المؤلفون: Katya Marjon, Michael J. Cameron, Phong Quang, Michelle F. Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L. Blake, Jeremy Travins, Marion Dorsch, Scott A. Biller, Kevin M. Marks

المصدر: Cell Reports, Vol 15, Iss 3, Pp 574-587 (2016)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716302996; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/bd77de65b22f4da89618bc5269d7f141

المؤلفون: Zenon Konteatis (2236249), Jeremy Travins (4810641), Stefan Gross (673951), Katya Marjon (10571777), Amelia Barnett (10571780), Everton Mandley (10571783), Brandon Nicolay (8213556), Raj Nagaraja (8413410), Yue Chen (73753), Yabo Sun (10571786), Zhixiao Liu (3719695), Jie Yu (150626), Zhixiong Ye (1370289), Fan Jiang (144211), Wentao Wei (2135263), Cheng Fang (611972), Yi Gao (112914), Peter Kalev (10571789), Marc L. Hyer (10571792), Byron DeLaBarre (673950), Lei Jin (120473), Anil K. Padyana (1833913), Lenny Dang (2035819), Joshua Murtie (4471198), Scott A. Biller (2035810), Zhihua Sui (27883), Kevin M. Marks (1277097)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Homozygous MTAP Deletion, allosteric MAT 2A inhibitors, adenosyl methionine, small-molecule inhibitors, cancer cells, block proliferation, Previous attempts, xenograft tumors, iterative structure-guided design, enzyme methionine adenosyltransferase 2, methylthioadenosine phosphorylase, SAM levels, MAT 2A, Fragment screening, bioavailable MAT 2A inhibitors, AG -270, target MAT 2A, MAT 2A inhibitors, CDKN 2A, First-in-Class Oral MAT 2A Inhibitor, NCT, tissue culture

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_AG-270_a_First-in-Class_Oral_MAT2A_Inhibitor_for_the_Treatment_of_Tumors_with_Homozygous_i_MTAP_i_Deletion/14387567

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01895.s001

المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d97954935b2f34d5dfe50e66a1f7f5
https://doi.org/10.1158/2159-8290.22531945.v1

المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd472a11c8ff29b3f26438ea494ea5d
https://doi.org/10.1158/2159-8290.22531936

المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf9f6f1fb6d2a1049263137b504fc3a
https://doi.org/10.1158/2159-8290.22531939

المؤلفون: Mingzong Li, Zenon Konteatis, Nelamangala Nagaraja, Yue Chen, Shubao Zhou, Guangning Ma, Stefan Gross, Katya Marjon, Marc L. Hyer, Everton Mandley, Max Lein, Anil K. Padyana, Lei Jin, Shuilong Tong, Rachel Peters, Joshua Murtie, Jeremy Travins, Matthew Medeiros, Peng Liu, Victoria Frank, Evan T. Judd, Scott A. Biller, Kevin M. Marks, Zhihua Sui, Samuel K. Reznik

المصدر: Journal of medicinal chemistry. 65(6)

مصطلحات موضوعية: S-Adenosylmethionine, Drug Design, Neoplasms, Drug Discovery, Molecular Medicine, Brain, Humans, Methionine Adenosyltransferase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd4665a566b3b92c2d5c0229953dea0
https://pubmed.ncbi.nlm.nih.gov/35293760

المؤلفون: Zenon, Konteatis, Jeremy, Travins, Stefan, Gross, Katya, Marjon, Amelia, Barnett, Everton, Mandley, Brandon, Nicolay, Raj, Nagaraja, Yue, Chen, Yabo, Sun, Zhixiao, Liu, Jie, Yu, Zhixiong, Ye, Fan, Jiang, Wentao, Wei, Cheng, Fang, Yi, Gao, Peter, Kalev, Marc L, Hyer, Byron, DeLaBarre, Lei, Jin, Anil K, Padyana, Lenny, Dang, Joshua, Murtie, Scott A, Biller, Zhihua, Sui, Kevin M, Marks

المصدر: Journal of medicinal chemistry. 64(8)

مصطلحات موضوعية: S-Adenosylmethionine, Structure-Activity Relationship, Binding Sites, Purine-Nucleoside Phosphorylase, Drug Design, Neoplasms, Homozygote, Humans, Methionine Adenosyltransferase, Enzyme Inhibitors, Molecular Dynamics Simulation, Crystallography, X-Ray

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::6ec9204e0504cb32589dbe975f9a1cd3
https://pubmed.ncbi.nlm.nih.gov/33829783

المؤلفون: Katharine, Yen, Jeremy, Travins, Fang, Wang, Muriel D, David, Erin, Artin, Kimberly, Straley, Anil, Padyana, Stefan, Gross, Byron, DeLaBarre, Erica, Tobin, Yue, Chen, Raj, Nagaraja, Sung, Choe, Lei, Jin, Zenon, Konteatis, Giovanni, Cianchetta, Jeffrey O, Saunders, Francesco G, Salituro, Cyril, Quivoron, Paule, Opolon, Olivia, Bawa, Véronique, Saada, Angelo, Paci, Sophie, Broutin, Olivier A, Bernard, Stéphane, de Botton, Benoît S, Marteyn, Monika, Pilichowska, YingXia, Xu, Cheng, Fang, Fan, Jiang, Wentao, Wei, Shengfang, Jin, Lee, Silverman, Wei, Liu, Hua, Yang, Lenny, Dang, Marion, Dorsch, Virginie, Penard-Lacronique, Scott A, Biller, Shin-San Michael, Su

المصدر: Cancer discovery. 7(5)

مصطلحات موضوعية: Leukemia, Myeloid, Acute, Mice, Triazines, Cell Line, Tumor, Mutation, Aminopyridines, Animals, Humans, Antineoplastic Agents, Xenograft Model Antitumor Assays, Isocitrate Dehydrogenase, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::0d30618427a82a8efe6855ead5edc951
https://pubmed.ncbi.nlm.nih.gov/28461409

المؤلفون: Anthony E. Klon, Jinming Zou, Zenon Konteatis, Siavash N. Meshkat, Charles H. Reynolds

المصدر: Drug Development Research. 72:130-137

مصطلحات موضوعية: Molecular dynamics, Crystallography, Drug discovery, Chemistry, Drug Discovery, Monte Carlo method, Protein model, Computational biology, Protein structure prediction, Protein target, Simulation methods, Grand canonical monte carlo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::136d12228975936aaf035b24bc8fb653
https://doi.org/10.1002/ddr.20409

المؤلفون: Jeffrey S. Wiseman, Siavash Meshkat, Jinming Zou, Zenon Konteatis, Anthony E. Klon

المصدر: Journal of Chemical Information and Modeling. 51:52-60

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, General Chemical Engineering, Amino Acid Motifs, Molecular Sequence Data, Allosteric regulation, Crystal structure, Library and Information Sciences, Crystallography, X-Ray, Ligands, p38 Mitogen-Activated Protein Kinases, Insert (molecular biology), Adenosine Triphosphate, Protein structure, Allosteric Regulation, Amino Acid Sequence, Protein Kinase Inhibitors, Peptide sequence, Chemistry, Binding protein, Proteins, General Chemistry, Protein superfamily, Computer Science Applications, Protein kinase domain, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Protein Kinases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b904e9fe3582307a8728d8cca8b1d49c
https://doi.org/10.1021/ci100256u

المؤلفون: Steven J. Freedman, Matthew Clark, Jinming Zou, Jeffrey S. Wiseman, Jennifer L. Ludington, George Talbot, Sia Meshkat, Zenon Konteatis

المصدر: Drug Development Research. 70:279-287

مصطلحات موضوعية: Drug, Flexibility (engineering), Biodefense, Computer science, Drug discovery, media_common.quotation_subject, Nanotechnology, Probability of success, Identification (information), Drug development, Risk analysis (engineering), Drug Discovery, Multiple treatments, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::78c08cdc8f5a8ea3d7b680d427268f69
https://doi.org/10.1002/ddr.20305

المؤلفون: Rui Liang, Lauri M. Tota, Kevin T. Chapman, Joseph L. Duffy, Xiaodong Yang, Frank Xiaoqing Liu, Guoqiang Jiang, Edward J. Brady, Brian A. Kirk, Song Zheng, Zenon Konteatis, James R. Tata, Mari R. Candelore, Deborah Szalkowski, Sharon Tong, Bei B. Zhang, Victor D.-H. Ding, Elizabeth Louise Campbell, Richard Saperstein, Sajjad A. Qureshi, Dan Xie, Peter Zafian

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:1401-1405

مصطلحات موضوعية: Molecular Structure, Chemistry, medicine.drug_class, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Carboxamide, Thiophenes, Biochemistry, Glucagon, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Receptors, Glucagon, medicine, Humans, Molecular Medicine, Structure–activity relationship, Molecular Biology, IC50, Lead compound, Glucagon receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02875fe32941a428c96a4c4eb4d22e48
https://doi.org/10.1016/j.bmcl.2005.01.003

المؤلفون: Jimmy R. Calaycay, Robert Rodrigues, Zenon Konteatis, Haideh Motamedi, Kevin T. Chapman, Ying-Duo Gao, Patrick R. Griffin, Sajjad A. Qureshi, Dawn E. Biazzo, Judith A. Boice, Ronald M. Kim, David F. Mark, Maria A. Bednarek

المصدر: Proceedings of the National Academy of Sciences. 96:12156-12161

مصطلحات موضوعية: Cell signaling, Biology, Cell Line, Colony-Forming Units Assay, Mice, Genes, Reporter, Escherichia coli, Tumor Cells, Cultured, medicine, Animals, Humans, Progenitor cell, Luciferases, Erythropoietin, Transcription factor, Multidisciplinary, Dose-Response Relationship, Drug, food and beverages, Anemia, Biological Sciences, Hematopoietic Stem Cells, Molecular biology, In vitro, Erythropoietin receptor, Cell culture, Drug Design, embryonic structures, STAT protein, Plasmids, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e351708b1ca25102682414687deec523
https://doi.org/10.1073/pnas.96.21.12156

المؤلفون: Kevin T. Chapman, Ronald M. Kim, Gary S. Kath, Craig K. Esser, Gregory W. King, Jiang Chang, Oyinda Oyelaran, Zenon Konteatis, Brian G. Uhrig

المصدر: Tetrahedron Letters. 40:4477-4480

مصطلحات موضوعية: Chemistry, Yield (chemistry), Organic Chemistry, Drug Discovery, Size-exclusion chromatography, Organic chemistry, Biochemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::43d5a0b82520ef6b8a5dd353be44dc62
https://doi.org/10.1016/s0040-4039(99)00812-6

المؤلفون: Salvatore J. Siciliano, Zenon Konteatis, Martin Springer, Dennis J. Underwood, Gail Van Riper, Julie A. DeMartino, Paul A. Fischer

المصدر: Journal of Biological Chemistry. 270:15966-15969

مصطلحات موضوعية: Agonist, Arginine, Stereochemistry, medicine.drug_class, Molecular Sequence Data, Complement C5a, Ligands, Models, Biological, Biochemistry, C5a receptor, Structure-Activity Relationship, Antigens, CD, medicine, Humans, Amino Acid Sequence, Receptor, Receptor, Anaphylatoxin C5a, Molecular Biology, Alanine, Binding Sites, Dose-Response Relationship, Drug, biology, Chemistry, Ligand, Mutagenesis, Cell Biology, Receptors, Complement, Rhodopsin, Mutation, biology.protein, Oligopeptides, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb94f21d625bbb76620181cf171b797
https://doi.org/10.1074/jbc.270.27.15966

المؤلفون: Michael Karpusas, Ted T. Fujimoto, Kyoung-Jin Lee, Eric B. Springman, Xiaomei Chai, Jennifer L. Ludington, Marina Bukhtiyarova, Kristofer K. Moffett, Enrique Luis Michelotti, Frank Guarnieri, Duyan Nguyen, Haridasan V M Namboodiri, Zenon Konteatis, Bruce D. Dorsey, Rupa Shetty

المصدر: Bioorganicmedicinal chemistry letters. 21(23)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Crystallography, X-Ray, Biochemistry, p38 Mitogen-Activated Protein Kinases, Dexamethasone, chemistry.chemical_compound, Enzyme activator, Inhibitory Concentration 50, Mice, Adenosine Triphosphate, Drug Discovery, Molecule, Animals, Humans, Computer Simulation, Enzyme Inhibitors, Molecular Biology, Oligopeptide, Molecular Structure, Drug discovery, Hydrogen bond, Kinase, Organic Chemistry, Combinatorial chemistry, Rats, Enzyme Activation, chemistry, Molecular Medicine, Adenosine triphosphate, Lead compound, Oligopeptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcee79c0b677f4c6c42f27ff031c8bea
https://pubmed.ncbi.nlm.nih.gov/22014550

المؤلفون: Jinming Zou, Siavash N. Meshkat, Anthony E. Klon, Zenon Konteatis

مصطلحات موضوعية: Molecular dynamics, Protein structure, Docking (molecular), Drug discovery, Computational chemistry, In silico, Monte Carlo method, Small Molecule Libraries, Computational biology, Biology, Binding site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b1f08a6a10d6a7dfdfafc63f9b6f9c14
https://doi.org/10.1016/b978-0-12-381274-2.00014-5

المؤلفون: G Van Riper, Zenon Konteatis, Stephen C. Bondy, S J Siciliano, Martin S. Springer, Lorraine Malkowitz, Julie A. DeMartino, Hugh Rosen, Thomas E. Rollins

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 91(4)

مصطلحات موضوعية: Neutrophils, Protein Conformation, Molecular Sequence Data, Complement C5a, Biology, Transfection, Models, Biological, C5a receptor, Structure-Activity Relationship, GTP-Binding Proteins, Humans, 5-HT5A receptor, Binding site, Cloning, Molecular, Receptor, Receptor, Anaphylatoxin C5a, Protease-activated receptor 2, G protein-coupled receptor, Multidisciplinary, Binding Sites, Membranes, Base Sequence, Dose-Response Relationship, Drug, Peptide Fragments, Receptors, Complement, Biochemistry, Mutagenesis, Signal transduction, Sequence Analysis, Binding domain, Signal Transduction, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f50bb4a529903a704eb11f5e03712e
https://pubmed.ncbi.nlm.nih.gov/8108389

المؤلفون: Siavash Meshkat, Anthony E. Klon, Jinming Zou, Jeffrey S. Wiseman, Zenon Konteatis

المصدر: Journal of Chemical Information & Modeling; Jan2011, Vol. 51 Issue 1, p52-60, 9p

المؤلفون: Zenon Konteatis, Harry G. Brittain

المصدر: Inorganica Chimica Acta. 40:51-57

مصطلحات موضوعية: Lanthanide, Ligand, Stereochemistry, Potentiometric titration, food and beverages, Medicinal chemistry, Inorganic Chemistry, chemistry.chemical_compound, Hydrolysis, chemistry, Stability constants of complexes, Materials Chemistry, Stereoselectivity, Titration, Malic acid, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ec93fbb457bc8edce79e73e5bdb09037
https://doi.org/10.1016/s0020-1693(00)91981-9