المؤلفون: Jungao, Zhu, Yuan, Zhao, Meifu, Lai, Yongli, Gu, Shixiang, Xu, Cangtao, Zhou, Haiyang, Lu

مصطلحات موضوعية: Physics - Accelerator Physics, Physics - Plasma Physics

URL الوصول: http://arxiv.org/abs/2209.01743

المؤلفون: Sarah Bond, Saeho Chong, Tuyen Nguyen, Justin Darcy, Saket Agarwal, Maja M. Janas, Jing-Tao Wu, Samantha Chigas, Yongli Gu, Ruth Allard

المصدر: Nucleic Acid Therapeutics

مصطلحات موضوعية: 0301 basic medicine, Small interfering RNA, Acetylgalactosamine, ASGPR, protein binding, Asialoglycoprotein Receptor, Plasma protein binding, Biochemistry, Protein–protein interaction, 03 medical and health sciences, 0302 clinical medicine, RNA interference, Drug Discovery, Genetics, Humans, RNA, Small Interfering, Molecular Biology, Chemistry, Blood Proteins, Ligand (biochemistry), Small molecule, Blood proteins, carbohydrates (lipids), GalNAc conjugate, 030104 developmental biology, siRNA, RNAi, 030220 oncology & carcinogenesis, Hepatocytes, Molecular Medicine, RNA Interference, lipids (amino acids, peptides, and proteins), Asialoglycoprotein receptor, Brief Communications

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03774b8b68b07398a9b85a3521e562f
https://doi.org/10.1089/nat.2020.0919

المؤلفون: Krishna Aluri, Scott Waldron, Karyn Schmidt, Maja M. Janas, Elena Castellanos-Rizaldos, Xiumin Liu, Michael Arciprete, Diane Ramsden, Jing Li, Vasant Jadhav, Robin McDougall, Christopher R. Brown, Bahru A. Habtemariam, Dale C. Guenther, Gabriel J. Robbie, Saket Agarwal, Muthiah Manoharan, Akshay Vaishnaw, Ivan Zlatev, Jeffrey Kurz, Jayaprakash K. Nair, Martin Maier, Saeho Chong, Sagar Agarwal, Christopher S. Theile, Steven Liou, Muthusamy Jayaraman, Varun Goel, Kevin Fitzgerald, Christopher MacLauchlin, Klaus Charisse, Joseph A Cichocki, Ju Liu, Yuanxin Xu, Peter F Smith, Jing-Tao Wu, Xuemei Zhang, Yongli Gu

المصدر: Drug Metabolism and Disposition. 50:781-797

مصطلحات موضوعية: Pharmacology, Small interfering RNA, Pharmacokinetics, Chemistry, In vivo, Pharmacodynamics, Pharmaceutical Science, Gene silencing, Distribution (pharmacology), PK/PD models, ADME

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fa4ae67a6f9cc6256cba922321905899
https://doi.org/10.1124/dmd.121.000428

المؤلفون: Jungao Zhu, Haiyang Lu, Yuan Zhao, Meifu Lai, Yongli Gu, Shixiang Xu, Cangtao Zhou

المصدر: Chinese Science Bulletin.

مصطلحات موضوعية: Multidisciplinary

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d3ccce8255ca63521fbbacfeab23614b
https://doi.org/10.1360/tb-2022-0380

المؤلفون: Shannon Gutierrez, Yuanxin Xu, Gabriel J. Robbie, Carrie Rocca, Samantha Chigas, James Butler, Saeho Chong, Yongli Gu, Sean Dennin, Joohwan Kim, Kirk Brown, Diana Najarian, Klaus Charisse

المصدر: Bioanalysis. 11:1927-1939

مصطلحات موضوعية: 0303 health sciences, Small interfering RNA, Oligonucleotide, Chemistry, 010401 analytical chemistry, Clinical Biochemistry, Ultrafiltration, Electrophoretic Mobility Shift Assay, Blood Proteins, General Medicine, Plasma protein binding, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, stomatognathic diseases, 03 medical and health sciences, Medical Laboratory Technology, Biochemistry, RNA interference, Antisense oligonucleotides, Electrophoretic mobility shift assay, RNA, Small Interfering, General Pharmacology, Toxicology and Pharmaceutics, Protein Binding, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b7581bfeec025b29eef6b77852f50a
https://doi.org/10.4155/bio-2019-0151

المؤلفون: Valerie A. Clausen, Brad Zerler, Jim Jiang, Jing-Tao Wu, Krishna Aluri, Joohwan Kim, Diane Ramsden, Sajida Iqbal, Yongli Gu, Saeho Chong, Sean Dennin

المصدر: Drug Metabolism and Disposition. 47:1183-1194

مصطلحات موضوعية: Small interfering RNA, Acetylgalactosamine, Oligonucleotides, Pharmaceutical Science, Pharmacology, Models, Biological, Inhibitory Concentration 50, Cytochrome P-450 Enzyme System, Cytochrome P-450 Enzyme Inhibitors, Humans, Medicine, Computer Simulation, Drug Interactions, RNA, Small Interfering, Cells, Cultured, Enzyme Assays, Cytochrome P-450 Enzyme Inducers, Mechanism (biology), Oligonucleotide, business.industry, Membrane Transport Proteins, RNA, Transporter, Small molecule, Recombinant Proteins, In vitro, Hepatocytes, Target protein, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4a78d55fd803e90138bc24c2878200
https://doi.org/10.1124/dmd.119.087098

المؤلفون: Robin, McDougall, Diane, Ramsden, Sagar, Agarwal, Saket, Agarwal, Krishna, Aluri, Michael, Arciprete, Christopher, Brown, Elena, Castellanos-Rizaldos, Klaus, Charisse, Saeho, Chong, Joseph, Cichocki, Kevin, Fitzgerald, Varun, Goel, Yongli, Gu, Dale, Guenther, Bahru, Habtemariam, Vasant, Jadhav, Maja, Janas, Muthusamy, Jayaraman, Jeffrey, Kurz, Jing, Li, Ju, Liu, Xiumin, Liu, Steven, Liou, Chris, Maclauchlin, Martin, Maier, Muthiah, Manoharan, Jayaprakash K, Nair, Gabriel, Robbie, Karyn, Schmidt, Peter, Smith, Christopher, Theile, Akshay, Vaishnaw, Scott, Waldron, Yuanxin, Xu, Xuemei, Zhang, Ivan, Zlatev, Jing-Tao, Wu

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 50(6)

مصطلحات موضوعية: Acetylgalactosamine, Hepatocytes, Humans, Asialoglycoprotein Receptor, RNA, Small Interfering, Porphyrias, Hepatic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::1ee09492e0ec47356243e1bb6d5c3b2c
https://pubmed.ncbi.nlm.nih.gov/34154993

المؤلفون: Swati Gupta, Diana Najarian, Elena Castellanos-Rizaldos, Sean Dennin, Kirk Brown, Yongli Gu, Joohwan Kim, Krishna Aluri, Christopher R. Brown, Jennifer Enders, Yuanxin Xu

المصدر: Nucleic acid therapeutics. 30(3)

مصطلحات موضوعية: 0301 basic medicine, Small interfering RNA, Glycol nucleic acid, Metabolite, Computational biology, Mass spectrometry, Biochemistry, Sensitivity and Specificity, Mass Spectrometry, RNAi Therapeutics, 03 medical and health sciences, chemistry.chemical_compound, Glycols, 0302 clinical medicine, Drug Discovery, Genetics, Humans, Precision Medicine, RNA, Small Interfering, Molecular Biology, Chemistry, Reverse Transcriptase Polymerase Chain Reaction, Assay sensitivity, Reverse transcriptase, 030104 developmental biology, Real-time polymerase chain reaction, 030220 oncology & carcinogenesis, Calibration, Molecular Medicine, Drug Monitoring

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cd66c5da3ced7eafd6c594437d7966
https://pubmed.ncbi.nlm.nih.gov/32202961

المؤلفون: Molecular Brain, Ting Yang, Dilyara Arslanova, Yongli Gu, Corinne Augelli-szafran, Weiming Xia

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b1/9c/Mol_Brain_2008_Nov_4_1_15.tar.gz

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.5063

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.5063

المؤلفون: Jing Zhang, Dennis J. Selkoe, Michael S. Wolfe, Wenjuan Ye, Han-Xun Wei, Dai Lu, Yongli Gu, Pamela Osenkowski, Corinne E. Augelli-Szafran, Vivien Sun

المصدر: Bioorg Med Chem Lett

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Naphthalenes, Cleavage (embryo), Biochemistry, Article, Propanolamines, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, Amyloid precursor protein, Animals, Humans, Protease Inhibitors, γ secretase, Receptor, Notch1, Molecular Biology, Amyloid beta-Peptides, 030102 biochemistry & molecular biology, biology, Chemistry, Organic Chemistry, Amino Alcohols, Peptide Fragments, Rats, 030104 developmental biology, Microsomes, Liver, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7871e2efb9ec024eb8ebe67104c6219
https://doi.org/10.1016/j.bmcl.2016.03.042

المؤلفون: Chaojuan, Xiang, Jiang, Xie, Yongli, Gu, Junfu, Xu, Kai, Lu

المصدر: 2015 34th Chinese Control Conference (CCC) ; volume 50, page 8545-8549

الاتاحة: http://dx.doi.org/10.1109/chicc.2015.7260991
http://xplorestaging.ieee.org/ielx7/7225914/7259602/07260991.pdf?arnumber=7260991

المؤلفون: Corinne E. Augelli-Szafran, Michael S. Wolfe, Yongli Gu, Dennis J. Selkoe, Jing Zhang, Han-Xun Wei, Dai Lu, Wenjuan Ye, Pamela Osenkowski

المصدر: Bioorg Med Chem Lett

مصطلحات موضوعية: 0301 basic medicine, Proteases, Benzylamines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Naphthalenes, 01 natural sciences, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Amide, Drug Discovery, Structure–activity relationship, Animals, Humans, Protease Inhibitors, Receptor, Notch1, Receptor, Molecular Biology, Benzofurans, Amyloid beta-Peptides, biology, Chemistry, Organic Chemistry, Biological activity, Amides, Peptide Fragments, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, biology.protein, Microsomes, Liver, Molecular Medicine, Signal transduction, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Isopropyl, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b031aeca784f22889539ebb4c372988
https://europepmc.org/articles/PMC8317589/

المؤلفون: Yongli Gu, Han-Xun Wei, Jing Zhang, Michael S. Wolfe, Corinne E. Augelli-Szafran, Dennis J. Selkoe, Dai Lu

المصدر: Bioorg Med Chem Lett

مصطلحات موضوعية: 0301 basic medicine, Pyridones, Clinical Biochemistry, Pharmaceutical Science, Cleavage (embryo), Inhibitory postsynaptic potential, Biochemistry, Article, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Animals, Humans, Protease Inhibitors, γ secretase, Receptor, Notch1, Receptor, Molecular Biology, Amyloid beta-Peptides, 030102 biochemistry & molecular biology, biology, Chemistry, Organic Chemistry, Receptor-mediated endocytosis, Peptide Fragments, Rats, 030104 developmental biology, Pyrimidines, biology.protein, Microsomes, Liver, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809b09da30c9157d5278f72c688eaf60
https://pubmed.ncbi.nlm.nih.gov/27038496

المؤلفون: Jane A. Phillips, Mark R. Parthun, Charles S. Hoffman, Yongli Gu, Laura J. Benson, Anthony T. Annunziato

المصدر: Journal of Biological Chemistry. 282:836-842

مصطلحات موضوعية: biology, Cell Biology, Histone acetyltransferase, SAP30, Biochemistry, Histone H4, Acetylation, Histone methyltransferase, Histone H2A, biology.protein, Histone octamer, HAT1, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7b7a2ee76673b71023e8aed80a9256bd
https://doi.org/10.1074/jbc.m607464200

المؤلفون: David M. Bolduc, Dennis J. Selkoe, Daniel R. Montagna, Michael S. Wolfe, Yongli Gu

المصدر: Proceedings of the National Academy of Sciences. 113

مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, biology, Chemistry, Nicastrin, Cleavage (embryo), 03 medical and health sciences, Transmembrane domain, 030104 developmental biology, Biochemistry, Ectodomain, biology.protein, Biophysics, APH-1, Lipid bilayer, Amyloid precursor protein secretase, Integral membrane protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8f90f08360f050301a73f9081abc12b7
https://doi.org/10.1073/pnas.1512952113

المؤلفون: Kevin Tong, Yongli Gu, Craig A. Mizzen, Anthony T. Annunziato, Richard G. Cook, Christine L. Strack, Tatyana Yakovleva, Courtney E. Barrows, Laura J. Benson

المصدر: Journal of Biological Chemistry. 281:9287-9296

مصطلحات موضوعية: DNA Replication, Acetylation, Cell Biology, Histone exchange, Biology, Biochemistry, Molecular biology, Chromatin, Chromatin remodeling, Nucleosomes, Cell biology, Histones, Cytosol, Histone H1, embryonic structures, Histone methylation, Histone H2A, Humans, Immunoprecipitation, Histone code, Nucleosome, Histone octamer, Protein Processing, Post-Translational, Molecular Biology, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0628e241d97e45ae7506b93285e444
https://doi.org/10.1074/jbc.m512956200

المؤلفون: Dai Lu, Yongli Gu, Jing Zhang, Han-Xun Wei, Wenjuan Ye, Michael S. Wolfe, Pamela Osenkowski, Corinne E. Augelli-Szafran, Ting Yang

المصدر: Current Alzheimer Research. 7:207-209

مصطلحات موضوعية: Proteases, biology, medicine.diagnostic_test, Drug discovery, Proteolysis, Notch signaling pathway, P3 peptide, Pharmacology, Cell biology, Neurology, Alpha secretase, biology.protein, medicine, Amyloid precursor protein, Neurology (clinical), Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c0642e91fd26bc7f7a5ff81274ffce70
https://doi.org/10.2174/156720510791050920

المؤلفون: Jianxin Cai, Yongli Gu, Xiaoming Ji, Jingzhou Yan, Guoyun Ru, Cheng, L., Choa, F.-S., Fan, J.

المصدر: (CLEO). Conference on Lasers and Electro-Optics, 2005. ; volume 74, page 562-564 Vol. 1

الاتاحة: http://dx.doi.org/10.1109/cleo.2005.201847
http://xplorestaging.ieee.org/ielx5/10505/33268/01572913.pdf?arnumber=1572913

المؤلفون: Corinne E. Augelli-Szafran, Jian Chen, Cuiman Cai, Han-Xun Wei, Dennis J. Selkoe, Jing Zhang, Yongli Gu, M. Michael Wolfe, Katherine Brogan

المصدر: Alzheimer's & Dementia. 9

مصطلحات موضوعية: Epidemiology, business.industry, Health Policy, Small molecule, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Disease therapy, Developmental Neuroscience, Cancer research, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Gamma secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6be4b83e293e1e685bd461f10cd8da13
https://doi.org/10.1016/j.jalz.2013.05.1687

المؤلفون: Dilyara Arslanova, Ting Yang, Weiming Xia, Corinne E. Augelli-Szafran, Yongli Gu

المصدر: Molecular Brain, Vol 1, Iss 1, p 15 (2008)
Molecular Brain

مصطلحات موضوعية: Embryo, Nonmammalian, Notch signaling pathway, Enzyme-Linked Immunosorbent Assay, lcsh:RC346-429, Substrate Specificity, 03 medical and health sciences, Cellular and Molecular Neuroscience, Amyloid beta-Protein Precursor, 0302 clinical medicine, Amyloid precursor protein, Basic Helix-Loop-Helix Transcription Factors, Animals, Protease Inhibitors, Molecular Biology, Gamma secretase, Zebrafish, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, 0303 health sciences, biology, Receptors, Notch, Research, HEK 293 cells, P3 peptide, Dipeptides, Zebrafish Proteins, Molecular biology, Recombinant Proteins, Protein Structure, Tertiary, Transmembrane domain, Phenotype, Gene Expression Regulation, Mutation, biology.protein, Signal transduction, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, 030217 neurology & neurosurgery, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489e2dd0f6a1e7c606c8e9b775122f40
http://www.molecularbrain.com/content/1/1/15