المؤلفون: Miller, Rachael, Paquette, Joseph, Barker, Alexandra, Sapp, Ellen, McHugh, Nicholas, Bramato, Brianna, Yamada, Nozomi, Alterman, Julia, Echeveria, Dimas, Yamada, Ken, Watts, Jonathan, Anaclet, Christelle, DiFiglia, Marian, Khvorova, Anastasia, Aronin, Neil

المصدر: Molecular Therapy: Nucleic Acids. 35(4)

مصطلحات موضوعية: CNS therapeutics, Huntington’s disease, MT: Oligonucleotides: Therapies and Applications, RNAi, brain delivery, genetic diseases, neurological disorders, oligonucleotide-based therapies, oligonucleotides

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0vd378pw
https://escholarship.org/content/qt0vd378pw/qt0vd378pw.pdf

المؤلفون: Inoue, Emiko, Taniguchi, Hiroya, Yamada, Ken

مصطلحات موضوعية: Economics - General Economics

URL الوصول: http://arxiv.org/abs/2008.04639

المؤلفون: Taniguchi, Hiroya, Yamada, Ken

مصطلحات موضوعية: Economics - General Economics

URL الوصول: http://arxiv.org/abs/2005.12600

المؤلفون: Yamada, Ken-ichi, Inokuma, Tsubasa

Relation: http://repo.lib.tokushima-u.ac.jp/files/public/11/118846/20231226112918976740/rsca_13_51_35904.pdf; http://repo.lib.tokushima-u.ac.jp/118846

الاتاحة: http://repo.lib.tokushima-u.ac.jp/118846

المؤلفون: Yamada, Naoya, Karasawa, Tadayoshi, Ito, Junya, Yamamuro, Daisuke, Morimoto, Kazushi, Nakamura, Toshitaka, Komada, Takanori, Baatarjav, Chintogtokh, Saimoto, Yuma, Jinnouchi, Yuka, Watanabe, Kazuhisa, Miura, Kouichi, Yahagi, Naoya, Nakagawa, Kiyotaka, Matsumura, Takayoshi, Yamada, Ken-ichi, Ishibashi, Shun, Sata, Naohiro, Conrad, Marcus, Takahashi, Masafumi

المصدر: Nature Communications ; volume 15, issue 1 ; ISSN 2041-1723

الاتاحة: http://dx.doi.org/10.1038/s41467-024-46386-6
https://www.nature.com/articles/s41467-024-46386-6.pdf
https://www.nature.com/articles/s41467-024-46386-6

المؤلفون: Belgrad, Jillian, Tang, Qi, Hildebrand, Sam, Summers, Ashley, Sapp, Ellen, Echeverria, Dimas, O’Reilly, Dan, Luu, Eric, Bramato, Brianna, Allen, Sarah, Cooper, David, Alterman, Julia, Yamada, Ken, Aronin, Neil, DiFiglia, Marian, Khvorova, Anastasia

المساهمون: CHDI Foundation, National Institutes of Health, NIH, Dake family fund, Hereditary Disease Foundation Postdoctoral Fellowship

المصدر: Nucleic Acids Research ; volume 52, issue 11, page 6099-6113 ; ISSN 0305-1048 1362-4962

الاتاحة: http://dx.doi.org/10.1093/nar/gkae368
https://academic.oup.com/nar/article-pdf/52/11/6099/58307062/gkae368.pdf

المؤلفون: Taniguchi, Hiroya, Yamada, Ken

مصطلحات موضوعية: Economics - General Economics

URL الوصول: http://arxiv.org/abs/1904.09857

المؤلفون: Oka, Tatsushi, Yamada, Ken

مصطلحات موضوعية: Economics - General Economics

URL الوصول: http://arxiv.org/abs/1903.03925

المؤلفون: Belgrad, Jillian, Tang, Qi, Hildebrand, Samuel, Summers, Ashley, Sapp, Ellen, Echeverria, Dimas, O'Reilly, Dan, Luu, Eric, Bramato, Brianna, Allen, Sarah, Cooper, David A, Alterman, Julia, Yamada, Ken, Aronin, Neil, DiFiglia, Marian, Khvorova, Anastasia

المساهمون: Medicine, Morningside Graduate School of Biomedical Sciences, Program in Molecular Medicine, RNA Therapeutics Institute, Jillian Belgrad, Samuel Hildebrand, Sarah Allen, David A Cooper

المصدر: bioRxiv : the preprint server for biology ; United States

مصطلحات موضوعية: Molecular Biology, siRNA, neurodegenerative disorders

Relation: bioRxiv; https://doi.org/10.1101/2023.12.19.572404; Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting di-valent siRNA scaffold supports potent multi-gene modulation in the central nervous system. bioRxiv [Preprint]. 2023 Dec 19:2023.12.19.572404. doi:10.1101/2023.12.19.572404. PMID: 38187561; PMCID: PMC10769306.; http://hdl.handle.net/20.500.14038/53084; bioRxiv : the preprint server for biology

الاتاحة: https://doi.org/10.1101/2023.12.19.572404
https://hdl.handle.net/20.500.14038/53084

المؤلفون: Miller, Rachael, Paquette, Joseph, Barker, Alexandra, Sapp, Ellen, McHugh, Nicholas, Bramato, Brianna, Yamada, Nozomi, Alterman, Julia F, Echeverria, Dimas, Yamada, Ken, Watts, Jonathan K, Anaclet, Christelle, DiFiglia, Marian, Khvorova, Anastasia, Aronin, Neil

المساهمون: Medicine, RNA Therapeutics Institute, Joseph Paquette

المصدر: bioRxiv : the preprint server for biology ; United States

مصطلحات موضوعية: Neuroscience, oligonucleotide therapeutics, acute neurotoxicity

Relation: bioRxiv; https://doi.org/10.1101/2024.06.06.597639; Miller R, Paquette J, Barker A, Sapp E, McHugh N, Bramato B, Yamada N, Alterman J, Echeveria D, Yamada K, Watts J, Anaclet C, DiFiglia M, Khvorova A, Aronin N. Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation. bioRxiv [Preprint]. 2024 Jun 8:2024.06.06.597639. doi:10.1101/2024.06.06.597639. PMID: 38895198; PMCID: PMC11185713.; http://hdl.handle.net/20.500.14038/53703; bioRxiv : the preprint server for biology

الاتاحة: https://doi.org/10.1101/2024.06.06.597639
https://hdl.handle.net/20.500.14038/53703

المؤلفون: Sun, Chunzhao, Nishikawa, Hiromichi, Inokuma, Tsubasa, Yamada, Ken-ichi

المصدر: Molecules; Jan2025, Vol. 30 Issue 2, p371, 17p

المؤلفون: Inokuma, Tsubasa, Yamada, Ken‐ichi

المساهمون: Takeda Science Foundation, Uehara Memorial Foundation, Japan Science Society

المصدر: The Chemical Record ; volume 23, issue 7 ; ISSN 1527-8999 1528-0691

الاتاحة: https://doi.org/10.1002/tcr.202300103
https://onlinelibrary.wiley.com/doi/pdf/10.1002/tcr.202300103

المؤلفون: Hariharan, Vignesh N, Shin, Minwook, Chang, Ching-Wen, O'Reilly, Daniel, Biscans, Annabelle, Yamada, Ken, Guo, Zhiru, Somasundaran, Mohan, Tang, Qi, Monopoli, Kathryn, Krishnamurthy, Pranathi Meda, Devi, Gitali, McHugh, Nicholas, Cooper, David A, Echeverria, Dimas, Cruz, John, Chan, Io Long, Liu, Ping, Lim, Sun-Young, McConnell, Jill, Singh, Satya Prakash, Hildebrand, Samuel, Sousa, Jacquelyn, Davis, Sarah M, Kennedy, Zachary, Ferguson, Chantal, Godinho, Bruno M D C, Thillier, Yann, Caiazzi, Jillian, Ly, Socheata, Muhuri, Manish, Kelly, Karen, Humphries, Fiachra, Cousineau, Alyssa, Parsi, Krishna Mohan, Li, Qi, Wang, Yang, Maehr, René, Gao, Guangping, Korkin, Dmitry, McDougall, William M, Finberg, Robert W., Fitzgerald, Katherine A, Wang, Jennifer P, Watts, Jonathan K, Khvorova, Anastasia

المساهمون: Biochemistry and Molecular Biotechnology, Diabetes Center of Excellence, Horae Gene Therapy Center, Li Weibo Institute for Rare Diseases Research, MassBiologics, Medicine, Microbiology and Physiological Systems, Morningside Graduate School of Biomedical Sciences, Pathology, Program in Innate Immunity, Program in Molecular Medicine, RNA Therapeutics Institute, David A Cooper, Samuel Hildebrand, Sarah M Davis

المصدر: Proceedings of the National Academy of Sciences of the United States of America ; 120 ; 11 ; e2219523120 ; United States

مصطلحات موضوعية: SARS-COV-2, antisense oligos, lung, mouse model, small interfering RNAs

Relation: Proceedings of the National Academy of Sciences; https://doi.org/10.1073/pnas.2219523120; Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2219523120. doi:10.1073/pnas.2219523120. Epub 2023 Mar 9. PMID: 36893269.; http://hdl.handle.net/20.500.14038/51911; Proceedings of the National Academy of Sciences of the United States of America

الاتاحة: https://doi.org/10.1073/pnas.2219523120
https://hdl.handle.net/20.500.14038/51911

المؤلفون: Yamada, Ken, Hildebrand, Samuel, Davis, Sarah M, Miller, Rachael, Conroy, Faith, Sapp, Ellen, Caiazzi, Jillian, Alterman, Julia F, Roux, Loic, Echeverria, Dimas, Hassler, Matthew R, Pfister, Edith L, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

المساهمون: Medicine, Morningside Graduate School of Biomedical Sciences, Program in Molecular Medicine, RNA Therapeutics Institute, Samuel Hildebrand, Sarah M. Davis, Rachael Miller

المصدر: Nucleic acids research ; 49 ; 21 ; 12069 ; 12088 ; United States ; England

Relation: Nucleic Acids Research; https://doi.org/10.1093/nar/gkab1126; Yamada K, Hildebrand S, Davis SM, Miller R, Conroy F, Sapp E, Caiazzi J, Alterman JF, Roux L, Echeverria D, Hassler MR, Pfister EL, DiFiglia M, Aronin N, Khvorova A. Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity. Nucleic Acids Res. 2021 Dec 2;49(21):12069-12088. doi:10.1093/nar/gkab1126. PMID: 34850120; PMCID: PMC8643693.; http://hdl.handle.net/20.500.14038/51989

الاتاحة: https://doi.org/10.1093/nar/gkab1126
https://hdl.handle.net/20.500.14038/51989

المؤلفون: Conroy, Faith, Miller, Rachael, Alterman, Julia F., Hassler, Matthew R, Echeverria, Dimas, Godinho, Bruno M D C, Knox, Emily G, Sapp, Ellen, Sousa, Jaquelyn, Yamada, Ken, Mahmood, Farah, Boudi, Adel, Kegel-Gleason, Kimberly, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia, Pfister, Edith L

المساهمون: Medicine, Morningside Graduate School of Biomedical Sciences, RNA Therapeutics Institute

المصدر: Nature communications ; 13 ; 1 ; 5802 ; United States ; England

Relation: Nature Communications; https://doi.org/10.1038/s41467-022-33061-x; Conroy F, Miller R, Alterman JF, Hassler MR, Echeverria D, Godinho BMDC, Knox EG, Sapp E, Sousa J, Yamada K, Mahmood F, Boudi A, Kegel-Gleason K, DiFiglia M, Aronin N, Khvorova A, Pfister EL. Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models. Nat Commun. 2022 Oct 3;13(1):5802. doi:10.1038/s41467-022-33061-x. PMID: 36192390; PMCID: PMC9530163.; http://hdl.handle.net/20.500.14038/51611

الاتاحة: https://doi.org/10.1038/s41467-022-33061-x
https://hdl.handle.net/20.500.14038/51611

المؤلفون: Lee, Bonggi, An, Hye Jin, Kim, Dae Hyun, Lee, Min-Kyeong, Jeong, Hyeon Hak, Chung, Ki Wung, Go, Younghoon, Seo, Arnold Y., Kim, Il Yong, Seong, Je Kyung, Yu, Byung Pal, Lee, Jaewon, Im, Eunok, Lee, In-Kyu, Lee, Myung-Shik, Yamada, Ken-ichi, Chung, Hae Young

المساهمون: Seong, Je Kyung

مصطلحات موضوعية: ASCORBIC-ACID, BODY-TEMPERATURE, WEIGHT-LOSS, BROWN FAT, ADIPOCYTES, DEFICIENCY, FGF21, HEALTHY, SMP30, COLD

Relation: Experimental and Molecular Medicine, Vol.54 No.11, pp.2036-2046; https://hdl.handle.net/10371/205007; 000888690000003; 2-s2.0-85142617837; 178486; ART002902388

الاتاحة: https://hdl.handle.net/10371/205007
https://doi.org/10.1038/s12276-022-00888-9

المؤلفون: Oka, Tatsushi, Yamada, Ken

المساهمون: 山田, 憲, 60753259

مصطلحات موضوعية: C21, C23, J31, J38, K31

Relation: http://hdl.handle.net/2433/279289; Journal of Human Resources; 58; 335; 362

الاتاحة: http://hdl.handle.net/2433/279289