المؤلفون: Shifali Shishodia (8610825), Marina Demetriades (716154), Dong Zhang (73558), Nok Yin Tam (11682099), Pratheesh Maheswaran (11682102), Caitlin Clunie-O’Connor (11682105), Anthony Tumber (765317), Ivanhoe K. H. Leung (10917799), Yi Min Ng (11682108), Thomas M. Leissing (11682111), Afaf H. El-Sagheer (1666675), Eidarus Salah (245308), Tom Brown (9263), Wei Shen Aik (4506667), Michael A. McDonough (716158), Christopher J. Schofield (233097)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, synthesized two series, selective fat mass, obesity associated protein, inducible factor prolyl, fe ­( ii, substrate binding sites, inhibitors fto catalyzes, 6 , substrate mimics, fto inhibitors, binding assays, vivo <, n <, using information, results illustrate, ray crystallography, proposed target, nucleic acids, kdms ), crystal structures

Relation: https://figshare.com/articles/journal_contribution/Structure-Based_Design_of_Selective_Fat_Mass_and_Obesity_Associated_Protein_FTO_Inhibitors/16991748

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01204.s001

المؤلفون: Gemma Davison, Mathew P. Martin, Shannon Turberville, Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sanderson, Ian Hope, Daniel J. Wood, Céline Cano, Jane A. Endicott, Ian R. Hardcastle, Martin E. M. Noble, Michael J. Waring

المصدر: Journal of Medicinal Chemistry. 65:15416-15432

مصطلحات موضوعية: Binding Sites, Protein Domains, Drug Discovery, Nuclear Proteins, Molecular Medicine, Cell Cycle Proteins, Ligands, Crystallography, X-Ray, Peptides, Transcription Factors, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f5f45f4a2b13dc353a06e52583b772
https://doi.org/10.1021/acs.jmedchem.2c01357

المؤلفون: Afaf H. El-Sagheer, Ivanhoe K. H. Leung, Tom Brown, Michael A. McDonough, Anthony Tumber, Nok Yin Tam, Caitlin Clunie-O'Connor, Dong Zhang, Marina Demetriades, Shifali Shishodia, Wei Shen Aik, Thomas M. Leissing, Eidarus Salah, Pratheesh Maheswaran, Yi Min Ng, Christopher J. Schofield

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Oxygenase, endocrine system diseases, AlkB, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Antineoplastic Agents, Crystallography, X-Ray, 010402 general chemistry, 01 natural sciences, Article, Mixed Function Oxygenases, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, Humans, Binding site, 030304 developmental biology, Demethylation, Histone Demethylases, chemistry.chemical_classification, 0303 health sciences, biology, Chemistry, nutritional and metabolic diseases, Substrate (chemistry), pathological conditions, signs and symptoms, 0104 chemical sciences, Enzyme, Biochemistry, Drug Design, biology.protein, Nucleic acid, Molecular Medicine

وصف الملف: text

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639c2be01f207a01903964a703615f30
https://ora.ox.ac.uk/objects/uuid:839b007e-dd4b-4bc0-ac22-ed37a4bd5169

المؤلفون: Stuart McCracken, Peter Banks, Alex Bainbridge, Arussa Maan, Scott Walker, Aparna Dutt, Benjamin McCullough, Kelly Coffey, Yi Min Ng, Dominic Jones, Huw D. Thomas, Craig N. Robson, Luke Gaughan, Laura Wilson, Kathryn Patterson, Joseph Smith

المصدر: Nucleic Acids Research

مصطلحات موضوعية: Male, Transcription, Genetic, AcademicSubjects/SCI00010, Mice, Nude, Biology, Protein Serine-Threonine Kinases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, LNCaP, Genetics, IKBKE, Enzalutamide, Animals, Humans, Hippo Signaling Pathway, 030304 developmental biology, Adaptor Proteins, Signal Transducing, Cell Proliferation, Regulation of gene expression, 0303 health sciences, Hippo signaling pathway, Cell growth, Gene regulation, Chromatin and Epigenetics, Prostatic Neoplasms, YAP-Signaling Proteins, I-kappa B Kinase, Androgen receptor, Gene Expression Regulation, Neoplastic, chemistry, Receptors, Androgen, 030220 oncology & carcinogenesis, Cancer research, Disease Progression, Signal transduction, Signal Transduction, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa3f184c5918f976c4125942733e61e
https://pubmed.ncbi.nlm.nih.gov/32324216

المؤلفون: Shishodia, Shifali, Demetriades, Marina, Dong Zhang, Nok Yin Tam, Maheswaran, Pratheesh, Clunie-O'Connor, Caitlin, Tumber, Anthony, Leung, Ivanhoe K. H., Yi Min Ng, Leissing, Thomas M., El-Sagheer, Afaf H., Salah, Eidarus, Brown, Tom, Wei Shen Aik, McDonough, Michael A., Schofield, Christopher J.

المصدر: Journal of Medicinal Chemistry; 11/25/2021, Vol. 64 Issue 22, p16609-16625, 17p

المؤلفون: Winson Y. Cheung, Yi Min Ng, Aydan Kesici, Leo Chen, Jinjin Shan, Thanh Thien Phan

المصدر: Journal of Clinical Oncology. 34:e13047-e13047

مصطلحات موضوعية: Cancer Research, Harm, Oncology, Nicotine delivery, business.industry, Environmental health, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bc7308ebf59a7f6753f7588046af4f92
https://doi.org/10.1200/jco.2016.34.15_suppl.e13047