المؤلفون: Paola Oliva, Asmita Pramanik, Young-Hwan Jung, Sarah A. Lewicki, Jamie M. Mwendwa, Jong Hwan Park, Kenneth A. Jacobson

المصدر: Cells, Vol 13, Iss 16, p 1366 (2024)

مصطلحات موضوعية: P2Y receptor, antagonist, nucleotide, GPCR, calcium, structure–activity relationship, Cytology, QH573-671

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/16/1366; https://doaj.org/toc/2073-4409

URL الوصول: https://doaj.org/article/b9a24a29bcbf4d588c5d7298259993dd

المؤلفون: Shanu Jain, Sai P. Pydi, Young-Hwan Jung, Mirko Scortichini, Efrat L. Kesner, Tadeusz P. Karcz, Donald N. Cook, Oksana Gavrilova, Jürgen Wess, Kenneth A. Jacobson

المصدر: JCI Insight, Vol 6, Iss 10 (2021)

مصطلحات موضوعية: Metabolism, Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2379-3708

URL الوصول: https://doaj.org/article/415ac4152bc74c40af64da7ddcf8b9cd

المؤلفون: Young-Hwan Jung, Yeo Ok Kim, Koon Mook Kang, Hyung Gon Lee, Borum Son, Xuehao Han, Eunseok Oh, Siwon Kim, Seon Hee Seo, Jong-Hyun Park, Ki Duk Park, Woong Mo Kim, Myung Ha Yoon, Yong-Chul Kim

المصدر: Pharmaceuticals, Vol 15, Iss 4, p 407 (2022)

مصطلحات موضوعية: neuropathic pain, multifunctional compound, multiple mechanisms of action, tianeptine, opioid receptor, neurotransmitter transporter, Medicine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/4/407; https://doaj.org/toc/1424-8247

URL الوصول: https://doaj.org/article/f336e7f773a0407694da045b1a934c52

المؤلفون: Zhiwei Wen (1689439), Veronica Salmaso (2609254), Young-Hwan Jung (3908977), Ngan B. Phung (8787740), Varun Gopinatth (10509097), Qasim Shah (12043177), Alexandra T. Patterson (12043180), John C. R. Randle (10509100), Zhoumou Chen (286777), Daniela Salvemini (286781), David I. Lieberman (6172415), Gregory S. Whitehead (12043183), Tadeusz P. Karcz (9217340), Donald N. Cook (9217346), Kenneth A. Jacobson (117993)

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Physiology, Pharmacology, Biotechnology, Evolutionary Biology, Infectious Diseases, Chemical Sciences not elsewhere classified, persistent key interactions, multiple polar groups, mouse asthma model, enhanced aqueous solubility, 1 ]­ hept, probe receptor affinity, high affinity naphthalene, fold higher affinity, displayed intermediate affinity, displayed higher affinity, rigidified piperidine derivatives, piperidine bridging moieties, bridged piperidine analogues, 42 , 34 , 30 , 24 , 143 , 1 , 50 , 14

Relation: https://figshare.com/articles/journal_contribution/Bridged_Piperidine_Analogues_of_a_High_Affinity_Naphthalene-Based_P2Y_sub_14_sub_R_Antagonist/19119322

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01964.s001

المؤلفون: Dilip K. Tosh (1668115), Christopher M. Brackett (6640094), Young-Hwan Jung (3908977), Zhan-Guo Gao (117989), Monimoy Banerjee (2048698), Brian S. J. Blagg (8480076), Kenneth A. Jacobson (117993)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, exhibit isoform selectivity, ATP binding site, Grp 94-Selective Inhibitors, adenosine receptor agonist, heat shock protein 90 kDa, inhibitor, NECA scaffold, Grp 94

Relation: https://figshare.com/articles/journal_contribution/Biological_Evaluation_of_5_i_N_i_Ethylcarboxamido_adenosine_Analogues_as_Grp94-Selective_Inhibitors/14135472

الاتاحة: https://doi.org/10.1021/acsmedchemlett.0c00509.s001

المؤلفون: Zhiwei, Wen, Veronica, Salmaso, Young-Hwan, Jung, Ngan B, Phung, Varun, Gopinatth, Qasim, Shah, Alexandra T, Patterson, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, David I, Lieberman, Gregory S, Whitehead, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson

المصدر: J Med Chem

مصطلحات موضوعية: Mice, Structure-Activity Relationship, Piperidines, Purinergic P2 Receptor Antagonists, Animals, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::da62c41535c927994c70d1b42266cae7
https://pubmed.ncbi.nlm.nih.gov/35113556

المؤلفون: Kenneth A. Jacobson, Donald N. Cook, Tadeusz P Karcz, John C R Randle, John M. Bennett, Varun Gopinatth, Zhiwei Wen, Ngan B. Phung, Daniela Salvemini, Young-Hwan Jung, David I. Lieberman, Veronica Salmaso, Zhoumou Chen

المصدر: Journal of Medicinal Chemistry. 64:5099-5122

مصطلحات موضوعية: Stereochemistry, Triazole, Molecular Dynamics Simulation, 01 natural sciences, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Piperidines, Animals, Binding Sites, Disease Models, Animal, Drug Design, Humans, Molecular Docking Simulation, Neuralgia, Prodrugs, Purinergic P2 Receptor Antagonists, Receptors, Purinergic P2, Solubility, Triazoles, Amide, Receptors, Drug Discovery, Structure–activity relationship, Hydroxymethyl, Carboxylate, 030304 developmental biology, 0303 health sciences, Purinergic P2, Animal, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Zwitterion, Disease Models, Molecular Medicine, Bioisostere, Piperidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8619de0d7c2d74a8325f516dd55228e
https://doi.org/10.1021/acs.jmedchem.1c00164

المؤلفون: Kenneth A. Jacobson, Dilip K. Tosh, Zhan-Guo Gao, Monimoy Banerjee, Brian S. J. Blagg, Christopher M. Brackett, Young-Hwan Jung

المصدر: ACS Medicinal Chemistry Letters. 12:373-379

مصطلحات موضوعية: biology, 010405 organic chemistry, Glucose-regulated protein, Chemistry, Endoplasmic reticulum, Organic Chemistry, Cancer, medicine.disease, 01 natural sciences, Biochemistry, Adenosine, Hsp90, 0104 chemical sciences, Metastasis, 010404 medicinal & biomolecular chemistry, Heat shock protein, Drug Discovery, medicine, biology.protein, medicine.drug, Biological evaluation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::44d332171e57abc0f4dd57584c533c52
https://doi.org/10.1021/acsmedchemlett.0c00509

المؤلفون: Young-Hwan, Jung, Qasim, Shah, Sarah A, Lewicki, Asmita, Pramanik, Varun, Gopinatth, Julie, Pelletier, Jean, Sévigny, Jamshed, Iqbal, Kenneth A, Jacobson

المصدر: Bioorganicmedicinal chemistry letters. 75

مصطلحات موضوعية: Mice, Structure-Activity Relationship, Halogens, Receptors, Purinergic P2, Animals, Humans, Benzopyrans, Uridine Diphosphate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::5c9c01fbb67fa98beaaa66f6c2e04575
https://pubmed.ncbi.nlm.nih.gov/36089113

المؤلفون: Kwang-sun Kim, Hee tae Kim, Hong Bum Cho, Hyejin Cho, Young Hwan Jung

المصدر: Clinica Chimica Acta; International Journal of Clinical Chemistry
Clinica Chimica Acta

مصطلحات موضوعية: 0301 basic medicine, Coronavirus disease 2019 (COVID-19), Clinical Biochemistry, Positive control, Biology, Synthetic positive template, Biochemistry, Article, Virus, 03 medical and health sciences, 0302 clinical medicine, Diagnosis, Humans, Gene, Biochemistry, medical, Detection limit, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Oligonucleotide, Biochemistry (medical), COVID-19, General Medicine, Molecular biology, Real-time RT-PCR, Reverse transcription polymerase chain reaction, 030104 developmental biology, Real-time polymerase chain reaction, 030220 oncology & carcinogenesis, Reagent Kits, Diagnostic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232da616922656dc7df5e2d52edd82c3
https://doi.org/10.1016/j.cca.2020.10.001

المؤلفون: Kenneth A. Jacobson, Fatma Mufti, Ngan B. Phung, Luigino Antonio Giancotti, Daniela Salvemini, Young-Hwan Jung, Jinha Yu, Zhoumou Chen

المصدر: ACS Medicinal Chemistry Letters. 11:1281-1286

مصطلحات موضوعية: P2Y receptor, 010405 organic chemistry, Chemistry, Ligand binding assay, Organic Chemistry, Chronic pain, Antagonist, Pharmacology, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Pharmacokinetics, In vivo, Drug Discovery, Neuropathic pain, medicine, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5294955a197573842d2dc091376c94e0
https://doi.org/10.1021/acsmedchemlett.0c00115

المؤلفون: Fatma Mufti, Young‐Hwan Jung, Luigino A. Giancotti, Jinha Yu, Zhoumou Chen, Ngan B. Phung, Kenneth A. Jacobson, Daniela Salvemini

المصدر: The FASEB Journal. 36

مصطلحات موضوعية: Genetics, Molecular Biology, Biochemistry, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3defa1d8be263e0c4f0ba2477d633fa5
https://doi.org/10.1096/fasebj.2022.36.s1.r2874

المؤلفون: Zhiwei Wen, Veronica Salmaso, Young-Hwan Jung, Ngan B. Phung, Varun Gopinatth, Qasim Shah, Alexandra T. Patterson, John C. R. Randle, Zhoumou Chen, Daniela Salvemini, David I. Lieberman, Gregory S. Whitehead, Tadeusz P. Karcz, Donald N. Cook, Kenneth A. Jacobson

مصطلحات موضوعية: Mice, Structure-Activity Relationship, Animals, Piperidines, Purinergic P2 Receptor Antagonists, Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a16138dcf66e0cf8b0d97c43fac4e0
http://hdl.handle.net/11577/3459804

المؤلفون: Gregory S. Whitehead, Tadeusz P. Karcz, Dilip K. Tosh, Young-Hwan Jung, Zhiwei Wen, Ryan G. Campbell, Varun Gopinatth, Zhan-Guo Gao, Kenneth A. Jacobson, Donald N. Cook

مصطلحات موضوعية: Pharmacology, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddab2d317b599110bf79f6e32515bd8
https://ruj.uj.edu.pl/xmlui/handle/item/303815

المؤلفون: Young-Hwan Jung, Qasim Shah, Sarah A. Lewicki, Asmita Pramanik, Varun Gopinatth, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Kenneth A. Jacobson

المصدر: Bioorganic & Medicinal Chemistry Letters. 75:128981

مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::025702eb379b2774f73b8bd8f01fbc39
https://doi.org/10.1016/j.bmcl.2022.128981

المؤلفون: Young-Hwan Jung, Sai Prasad Pydi, Jürgen Wess, Efrat L Kesner, Tadeusz P Karcz, Shanu Jain, Mirko Scortichini, Kenneth A. Jacobson, Oksana Gavrilova, Donald N. Cook

المصدر: JCI Insight

مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, medicine.medical_specialty, medicine.drug_class, Lipolysis, Adipose tissue, Type 2 diabetes, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Internal medicine, Adipocyte, medicine, Adipocytes, Glucose homeostasis, Animals, Obesity, Receptor, Chemistry, Diabetes, General Medicine, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Metabolism, Glucose, 030220 oncology & carcinogenesis, Receptors, Purinergic P2Y, Purinergic P2Y Receptor Antagonists, Endogenous agonist, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac55fa96e124f3dc71a03e8fa72e7bc
http://europepmc.org/articles/PMC8262345

المؤلفون: Ken Jacobson, Donald N. Cook, Mirko Scortichini, Sai Prasad Pydi, Oksana Gavrilova, Efrat L Kesner, Young-Hwan Jung, Tadeusz P Karcz, Jürgen Wess, Shanu Jain

المصدر: The FASEB Journal. 35

مصطلحات موضوعية: medicine.medical_specialty, Chemistry, Lipid mobilization, Biochemistry, chemistry.chemical_compound, Endocrinology, Internal medicine, Adipocyte, Genetics, medicine, Glucose homeostasis, Whole body, Receptor, Molecular Biology, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::170a36868db8a95bfb267ce03b654b97
https://doi.org/10.1096/fasebj.2021.35.s1.02001

المؤلفون: Young-Hwan, Jung, Veronica, Salmaso, Zhiwei, Wen, John M, Bennett, Ngan B, Phung, David I, Lieberman, Varun, Gopinatth, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson

المصدر: J Med Chem

مصطلحات موضوعية: Binding Sites, Receptors, Purinergic P2, Molecular Dynamics Simulation, Triazoles, Article, Molecular Docking Simulation, Disease Models, Animal, Mice, Structure-Activity Relationship, Piperidines, Solubility, Drug Design, Purinergic P2 Receptor Antagonists, Animals, Humans, Neuralgia, Prodrugs

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::2538a8e3308d6a52460a78072272a801
https://pubmed.ncbi.nlm.nih.gov/33787273

المؤلفون: Young-Hwan, Jung, Shanu, Jain, Varun, Gopinatth, Ngan B, Phung, Zhan-Guo, Gao, Kenneth A, Jacobson

المصدر: Bioorg Med Chem Lett

مصطلحات موضوعية: Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, Receptors, Purinergic P2, Purinergic P2Y Receptor Antagonists, Humans, Benzopyrans, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::6e0b3bced1f28e29dfac11377d1858be
https://pubmed.ncbi.nlm.nih.gov/33831560

المؤلفون: Dilip K, Tosh, Christopher M, Brackett, Young-Hwan, Jung, Zhan-Guo, Gao, Monimoy, Banerjee, Brian S J, Blagg, Kenneth A, Jacobson

المصدر: ACS Med Chem Lett

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::876c868126a433fc51a862862f36cf37
https://pubmed.ncbi.nlm.nih.gov/33738064