المؤلفون: Somnath Mukherjee, Satchal K. Erramilli, Mark Ammirati, Frances J. D. Alvarez, Kimberly F. Fennell, Michael D. Purdy, Blazej M. Skrobek, Katarzyna Radziwon, John Coukos, Yanyong Kang, Przemysław Dutka, Xiang Gao, Xiayang Qiu, Mark Yeager, H. Eric Xu, Seungil Han, Anthony A. Kossiakoff

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/c4e601bd5c28456ba07689558d4667e5

المؤلفون: Karen S. Conrad, Ting-Wen Cheng, Daniel Ysselstein, Saskia Heybrock, Lise R. Hoth, Boris A. Chrunyk, Christopher W. am Ende, Dimitri Krainc, Michael Schwake, Paul Saftig, Shenping Liu, Xiayang Qiu, Michael D. Ehlers

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/89053b7dbfca4e9d97832de177661289

المؤلفون: Xiaodi Yu, Olga Plotnikova, Paul D Bonin, Timothy A Subashi, Thomas J McLellan, Darren Dumlao, Ye Che, Yin Yao Dong, Elisabeth P Carpenter, Graham M West, Xiayang Qiu, Jeffrey S Culp, Seungil Han

المصدر: eLife, Vol 8 (2019)

مصطلحات موضوعية: SLC1A5, ASCT2, glutamine transporter, solute carrier, cryo-EM, outward-facing conformation, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/48120; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/a33c8724acd14c1bb4ac82ee1b35322f

المؤلفون: Ronald W. Clark, David Cunningham, Yang Cong, Timothy A. Subashi, George T. Tkalcevic, David B. Lloyd, James G. Boyd, Boris A. Chrunyk, George A. Karam, Xiayang Qiu, Ing-Kae Wang, Omar L. Francone

المصدر: Journal of Lipid Research, Vol 51, Iss 5, Pp 967-974 (2010)

مصطلحات موضوعية: atherosclerosis, high density lipoprotein, lipopolysaccharide, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S002222752041051X; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/90ebce87c8a64100a15f3130a1645823

المؤلفون: Ye Che, Alexey V. Gribenko, Xi Song, Luke D. Handke, Kari S. Efferen, Kristin Tompkins, Srinivas Kodali, Lorna Nunez, A. Krishna Prasad, Lynn M. Phelan, Mark Ammirati, Xiaodi Yu, Joshua A. Lees, Wei Chen, Lyndsey Martinez, Vidia Roopchand, Seungil Han, Xiayang Qiu, John P. DeVincenzo, Kathrin U. Jansen, Philip R. Dormitzer, Kena A. Swanson

المصدر: Science Translational Medicine. 15

مصطلحات موضوعية: General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e71cd958b12d08fd24c41d4488d0fa2c
https://doi.org/10.1126/scitranslmed.ade6422

المؤلفون: Yuhang Liu, Ye Che, Philip R. Dormitzer, Xinzhen Yang, Seungil Han, Kyle P. Heim, Xiaoyuan Chi, Xiayang Qiu

المصدر: Science Advances

مصطلحات موضوعية: Host cell membrane, Human cytomegalovirus, 0303 health sciences, Fusion, Multidisciplinary, 030306 microbiology, Chemistry, Cryo-electron microscopy, Lipid bilayer fusion, virus diseases, SciAdv r-articles, medicine.disease, Cell biology, 03 medical and health sciences, Transmembrane domain, Viral envelope, Antigen, Structural Biology, medicine, Research Articles, 030304 developmental biology, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5798c05f687fac7dcf40269a017b7405
http://europepmc.org/articles/PMC7935361

المؤلفون: Xiayang Qiu, Olga Plotnikova, Thomas J. McLellan, Graham M. West, Timothy A. Subashi, Y.Y. Dong, Elisabeth P. Carpenter, Seungil Han, Darren Dumlao, Paul D. Bonin, Xiaodi Yu, Ye Che, Jeffrey S. Culp

المصدر: eLife
eLife, Vol 8 (2019)

مصطلحات موضوعية: 0301 basic medicine, Amino Acid Transport System ASC, glutamine transporter, SLC1A5, QH301-705.5, Cryo-electron microscopy, Protein Conformation, Science, Structural Biology and Molecular Biophysics, solute carrier, Glutamine, Short Report, General Biochemistry, Genetics and Molecular Biology, Domain (software engineering), Minor Histocompatibility Antigens, 03 medical and health sciences, 0302 clinical medicine, Humans, Biology (General), General Immunology and Microbiology, Chemistry, General Neuroscience, Molecular biophysics, Cholesterol binding, Cryoelectron Microscopy, Transporter, General Medicine, ASCT2, 3. Good health, Transport protein, Solute carrier family, outward-facing conformation, 030104 developmental biology, Structural biology, Biophysics, Medicine, cryo-EM, 030217 neurology & neurosurgery, Human, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a466470cadf94e6122c7dcdd5bfcc94
http://europepmc.org/articles/PMC6800002

المؤلفون: Olga Plotnikova, Jeffrey S. Culp, Thomas J. McLellan, Y.Y. Dong, Darren Dumlao, Xiayang Qiu, Xiaodi Yu, Ye Che, Elisabeth P. Carpenter, Graham M. West, Paul D. Bonin, Timothy A. Subashi, Seungil Han

مصطلحات موضوعية: Glutamine, Cryo-electron microscopy, Chemistry, Biophysics, Transporter

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d6535cfe5652486f9831ba6924fd7aee
https://doi.org/10.7554/elife.48120.027

المؤلفون: Nagarajan Vaidehi, Xiaomin Chen, Kimberly F. Fennell, Christopher G. Tate, Veerabahu Shanmugasundaram, Manbir Sandhu, Ye Che, Soumadwip Ghosh, Srisairam Achuthan, XiaoJie Yao, Xiayang Qiu, Matthew C. Griffor, Sanychen Muk

المصدر: Biophys J

مصطلحات موضوعية: Prioritization, Protein domain, Mutant, Biophysics, Stability (learning theory), Biology, Molecular Dynamics Simulation, medicine.disease_cause, 010402 general chemistry, Machine learning, computer.software_genre, 01 natural sciences, Machine Learning, 03 medical and health sciences, 0302 clinical medicine, Protein Domains, medicine, Humans, Receptor, Anaphylatoxin C5a, 030304 developmental biology, G protein-coupled receptor, Mutation, 0303 health sciences, Alanine, business.industry, Protein Stability, HEK 293 cells, SUPERFAMILY, Articles, Alanine scanning, 0104 chemical sciences, HEK293 Cells, Membrane protein, Amino Acid Substitution, Artificial intelligence, business, computer, Sequence Analysis, 030217 neurology & neurosurgery, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599a7ff925b44a4bd8087e0c092b97f6
https://pubmed.ncbi.nlm.nih.gov/31703801

المؤلفون: Xiayang Qiu, Jeffrey S. Culp, Yinyao Dong, Darren Dumlao, Xiaodi Yu, Thomas J. McLellan, Ye Che, Paul D. Bonin, Olga Plotnikova, Elisabeth P. Carpenter, Seungil Han, Graham M. West, Timothy A. Subashi

مصطلحات موضوعية: 0303 health sciences, Mechanism (biology), Chemistry, Cholesterol binding, Substrate (chemistry), Transporter, 3. Good health, Domain (software engineering), Glutamine, 03 medical and health sciences, Domain interface, 0302 clinical medicine, 030220 oncology & carcinogenesis, Biophysics, Function (biology), 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e375ab389a77edbb643aca03e7e020
https://doi.org/10.1101/622563

المؤلفون: Suman Luthra, Graham M. West, Jeremy T. Starr, Matthew Frank Brown, Matthew F. Calabrese, Jinshan Chen, Hongyao Zhu, Xiayang Qiu, Daniel P. Uccello, Matthew Merrill Hayward, Jeanne S. Chang, Jotham Wadsworth Coe, Kathleen A. Farley, Kris A. Borzilleri, Mark C. Noe, Justin I. Montgomery, Adam M. Gilbert, Veerabahu Shanmugasundaram, Lara C. Czabaniuk, Robert M. Oliver, Carmen N. Garcia-Irrizary, Brandon P. Schuff, Chuong Nguyen, Yingrong Xu, James Schiemer, Jaymin C. Shah, Xidong Feng, Mark Niosi, Jennifer A. Young, WeiDong Ding, Ayman El-Kattan, Adelajda Zorba, James F. Smith

مصطلحات موضوعية: 0301 basic medicine, Ubiquitin-Protein Ligases, Cooperativity, Ligands, 03 medical and health sciences, hemic and lymphatic diseases, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Polyubiquitin, Cells, Cultured, Multidisciplinary, biology, Chemistry, Cereblon, Proteolysis targeting chimera, Ubiquitination, Protein-Tyrosine Kinases, Ubiquitin ligase, Cell biology, Rats, 030104 developmental biology, Proteasome, PNAS Plus, Proteolysis, biology.protein, Thermodynamics, Target protein, Tyrosine kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf434de63be490efb6416cf59a222839
https://europepmc.org/articles/PMC6077745/

المؤلفون: Mingzhu Wang, Xiayang Qiu, Na Yang, Duanfang Cao, Hualiang Jiang, Dongxiang Liu, Rui-Ming Xu

المصدر: Genes & Development. 29:1316-1325

مصطلحات موضوعية: Models, Molecular, endocrine system diseases, Allosteric regulation, Peptide, Stimulation, Resveratrol, Enzyme activator, chemistry.chemical_compound, Sirtuin 1, Stilbenes, Genetics, chemistry.chemical_classification, biology, In vitro toxicology, food and beverages, Substrate (chemistry), Protein Structure, Tertiary, Enzyme Activation, enzymes and coenzymes (carbohydrates), chemistry, Biochemistry, biology.protein, biological phenomena, cell phenomena, and immunity, Crystallization, hormones, hormone substitutes, and hormone antagonists, Research Paper, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59e11694ed3b05ef5a8813be9fa3562
https://doi.org/10.1101/gad.265462.115

المؤلفون: Graham M. West, Laura J. Byrnes, Justin Hall, Yingrong Xu, Xiayang Qiu

المصدر: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, congenital, hereditary, and neonatal diseases and abnormalities, Protein Conformation, Adenylyl Imidodiphosphate, lcsh:Medicine, Cystic Fibrosis Transmembrane Conductance Regulator, Plasma protein binding, Quinolones, Aminophenols, Cystic fibrosis, Article, Ivacaftor, 03 medical and health sciences, Protein stability, medicine, Humans, Binding site, lcsh:Science, Multidisciplinary, Binding Sites, 030102 biochemistry & molecular biology, biology, Chemistry, Protein Stability, lcsh:R, Cryoelectron Microscopy, Deuterium Exchange Measurement, respiratory system, medicine.disease, Molecular biology, Cystic fibrosis transmembrane conductance regulator, respiratory tract diseases, Adenosine Diphosphate, 030104 developmental biology, biology.protein, Thermodynamics, Hydrogen–deuterium exchange, lcsh:Q, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c7ecd8e77278399a8ef819fa6c5dde
https://pubmed.ncbi.nlm.nih.gov/29549268

المؤلفون: Darren A. Cusanovich, Andrew Adey, Dana Jackson, Cole Trapnell, Jonathan S. Packer, Frank J. Steemers, Jay Shendure, Xiayang Qiu, José L. McFaline-Figueroa, Riza M. Daza, Sanjay Srivatsan, Anna Minkina, Hannah A. Pliner

مصطلحات موضوعية: Genetics, Regulation of gene expression, 0303 health sciences, Computational biology, Biology, MyoD, Chromatin remodeling, Chromatin, 03 medical and health sciences, 0302 clinical medicine, Histone, biology.protein, Human genome, Transcription factor, 030217 neurology & neurosurgery, ChIA-PET, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e09daed2a26c4d0412bb552b5410d29
https://doi.org/10.1101/155473

المؤلفون: Eric T. Baima, Kimberly F. Fennell, John P. Mueller, Dennis E. Danley, Xiayang Qiu, Shenping Liu, Boris A. Chrunyk, Mahmoud N. Mansour

المصدر: Protein Science. 24:20-26

مصطلحات موضوعية: chemistry.chemical_classification, biology, Chemistry, Stereochemistry, Allosteric regulation, Isopentenyl pyrophosphate, Biochemistry, Pyrophosphate, Terpenoid, chemistry.chemical_compound, A-site, Enzyme, Enzyme inhibitor, biology.protein, Binding site, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1e27eb25ec24e10524fde284b98fa001
https://doi.org/10.1002/pro.2579

المؤلفون: Seungil Han, Aaron C. Smith, Melissa S. Harris, Timothy A. Subashi, Shawn Cabral, Lise R. Hoth, Nicole Caspers, Francis Rajamohan, Philip A. Carpino, Parag Sahasrabudhe, Ravi G. Kurumbail, Hong Wang, Jessica Ward, Edward L. Conn, Kris A. Borzilleri, James A. Landro, Jane M. Withka, Janice A. Brown, Russell A. Miller, Kimberly O. Cameron, Allyn T. Londregan, Richard K. Frisbie, Xiayang Qiu, Matthew F. Calabrese, Allan R. Reyes, Rachelle Magyar, Kieran F. Geoghegan

المصدر: Structure. 22:1161-1172

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Allosteric regulation, Regulator, Thiophenes, AMP-Activated Protein Kinases, Ligands, Structure-Activity Relationship, 03 medical and health sciences, Enzyme activator, Drug Delivery Systems, 0302 clinical medicine, AMP-activated protein kinase, Structural Biology, Heterotrimeric G protein, Humans, Protein Isoforms, Phosphorylation, Kinase activity, Protein kinase A, Nuclear Magnetic Resonance, Biomolecular, Molecular Biology, 030304 developmental biology, 0303 health sciences, Molecular Structure, biology, Chemistry, Biphenyl Compounds, AMPK, Surface Plasmon Resonance, Adenosine Monophosphate, Cell biology, Enzyme Activation, Kinetics, Biochemistry, Pyrones, biology.protein, Allosteric Site, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd50c7fbe572bff161a6831596533302
https://doi.org/10.1016/j.str.2014.06.009

المؤلفون: Ann Aulabaugh, Rafael G. Silva, Kieran F. Geoghegan, Xiayang Qiu

المصدر: Analytical Biochemistry. 450:63-69

مصطلحات موضوعية: Molecular Sequence Data, Biophysics, P70-S6 Kinase 1, Protein Serine-Threonine Kinases, Biology, MAP3K7, Biochemistry, Mass Spectrometry, MAP2K7, Casein kinase 2, alpha 1, Amino Acid Sequence, Phosphorylation, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Enzyme Assays, MAPK14, Cyclin-dependent kinase 2, Cell Biology, Staurosporine, Molecular biology, Protein Structure, Tertiary, nervous system diseases, biology.protein, Cyclin-dependent kinase 9

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b381487634df5645410afc1e2564ad
https://doi.org/10.1016/j.ab.2014.01.007

المؤلفون: Karen Atkinson, Timothy P. Rolph, Kris A. Borzilleri, Robert J. Aiello, Levenia Baker, Xiayang Qiu, Theresa D’Aquila, Angel Guzman-Perez, Meihua Tu, Xi Song, Jeffrey A. Pfefferkorn, Shenping Liu, David R. Derksen, Boris A. Chrunyk, James A. Landro, John Litchfield, Kevin J. Filipski, Jane M. Withka, Patricia Bourassa, Francis Bourbonais, Nicole Barrucci

المصدر: Med. Chem. Commun.. 5:802-807

مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Activator (genetics), Glucokinase, Organic Chemistry, Pharmaceutical Science, Biology, Hypoglycemia, medicine.disease, Biochemistry, Receptor–ligand kinetics, Enzyme, Therapeutic index, chemistry, In vivo, Pharmacodynamics, Drug Discovery, medicine, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4e8d245e5965543e527636b54f722cb3
https://doi.org/10.1039/c4md00027g

المؤلفون: Li Xing, Jane M. Withka, Guoyun Bai, Mark E. Bunnage, Bruce Allen Lefker, Leslie Anthony Dakin, Sheng Tan, Shenping Liu, Mary Ellen Banker, Parag Sahasrabudhe, Ariamala Gopalsamy, Atli Thorarensen, Hua Xu, Jennifer A. Young, Joerg Bussenius, Boris A. Chrunyk, Jinshan M. Chen, Kieran F. Geoghegan, Stephen W. Wright, Suman Shanker, Jeremy T. Starr, Paul Balbo, Xiayang Qiu, Zuojun Guo, Wei Li, Lyn H. Jones, Fabien Vincent, Lise R. Hoth

المصدر: Scientific Reports

مصطلحات موضوعية: Keratinocytes, 0301 basic medicine, Macrocyclic Compounds, Plasma protein binding, Molecular Dynamics Simulation, Pharmacology, Peptides, Cyclic, Article, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, Immune system, Humans, Structure–activity relationship, Binding site, Receptor, Cells, Cultured, Peptide ligand, Binding Sites, Multidisciplinary, biology, Interleukin-17, 030104 developmental biology, Drug Design, biology.protein, Interleukin 17, Antibody, Algorithms, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d84fd35679a6248c177be87226d5378

المؤلفون: Gary Woodnutt, Shenping Liu, Wei Li, Jane M. Withka, Xidong Feng, Boris A. Chrunyk, Wood Lauren Diane, Xiayang Qiu, Suman Shanker, Mary Ellen Banker, Parag Sahasrabudhe, Abhijit Bhat, Ping Jin, Curt Bradshaw, Bryan Oates, Rodney W. Lappe, Xi Song, David Tumelty, Matt Griffor, Gang Chen, Judith Jimenez, Atli Thorarensen, Joel Desharnais

المصدر: Scientific Reports

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, medicine.drug_class, Peptide, Plasma protein binding, Biology, Crystallography, X-Ray, Monoclonal antibody, Article, Proinflammatory cytokine, 03 medical and health sciences, 0302 clinical medicine, Protein structure, stomatognathic system, Peptide Library, medicine, Humans, Mass Screening, Enzyme Inhibitors, Peptide library, Cells, Cultured, Mass screening, chemistry.chemical_classification, Receptors, Interleukin-17, Multidisciplinary, Interleukin-17, Amino acid, 030104 developmental biology, Amino Acid Substitution, Biochemistry, chemistry, Mutagenesis, Peptides, Protein Binding, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9796141dae1e283b99185a98fb649d86
https://doi.org/10.1038/srep26071