المؤلفون: Corin Miller, Michele J Pachanski, Melissa E Kirkland, Daniel T Kosinski, Joel Mane, Michelle Bunzel, Jin Cao, Sarah Souza, Brande Thomas-Fowlkes, Jerry Di Salvo, Adam B Weinglass, Xiaoyan Li, Robert W Myers, Kevin Knagge, Paul E Carrington, William K Hagmann, Maria E Trujillo

المصدر: PLoS ONE, Vol 12, Iss 5, p e0176182 (2017)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC5441580?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/4297f4182b9a42c8a0259dfa0c87b6cf

المؤلفون: Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Haiqun Tang, Shu-Wei Yang, Jianping Pan, Yuriko Root, Reynalda Keh de Jesus, Christine Yang, Winnie Prosise, Priya Dayananth, Asra Mirza, Alex G. Therien, Katherine Young, Amy Flattery, Charles Garlisi, Rumin Zhang, Donald Chu, Payal Sheth, Inhou Chu, Jin Wu, Carrie Markgraf, Hai-Young Kim, Ronald Painter, Todd W. Mayhood, Edward DiNunzio, Daniel F. Wyss, Alexei V. Buevich, Thierry Fischmann, Alexander Pasternak, Shuzhi Dong, Jacqueline D. Hicks, Artjohn Villafania, Lianzhu Liang, Nicholas Murgolo, Todd Black, William K. Hagmann, Jim Tata, Emma R. Parmee, Ann E. Weber, Jing Su, Haifeng Tang

المصدر: Journal of Medicinal Chemistry. 65:16234-16251

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72a226d0f459e4620537979c8da4d4d
https://doi.org/10.1021/acs.jmedchem.2c00766

المؤلفون: Barbara Pio, Ravi P. Nargund, Yan Guo, Daniel Kosinski, Josien Hubert B, Michael Wright, Michele Pachanski, Harry R. Chobanian, Xiaoping Zhang, Richard Tschirret-Guth, Melissa Kirkland, Andrew D. Howard, Sarah Souza, Eric R. Ashley, Robert K. Orr, Steven L. Colletti, Joel Mane, Jerry Di Salvo, Michael W. Miller, Boonlert Cheewatrakoolpong, Koppara Samuel, William K. Hagmann, James Lamca, Juliann Ehrhart, Maria E. Trujillo, Jackie Shang, Qing Chen, Adam B. Weinglass, Randal M. Bugianesi

المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1842-1848

مصطلحات موضوعية: Agonist, endocrine system, medicine.drug_class, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Enteroendocrine cell, 01 natural sciences, Biochemistry, Receptors, G-Protein-Coupled, Free fatty acid receptor 1, Drug Discovery, medicine, Humans, Receptor, Mode of action, Molecular Biology, geography, geography.geographical_feature_category, 010405 organic chemistry, Chemistry, Organic Chemistry, Islet, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Mechanism of action, Drug Design, Indans, Molecular Medicine, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67130fd906c302e54806df711af08d1b
https://doi.org/10.1016/j.bmcl.2019.04.050

المؤلفون: Melissa Kirkland, Randal M. Bugianesi, Melodie Christensen, Maria E. Trujillo, Michele Pachanski, Richard Tschirret-Guth, Josien Hubert B, Adam B. Weinglass, Sarah Souza, Ravi P. Nargund, Christopher W. Plummer, Andrew D. Howard, Joel Mane, Louis-Charles Campeau, Robert K. Orr, Daniel Kosinski, Xiaoping Zhang, Boonlert Cheewatrakoolpong, Jerry Di Salvo, Michael W. Miller, William K. Hagmann, Helen Chen, Steven L. Colletti, Andrew Nolting, Michael Wright, Matthew J. Clements, Murali Rajagopalan

المصدر: ACS Medicinal Chemistry Letters. 8:221-226

مصطلحات موضوعية: 0301 basic medicine, endocrine system, medicine.medical_specialty, business.industry, Pancreatic islets, Organic Chemistry, Tachyphylaxis, Hypoglycemia, medicine.disease, Biochemistry, Partial agonist, 03 medical and health sciences, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Tolerability, Internal medicine, Diabetes mellitus, Free fatty acid receptor 1, Drug Discovery, medicine, Receptor, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6942c1dd589ae2364bd7ea069018de04
https://doi.org/10.1021/acsmedchemlett.6b00443

المؤلفون: Dann L. Parker, Randal M. Bugianesi, Birgit T. Priest, Feroze Ujjainwalla, Edward C. Sherer, Stanley Mitelman, Sharon Tong, Matthew Lombardo, William K. Hagmann, Ravi P. Nargund, Melissa Costa, Christopher Joseph Sinz, Anka G. Ehrhardt, Scott D. Edmondson, Ravi Kurukulasuriya, Xiaofang Li, Karen H. Dingley, Kate Bender, Kevin S. Ratliff, Jonathan E. Wilson

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:2947-2951

مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Diabetes Mellitus, Experimental, Receptors, G-Protein-Coupled, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, In vivo, Diabetes mellitus, Drug Discovery, medicine, Animals, Oral glucose tolerance, Molecular Biology, Mice, Knockout, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Glucose Tolerance Test, Triazoles, medicine.disease, Rats, Oxazepines, 030104 developmental biology, Molecular Medicine, Oxazepine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f4fd9aaf407b2d77d08816feb7cb20
https://doi.org/10.1016/j.bmcl.2016.04.018

المؤلفون: Donald Nelson, Gary G. Chicchi, James Dellureficio, Ravi P. Nargund, Peter H. Dobbelaar, Liangqin Guo, Kwei-Lan Tsao, Janet S. Kerr, Bei Zhang, Zhong Lai, Patricia R. Bunting, Shrenik K. Shah, Raman K. Bakshi, Qingmei Hong, Hongbo Qi, Guillermo Fernandez, Mikhail Reibarkh, Qing Shao, Quang Truong, Koppara Samuel, Jian Liu, Sylvia Volksdorf, Zhixiong Ye, Yun-Ping Zhou, Margaret Wu, Cai Li, Stan Mitelman, Andrew D. Howard, Wu Du, Maria E. Trujillo, George J. Eiermann, Shuwen He, Vijay Bhasker G. Reddy, Tianying Jian, Pierre Morissette, Patrick Fitzgerald, Dorina Trusca, Sharon Tong, William K. Hagmann

المصدر: ACS Medicinal Chemistry Letters. 5:748-753

مصطلحات موضوعية: biology, business.industry, Organic Chemistry, hERG, Antagonist, In vitro toxicology, Type 2 diabetes, Pharmacology, medicine.disease, Biochemistry, QT interval, Somatostatin, Drug Discovery, biology.protein, Medicine, cardiovascular diseases, Receptor, business, Antagonism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced576c72131916fe1527dabb0d36e73
https://doi.org/10.1021/ml500028c

المؤلفون: Daniel Kosinski, Melissa Kirkland, Michelle Bunzel, Jin Cao, Robert W. Myers, Adam B. Weinglass, Kevin Knagge, Michele Pachanski, Sarah Souza, William K. Hagmann, Joel Mane, Xiaoyan Li, Maria E. Trujillo, Corin O. Miller, Paul E. Carrington, Jerry Di Salvo, Brande Thomas-Fowlkes

المصدر: PLoS ONE, Vol 12, Iss 5, p e0176182 (2017)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, Partial Agonists, Time Factors, Physiology, medicine.medical_treatment, Drug Evaluation, Preclinical, lcsh:Medicine, Spectrum analysis techniques, Biochemistry, Receptors, G-Protein-Coupled, Tissue Culture Techniques, 0302 clinical medicine, Endocrinology, Glucose Metabolism, Medicine and Health Sciences, Glucose homeostasis, Insulin, lcsh:Science, Mice, Knockout, Multidisciplinary, Chemistry, Organic Compounds, Monosaccharides, Drugs, Fasting, Blood Sugar, Body Fluids, Blood, Liver, Physical Sciences, Carbohydrate Metabolism, Anatomy, Research Article, medicine.medical_specialty, endocrine system, Endocrine Disorders, Carbohydrates, Blood sugar, 030209 endocrinology & metabolism, CHO Cells, Carbohydrate metabolism, Partial agonist, Blood Plasma, Diabetes Mellitus, Experimental, 03 medical and health sciences, Cricetulus, NMR spectroscopy, Internal medicine, Free fatty acid receptor 1, Diabetes mellitus, medicine, Diabetes Mellitus, Animals, Humans, Hypoglycemic Agents, Benzopyrans, Rats, Wistar, Pharmacology, Diabetic Endocrinology, Organic Chemistry, lcsh:R, Chemical Compounds, Biology and Life Sciences, medicine.disease, Hormones, Rats, Research and analysis methods, 030104 developmental biology, Glucose, HEK293 Cells, Metabolism, Gluconeogenesis, Metabolic Disorders, Thiazolidinediones, lcsh:Q

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bfccec2b21e6b21432c0056bc58040
http://europepmc.org/articles/PMC5441580?pdf=render

المؤلفون: John S. Debenham, Dann L. Parker, Birgit T. Priest, Ravi P. Nargund, Feroze Ujjainwalla, Randal M. Bugianesi, Michele Pachanski, Liangqin Guo, William K. Hagmann, George J. Eiermann, Yi Zang, Ramzi F. Sweis, Andrew D. Howard, Jenna L. Terebetski, Melissa Kirkland, Yue Feng, Gino Salituro, Derun Li, Christopher Joseph Sinz, Stan Mitelman, Maria E. Trujillo, Scott D. Edmondson, Karen H. Dingley, Jin Shang, Nicole Buist, Xiaofang Li, Weiguo Liu, Mary Ann Powles, Terri M. Kelly, Edward C. Sherer

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Organic Chemistry, Triazole, Type 2 Diabetes Mellitus, Glucose excursion, Type 2 diabetes, Metabolic stability, medicine.disease, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Endocrinology, chemistry, Internal medicine, Drug Discovery, medicine, Deficient mouse, Potency, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05666abdc0e69d7961b4edf099a12f0b
https://europepmc.org/articles/PMC5150677/

المؤلفون: Maria Madeira, Wendy D. Cornell, Andreas Verras, Robert P. Sheridan, William K. Hagmann, Edward C. Sherer, Drew Roberts, Kelly Bleasby

المصدر: Molecular Informatics. 31:231-245

مصطلحات موضوعية: Quantitative structure–activity relationship, Molecular model, Chemistry, business.industry, Organic Chemistry, Cross prediction, Computer Science Applications, Random forest, Passive permeability, Structural Biology, Permeability (electromagnetism), Drug Discovery, Line (geometry), Molecular Medicine, Artificial intelligence, business, Biological system, ADME

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1717dbba022571f437d8cdac9557d1
https://doi.org/10.1002/minf.201100157

المؤلفون: Zhong Lai, Shuwen He, William K. Hagmann, Ravi P. Nargund, Mikhail Reibarkh, David X. Yang, Qingmei Hong

المصدر: Tetrahedron Letters. 51:4361-4364

مصطلحات موضوعية: Chemistry, Organic Chemistry, Drug Discovery, Organic chemistry, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::54531951b34deb9aaafa8640cfb94e9d
https://doi.org/10.1016/j.tetlet.2010.06.053

المؤلفون: Laurie G. Castonguay, Sookhee Ha, Lex H.T. Van der Ploeg, Chun-Pyn Shen, Ihor E. Kopka, Zhege J. Lao, Mark T. Goulet, Linus S. Lin, William K. Hagmann, Tung M. Fong, James P. Jewell, Thomas J. Lanza

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4757-4761

مصطلحات موضوعية: Models, Molecular, Molecular model, Pyridines, medicine.drug_class, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Carboxamide, Context (language use), Biochemistry, Chemical synthesis, Taranabant, Receptor, Cannabinoid, CB1, Drug Discovery, medicine, Humans, Inverse agonist, Computer Simulation, Homology modeling, Molecular Biology, Chemistry, Organic Chemistry, Amides, Molecular Medicine, Anti-Obesity Agents, Cannabinoid, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737e62d3613615a82eb8f34fb466c9e0
https://doi.org/10.1016/j.bmcl.2010.06.127

المؤلفون: Kenneth Alves, Thomas S. Reger, Kelly M. Treonze, Susan Nicolich, Patricia Kellerhouse, Salony Maniar, Paul A. Fischer, Donald W. Nicholson, Jasmine Zunic, Russell B. Lingham, Donald F. Hora, Peppi Prasit, Nicholas D. Smith, Richard A. Mumford, Keith Judd, Alison A. Kulick, Donald Thompson, Qian Si, William K. Hagmann, Benito Munoz, Ken Vakerich

المصدر: Veterinary Immunology and Immunopathology. 130:79-87

مصطلحات موضوعية: Male, medicine.drug_class, Immunology, Integrin alpha4beta1, Pharmacology, Binding, Competitive, Peripheral blood mononuclear cell, Rats, Sprague-Dawley, Dogs, Leukocytes, medicine, Animals, Potency, Horses, Leukocytosis, Receptor, IC50, Recurrent airway obstruction, Whole blood, General Veterinary, business.industry, Flow Cytometry, medicine.disease, Receptor antagonist, Macaca mulatta, Rats, Airway Obstruction, Female, Horse Diseases, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2519d0b2f73ce500e2d2ca3d32c8e1
https://doi.org/10.1016/j.vetimm.2009.01.011

المؤلفون: Gerard R. Kieczykowski, Carrie P. Jones, Ping Liu, Junying Wang, Conrad E. Raab, Qian Si, Xinchun Tong, Thomas J. Lanza, Anne Schuelke, Kelly M. Treonze, Richard A. Mumford, Salony Manior, Stella H. Vincent, James V. Pivnichny, Gloria C. Koo, James P. Jewell, William K. Hagmann, Regina W. Wang, Philip Davies, Linus S. Lin, Malcolm MacCoss

المصدر: Journal of Medicinal Chemistry. 52:3449-3452

مصطلحات موضوعية: chemistry.chemical_classification, Sulfonyl, Dipeptide, Stereochemistry, medicine.drug_class, Antagonist, Peptide, Phenylalanine, Carboxamide, Biological activity, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Molecular Medicine, Proline

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3a2b44376091abb5e0b00c51b9e55a39
https://doi.org/10.1021/jm900257b

المؤلفون: Sloan Stribling, Donald F. Thompson, Junying Wang, Xinchun Tong, Lauren P. Shearman, Cathy C. R.-R. Huang, Joana Achanfuo-Yeboah, Susan Nicolich, Andrea Frassetto, Tung M. Fong, Donald F. Hora, Chun-Pyn Shen, Nancy N. Tsou, Alison M. Strack, Richard G. Ball, Julie Lao, Gerard J. Hickey, Terry D. Faidley, Jeffrey J. Hale, Joan M. Fletcher, William K. Hagmann, Petr Vachal, Richard Z. Chen, Jing Chen Xiao

المصدر: Journal of Medicinal Chemistry. 52:2550-2558

مصطلحات موضوعية: Models, Molecular, Drug Inverse Agonism, medicine.medical_treatment, Biological Availability, In Vitro Techniques, Pharmacology, Piperazines, Eating, Structure-Activity Relationship, Dogs, Receptor, Cannabinoid, CB1, In vivo, Drug Discovery, medicine, Animals, Humans, Potency, Inverse agonist, Structure–activity relationship, Receptor, Sulfonamides, Chemistry, Body Weight, Antagonist, Stereoisomerism, Macaca mulatta, Rats, Biochemistry, Hepatocytes, Microsomes, Liver, Molecular Medicine, Anti-Obesity Agents, Cannabinoid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1ab0a834361355e6b35a585e3c5f9d
https://doi.org/10.1021/jm900063x

المؤلفون: Terence G. Hamill, Brett Connolly, Ping Liu, Tung M. Fong, Christine Ryan, Richard Hargreaves, Linus S. Lin, Mark T. Goulet, Amy Vanko, Wai-Si Eng, William K. Hagmann, James P. Jewell, H. Donald Burns, Sandra Sanabria

المصدر: Molecular Imaging and Biology. 11:246-252

مصطلحات موضوعية: Cancer Research, Cannabinoid receptor, Pyridines, medicine.medical_treatment, Ligands, Tritium, Receptor, Cannabinoid, CB1, In vivo, medicine, Animals, Inverse agonist, Tissue Distribution, Radiology, Nuclear Medicine and imaging, Carbon Radioisotopes, IC50, Chemistry, business.industry, Brain, Pet imaging, Ligand (biochemistry), Amides, Macaca mulatta, In vitro, Oncology, Positron-Emission Tomography, Biophysics, Autoradiography, Cannabinoid, Radiopharmaceuticals, Nuclear medicine, business, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bc2ff712b2f92b6b1cb1730f93c1a0
https://doi.org/10.1007/s11307-008-0194-8

المؤلفون: Jing Chen Xiao, James P. Jewell, Chun-Pyn Shen, Tung M. Fong, William K. Hagmann, Linus S. Lin

المصدر: Brain Research. 1238:36-43

مصطلحات موضوعية: AM251, Cannabinoid receptor, medicine.medical_treatment, CHO Cells, In Vitro Techniques, Biology, Polymerase Chain Reaction, chemistry.chemical_compound, Cricetulus, Receptor, Cannabinoid, CB1, Cricetinae, Cannabinoid receptor type 2, medicine, Animals, Humans, Inverse agonist, RNA, Messenger, Receptor, Molecular Biology, General Neuroscience, Brain, Alternative Splicing, Virodhamine, chemistry, Biochemistry, GPR18, Neurology (clinical), Cannabinoid, Developmental Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea7547dbdde090a346e6a17e0a9269a
https://doi.org/10.1016/j.brainres.2008.08.027

المؤلفون: William K. Hagmann

المصدر: Journal of Medicinal Chemistry. 51:4359-4369

مصطلحات موضوعية: Sitagliptina, Chemistry, Cysteine Endopeptidases, Chemistry, Pharmaceutical, Fluorine Compounds, Stereoisomerism, Fluorine, Biochemistry, Drug Discovery, Animals, Humans, Molecular Medicine, Organic chemistry, Enzyme Inhibitors, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908fbf224c0ea0fafb53ed0fd8419b6c
https://doi.org/10.1021/jm800219f

المؤلفون: Ginger X. Yang, Ermengilda McCauley, Linda L. Chang, John A. Schmidt, Richard A. Mumford, William K. Hagmann

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1688-1691

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Integrin, Biphenyl derivatives, Pharmaceutical Science, Integrin alpha4beta1, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Receptors, Very Late Antigen, immune system diseases, hemic and lymphatic diseases, Drug Discovery, Side chain, Peptide bond, Molecular Biology, chemistry.chemical_classification, Dipeptide, Molecular Structure, biology, Organic Chemistry, VLA-4, hemic and immune systems, Dipeptides, respiratory system, Sulfonamide, chemistry, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c62040f9e481e579d8fd6ad69798042
https://doi.org/10.1016/j.bmcl.2008.01.045

المؤلفون: D. Euan MacIntyre, Yue Feng, Lauren P. Shearman, Xiao-Ming Guan, Mark T. Goulet, Christopher W. Plummer, Sharon Tong, Quang Truong, D. Sloan Stribling, Donald J. Marsh, Junying Wang, Hong Yu, Kimberly Rosko, Sander G. Mills, Paul E. Finke, Alison M. Strack, Stephanie K. Spann, L. H. T. Van Der Ploeg, Shrenik K. Shah, Douglas J. MacNeil, Ramon E. Camacho, Joseph M. Metzger, William K. Hagmann, Tung M. Fong

المصدر: European Journal of Pharmacology. 579:215-224

مصطلحات موضوعية: Male, medicine.medical_specialty, Cannabinoid receptor, Drug Inverse Agonism, medicine.drug_class, medicine.medical_treatment, Administration, Oral, In Vitro Techniques, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB2, Eating, Mice, Dexfenfluramine, Receptor, Cannabinoid, CB1, In vivo, Internal medicine, medicine, Animals, Humans, Inverse agonist, Obesity, Receptor, Mice, Knockout, Pharmacology, Dose-Response Relationship, Drug, Chemistry, Imidazoles, Brain, Receptor antagonist, Rats, Disease Models, Animal, Endocrinology, Autoradiography, Anti-Obesity Agents, Cannabinoid, Ex vivo, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49649d7b8bc67415f284cf71a0a449db
https://doi.org/10.1016/j.ejphar.2007.10.033

المؤلفون: Joan M. Fletcher, William K. Hagmann, Petr Vachal

المصدر: Tetrahedron Letters. 48:5761-5765

مصطلحات موضوعية: Substitution reaction, chemistry.chemical_classification, Tertiary amine, Aryl, Organic Chemistry, General Medicine, Alkylation, Biochemistry, Medicinal chemistry, Adduct, chemistry.chemical_compound, chemistry, Nucleophile, Drug Discovery, Organic chemistry, lipids (amino acids, peptides, and proteins), Amine gas treating, Phenols, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91dc696e89eb68c16a3a6df4788da559
https://doi.org/10.1016/j.tetlet.2007.06.091