المؤلفون: Leire Iralde-Lorente, Ylenia Cau, Letizia Clementi, Lorenzo Franci, Giusy Tassone, Daniela Valensin, Mattia Mori, Adriano Angelucci, Mario Chiariello, Maurizio Botta

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 657-664 (2019)

مصطلحات موضوعية: 14-3-3, protein–protein interaction, c-abl, leukaemia, 4-aminoantipyrine, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/0387ca67151143d8bee11b1f00a12246

المؤلفون: Piotr Maj, Mattia Mori, Justyna Sobich, Joanna Markowicz, Łukasz Uram, Zbigniew Zieliński, Deborah Quaglio, Andrea Calcaterra, Ylenia Cau, Bruno Botta, Wojciech Rode

المصدر: Molecules, Vol 25, Iss 12, p 2894 (2020)

مصطلحات موضوعية: thymidylate synthase, inhibitor, nematocidal activity, cytotoxicity, xanthones, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/12/2894; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/999f4eff582449428a6208401ac6f6a0

المؤلفون: Leire Iralde-Lorente, Giusy Tassone, Ylenia Cau, Claire Munier, Lorenzo Franci, Cecilia Pozzi, Adriano Angelucci, Mario Chiariello, Matthew Perry, Stefano Mangani, Maurizio Botta

المصدر: Proceedings, Vol 22, Iss 1, p 17 (2019)

مصطلحات موضوعية: 14-3-3, Protein-protein interactions, c-Abl, chronic myeloid leukemia (CML), General Works

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2504-3900/22/1/17; https://doaj.org/toc/2504-3900

URL الوصول: https://doaj.org/article/bae4c4cff99d45deba1ba399c8422f85

المؤلفون: Ylenia Cau, Daniela Vullo, Mattia Mori, Elena Dreassi, Claudiu T. Supuran, Maurizio Botta

المصدر: Molecules, Vol 23, Iss 1, p 17 (2017)

مصطلحات موضوعية: carbonic anhydrase inhibitors (CAIs), carboxylic acid, tumor-associated isoforms, isoform selectivity, molecular modeling, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/23/1/17; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/c6055493e91b4d82ba896f01c047810b

المؤلفون: Gaia Giuntini, Sara Monaci, Ylenia Cau, Mattia Mori, Antonella Naldini, Fabio Carraro

المصدر: Cancers; Volume 12; Issue 10; Pages: 3018

مصطلحات موضوعية: carbonic anhydrase, hedgehog, cyclopamine, small molecules, acetazolamide, motility, metalloproteinases, FAK, cancer

وصف الملف: application/pdf

Relation: Cancer Therapy; https://dx.doi.org/10.3390/cancers12103018

الاتاحة: https://doi.org/10.3390/cancers12103018

المؤلفون: Loes M. Stevers, Eline Sijbesma, Maurizio Botta, Carol MacKintosh, Tomas Obsil, Isabelle Landrieu, Ylenia Cau, Andrew J. Wilson Wilson, Anna Karawajczyk, Jan Eickhoff, Jeremy Davis, Michael Hann, GGavin O'Mahony, Richard G. Doveston, Luc Brunsveld, Christian Ottmann

مصطلحات موضوعية: Uncategorized, IR content

Relation: 2381/42277; https://figshare.com/articles/journal_contribution/Modulators_of_14-3-3_Protein-Protein_Interactions_/10202417

الاتاحة: https://figshare.com/articles/journal_contribution/Modulators_of_14-3-3_Protein-Protein_Interactions_/10202417

المؤلفون: Anna Maria Calvani, Jacopo Cusinato, Mattia Mori, Ylenia Cau

المصدر: Expert Opinion on Therapeutic Patents

مصطلحات موضوعية: Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.drug_class, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus, remdesivir, antiviral drugs, COVID-19, drug repurposing, SARS-CoV-2, 01 natural sciences, Antiviral Agents, 03 medical and health sciences, 0302 clinical medicine, Clinical investigation, Drug Discovery, Pandemic, medicine, Humans, Intensive care medicine, Repurposing, Pharmacology, Alanine, business.industry, Drug Repositioning, General Medicine, Adenosine Monophosphate, 0104 chemical sciences, COVID-19 Drug Treatment, 010404 medicinal & biomolecular chemistry, Drug repositioning, 030220 oncology & carcinogenesis, Preparedness, Female, Antiviral drug, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0674e9f9080c44aef0bb3bd2e82678c6
https://pubmed.ncbi.nlm.nih.gov/33283567

المؤلفون: Ylenia Cau, Loes M. Stevers, Jeremy Martin Davis, Eline Sijbesma, Maurizio Botta, Carol MacKintosh, Andrew J. Wilson, Christian Ottmann, Isabelle Landrieu, Jan Eickhoff, Richard G. Doveston, Luc Brunsveld, GGavin O'Mahony, Tomas Obsil, Anna Karawajczyk, Michael M. Hann

المساهمون: CNRS, Université de Lille, Eindhoven University of Technology [Eindhoven] [TU/e], Università degli Studi di Siena = University of Siena [UNISI], University of Dundee, Charles University [Prague] [CU], Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, University of Leeds, GlaxoSmithKline [Stevenage, UK] [GSK], AstraZeneca, Chemical Biology, Eindhoven University of Technology [Eindhoven] (TU/e), Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, College of Life Sciences, MRC Protein Phosphorylation Unit, University of Pragues, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Universität Duisburg-Essen [Essen], UCB Pharma Slough, AstraZeneca (AstraZeneca), Technische Universiteit Eindhoven (TU/e), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Università degli Studi di Siena = University of Siena (UNISI), Charles University [Prague] (CU), Université de Lille-Centre National de la Recherche Scientifique (CNRS), School of Chemistry [Leeds], Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Medicinal Chemistry, 61(9), 3755-3778. American Chemical Society
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2017, ⟨10.1021/acs.jmedchem.7b00574⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (9), pp.3755-3778. ⟨10.1021/acs.jmedchem.7b00574⟩
Journal of Medicinal Chemistry, 2017, 61 (9), pp.3755-3778. ⟨10.1021/acs.jmedchem.7b00574⟩
Journal of Medicinal Chemistry, American Chemical Society, 2017, 61 (9), pp.3755-3778. ⟨10.1021/acs.jmedchem.7b00574⟩

مصطلحات موضوعية: 0301 basic medicine, Nanotechnology, Computational biology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Protein–protein interaction, 03 medical and health sciences, Drug Discovery, Animals, Humans, [CHIM]Chemical Sciences, Peptides and proteins, Monomers, Crystal structure, Inhibitors, Inhibition, 14-3-3 protein, ComputingMilieux_MISCELLANEOUS, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Chemistry, Protein Stability, Drug Discovery3003 Pharmaceutical Science, Small molecule, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], 030104 developmental biology, 14-3-3 Proteins, Molecular Medicine, Perspective, Medical science, Biologie, Protein Binding

وصف الملف: application/rdf+xml; charset=utf-8; application/octet-stream; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae0a5b472d67707d90db7bf32f71729
https://doi.org/10.1021/acs.jmedchem.7b00574

المؤلفون: Mattia Mori, Lorenzo Franci, Daniela Valensin, Letizia Clementi, Leire Iralde-Lorente, Adriano Angelucci, Maurizio Botta, Mario Chiariello, Ylenia Cau, G. Tassone

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 657-664 (2019)

مصطلحات موضوعية: 14-3-3, 4-aminoantipyrine, c-Abl, leukaemia, protein–protein interaction, 14-3-3 Proteins, Antineoplastic Agents, Benzamides, Cell Proliferation, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, HeLa Cells, Humans, K562 Cells, Molecular Structure, Protein Binding, Pyrazoles, Structure-Activity Relationship, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Plasma protein binding, Drug Screening Assays, 01 natural sciences, law.invention, Protein–protein interaction, Dose-Response Relationship, law, Drug Discovery, Structure–activity relationship, 14-3-3 protein, 010405 organic chemistry, Chemistry, Cell growth, lcsh:RM1-950, Antitumor, General Medicine, Nuclear magnetic resonance spectroscopy, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, lcsh:Therapeutics. Pharmacology, Biochemistry, Recombinant DNA, Drug, K562 cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d7e3bed3b88225dda4790ae10c0305
https://pubmed.ncbi.nlm.nih.gov/30727786

المؤلفون: Mattia Mori, Claudiu T. Supuran, Ylenia Cau, Maurizio Botta

المصدر: Organic & Biomolecular Chemistry. 14:8322-8330

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Coumaric Acids, Protein Conformation, chemistry.chemical_element, Zinc, 01 natural sciences, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Caffeic Acids, Bacterial Proteins, Catalytic Domain, Carbonic anhydrase, Caffeic acid, Humans, Structure–activity relationship, Amino Acid Sequence, Physical and Theoretical Chemistry, Carbonic Anhydrase Inhibitors, Carbonic Anhydrases, chemistry.chemical_classification, biology, Organic Chemistry, Active site, Esters, Mycobacterium tuberculosis, biology.organism_classification, 0104 chemical sciences, Kinetics, 010404 medicinal & biomolecular chemistry, Cytosol, 030104 developmental biology, Enzyme, chemistry, biology.protein, Propionates, Bacteria, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5d2a627e1a552769c2fdfc416081cb
https://doi.org/10.1039/c6ob01477a

المؤلفون: Ilaria Laurenzana, Mattia Mori, Daniela Vullo, Claudiu T. Supuran, Ylenia Cau, Giulia Vignaroli, Antonella Caivano, Maurizio Botta

المصدر: ACS Chemical Biology. 10:1964-1969

مصطلحات موضوعية: medicine.drug_class, In silico, Predictive capability, Antineoplastic Agents, Computational biology, Pharmacology, Biology, Biochemistry, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Carbonic anhydrase, medicine, Humans, Computer Simulation, Carbonic anhydrase inhibitor, Carbonic Anhydrase Inhibitors, Carbonic Anhydrases, Cell Proliferation, Molecular Medicine, Drug discovery, Drug Repositioning, General Medicine, In vitro, Molecular Docking Simulation, Drug repositioning, 14-3-3 Proteins, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fec01f1b34588ff5572706582ba6fc5
https://doi.org/10.1021/acschembio.5b00337

المؤلفون: Iuni M. L. Trist, Arianna Loregian, Giancarlo Grossi, Francesca Musumeci, Maurizio Botta, Giorgio Palù, Davide Deodato, Giulio Nannetti, Ilaria D'Agostino, Anna Lucia Fallacara, Ylenia Cau, Silvia Schenone, Ilaria Giacchello

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, RdRp, Molecular model, Cell Survival, Pyridines, Amino acid coupling, Anti-Influenza, Diphenyl-pyridine, PA-PB1, SPPS, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Computational biology, Amino Acids, Animals, Antiviral Agents, Dogs, Dose-Response Relationship, Drug, HEK293 Cells, Humans, Madin Darby Canine Kidney Cells, Molecular Structure, Orthomyxoviridae, RNA Replicase, Small Molecule Libraries, Structure-Activity Relationship, Virus, Dose-Response Relationship, 03 medical and health sciences, chemistry.chemical_compound, Models, RNA polymerase, Drug Discovery, Biological evaluation, chemistry.chemical_classification, Chemistry, Mechanism (biology), Rational design, Treatment options, Molecular, General Medicine, RNA-Dependent RNA Polymerase, Amino acid, 030104 developmental biology, Drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674976e7738a4bf445d99c2fdd826571
http://hdl.handle.net/11365/1063334

المؤلفون: Mattia Mori, Ylenia Cau, Maurizio Botta, Daniela Vullo, Elena Dreassi, Claudiu T. Supuran

المصدر: Molecules; Volume 23; Issue 1; Pages: 17
Molecules, Vol 23, Iss 1, p 17 (2017)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, alpha-Helical, Molecular model, Amino Acid Motifs, Pharmaceutical Science, 01 natural sciences, Analytical Chemistry, Catalytic Domain, Drug Discovery, Carbonic anhydrase inhibitors (CAIs), Carboxylic acid, Isoform selectivity, Molecular modeling, Tumor-associated isoforms, Organic Chemistry, Carbonic Anhydrase Inhibitors, Carbonic Anhydrases, carbonic anhydrase inhibitors (CAIs), carboxylic acid, isoform selectivity, molecular modeling, tumor-associated isoforms, chemistry.chemical_classification, biology, Neoplasm Proteins, Molecular Docking Simulation, Biochemistry, Chemistry (miscellaneous), Molecular Medicine, Thermodynamics, Selectivity, Protein Binding, Gene isoform, Antineoplastic Agents, Selective inhibition, Article, lcsh:QD241-441, 03 medical and health sciences, Structure-Activity Relationship, lcsh:Organic chemistry, Antigens, Neoplasm, Carbonic anhydrase, Potency, Humans, Protein Interaction Domains and Motifs, Physical and Theoretical Chemistry, Carbonic Anhydrase IX, Dose-Response Relationship, Drug, Sequence Homology, Amino Acid, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Kinetics, 030104 developmental biology, chemistry, Drug Design, Nitrobenzoates, biology.protein, Protein Conformation, beta-Strand, Sequence Alignment

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58232d3bd5cef224dfb0372b9db8be52
http://hdl.handle.net/2158/1109594

المؤلفون: Daniela Valensin, Mattia Mori, Ylenia Cau, Sara Draghi, Maurizio Botta

المصدر: Current medicinal chemistry. 25(1)

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Plasma protein binding, Computational biology, Biology, Biochemistry, Protein–protein interaction, Small Molecule Libraries, 03 medical and health sciences, Protein-protein interaction, Neoplasms, medicine, Humans, Neurodegeneration, Phosphorylation, 14-3-3, Cancer, Pharmacology, Drug discovery, Organic Chemistry, Small molecules, Neurodegenerative Diseases, medicine.disease, Molecular medicine, Small molecule, Cell biology, 14-3-3 Proteins, Protein Binding, Molecular Medicine, 030104 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be0ed3e4eb1b95b1cd71269e1631b7e
https://pubmed.ncbi.nlm.nih.gov/28462702

المؤلفون: Giulia Vignaroli, Pierpaolo Calandro, Ylenia Cau, Lucia Dello Iacono, Daniela Valensin, Mario Chiariello, Mattia Mori, Maurizio Botta

المصدر: Bioorganicmedicinal chemistry letters. 26(3)

مصطلحات موضوعية: 0301 basic medicine, Lead compound, Magnetic Resonance Spectroscopy, Clinical Biochemistry, Chemical biology, Pharmaceutical Science, Phthalimides, Biochemistry, Protein–protein interaction, Phthalimide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Molecule, Humans, Protein Interaction Domains and Motifs, Molecular Biology, 14-3-3, Bioactive form, Drug discovery, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Chemical instability, Nuclear magnetic resonance spectroscopy, Hydrogen-Ion Concentration, Combinatorial chemistry, Chemical transformation, NMR, Molecular Medicine, 3003, 030104 developmental biology, chemistry, 14-3-3 Proteins, 030220 oncology & carcinogenesis, Benzamides, Pyrazoles, Derivative (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b467f095e7e930b4815df0138e67480f
https://pubmed.ncbi.nlm.nih.gov/26774582

المؤلفون: Marco Lalle, Maurizio Botta, Andrea Ilari, Mattia Mori, Ylenia Cau, Annarita Fiorillo

مصطلحات موضوعية: Models, Molecular, General Chemical Engineering, Protozoan Proteins, Computational biology, Plasma protein binding, Molecular Dynamics Simulation, Library and Information Sciences, Biology, Crystallography, X-Ray, medicine.disease_cause, 01 natural sciences, Protein–protein interaction, 03 medical and health sciences, Protein structure, medicine, Humans, Giardia lamblia, Phosphorylation, 14-3-3 protein, 030304 developmental biology, 0303 health sciences, 010405 organic chemistry, General Chemistry, Small molecule, 0104 chemical sciences, 3. Good health, Computer Science Applications, 14-3-3 Proteins, Biochemistry, Peptides, Hydrophobic and Hydrophilic Interactions, Protein Processing, Post-Translational, Function (biology), Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ffe9fefd675188455f428bee6fe342
http://hdl.handle.net/11365/1120438

المؤلفون: Ylenia Cau, G. Tassone, Mario Chiariello, Maurizio Botta, Mattia Mori, Stefano Mangani, Perry Matthew, Cecilia Pozzi, Lorenzo Franci, Leire Iralde-Lorente, Letizia Clementi, Adriano Angelucci, Claire C. Munier

المصدر: ACS Chemical Biology

مصطلحات موضوعية: 0301 basic medicine, Inosine monophosphate, Antineoplastic Agents, Crystallography, X-Ray, Drug Screening Assays, 01 natural sciences, Biochemistry, Protein–protein interaction, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Inosine Monophosphate, hemic and lymphatic diseases, medicine, Humans, Amino Acid Sequence, Pyridoxal phosphate, Proto-Oncogene Proteins c-abl, Cytotoxicity, Cell Nucleus, Crystallography, ABL, 010405 organic chemistry, Chemistry, 14-3-3 Proteins, Drug Screening Assays, Antitumor, Exoribonucleases, K562 Cells, Organophosphates, Protein Binding, Pyridoxal Phosphate, Sequence Alignment, Myeloid leukemia, Antitumor, General Medicine, medicine.disease, 3. Good health, 0104 chemical sciences, Leukemia, 030104 developmental biology, X-Ray, Molecular Medicine, K562 cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a52e19ef902b4983816469eebd5bd4