المؤلفون: Cheng, Miffy Hok Yan, Leung, Jerry, Zhang, Yao, Strong, Colton, Basha, Genc, Momeni, Arash, Chen, Yihang, Jan, Eric, Abdolahzadeh, Amir, Wang, Xinying, Kulkarni, Jayesh A., Witzigmann, Dominik, Cullis, Pieter R.

المساهمون: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

المصدر: Advanced Materials ; volume 35, issue 31 ; ISSN 0935-9648 1521-4095

الاتاحة: https://doi.org/10.1002/adma.202303370
https://onlinelibrary.wiley.com/doi/pdf/10.1002/adma.202303370

المؤلفون: Uhl, Philipp, Bajraktari‐Sylejmani, Gzona, Witzigmann, Dominik, Bay, Cindy, Zimmermann, Stefan, Burhenne, Jürgen, Weiss, Johanna, Haefeli, Walter E., Sauter, Max

المساهمون: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Medizinischen Fakultät Heidelberg, Universität Heidelberg, Bundesministerium für Bildung und Forschung

المصدر: Advanced Therapeutics ; volume 6, issue 10 ; ISSN 2366-3987 2366-3987

الاتاحة: http://dx.doi.org/10.1002/adtp.202300021
https://onlinelibrary.wiley.com/doi/pdf/10.1002/adtp.202300021

المؤلفون: Chander, Nisha, Basha, Genc, Yan Cheng, Miffy Hok, Witzigmann, Dominik, Cullis, Pieter R.

المساهمون: Networks of Centres of Excellence of Canada, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, NanoMedicines Innovation Network, University of Pune, Canadian Institutes of Health Research

المصدر: Molecular Therapy - Methods & Clinical Development ; volume 30, page 235-245 ; ISSN 2329-0501

الاتاحة: http://dx.doi.org/10.1016/j.omtm.2023.06.005
https://api.elsevier.com/content/article/PII:S2329050123000955?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2329050123000955?httpAccept=text/plain

المؤلفون: Bolsoni, Juliana, Liu, Danny, Mohabatpour, Fatemeh, Ebner, Ronja, Sadhnani, Gaurav, Tafech, Belal, Leung, Jerry, Shanta, Selina, An, Kevin, Morin, Tessa, Chen, Yihang, Arguello, Alfonso, Choate, Keith, Jan, Eric, Ross, Colin J.D., Brambilla, Davide, Witzigmann, Dominik, Kulkarni, Jayesh, Cullis, Pieter R., Hedtrich, Sarah

المساهمون: Canadian Institutes of Health Research, LEO Fondet, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Faculty of Pharmaceutical Sciences, University of British Columbia, NanoMedicines Innovation Network, Stiftung Charité

المصدر: ACS Nano ; volume 17, issue 21, page 22046-22059 ; ISSN 1936-0851 1936-086X

الاتاحة: http://dx.doi.org/10.1021/acsnano.3c08644
https://pubs.acs.org/doi/pdf/10.1021/acsnano.3c08644

المؤلفون: CDL Nanomedicine, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health, Francia, Valentina, Zhang, Yao, Cheng, Miffy Hok Yan, Schiffelers, Raymond M, Witzigmann, Dominik, Cullis, Pieter R

URL: https://doi.org/10.1073/pnas.2307803120
http://hdl.handle.net/1874/453318
https://dspace.library.uu.nl/handle/1874/453318
http://www.scopus.com/inward/record.url?scp=85186846833&partnerID=8YFLogxK
0027-8424
Proceedings of the National Academy of Sciences of the United States of America
121
11
e2307803120

المؤلفون: Quick, Joslyn, Santos, Nancy Dos, Cheng, Miffy H.Y., Chander, Nisha, Brimacombe, Cedric A., Kulkarni, Jayesh, van der Meel, Roy, Tam, Yuen Yi C., Witzigmann, Dominik, Cullis, Pieter R.

المصدر: Quick , J , Santos , N D , Cheng , M H Y , Chander , N , Brimacombe , C A , Kulkarni , J , van der Meel , R , Tam , Y Y C , Witzigmann , D & Cullis , P R 2022 , ' Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy ' , Journal of Controlled Release , vol. 349 , pp. 174-183 . https://doi.org/10.1016/j.jconrel.2022.06.051

مصطلحات موضوعية: Androgen receptor, Gene therapy, Lipid nanoparticle, Prostate cancer, siRNA, Splice variant, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الاتاحة: https://research.tue.nl/en/publications/1b4fac50-f6ee-455e-ba48-59a392303aad
https://doi.org/10.1016/j.jconrel.2022.06.051
https://pure.tue.nl/ws/files/217016534/1_s2.0_S0168365922003935_main.pdf
http://www.scopus.com/inward/record.url?scp=85133727560&partnerID=8YFLogxK

المؤلفون: Pattipeiluhu, Roy, Arias-Alpizar, Gabriela, Basha, Genc, Chan, Karen Y.T., Bussmann, Jeroen, Sharp, Thomas H., Moradi, Mohammad Amin, Sommerdijk, Nico, Harris, Edward N., Cullis, Pieter R., Kros, Alexander, Witzigmann, Dominik, Campbell, Frederick

المصدر: Pattipeiluhu , R , Arias-Alpizar , G , Basha , G , Chan , K Y T , Bussmann , J , Sharp , T H , Moradi , M A , Sommerdijk , N , Harris , E N , Cullis , P R , Kros , A , Witzigmann , D & Campbell , F 2022 , ' Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System ' , Advanced Materials , vol. 34 , no. 16 , 2201095 . https://doi.org/10.1002/adma.202201095

مصطلحات موضوعية: embryonic zebrafish, lipid nanoparticles, mRNA delivery, reticuloendothelial system, stabilin-2, Mononuclear Phagocyte System/metabolism, RNA, Small Interfering/genetics, Lipids, Zebrafish, Messenger/metabolism, Nanoparticles, Tissue Distribution, Animals, Liver/metabolism, Mice, Liposomes

وصف الملف: application/pdf

Relation: https://research.tue.nl/en/publications/73778fbd-7809-4088-ae66-5fb8268649b6

الاتاحة: https://research.tue.nl/en/publications/73778fbd-7809-4088-ae66-5fb8268649b6
https://doi.org/10.1002/adma.202201095
https://pure.tue.nl/ws/files/203457422/Advanced_Materials_2022_Pattipeiluhu_Anionic_Lipid_Nanoparticles_Preferentially_Deliver_mRNA_to_the_Hepatic.pdf
http://www.scopus.com/inward/record.url?scp=85125992936&partnerID=8YFLogxK

المؤلفون: Basha, Genc, Cottle, Andrew G., Pretheeban, Thavaneetharajah, Chan, Karen YT., Witzigmann, Dominik, Young, Robert N., Rossi, Fabio MV., Cullis, Pieter R.

المصدر: Molecular Therapy ; volume 30, issue 9, page 3034-3051 ; ISSN 1525-0016

الاتاحة: http://dx.doi.org/10.1016/j.ymthe.2022.06.012
https://api.elsevier.com/content/article/PII:S1525001622003720?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1525001622003720?httpAccept=text/plain

المؤلفون: Chander, Nisha, Morstein, Johannes, Bolten, Jan S., Shemet, Andrej, Cullis, Pieter R., Trauner, Dirk, Witzigmann, Dominik

المصدر: Small, 17(21), 2008198, (2021-05-27)

مصطلحات موضوعية: cancer, doxorubicin, liposome, photoswitch, triggered drug release

Relation: https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fsmll.202008198&file=smll202008198-sup-0001-SuppMat.pdf; https://doi.org/10.1002/smll.202008198

الاتاحة: https://doi.org/10.1002/smll.202008198

المؤلفون: Rothgangl, Tanja, Dennis, Melissa K, Lin, Paulo J C, Oka, Rurika, Witzigmann, Dominik, Villiger, Lukas, Qi, Weihong, Hruzova, Martina, Kissling, Lucas, Lenggenhager, Daniela, Borrelli, Costanza, Egli, Sabina, Frey, Nina, Bakker, Noëlle, Walker, John A, Kadina, Anastasia P, Victorov, Denis V, Pacesa, Martin, Kreutzer, Susanne, Kontarakis, Zacharias, Moor, Andreas, Jinek, Martin, Weissman, Drew, Stoffel, Markus, van Boxtel, Ruben, Holden, Kevin, Pardi, Norbert, Thöny, Beat, Häberle, Johannes, Tam, Ying K, Semple, Sean C, Schwank, Gerald

المصدر: Rothgangl, Tanja; Dennis, Melissa K; Lin, Paulo J C; Oka, Rurika; Witzigmann, Dominik; Villiger, Lukas; Qi, Weihong; Hruzova, Martina; Kissling, Lucas; Lenggenhager, Daniela; Borrelli, Costanza; Egli, Sabina; Frey, Nina; Bakker, Noëlle; Walker, John A; Kadina, Anastasia P; Victorov, Denis V; Pacesa, Martin; Kreutzer, Susanne; Kontarakis, Zacharias; Moor, Andreas; Jinek, Martin; Weissman, Drew; Stoffel, Markus; van Boxtel, Ruben; Holden, Kevin; Pardi, Norbert; Thöny, Beat; Häberle, Johannes; Tam, Ying K; Semple, Sean C; Schwank, Gerald (2021). In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels. Nature Biotechnology, 39(8):949-957.

مصطلحات موضوعية: Department of Biochemistry, Institute of Pathology and Molecular Pathology, Functional Genomics Center Zurich, Medical Clinic, Institute of Pharmacology and Toxicology, 610 Medicine & health

وصف الملف: application/pdf

Relation: https://www.zora.uzh.ch/id/eprint/206012/1/Rothgangl_NatBio_41587_2021_Article_933.pdf; info:pmid/34012094; urn:issn:1087-0156

الاتاحة: https://www.zora.uzh.ch/id/eprint/206012/
https://www.zora.uzh.ch/id/eprint/206012/1/Rothgangl_NatBio_41587_2021_Article_933.pdf

المؤلفون: Villiger, Lukas, Rothgangl, Tanja, Witzigmann, Dominik, Oka, Rurika, Lin, Paulo J C, Qi, Weihong, Janjuha, Sharan, Berk, Christian, Ringnalda, Femke, Beattie, Mitchell B, Stoffel, Markus, Thöny, Beat, Hall, Jonathan, Rehrauer, Hubert, van Boxtel, Ruben, Tam, Ying K, Schwank, Gerald

المصدر: Villiger, Lukas; Rothgangl, Tanja; Witzigmann, Dominik; Oka, Rurika; Lin, Paulo J C; Qi, Weihong; Janjuha, Sharan; Berk, Christian; Ringnalda, Femke; Beattie, Mitchell B; Stoffel, Markus; Thöny, Beat; Hall, Jonathan; Rehrauer, Hubert; van Boxtel, Ruben; Tam, Ying K; Schwank, Gerald (2021). In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA. Nature Biomedical Engineering, 5(2):179-189.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, Functional Genomics Center Zurich, Medical Clinic, 570 Life sciences, biology, 610 Medicine & health

وصف الملف: application/pdf

Relation: https://www.zora.uzh.ch/id/eprint/200499/1/s41551-020-00671-z_%283%29.pdf; https://www.zora.uzh.ch/id/eprint/200499/8/EMS114737.pdf; info:pmid/33495639; urn:issn:2157-846X

الاتاحة: https://www.zora.uzh.ch/id/eprint/200499/
https://www.zora.uzh.ch/id/eprint/200499/8/EMS114737.pdf

المؤلفون: Uhl, Philipp, Sauter, Max, Hertlein, Tobias, Witzigmann, Dominik, Laffleur, Flavia, Hofhaus, Götz, Fidelj, Veronika, Tursch, Anja, Özbek, Suat, Hopke, Elisa, Haberkorn, Uwe, Bernkop-Schnürch, Andreas, Ohlsen, Knut, Fricker, Gert, Mier, Walter

مصطلحات موضوعية: cell-penetrating peptides, liposomal nanocarrier, oral peptide delivery, tetraether lipids, vancomycin

جغرافية الموضوع: UI:AE:MN, UI:CP:AB

وصف الملف: text/html

Relation: vignette : https://diglib.uibk.ac.at/titlepage/urn/urn:nbn:at:at-ubi:3-26782/128; urn:nbn:at:at-ubi:3-26782; https://resolver.obvsg.at/urn:nbn:at:at-ubi:3-26782; local:99146928641303331; system:AC16604656

الاتاحة: https://doi.org/10.1002/adtp.202000247
https://diglib.uibk.ac.at/doi/10.1002/adtp.202000247
https://resolver.obvsg.at/urn:nbn:at:at-ubi:3-26782

المؤلفون: Kulkarni, Jayesh A., Witzigmann, Dominik, Thomson, Sarah B., Chen, Sam, Leavitt, Blair R., Cullis, Pieter R., van der Meel, Roy

المصدر: Kulkarni , J A , Witzigmann , D , Thomson , S B , Chen , S , Leavitt , B R , Cullis , P R & van der Meel , R 2021 , ' Author Correction : The current landscape of nucleic acid therapeutics (Nature Nanotechnology, (2021), 16, 6, (630-643), 10.1038/s41565-021-00898-0) ' , Nature Nanotechnology , vol. 16 , no. 7 , pp. 841 . https://doi.org/10.1038/s41565-021-00937-w

وصف الملف: application/pdf

الاتاحة: https://research.tue.nl/en/publications/215784b1-3327-427d-be20-e8a3021cafd8
https://doi.org/10.1038/s41565-021-00937-w
https://pure.tue.nl/ws/files/182741269/s41565_021_00937_w.pdf
http://www.scopus.com/inward/record.url?scp=85112121494&partnerID=8YFLogxK

المؤلفون: Kulkarni, Jayesh A., Witzigmann, Dominik, Thomson, Sarah B., Chen, Sam, Leavitt, Blair R., Cullis, Pieter R., van der Meel, Roy

المصدر: Kulkarni , J A , Witzigmann , D , Thomson , S B , Chen , S , Leavitt , B R , Cullis , P R & van der Meel , R 2021 , ' The current landscape of nucleic acid therapeutics ' , Nature Nanotechnology , vol. 16 , no. 6 , pp. 630-643 . https://doi.org/10.1038/s41565-021-00898-0

الاتاحة: https://research.tue.nl/en/publications/0e5dceaf-5712-49cd-9edf-6989fb451030
https://doi.org/10.1038/s41565-021-00898-0
http://www.scopus.com/inward/record.url?scp=85107269325&partnerID=8YFLogxK

المؤلفون: Schoenmaker, Linde, Witzigmann, Dominik, Kulkarni, Jayesh A, Verbeke, Rein, Kersten, Gideon, Jiskoot, Wim, Crommelin, Daan J A

المساهمون: Afd Pharmaceutics, Pharmaceutics

مصطلحات موضوعية: COVID-19, COVID-19 Vaccines, Humans, Lipids, Nanoparticles, RNA, Messenger, Small Interfering, SARS-CoV-2

وصف الملف: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/419445

الاتاحة: https://dspace.library.uu.nl/handle/1874/419445

المؤلفون: Chen, Kent T.J., Militao, Gardenia G.C., Anantha, Malathi, Witzigmann, Dominik, Leung, Ada W.Y., Bally, Marcel B.

المساهمون: Canadian Institutes of Health Research, Canadian Cancer Society Research Institute

المصدر: Journal of Controlled Release ; volume 333, page 246-257 ; ISSN 0168-3659

الاتاحة: http://dx.doi.org/10.1016/j.jconrel.2021.03.042
https://api.elsevier.com/content/article/PII:S016836592100153X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S016836592100153X?httpAccept=text/plain

المؤلفون: Witzigmann, Dominik, Grossen, Philip, Quintavalle, Cristina, Lanzafame, Manuela, Schenk, Susanne H., Tran, Xue-Ting, Englinger, Bernhard, Hauswirth, Patrick, Grünig, David, van Schoonhoven, Sushilla, Krähenbühl, Stephan, Terracciano, Luigi M., Berger, Walter, Piscuoglio, Salvatore, Quagliata, Luca, Rommelaere, Jean, Nüesch, Jürg P.F., Huwyler, Jörg

المساهمون: Novartis AG, Swiss National Science Foundation, Oncosuisse

المصدر: Journal of Controlled Release ; volume 334, page 138-152 ; ISSN 0168-3659

الاتاحة: http://dx.doi.org/10.1016/j.jconrel.2021.04.023
https://api.elsevier.com/content/article/PII:S0168365921001899?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0168365921001899?httpAccept=text/plain

المؤلفون: Francia, Valentina, Yao Zhang, Hok Yan Cheng, Miffy, Schiffelers, Raymond M., Witzigmann, Dominik, Cullis, Pieter R.

المصدر: Proceedings of the National Academy of Sciences of the United States of America; 3/12/2024, Vol. 121 Issue 11, p1-8, 16p

مصطلحات موضوعية: MAGNETIC separation, IRON oxide nanoparticles, GEL permeation chromatography, NUCLEIC acids, LIPIDS

المؤلفون: Buck, Jonas, Mueller, Dennis, Mettal, Ute, Ackermann, Miriam, Grisch-Chan, Hiu Man, Thöny, Beat, Zumbuehl, Andreas, Huwyler, Jörg, Witzigmann, Dominik

المصدر: Buck, Jonas; Mueller, Dennis; Mettal, Ute; Ackermann, Miriam; Grisch-Chan, Hiu Man; Thöny, Beat; Zumbuehl, Andreas; Huwyler, Jörg; Witzigmann, Dominik (2020). Improvement of DNA Vector Delivery of DOTAP Lipoplexes by Short-Chain Aminolipids. ACS Omega, 5(38):24724-24732.

مصطلحات موضوعية: Medical Clinic, 610 Medicine & health

وصف الملف: application/pdf

Relation: https://www.zora.uzh.ch/id/eprint/194382/1/ao0c03303.pdf; info:pmid/33015490; urn:issn:2470-1343

الاتاحة: https://www.zora.uzh.ch/id/eprint/194382/
https://www.zora.uzh.ch/id/eprint/194382/1/ao0c03303.pdf
https://doi.org/10.1021/acsomega.0c03303

المؤلفون: Witzigmann, Dominik, Kulkarni, Jayesh A., Leung, Jerry, Chen, Sam, Cullis, Pieter R., van der Meel, Roy

المصدر: Witzigmann , D , Kulkarni , J A , Leung , J , Chen , S , Cullis , P R & van der Meel , R 2020 , ' Lipid nanoparticle technology for therapeutic gene regulation in the liver ' , Advanced Drug Delivery Reviews , vol. 159 , pp. 344-363 . https://doi.org/10.1016/j.addr.2020.06.026

مصطلحات موضوعية: CRISPR/Cas9, DNA, gene editing, gene expression, gene silencing, Gene therapy, guide RNA (gRNA), hepatocyte, lipid nanoparticle (LNP), lipids, liver, messenger RNA (mRNA), small interfering RNA (siRNA), /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الاتاحة: https://research.tue.nl/en/publications/77223832-4cb9-49aa-8175-c2c79d8a32be
https://doi.org/10.1016/j.addr.2020.06.026
https://pure.tue.nl/ws/files/174160524/publisher_version.pdf
http://www.scopus.com/inward/record.url?scp=85087897424&partnerID=8YFLogxK