المؤلفون: David Norton (1697866), William G. Bonnette (11173075), James F. Callahan (572409), Maria G. Carr (2272138), Charlotte M. Griffiths-Jones (4044440), Tom D. Heightman (236769), Jeffrey K. Kerns (572412), Hong Nie (2722792), Sharna J. Rich (1541815), Caroline Richardson (572406), William Rumsey (2375170), Yolanda Sanchez (213896), Marcel L. Verdonk (2079703), Henriëtte M. G. Willems (6634883), William E. Wixted (11614586), Lawrence Wolfe (6634886), Alison J.-A. Woolford (2074540), Zining Wu (440596), Thomas G. Davies (572415)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Pharmacology, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, Chemical Sciences not elsewhere classified, novel chemical series, mediated cytoprotective response, high target affinity, chemically distinct series, associated protein 1, original fragment screen, based drug discovery, guided discovery, based approaches, based activity, protein keap1, tool compound, risk projects, recently described, pharmacophoric information, pharmacological intervention, new lead, molecule activators, like ech

Relation: https://figshare.com/articles/journal_contribution/Fragment-Guided_Discovery_of_Pyrazole_Carboxylic_Acid_Inhibitors_of_the_Kelch-like_ECH-Associated_Protein_1_Nuclear_Factor_Erythroid_2_Related_Factor_2_KEAP1_NRF2_Protein_Protein_Interaction/16890596

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01351.s001

المؤلفون: Zhuming Zhang (1846087), Avijit Ghosh (1428496), Peter J. Connolly (2456890), Peter King (234747), Thomas Wilde (6057116), Jianyao Wang (640348), Yawei Dong (2365990), Xueliang Li (585599), Daohong Liao (1393399), Hao Chen (5190), Gaochao Tian (2465608), Javier Suarez (2289811), William G. Bonnette (11173075), Vineet Pande (2538973), Karen A. Diloreto (11154645), Yifan Shi (4269262), Shefali Patel (11154648), Beth Pietrak (1940869), Lawrence Szewczuk (11154651), Carlo Sensenhauser (2181964), Shannon Dallas (7945637), James P. Edwards (2428411), Kurtis E. Bachman (5679542), David C. Evans (203487)

مصطلحات موضوعية: Biochemistry, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, adenoma progression, Colorectal Cancer, vivo 18 F-FDG uptake attenuation, efficacy proxy, survival extension, COX -2 inhibitors, COX -2-mediated CRC disease chemopr., colorectal adenomas, APC, exposure, chemoprotective effects, COX -2 inhibition, vivo dose-dependent inhibition

Relation: https://figshare.com/articles/journal_contribution/Gut-Restricted_Selective_Cyclooxygenase_2_COX-2_Inhibitors_for_Chemoprevention_of_Colorectal_Cancer/15019026

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00890.s003

المؤلفون: David Norton (1697866), William G. Bonnette (11173075), James F. Callahan (572409), Maria G. Carr (2272138), Charlotte M. Griffiths-Jones (4044440), Tom D. Heightman (236769), Jeffrey K. Kerns (572412), Hong Nie (2722792), Sharna J. Rich (1541815), Caroline Richardson (572406), William Rumsey (2375170), Yolanda Sanchez (213896), Marcel L. Verdonk (2079703), Henriëtte M. G. Willems (6634883), William E. Wixted (11614586), Lawrence Wolfe (6634886), Alison J.-A. Woolford (2074540), Zining Wu (440596), Thomas G. Davies (572415)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Pharmacology, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, Chemical Sciences not elsewhere classified, novel chemical series, mediated cytoprotective response, high target affinity, chemically distinct series, associated protein 1, original fragment screen, based drug discovery, guided discovery, based approaches, based activity, protein keap1, tool compound, risk projects, recently described, pharmacophoric information, pharmacological intervention, new lead, molecule activators, like ech

Relation: https://figshare.com/articles/dataset/Fragment-Guided_Discovery_of_Pyrazole_Carboxylic_Acid_Inhibitors_of_the_Kelch-like_ECH-Associated_Protein_1_Nuclear_Factor_Erythroid_2_Related_Factor_2_KEAP1_NRF2_Protein_Protein_Interaction/16890599

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01351.s002

المؤلفون: Zhuming Zhang (1846087), Avijit Ghosh (1428496), Peter J. Connolly (2456890), Peter King (234747), Thomas Wilde (6057116), Jianyao Wang (640348), Yawei Dong (2365990), Xueliang Li (585599), Daohong Liao (1393399), Hao Chen (5190), Gaochao Tian (2465608), Javier Suarez (2289811), William G. Bonnette (11173075), Vineet Pande (2538973), Karen A. Diloreto (11154645), Yifan Shi (4269262), Shefali Patel (11154648), Beth Pietrak (1940869), Lawrence Szewczuk (11154651), Carlo Sensenhauser (2181964), Shannon Dallas (7945637), James P. Edwards (2428411), Kurtis E. Bachman (5679542), David C. Evans (203487)

مصطلحات موضوعية: Biochemistry, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, adenoma progression, Colorectal Cancer, vivo 18 F-FDG uptake attenuation, efficacy proxy, survival extension, COX -2 inhibitors, COX -2-mediated CRC disease chemopr., colorectal adenomas, APC, exposure, chemoprotective effects, COX -2 inhibition, vivo dose-dependent inhibition

Relation: https://figshare.com/articles/dataset/Gut-Restricted_Selective_Cyclooxygenase_2_COX-2_Inhibitors_for_Chemoprevention_of_Colorectal_Cancer/15019023

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00890.s002

المؤلفون: Zhuming Zhang (1846087), Avijit Ghosh (1428496), Peter J. Connolly (2456890), Peter King (234747), Thomas Wilde (6057116), Jianyao Wang (640348), Yawei Dong (2365990), Xueliang Li (585599), Daohong Liao (1393399), Hao Chen (5190), Gaochao Tian (2465608), Javier Suarez (2289811), William G. Bonnette (11173075), Vineet Pande (2538973), Karen A. Diloreto (11154645), Yifan Shi (4269262), Shefali Patel (11154648), Beth Pietrak (1940869), Lawrence Szewczuk (11154651), Carlo Sensenhauser (2181964), Shannon Dallas (7945637), James P. Edwards (2428411), Kurtis E. Bachman (5679542), David C. Evans (203487)

مصطلحات موضوعية: Biochemistry, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, adenoma progression, Colorectal Cancer, vivo 18 F-FDG uptake attenuation, efficacy proxy, survival extension, COX -2 inhibitors, COX -2-mediated CRC disease chemopr., colorectal adenomas, APC, exposure, chemoprotective effects, COX -2 inhibition, vivo dose-dependent inhibition

Relation: https://figshare.com/articles/dataset/Gut-Restricted_Selective_Cyclooxygenase_2_COX-2_Inhibitors_for_Chemoprevention_of_Colorectal_Cancer/15019020

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00890.s001