1021/acscentsci.1c00519.s001

المؤلفون: Zilei Xia^1,2, Jiadong Hu^1,2, Zhigao Shen², Xiaolong Wan³, Qizheng Yao², Yisheng Lai², Jin-Ming Gao¹, Weiqing Xie^1,3 xiewqsioc@aliyun.com

المصدر: Organic Letters. Jan2016, Vol. 18 Issue 1, p80-83. 4p.

مصطلحات موضوعية: *ENANTIOSELECTIVE catalysis, *RING formation (Chemistry), *SILANOLS, *NUCLEOPHILIC reactions, *SILICON compounds