المؤلفون: Xuan Zhou (329338), William F. Kiesman (1805011), Wuming Yan (1598086), Hong Jiang (79543), Firoz D. Antia (5748698), Jing Yang (13969), Yannick A. Fillon (2673004), Li Xiao (307908), Xianglin Shi (13689)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Biotechnology, Marine Biology, Chemical Sciences not elsewhere classified, ∼ 3 kg, reducing production time, manufacture large quantities, four additional tetra, novel convergent liquid, assembly steps demonstrated, similar impurity profile, scale convergent liquid, fragments containing tetra, phase oligonucleotide synthesis, applying standard full, convergent assembly, phase synthesis, standard solid, oligonucleotide therapeutics, g scale, impurity generation, impurity control, reactions made, purities suitable, provide oligonucleotides, pentamer fragments

Relation: https://figshare.com/articles/journal_contribution/Development_of_Kilogram-Scale_Convergent_Liquid-Phase_Synthesis_of_Oligonucleotides/17064241

الاتاحة: https://doi.org/10.1021/acs.joc.1c01756.s001

المؤلفون: Fredrik Haeffner, Thomas C. Pickel, April Hou, Donald G. Walker, William F. Kiesman, Xianglin Shi

المصدر: Chemistry – A European Journal. 29

مصطلحات موضوعية: Organic Chemistry, General Chemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af94956ab3c4a50e2087af9f574cf61
https://doi.org/10.1002/chem.202203331

المؤلفون: Hanspeter Matzinger, Vincent Couming, Daw-Iong Albert Kwok, Daniel Patience, Roman Kuhn, John Guzowski, Chaozhan Gu, Thiemo Stucki, Erwin Irdam, William F. Kiesman, Markus Stöckli, Michael Thut, Markus Grohmann, Michael Nonnenmacher, Benjamin Haefner, Wenli Liang, Robbie Chen, Paolangelo Cerea, Suzanne M. Opalka, Donald G. Walker, Stefan Sahli, Frederick Osei-Yeboah, Erin M. O’Brien, Joerg Lotz, Xin Zhang, Tamera Mack

المصدر: Organic Process Research & Development. 24:2814-2829

مصطلحات موضوعية: medicine.medical_specialty, Use dependent, 010405 organic chemistry, Manufacturing process, business.industry, Organic Chemistry, Late stage, 010402 general chemistry, medicine.disease, 01 natural sciences, 0104 chemical sciences, Sodium channel blocker, Trigeminal neuralgia, Internal medicine, medicine, Cardiology, Physical and Theoretical Chemistry, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::88a9364996ef756750c70c536e191a34
https://doi.org/10.1021/acs.oprd.0c00427

المؤلفون: Michael Williams, William F. Kiesman, Gerard M. P. Giblin, Adrian Heseltine, David T. MacPherson, James A. Ramsden, Ravi Vadali, David R Witty

المصدر: Organic Process Research & Development. 24:2802-2813

مصطلحات موضوعية: Use dependent, Sodium channel blocker, Chemistry, Proof of concept, Organic Chemistry, Physical and Theoretical Chemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b6912304c8c05f1fa22e5aed2df15343
https://doi.org/10.1021/acs.oprd.0c00382

المؤلفون: Chaomin Li, Yiqing Lin, John Guzowski, Lloyd Franklin, Brian T. Hopkins, Michael MacPhee, Daniel Patience, Bin Ma, Zheng Fengmei, Michael Humora, Robbie Chen, Erin M. O’Brien, George A. Moniz, William F. Kiesman, Steven Ferguson, Tamera Mack

المصدر: Organic Process Research & Development. 24:1199-1206

مصطلحات موضوعية: biology, 010405 organic chemistry, Process development, Chemistry, Scale (chemistry), Organic Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Scientific method, biology.protein, Bruton's tyrosine kinase, Process optimization, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c7697bd2139a22f282f464a8ae16c611
https://doi.org/10.1021/acs.oprd.0c00087

المؤلفون: Robert S. Gronke, Yannick Fillon, William F. Kiesman, Wuming Yan, Armin Delavari, Xuan Zhou, Li Xiao, Jing Yang, Hong Jiang, Firoz D. Antia, Xianglin Shi

مصطلحات موضوعية: Oligonucleotide, Computer science, Scalability, Convergent synthesis, Computational biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9c6498ee12b65a5e24a7c70aac319e21
https://doi.org/10.21203/rs.3.rs-594481/v1

المؤلفون: Lloyd Franklin, Brian T. Hopkins, Daniel Patience, Bin Ma, Chaomin Li, Tamera Mack, William F. Kiesman, Erin M. O’Brien, Robbie Chen

المصدر: ACS Symposium Series ISBN: 9780841298644
ACS Symposium Series

مصطلحات موضوعية: biology, Chemistry, Process development, biology.protein, Cancer research, Bruton's tyrosine kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4d85ab845f6794864aac7187a1c90157
https://doi.org/10.1021/bk-2020-1369.ch010

المؤلفون: Robbie Chen, Michael Williams, Erwin Irdam, William F. Kiesman, Erin M. O’Brien, David T. MacPherson, John Guzowski, Stefan Sahli, Daw-Iong Albert Kwok, Suzanne M. Opalka, Daniel Patience, Tamera Mack, Couming Vinny, David R. Witty, Gerard M. P. Giblin, Wenli Liang, Frederick Osei-Yeboah, Donald G. Walker

المصدر: ACS Symposium Series ISBN: 9780841298644
ACS Symposium Series

مصطلحات موضوعية: Use dependent, Sodium channel blocker, Chemistry, Pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2e4cceca12b83c7db91f5153ed597b3c
https://doi.org/10.1021/bk-2020-1369.ch001

المؤلفون: Austen Ng, Hong Jiang, Jimin Yang, William F. Kiesman, Firoz D. Antia, Xianglin Shi, Jessica A. Stolee, Yannick Fillon, Li Xiao

المصدر: The Journal of organic chemistry. 83(19)

مصطلحات موضوعية: 0301 basic medicine, In situ, Phosphorothioate Oligonucleotides, Base Sequence, Oligonucleotide, Chemistry, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, Solid-phase synthesis, Elongation, Solid-Phase Synthesis Techniques, Sulfur

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae14497101a4214bf00c1644673469a
https://pubmed.ncbi.nlm.nih.gov/30179468

المؤلفون: Magnus C. Eriksson, Marjorie Egan, Gerald A. Wächter, Margaret M. Faul, Zhihong Ge, Ingrid Mergelsberg, Mark D. Argentine, John D. Orr, Fred Hicks, William F. Kiesman, Maciej Smulkowski

المصدر: Organic Process Research & Development. 19:915-924

مصطلحات موضوعية: Active ingredient, Engineering management, Process (engineering), Manufacturing process, media_common.quotation_subject, Organic Chemistry, Good manufacturing practice, Quality (business), Business, Physical and Theoretical Chemistry, Commercialization, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e567bebccad0d66e50875bb34c959c98
https://doi.org/10.1021/acs.oprd.5b00079

المؤلفون: Nicholas Murray Thomson, John Lepore, Carla V. Luciani, Sushil K. Srivastava, Erwin Irdam, Robert A. Singer, Kevin D. Seibert, William F. Kiesman, Luke Schenck

المصدر: Organic Process Research & Development. 19:935-948

مصطلحات موضوعية: Upstream (petroleum industry), Process (engineering), Computer science, media_common.quotation_subject, Organic Chemistry, Control (management), Process design, Risk analysis (engineering), Order (business), Quality (business), Product (category theory), Physical and Theoretical Chemistry, Critical quality attributes, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::62c9cef8f5be7697fc374b346e5194b4
https://doi.org/10.1021/acs.oprd.5b00146

المؤلفون: Markus Grohmann, Hexi Chang, Daw-Iong Albert Kwok, Xianglin Shi, William F. Kiesman

المصدر: Organic Process Research & Development. 19:437-443

مصطلحات موضوعية: chemistry.chemical_classification, Recrystallization (geology), Hydrochloride, Organic Chemistry, Free base, Salt (chemistry), Methanesulfonic acid, Dimethylacetamide, chemistry.chemical_compound, chemistry, Impurity, Yield (chemistry), Organic chemistry, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::40381e08f18caf37ffff6cb8febf6c21
https://doi.org/10.1021/op5003903

المؤلفون: Kevin D. Seibert, Srinivas Tummala, Shailendra Bordawekar, Phenix Brian Dean, Daniel J. Kumke, Nicholas Murray Thomson, Erwin Irdam, William F. Kiesman

المصدر: Organic Process Research & Development. 19:925-934

مصطلحات موضوعية: Computer science, business.industry, media_common.quotation_subject, Organic Chemistry, Laboratory scale, Commercialization, Manufacturing engineering, Product lifecycle, Quality (business), Physical and Theoretical Chemistry, business, Design space, media_common, Pharmaceutical industry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8c1ad534e4483ae4c3cb39fd22a07fdf
https://doi.org/10.1021/op500187u

المؤلفون: Margaret M. Faul, Fred Hicks, William F. Kiesman, Maciej Smulkowski, John D. Orr, Carl A. Busacca, Steven Pfeiffer, Magnus C. Eriksson

المصدر: Organic Process Research & Development. 18:594-600

مصطلحات موضوعية: Knowledge management, business.industry, Process (engineering), media_common.quotation_subject, Organic Chemistry, Control (management), Late stage, Quality (business), Physical and Theoretical Chemistry, business, Commercialization, Pharmaceutical industry, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6193f367ef1597440423f9b56d87e9b0
https://doi.org/10.1021/op5000607

المؤلفون: Steven Pfeiffer, John D. Orr, Maciej Smulkowski, Carl A. Busacca, Fred Hicks, William F. Kiesman, Margaret M. Faul, Magnus C. Eriksson

المصدر: Organic Process Research & Development. 18:587-593

مصطلحات موضوعية: Knowledge management, Process (engineering), business.industry, media_common.quotation_subject, Interpretation (philosophy), Organic Chemistry, Perspective (graphical), Quality (business), Context (language use), Business, Physical and Theoretical Chemistry, Commercialization, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1355b3d28d0a557d2664084e6c5cc122
https://doi.org/10.1021/op500059k

المؤلفون: Ahmed F. Abdel-Magid, Jaan A. Pesti, Rajappa Vaidyanathan, Debra J. Wallace, Ian Mangion, Paul Coleman, Seb Caille, John G. Allen, Xianglin Shi, William F. Kiesman, Donald G. Walker, Hidenori Takahashi, Alessandra Bartolozzi, Thomas Simpson, Keith Fandrick, Jason Mulder, Jean-Nicolas Desrosiers, Nitin Patel, Xingzhong Zeng, Daniel Fandrick, Carl A. Busacca, Jinhua J. Song, Chris H. Senanayake, Timothy P. Heffron, Andrew McClory, Andreas Stumpf, Jason D. Burch, Benjamin D. Sherry, Donald R. Gauthier, Louis-Charles Campeau, Jessica E. Reed, Jeff B. Smaill, Shu Yu, Olivier Dirat, Jed L. Hubbs, Nathan O. Fuller, Wesley F. Austin, Ruichao Shen, Brian S. Bronk, Gerald J. Tanoury, Stephen Eastham, Cristian L. Harrison, Benjamin J. Littler, Piero L. Ruggiero, Zhifeng Ye, Anne-Laure Grillo

Resource Type: eBook.

الموضوعات: Chemistry, Pharmaceutical--methods, Drug Discovery, Technology, Pharmaceutical, Pharmaceutical Preparations--chemistry

Categories: MEDICAL / Pharmacy, SCIENCE / Chemistry / Clinical, SCIENCE / Chemistry / Inorganic

المؤلفون: William F. Kiesman, John Guzowski, Michael Humora, Albert Kwok, Edward J. Delaney, Erwin Irdam, Amy D. Moran

المصدر: Organic Process Research & Development. 16:232-239

مصطلحات موضوعية: chemistry.chemical_classification, organic chemicals, Carboxylic acid, fungi, Organic Chemistry, Sulfuric acid, Catalysis, chemistry.chemical_compound, Dimethyl sulfate, Reaction rate constant, chemistry, Yield (chemistry), Organic chemistry, Dimethyl ether, Methanol, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fdff3b6d30675c2b48aa5c6bce465cf4
https://doi.org/10.1021/op200323j

المؤلفون: Xianglin Shi, William F. Kiesman, Donald G. Walker

المصدر: Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1 ISBN: 9780841231894
Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1

مصطلحات موضوعية: biology, Chemistry, biology.protein, Cancer research, Hsp90

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e599c46e7383fbb502c1418964f5bebf
https://doi.org/10.1021/bk-2016-1239.ch003

المؤلفون: William F. Kiesman, Petter Russell C, Hexi Chang

المصدر: Synthetic Communications. 37:1267-1272

مصطلحات موضوعية: chemistry.chemical_compound, Adenosine A1 receptor, chemistry, Bicyclic molecule, Yield (chemistry), Organic Chemistry, Antagonist, Organic chemistry, Combinatorial chemistry, Octane

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ae859c8587b0e1464e397e45fec52ffe
https://doi.org/10.1080/00397910701216120

المؤلفون: Patrick Conlon, William F. Kiesman

المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 50:219-223

مصطلحات موضوعية: chemistry.chemical_classification, Bicyclic molecule, Stereochemistry, Carboxylic acid, Organic Chemistry, Antagonist, Uracil, Biochemistry, Adenosine, Chemical synthesis, Analytical Chemistry, chemistry.chemical_compound, Adenosine A1 receptor, chemistry, In vivo, Drug Discovery, medicine, Radiology, Nuclear Medicine and imaging, Spectroscopy, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::97e6c05690ade4dfca4aa30a17907921
https://doi.org/10.1002/jlcr.1237