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1
المؤلفون: Kim Fischer, Bryan Laffitte, Jason D. Jacintho, Christopher Baccei, Catherine Lee, Karin J. Stebbins, Alex R. Broadhead, Davorka Messmer, Lucia Correa, Daniel S. Lorrain, Peppi Prasit, Austin Chen, Nicholas Simon Stock, Yalda Bravo
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:503-508
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Antineoplastic Agents, Pharmacology, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, Dogs, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, PPAR alpha, PPAR delta, Molecular Biology, Cell Proliferation, Ovarian Neoplasms, chemistry.chemical_classification, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Antagonist, Cancer, Neoplasms, Experimental, medicine.disease, Small molecule, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Toxicity, Molecular Medicine, Female, Peroxisome proliferator-activated receptor delta, Drug Screening Assays, Antitumor, Antagonism
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2
المؤلفون: Russell Dahl, Nicholas D. P. Cosford, Chen-Ting Ma, Anthony B. Pinkerton, Michael R. Jackson, Yalda Bravo, Eduard Sergienko, Qing Sun, José Luis Millán
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:31-34
مصطلحات موضوعية: Niacinamide, 0301 basic medicine, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Biochemistry, Mineralization (biology), Article, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Extracellular, Animals, Enzyme Inhibitors, Molecular Biology, Whole blood, Sulfonamides, Nicotinamide, Chemistry, Organic Chemistry, Alkaline Phosphatase, medicine.disease, Phosphate, 030104 developmental biology, Molecular Medicine, Alkaline phosphatase, Half-Life, Calcification
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3
المؤلفون: Jason D. Jacintho, Yalda Bravo, Lucia Correa, Xiao-Jie Yan, Davorka Messmer, Karin J. Stebbins, Geraldine Cabrera, Nicholas Simon Stock, Daniel S. Lorrain, Austin Chen, Nicholas Chiorazzi, Kymmy Lorrain, David Spaner, Peppi Prasit
المصدر: Molecular Medicine. 21:410-419
مصطلحات موضوعية: Transcriptional Activation, Cell Survival, Chronic lymphocytic leukemia, Aminopyridines, Peroxisome proliferator-activated receptor, Apoptosis, Biology, Mice, Downregulation and upregulation, immune system diseases, Cell Line, Tumor, hemic and lymphatic diseases, Genetics, medicine, Animals, Humans, PPAR alpha, Receptor, neoplasms, Molecular Biology, Genetics (clinical), Cell Proliferation, chemistry.chemical_classification, Sulfonamides, Cell growth, Fatty Acids, Articles, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Cell biology, Gene Expression Regulation, Neoplastic, Leukemia, chemistry, Cell culture, Molecular Medicine
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4
المؤلفون: Jason D. Jacintho, Richard Bundey, Nicholas Simon Stock, Alex R. Broadhead, Karin J. Stebbins, Austin Chen, Ryan C. Clark, Lucia Correa, Yalda Bravo, Christopher Baccei, Peppi Prasit, Davorka Messmer, Daniel S. Lorrain
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:2267-2272
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Biochemistry, Mice, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Potency, PPAR alpha, Oxazoles, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Molecular Structure, Phenylurea Compounds, Organic Chemistry, Antagonist, Triazoles, Butyrates, chemistry, Nuclear receptor, Tyrosine, Molecular Medicine, Propionates, Selectivity, Linker
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5
المؤلفون: Peppi Prasit, Daniel S. Lorrain, Davorka Messmer, Karin J. Stebbins, Lucia Correa, Austin Chen, Richard Bundey, Geraldine Cabrera, Alex R. Broadhead, Nicholas Simon Stock, Christopher Baccei, Yalda Bravo
المصدر: European journal of pharmacology. 809
مصطلحات موضوعية: 0301 basic medicine, Peroxisome proliferator-activated receptor, Aminopyridines, Neovascularization, Physiologic, Pharmacology, Biology, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, In vivo, Cell Line, Tumor, Animals, Humans, PPAR alpha, Viability assay, Neoplasm Metastasis, Receptor, Beta oxidation, Gene knockout, Cell Proliferation, chemistry.chemical_classification, Sulfonamides, Rats, Fibroblast Growth Factors, 030104 developmental biology, Nuclear receptor, chemistry, 030220 oncology & carcinogenesis
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6
المؤلفون: Bobby G. Ng, Vandana Sharma, Yalda Bravo, Hudson H. Freeze, Nicholas D. P. Cosford, Ping He, David A. Scott, Russell Dahl, Mie Ichikawa
المصدر: Journal of Biological Chemistry. 286:39431-39438
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Glycosylation, animal structures, Glycobiology and Extracellular Matrices, Mannose, macromolecular substances, Biology, Biochemistry, chemistry.chemical_compound, Congenital Disorders of Glycosylation, N-linked glycosylation, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Mannosephosphates, Zebrafish, chemistry.chemical_classification, Mannose-6-Phosphate Isomerase, Cell Biology, Fibroblasts, carbohydrates (lipids), Enzyme, chemistry, Phosphotransferases (Phosphomutases), Mutation, Additions and Corrections, lipids (amino acids, peptides, and proteins), Glycoprotein, Phosphomannomutase, HeLa Cells
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7
المؤلفون: José Luis Millán, Pooi San Lee, Colin Farquharson, Nicholas D. P. Cosford, Eduard Sergienko, Raveendra Panickar Dhanya, Layton H. Smith, Peter Teriete, Yalda Bravo, Tina Kiffer-Moreira, Russell Dahl, Santhi Ganji
مصطلحات موضوعية: Phosphoric monoester hydrolases, Clinical Biochemistry, Phosphatase, Pharmaceutical Science, Biochemistry, Article, Small Molecule Libraries, Mice, Structure-Activity Relationship, Drug Discovery, High-Throughput Screening Assays, Structure–activity relationship, Animals, Humans, Benzothiazoles, Enzyme Inhibitors, Molecular Biology, ADME, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Hydrogen-Ion Concentration, Small molecule, In vitro, Phosphoric Monoester Hydrolases, Drug Design, Benzamides, Hepatocytes, Molecular Medicine
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8
المؤلفون: Eduard Sergienko, Vandana Sharma, Layton H. Smith, Yalda Bravo, Ying Su, Brock Brown, Justin Rascon, Li Yang, Michael Vicchiarelli, Arianna Mangravita-Novo, Russell Dahl, Hudson H. Freeze, Mie Ichikawa, Michael P Hedrick, Nicholas D. P. Cosford, Raveendra-Panickar Dhanya, Derek Stonich
المصدر: Journal of medicinal chemistry. 54(10)
مصطلحات موضوعية: Chemistry, Pharmaceutical, Administration, Oral, Pharmacology, Permeability, Article, Inhibitory Concentration 50, Structure-Activity Relationship, Congenital Disorders of Glycosylation, Pharmacokinetics, In vivo, Drug Discovery, medicine, Structure–activity relationship, Combinatorial Chemistry Techniques, Humans, chemistry.chemical_classification, Mannose-6-Phosphate Isomerase, Chemistry, medicine.disease, Bioavailability, Thiazoles, Enzyme, Biochemistry, Models, Chemical, Drug Design, Molecular Medicine, Congenital disorder of glycosylation, Phosphomannomutase
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9
المؤلفون: Davorka Messmer, Kymmy Lorrain, Karin Stebbins, Yalda Bravo, Nicholas Stock, Geraldine Cabrera, Lucia Correa, Austin Chen, Jason Jacintho, Nicholas Chiorazzi, Xiao Jie Yan, David Spaner, Peppi Prasit, Daniel Lorrain
المصدر: Molecular Medicine. 21:665-665
مصطلحات موضوعية: Genetics, Molecular Medicine, Molecular Biology, Genetics (clinical)
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10
المؤلفون: Richard Bundey, Davorka Messmer, Peppi Prasit, Geraldine Cabrera, Jason D. Jacintho, Yalda Bravo, Michael M Poon, Nicholas Simon Stock, Daniel S. Lorrain, Kymmy Lorrain, Austin Chen, Lucia Correa, Karin J. Stebbins, David Spaner
المصدر: Blood. 120:3879-3879
مصطلحات موضوعية: business.industry, Chronic lymphocytic leukemia, Immunology, Interleukin, Carboxyfluorescein succinimidyl ester, Cell Biology, Hematology, medicine.disease, Biochemistry, Fludarabine, Leukemia, chemistry.chemical_compound, Interleukin 10, chemistry, Apoptosis, Cancer cell, medicine, Cancer research, business, medicine.drug