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1Academic Journal
المؤلفون: Zak, Krzysztof M., Waterson, Alex G., Geist, Leonhard, Braun, Nina, Hauer, Katja, Rumpel, Klaus, Ramharter, Juergen, Stadtmueller, Heinz, Wolkerstorfer, Bernhard, Schoenbauer, David, Cui, Jianwen, Phan, Jason, Abbott, Jason R., Sarkar, Dhruba, Hodges, Timothy R., Arnold, Allison, Sensintaffar, John L., Fesik, Stephen W., Kessler, Dirk
المصدر: Journal of Medicinal Chemistry ; ISSN 0022-2623 1520-4804
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2Academic Journal
المؤلفون: Böttcher, Jark, Fuchs, Julian E., Mayer, Moriz, Kahmann, Jan, Zak, Krzysztof M., Wunberg, Tobias, Woehrle, Simon, Kessler, Dirk
المصدر: Archiv der Pharmazie ; volume 357, issue 6 ; ISSN 0365-6233 1521-4184
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3Academic Journal
المؤلفون: Gerstberger, Thomas, Berger, Helmut, Büttner, Frank H., Gmachl, Michael, Kessler, Dirk, Koegl, Manfred, Lucas, Simon, Martin, Laetitia J., Mayer, Moriz, McConnell, Darryl B., Mitzner, Sophie, Scholz, Guido, Treu, Matthias, Wolkerstorfer, Bernhard, Zahn, Stephan, Zak, Krzysztof M., Jaeger, Philipp A., Ettmayer, Peter
المصدر: Journal of Medicinal Chemistry ; volume 67, issue 14, page 11701-11711 ; ISSN 0022-2623 1520-4804
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4Academic Journal
المؤلفون: Wątor, Elżbieta, Wilk, Piotr, Biela, Artur, Rawski, Michał, Zak, Krzysztof M., Steinchen, Wieland, Bange, Gert, Glatt, Sebastian, Grudnik, Przemysław
المساهمون: Narodowe Centrum Nauki, Fundacja na rzecz Nauki Polskiej
المصدر: Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723
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5Academic Journal
المؤلفون: Biebl, Maximilian M., Delhommel, Florent, Faust, Ofrah, Zak, Krzysztof M., Agam, Ganesh, Guo, Xiaoyan, Mühlhofer, Moritz, Dahiya, Vinay, Hillebrand, Daniela, Popowicz, Grzegorz M., Kampmann, Martin, Lamb, Don C., Rosenzweig, Rina, Sattler, Michael, Buchner, Johannes
مصطلحات موضوعية: info:eu-repo/classification/ddc
وصف الملف: application/pdf
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6Academic Journal
المؤلفون: Münzker, Lena, Kimani, Serah W., Fowkes, Milan M., Dong, Aiping, Zheng, Hong, Li, Yanjun, Dasovich, Morgan, Zak, Krzysztof M., Leung, Anthony K. L., Elkins, Jonathan M., Kessler, Dirk, Arrowsmith, Cheryl H., Halabelian, Levon, Böttcher, Jark
المصدر: Communications Biology; 7/24/2024, Vol. 7 Issue 1, p1-15, 15p
مصطلحات موضوعية: UBIQUITIN ligases, LIGASES, BINDING site assay, SMALL molecules
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7Academic Journal
المؤلفون: Borchard, Sabine, Raschke, Stefanie, Zak, Krzysztof M, Eberhagen, Carola, Einer, Claudia, Weber, Elisabeth, Müller, Sandra M, Michalke, Bernhard, Lichtmannegger, Josef, Wieser, Albrecht, Rieder, Tamara, Popowicz, Grzegorz M, Adamski, Jerzy, Klingenspor, Martin, Coles, Andrew H, Viana, Ruth, Vendelbo, Mikkel H, Sandahl, Thomas D, Schwerdtle, Tanja, Plitz, Thomas, Zischka, Hans
المصدر: Borchard , S , Raschke , S , Zak , K M , Eberhagen , C , Einer , C , Weber , E , Müller , S M , Michalke , B , Lichtmannegger , J , Wieser , A , Rieder , T , Popowicz , G M , Adamski , J , Klingenspor , M , Coles , A H , Viana , R , Vendelbo , M H , Sandahl , T D , Schwerdtle , T , Plitz , T & Zischka , H 2021 , ' Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage ....
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8Academic Journal
المؤلفون: Zak, Krzysztof M, Bostock, Mark J, Waligorska, Irena, Thøgersen, Ida B, Enghild, Jan J, Popowicz, Grzegorz M, Grudnik, Przemyslaw, Potempa, Jan, Ksiazek, Miroslaw
المصدر: Zak , K M , Bostock , M J , Waligorska , I , Thøgersen , I B , Enghild , J J , Popowicz , G M , Grudnik , P , Potempa , J & Ksiazek , M 2021 , ' Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia ' , Journal of Enzyme Inhibition and Medicinal Chemistry , vol. 36 , no. 1 , pp. 1267-1281 . https://doi.org/10.1080/14756366.2021.1937619
مصطلحات موضوعية: NMR-based fragment screening, Periodontitis, Tannerella forsythia, protease inhibitors, proteolysis, GINGIPAINS, ACTIVATION, MECHANISM, NMR-SPECTROSCOPY, PORPHYROMONAS-GINGIVALIS, PREVALENCE, SUPPRESSION, RED COMPLEX, VIRULENCE FACTORS, PERIODONTAL HEALTH
Relation: https://pure.au.dk/portal/da/publications/latency-thermal-stability-and-identification-of-an-inhibitory-compound-of-mirolysin-a-secretory-protease-of-the-human-periodontopathogen-tannerella-forsythia(edb79c73-87d5-415f-ac55-16d006fe8005).html
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9Academic Journal
المؤلفون: Gaussmann, Stefan, Peschel, Rebecca, Ott, Julia, Zak, Krzysztof M., Sastre, Judit, Delhommel, Florent, Popowicz, Grzegorz M., Boekhoven, Job, Schliebs, Wolfgang, Erdmann, Ralf, Sattler, Michael
المصدر: Nature Communications; 4/18/2024, Vol. 15 Issue 1, p1-17, 17p
مصطلحات موضوعية: PEPTIDES, PEROXISOMES, CRYSTAL structure
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10Academic Journal
المؤلفون: Softley, Charlotte A., Zak, Krzysztof M., Bostock, Mark J., Fino, Roberto, Zhou, Richard Xu, Kolonko, Marta, Mejdi-Nitiu, Ramona, Meyer, Hannelore, Sattler, Michael, Popowicz, Grzegorz M.
المساهمون: Bundesministerium für Bildung und Forschung, Narodowe Centrum Nauki, MNiSW | Krajowy Naukowy Osrodek Wiodacy, EU | Horizon 2020 Framework Programme
المصدر: Antimicrobial Agents and Chemotherapy ; volume 64, issue 6 ; ISSN 0066-4804 1098-6596
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11Academic Journal
المؤلفون: Zak, Krzysztof M., Kalińska, Magdalena, Wątor, Elżbieta, Kuśka, Katarzyna, Krutyhołowa, Rościsław, Dubin, Grzegorz, Popowicz, Grzegorz M., Grudnik, Przemysław
مصطلحات موضوعية: info:eu-repo/classification/ddc
وصف الملف: application/pdf
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12Academic Journal
المؤلفون: Huang, Weiqian, Lan, Dongming, Popowicz, Grzegorz M., Zak, Krzysztof M., Zhao, Zexin, Yuan, Hong, Yang, Bo, Wang, Yonghua
المساهمون: National Natural Science Foundation of China
المصدر: The FEBS Journal ; volume 286, issue 12, page 2366-2380 ; ISSN 1742-464X 1742-4658
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13Academic Journal
المؤلفون: Skalniak, Lukasz, Zak, Krzysztof M, Guzik, Katarzyna, Magiera, Katarzyna, Musielak, Bogdan, Pachota, Magdalena, Szelazek, Bozena, Kocik, Justyna, Grudnik, Przemyslaw, Tomala, Marcin, Krzanik, Sylwia, Pyrc, Krzysztof, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A
المصدر: Skalniak , L , Zak , K M , Guzik , K , Magiera , K , Musielak , B , Pachota , M , Szelazek , B , Kocik , J , Grudnik , P , Tomala , M , Krzanik , S , Pyrc , K , Dömling , A , Dubin , G & Holak , T A 2017 , ' Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells ' , Oncotarget , vol. 8 , no. 42 , pp. 72167-72181 . https://doi.org/10.18632/oncotarget.20050
مصطلحات موضوعية: Journal Article, PD-1, PD-L1, small-molecules, immune checkpoint blockade, INHIBITOR, PROTEIN-PROTEIN INTERACTIONS, DEATH LIGAND 1, CANCER-THERAPY, BLOCKADE, PATHWAY, CRYSTALLOGRAPHY, IMMUNOTHERAPY, EXPRESSION, ANTIBODIES
وصف الملف: application/pdf
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14Academic Journal
المؤلفون: Magiera-Mularz, Katarzyna, Skalniak, Lukasz, Zak, Krzysztof M, Musielak, Bogdan, Rudzinska-Szostak, Ewa, Berlicki, Łukasz, Kocik, Justyna, Grudnik, Przemyslaw, Sala, Dominik, Zarganes-Tzitzikas, Tryfon, Shaabani, Shabnam, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A
المصدر: Magiera-Mularz , K , Skalniak , L , Zak , K M , Musielak , B , Rudzinska-Szostak , E , Berlicki , Ł , Kocik , J , Grudnik , P , Sala , D , Zarganes-Tzitzikas , T , Shaabani , S , Dömling , A , Dubin , G & Holak , T A 2017 , ' Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint ' , Angewandte Chemie - International Edition , vol. 56 , no. 44 , pp. 13732-13735 . https://doi.org/10.1002/anie.201707707
مصطلحات موضوعية: Journal Article, CANCER-IMMUNOTHERAPY, MONOCLONAL-ANTIBODIES, BLOCKADE, THERAPY, FUTURE
وصف الملف: application/pdf
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15Academic Journal
المؤلفون: Guzik, Katarzyna, Zak, Krzysztof M., Grudnik, Przemyslaw, Magiera, Katarzyna, Musielak, Bogdan, Törner, Ricarda, Skalniak, Lukasz, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
المصدر: Guzik , K , Zak , K M , Grudnik , P , Magiera , K , Musielak , B , Törner , R , Skalniak , L , Dömling , A , Dubin , G & Holak , T A 2017 , ' Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1 ' , Journal of Medicinal Chemistry , vol. 60 , no. 13 , pp. 5857-5867 . https://doi.org/10.1021/acs.jmedchem.7b00293
مصطلحات موضوعية: (2 methyl 3 biphenylyl)methanol, 1 [[3 bromo 4 [(2 methyl 3 phenylphenyl)methoxy]phenyl]methyl]piperidine 2 carboxylic acid, 1 [[5 chloro 2 [(3 cyanophenyl)methoxy] 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy]phenyl] methyl] 4 hydroxypyrrolidine 2 carboxylic acid hydrochloride, 2 [[[2 [(3 cyanophenyl)methoxy] 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 5 methylphenyl] methyl]amino] 3 hydroxypropanoic acid hydrochloride, 2 [[[2,6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]phenyl]methyl]amino] 3 methylbutan 1 ol hydrochloride, 2 methoxy 6 [(2 methyl 3 phenylphenyl)methoxy]pyridine 3 carbaldehyde, 2,6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]benzaldehyde, 3 [4 chloro 5 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formylphenoxymethyl]benzonitrile, 3 [5 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formyl 4 methylphenoxymethyl]benzonitrile, 3 bromo 4 [(2 methyl 3 phenylphenyl)methoxy]benzaldehyde, 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxy 5 methylbenzaldehyde, 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2,5 difluorobenzaldehyde, 4 [[[4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2methylphenyl]methoxy] 2,5 difluorophenyl]methyl]amino] 3 hydroxybutanoic acid hydrochloride, 5 chloro 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxybenzaldehyde, [3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methanol, immunomodulating agent, n [2 [[[2 methoxy 6 [(2 methyl 3 phenylphenyl)methoxy]pyridin 3 yl]methyl]amino]ethyl]acetamide hydrochloride, programmed death 1 ligand 1, protein inhibitor, unclassified drug, article, cancer immunotherapy, crystallization, dimerization, drug determination, drug structure, drug synthesis, heteronuclear multiple quantum coherence, human, hydrophobicity
وصف الملف: application/pdf
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16Academic Journal
المؤلفون: Zak, Krzysztof M., Grudnik, Przemyslaw, Magiera, Katarzyna, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
المصدر: Zak , K M , Grudnik , P , Magiera , K , Dömling , A , Dubin , G & Holak , T A 2017 , ' Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2 ' , Structure , vol. 25 , no. 8 , pp. 1163-1174 . https://doi.org/10.1016/j.str.2017.06.011
مصطلحات موضوعية: PROGRAMMED DEATH 1, CANCER-IMMUNOTHERAPY, COMBINATION IMMUNOTHERAPY, ANTIBODY PEMBROLIZUMAB, CRYSTAL-STRUCTURE, BREAST-CANCER, B7 FAMILY, BLOCKADE, THERAPY, COMPLEX
وصف الملف: application/pdf
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17Academic Journal
المؤلفون: Zak, Krzysztof M., Grudnik, Przemyslaw, Guzik, Katarzyna, Zieba, Bartosz J., Musielak, Bogdan, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
المصدر: Zak , K M , Grudnik , P , Guzik , K , Zieba , B J , Musielak , B , Dömling , A , Dubin , G & Holak , T A 2016 , ' Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1) ' , Oncotarget , vol. 7 , no. 21 , pp. 30323-30335 . https://doi.org/10.18632/oncotarget.8730
مصطلحات موضوعية: Checkpoint inhibitor, Immunotherapy, Small molecule, X-ray structure, bms 202, bms 242, bms 37, bms 8, programmed death 1 ligand 1, programmed death 1 receptor, protein inhibitor, unclassified drug, article, binding affinity, complex formation, conformational transition, controlled study, crystal structure, drug potency, drug protein binding, drug research, drug structure, drug synthesis, drug targeting, human, inhibition kinetics, molecular dynamics, nuclear magnetic resonance spectroscopy, protein protein interaction, protein stability
وصف الملف: application/pdf
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18Academic Journal
المؤلفون: Surmiak, Ewa, Twarda-Clapa, Aleksandra, Zak, Krzysztof M., Musielak, Bogdan, Tomala, Marcin D., Kubica, Katarzyna, Grudnik, Przemyslaw, Madej, Mariusz, Jablonski, Mateusz, Potempa, Jan, Kalinowska-Tluscik, Justyna, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
المصدر: Surmiak , E , Twarda-Clapa , A , Zak , K M , Musielak , B , Tomala , M D , Kubica , K , Grudnik , P , Madej , M , Jablonski , M , Potempa , J , Kalinowska-Tluscik , J , Dömling , A , Dubin , G & Holak , T A 2016 , ' A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction ' , ACS chemical biology , vol. 11 , no. 12 , pp. 3310-3318 . https://doi.org/10.1021/acschembio.6b00596
مصطلحات موضوعية: PROTEIN-PROTEIN INTERACTIONS, SMALL-MOLECULE INHIBITORS, STRUCTURE-BASED DESIGN, TUMOR-SUPPRESSOR P53, MDM2-P53 INTERACTION, NMR-SPECTROSCOPY, LIGAND-BINDING, DRUG DISCOVERY, CANCER-THERAPY, POTENT
وصف الملف: application/pdf
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19Academic Journal
المؤلفون: Neochoritis, Constantinos G., Wang, Kan, Estrada-Ortiz, Natalia, Herdtweck, Eberhardt, Kubica, Katarzyna, Twarda, Aleksandra, Zak, Krzysztof M., Holak, Tad A., Dömling, Alexander
المصدر: Neochoritis , C G , Wang , K , Estrada-Ortiz , N , Herdtweck , E , Kubica , K , Twarda , A , Zak , K M , Holak , T A & Dömling , A 2015 , ' 2,30-Bis(10H-indole) heterocycles: New p53/MDM2/MDMX antagonists. ' , Bioorganic and Medicinal Chemistry Letters , vol. 25 , no. 24 , pp. 5661-5666 . https://doi.org/10.1016/j.bmcl.2015.11.019
مصطلحات موضوعية: DISCOVERY, ACYLATION, TRANSIENT PROTEIN STATES, MDM2-P53 INTERACTION, P53, INHIBITORS, CANCER, MDMX, DEGRADATION, CHEMISTRY
وصف الملف: application/pdf
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20Academic Journal
المؤلفون: Zak, Krzysztof M., Kitel, Radoslaw, Przetocka, Sara, Golik, Przemyslaw, Guzik, Katarzyna, Musielak, Bogdan, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
المصدر: Zak , K M , Kitel , R , Przetocka , S , Golik , P , Guzik , K , Musielak , B , Dömling , A , Dubin , G & Holak , T A 2015 , ' Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1 ' , Structure , vol. 23 , no. 12 , pp. 2341-2348 . https://doi.org/10.1016/j.str.2015.09.010
مصطلحات موضوعية: human programmed death 1, membrane protein, programmed death 1, programmed death 1 ligand 1, unclassified drug, article, conformational transition, crystal structure, ligand binding, priority journal, protein protein interaction, protein structure, stoichiometry
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/1e97afc0-0467-460f-b71c-9b2f9679cef8
https://research.rug.nl/en/publications/1e97afc0-0467-460f-b71c-9b2f9679cef8
https://doi.org/10.1016/j.str.2015.09.010
https://pure.rug.nl/ws/files/85554314/Structure_of_the_Complex_of_Human_Programmed_Death_1_PD_1_and_Its_Ligand.pdf
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