المؤلفون: Taku Shibue, Yasumichi Fukuda, 澁江 卓, 福田 保路

المصدر: Proceedings of the Symposium on Progress in Organic Reactions and Syntheses. 2008, :13

المؤلفون: Kazuhiko Nakatani, Shiro Terashima, Yasumichi Fukuda, Yoshio Ito, 中谷 和彦, 伊藤 芳雄, 寺島 孜郎, 福田 保路

المصدر: Symposium on the Chemistry of Natural Products, symposium papers. 1990, :686

المؤلفون: Futoshi Shiga, Hirosuke Furuta, Shiro Terashima, Yasumichi Fukuda, Yasuo Omori, 古田 浩祐, 大森 康男, 寺島 孜郎, 志賀 太, 福田 保路

المصدر: Symposium on the Chemistry of Natural Products, symposium papers. 1994, :641

المؤلفون: Sheo B. Singh, Christopher M. Tan, David Kaelin, Peter T. Meinke, Lynn Miesel, David B. Olsen, Hideyuki Fukuda, Ryuta Kishii, Masaya Takei, Kohei Ohata, Tomoko Takeuchi, Taku Shibue, Hisashi Takano, Akinori Nishimura, Yasumichi Fukuda

المصدر: Bioorganicmedicinal chemistry letters. 75

مصطلحات موضوعية: DNA Topoisomerase IV, Staphylococcus aureus, Topoisomerase Inhibitors, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Biochemistry, Anti-Bacterial Agents, Structure-Activity Relationship, DNA Gyrase, Thioinosine, Drug Discovery, Molecular Medicine, Topoisomerase II Inhibitors, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88fe127252145bd1368ad8cd0c89f1d
https://pubmed.ncbi.nlm.nih.gov/35609741

المؤلفون: Jingjun Yin, Kouhei Oohata, Peter T. Meinke, Armando Lagrutta, David E. Kaelin, Lynn Miesel, Charles Gill, Hideyuki Fukuda, Charles G. Garlisi, Sheo B. Singh, Yasumichi Fukuda, Christopher M. Tan, Toussaint Nathalie Y, Taku Shibue, Tomoko Takeuchi, Hisashi Takano, Ryuta Kishii, Masaya Takei, David B. Olsen, Akinori Nishimura, Jin Wu, Takayuki Tsuchiya

المصدر: Antimicrobial Agents and Chemotherapy. 60:4830-4839

مصطلحات موضوعية: DNA Topoisomerase IV, DNA, Bacterial, Staphylococcus aureus, medicine.drug_class, Topoisomerase IV, Microbial Sensitivity Tests, medicine.disease_cause, 01 natural sciences, DNA gyrase, Cell Line, Cyclooctanes, Mice, chemistry.chemical_compound, Dogs, In vivo, Escherichia coli, medicine, Animals, Humans, Topoisomerase II Inhibitors, Experimental Therapeutics, Pharmacology (medical), Rats, Wistar, Escherichia coli Infections, Pharmacology, biology, 010405 organic chemistry, Chemistry, Topoisomerase, Staphylococcal Infections, In vitro, Anti-Bacterial Agents, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, DNA Topoisomerases, Type II, Infectious Diseases, Biochemistry, DNA Gyrase, biology.protein, Topoisomerase inhibitor, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d13383dbf940731b0d5857d379597c7
https://doi.org/10.1128/aac.00619-16

المؤلفون: Lynn Miesel, Akinori Nishimura, Masanobu Yajima, Peter T. Meinke, Christopher M. Tan, Kohei Ohata, Xiu Wang, Sheo B. Singh, Yonggang Liao, David B. Olsen, Masaya Takei, Changqing Wei, Taku Shibue, Takeshi Shibata, Hideyuki Fukuda, Armando Lagrutta, David E. Kaelin, Xuanjia Peng, Yasumichi Fukuda, Jin Wu, Ryuta Kishii

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:3636-3643

مصطلحات موضوعية: DNA Topoisomerase IV, ERG1 Potassium Channel, Staphylococcus aureus, Topoisomerase Inhibitors, Topoisomerase IV, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Chemistry Techniques, Synthetic, Microbial Sensitivity Tests, Heterocyclic Compounds, 2-Ring, Biochemistry, Chemical synthesis, DNA gyrase, Cyclooctanes, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Amide, Drug Discovery, medicine, Animals, Moiety, Structure–activity relationship, Naphthyridines, Molecular Biology, biology, Organic Chemistry, Staphylococcal Infections, Ether-A-Go-Go Potassium Channels, Anti-Bacterial Agents, chemistry, biology.protein, Molecular Medicine, Linker, Topoisomerase inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2677d36308cca1fc4c26269ddc1514
https://doi.org/10.1016/j.bmcl.2015.06.057

المؤلفون: Ryuta Kishii, Carl J. Balibar, Masaya Takei, Charles G. Garlisi, Sheo B. Singh, Katherine Young, Jun Lu, Priya Dayananth, Yasumichi Fukuda, Sookhee Ha

المصدر: Antimicrobial Agents and Chemotherapy. 59:3474-3481

مصطلحات موضوعية: Acinetobacter baumannii, Staphylococcus aureus, medicine.drug_class, Topoisomerase IV, Antibiotics, Microbial Sensitivity Tests, Biology, medicine.disease_cause, DNA gyrase, Microbiology, Antibiotic resistance, Escherichia coli, medicine, Pyrroles, Experimental Therapeutics, Pharmacology (medical), Antibacterial agent, Pharmacology, Pseudomonas aeruginosa, biology.organism_classification, Virology, Pyrrolidinones, Anti-Bacterial Agents, Infectious Diseases, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0464db2c243d447cfe2dadd2c0a32f14
https://doi.org/10.1128/aac.00382-15

المؤلفون: Leo A. Joyce, David E. Kaelin, Peter T. Meinke, Takeshi Shibata, Keith W. Rickert, Masaya Takei, Sangita B. Patel, Changqing Wei, Xiu Wang, Xuanjia Peng, David B. Olsen, Armando Lagrutta, Jun Lu, Masanobu Yajima, Yasumichi Fukuda, Jin Wu, Mitsuhito Shibasaki, Hideyuki Fukuda, Lynn Miesel, Christopher M. Tan, Stephen M. Soisson, Todd A. Black, Ryuta Kishii, Robert F. Smith, Ravi P. Nargund, Edward C. Sherer, Hisashi Takano, Sheo B. Singh, Akinori Nishimura

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:1831-1835

مصطلحات موضوعية: Models, Molecular, Stereochemistry, medicine.drug_class, Clinical Biochemistry, hERG, Pharmaceutical Science, Microbial Sensitivity Tests, Gram-Positive Bacteria, medicine.disease_cause, Biochemistry, DNA gyrase, Cyclooctanes, Structure-Activity Relationship, Gram-Negative Bacteria, Drug Discovery, medicine, Topoisomerase II Inhibitors, Moiety, Naphthyridines, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Anti-Bacterial Agents, DNA Topoisomerases, Type II, Staphylococcus aureus, biology.protein, Molecular Medicine, Enantiomer, Antibacterial activity, Topoisomerase inhibitor, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004e6e7ff7e7a7d762ad92dba34bd9d3
https://doi.org/10.1016/j.bmcl.2015.03.044

المؤلفون: Kohei Ohata, Lynn Miesel, Yasumichi Fukuda, Hideyuki Fukuda, Armando Lagrutta, Ryuta Kishii, Peter T. Meinke, Jin Wu, Tomoko Takeuchi, Yonggang Liao, David B. Olsen, Xiu Wang, David E. Kaelin, Takeshi Shibata, Xuanjia Peng, Akinori Nishimura, Christopher M. Tan, Masaya Takei, Changqing Wei, Sheo B. Singh

المصدر: MedChemComm. 6:1773-1780

مصطلحات موضوعية: Pharmacology, biology, Topoisomerase IV, Chemistry, medicine.drug_class, Stereochemistry, Organic Chemistry, hERG, Pharmaceutical Science, Quinolone, Biochemistry, DNA gyrase, Drug Discovery, biology.protein, medicine, Molecular Medicine, Moiety, Enantiomer, Linker, Topoisomerase inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7a411fc472d942f6dbae75dc3cc2d655
https://doi.org/10.1039/c5md00297d

المؤلفون: Yasumichi Fukuda, Taku Shibue

المصدر: Tetrahedron Letters. 55:4102-4104

مصطلحات موضوعية: Chemistry, Group (periodic table), Organic Chemistry, Drug Discovery, Organic chemistry, chemistry.chemical_element, Biochemistry, Copper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4f08ad98cf281620ed1d848833b3cba2
https://doi.org/10.1016/j.tetlet.2014.05.098

المؤلفون: Takashi Komine, Yasumichi Fukuda, Tatsuhiro Saito, Yoshikazu Asahina, Akihiko Kojima, Taku Shibue, Hisashi Takano

المصدر: Journal of Medicinal Chemistry. 51:6558-6562

مصطلحات موضوعية: Microbial Viability, Molecular Structure, Nitrile, Bicyclic molecule, medicine.drug_class, Chemistry, Stereochemistry, Antibiotics, Ring (chemistry), Chemical synthesis, Anti-Bacterial Agents, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Antibacterial activity, Oxazolidinones, Antibacterial agent

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09305bc38788cee7075d919cdefdebaf
https://doi.org/10.1021/jm800800c

المؤلفون: Kimura Tetsuya, Yoshikazu Asahina, Yasumichi Fukuda, Masaya Takei

المصدر: Journal of Medicinal Chemistry. 51:3238-3249

مصطلحات موضوعية: Male, Pyrrolidines, Stereochemistry, Carboxylic acid, Substituent, Microbial Sensitivity Tests, Quinolones, Gram-Positive Bacteria, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Resistance, Bacterial, Gram-Negative Bacteria, Drug Discovery, Animals, Moiety, Antibacterial agent, chemistry.chemical_classification, Mice, Inbred ICR, Chemistry, Stereoisomerism, Anti-Bacterial Agents, Benzoxazines, Molecular Medicine, Phototoxicity, Antibacterial activity, Clinafloxacin, Fluoroquinolones

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d85defbaeb732c63be3bf29d68a359f
https://doi.org/10.1021/jm701428b

المؤلفون: Ryuta Kishii, David E. Kaelin, Armando Lagrutta, David B. Olsen, Peter T. Meinke, Kohei Ohata, Jin Wu, Sheo B. Singh, Hideyuki Fukuda, Lynn Miesel, Tomoko Takeuchi, Hisashi Takano, Akinori Nishimura, Yasumichi Fukuda, Masaya Takei, Takeshi Shibata, Haruaki Kurasaki, Christopher M. Tan

المصدر: Bioorganicmedicinal chemistry letters. 25(17)

مصطلحات موضوعية: ERG1 Potassium Channel, Staphylococcus aureus, medicine.drug_class, Topoisomerase IV, Stereochemistry, Clinical Biochemistry, hERG, Enterococcus faecium, Drug Evaluation, Preclinical, Pharmaceutical Science, Ether, Chemistry Techniques, Synthetic, Microbial Sensitivity Tests, Biochemistry, DNA gyrase, Rats, Sprague-Dawley, chemistry.chemical_compound, Cyclooctanes, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Structure–activity relationship, Animals, Topoisomerase II Inhibitors, Naphthyridines, Molecular Biology, Alkyl, chemistry.chemical_classification, biology, Organic Chemistry, Staphylococcal Infections, Ether-A-Go-Go Potassium Channels, Anti-Bacterial Agents, Mice, Inbred C57BL, chemistry, DNA Gyrase, biology.protein, Molecular Medicine, Topoisomerase inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50eef89ff9ae0c2472947cdaa6e487b
https://pubmed.ncbi.nlm.nih.gov/26152426

المؤلفون: Peter T. Meinke, Kohei Ohata, Xiu Wang, Ravi P. Nargund, David E. Kaelin, Tomoko Takeuchi, Hisashi Takano, Christopher M. Tan, Hideyuki Fukuda, Lynn Miesel, Xuanjia Peng, Yasumichi Fukuda, Akinori Nishimura, Masaya Takei, Changqing Wei, Sheo B. Singh, Shizuka Ban, Taku Shibue, Armando Lagrutta, Todd A. Black, Charles Gill, David B. Olsen, Jin Wu, Ryuta Kishii

المصدر: Bioorganicmedicinal chemistry letters. 25(12)

مصطلحات موضوعية: Acinetobacter baumannii, Staphylococcus aureus, medicine.drug_class, Stereochemistry, Topoisomerase Inhibitors, Clinical Biochemistry, hERG, Pharmaceutical Science, Microbial Sensitivity Tests, medicine.disease_cause, Biochemistry, DNA gyrase, Structure-Activity Relationship, Bacterial Proteins, Drug Discovery, medicine, Escherichia coli, Moiety, Naphthyridines, Molecular Biology, Oxazoles, Bicyclic molecule, biology, Chemistry, Organic Chemistry, Anti-Bacterial Agents, DNA Gyrase, Pseudomonas aeruginosa, biology.protein, Molecular Medicine, Antibacterial activity, Topoisomerase inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fccf7e247dbee77a91c503236ee840
https://pubmed.ncbi.nlm.nih.gov/25978963

المؤلفون: Taku Shibue, Yasumichi Fukuda

المصدر: The Journal of organic chemistry. 79(15)

مصطلحات موضوعية: Cyclopropanes, Olefin fiber, Ethylene, Molecular Structure, Cyclopropanation, Stereochemistry, Organic Chemistry, Stereoisomerism, Alkenes, Ethylenes, Catalysis, chemistry.chemical_compound, chemistry, Cyclization, Organic chemistry, Molecule, Stereoselectivity, Diazo, Sulfhydryl Compounds, Azo Compounds

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5594bd938560f08ca542d300ad0ada
https://pubmed.ncbi.nlm.nih.gov/25010939

المؤلفون: Kevin J. Lumb, Stephen M. Soisson, Masaya Takei, Nandini Sharma, Sangita B. Patel, Yasumichi Fukuda, Jun Lu, Ryuta Kishii, Sheo B. Singh

المصدر: ACS chemical biology. 9(9)

مصطلحات موضوعية: DNA Topoisomerase IV, Models, Molecular, Staphylococcus aureus, Topoisomerase IV, Stereochemistry, Protein Conformation, Topoisomerase Inhibitors, Naphthalenes, medicine.disease_cause, Crystallography, X-Ray, Biochemistry, DNA gyrase, Antibiotic resistance, Protein structure, medicine, Moiety, Topoisomerase II Inhibitors, Pyrroles, Binding site, Novobiocin, Binding Sites, biology, Molecular Structure, General Medicine, Pyrrolidinones, Aminoglycosides, DNA Gyrase, biology.protein, Molecular Medicine, Protein Multimerization, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5649e4ba4d775bb4a2514cdd7dd6772
https://pubmed.ncbi.nlm.nih.gov/24992706

المؤلفون: Hirosuke Furuta, Shigeki Seto, Shiro Terashima, Yasumichi Fukuda, Hiroyuki Ebisu, Yasuo Oomori

المصدر: Journal of Medicinal Chemistry. 44:1396-1406

مصطلحات موضوعية: Indoles, medicine.drug_class, Stereochemistry, Transplantation, Heterologous, Mice, Nude, Carboxamide, Benzylidene Compounds, Chemical synthesis, Duocarmycins, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Tumor Cells, Cultured, medicine, Animals, Humans, Urea, Pyrroles, Cytotoxicity, Antineoplastic Agents, Alkylating, Indole test, Chemistry, Mitomycin C, In vitro, Molecular Medicine, Drug Screening Assays, Antitumor, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63b441e558efcf7a3ab74a303259774
https://doi.org/10.1021/jm000107x

المؤلفون: Yasumichi Fukuda, Hiroyuki Ebisu, Shiro Terashima, Yoshie Kusama, Yasuo Oomori, Hirosuke Furuta

المصدر: Journal of Medicinal Chemistry. 42:1448-1458

مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Transplantation, Heterologous, Antineoplastic Agents, Carboxamide, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Tumor Cells, Cultured, medicine, Animals, Humans, Prodrugs, Pyrroles, Cytotoxicity, Benzofurans, Cisplatin, Mice, Inbred BALB C, Trifluoromethyl, Carzelesin, Stereoisomerism, Prodrug, chemistry, Molecular Medicine, Female, Drug Screening Assays, Antitumor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f6cab4ac24e0641242088d50ddf273
https://doi.org/10.1021/jm980668c

المؤلفون: Hideyuki Fukuda, Jun Lu, Armando Lagrutta, Yasumichi Fukuda, David E. Kaelin, Lynn Miesel, Christopher M. Tan, Sheo B. Singh, Robert F. Smith, Masaya Takei, Changqing Wei, Peter T. Meinke, Stephen M. Soisson, Sangita B. Patel, Bradley Prudence K, Keith W. Rickert, David B. Olsen, Ryuta Kishii, Jin Wu

المصدر: ACS medicinal chemistry letters. 5(5)

مصطلحات موضوعية: biology, medicine.drug_class, Organic Chemistry, hERG, Antibiotics, Pharmacology, Quinolone, Biochemistry, DNA gyrase, Antibiotic resistance, Drug Discovery, biology.protein, medicine, Type II topoisomerase, Linker, Topoisomerase inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4323df5371e6a424594be7b68ed9d1ae
https://pubmed.ncbi.nlm.nih.gov/24900889

المؤلفون: Yasuo Oomori, Futoshi Shiga, Yoshie Kusama, Hirosuke Furuta, Shiro Terashima, Yasumichi Fukuda, Hiroyuki Ebisu

المصدر: Bioorganic & Medicinal Chemistry Letters. 7:1683-1688

مصطلحات موضوعية: Antitumor activity, Oxidative cyclization, Trifluoromethyl, Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, In vitro, chemistry.chemical_compound, Established cell line, In vivo, Drug Discovery, Molecular Medicine, Enantiomer, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::434c0d2d9e2ac6fc48770f27925be96b
https://doi.org/10.1016/s0960-894x(97)00288-6