المؤلفون: Munjal Patel, Francesco Bellanti, Naveen M. Daryani, Nadia Noormohamed, David W. Hilbert, Katherine Young, Pooja Kulkarni, William Copalu, Ferdous Gheyas, Matthew L. Rizk

المصدر: Clinical and Translational Science, Vol 15, Iss 2, Pp 396-408 (2022)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

URL الوصول: https://doaj.org/article/2fe004e1c4e6439c87c133441ff0e7a8

المؤلفون: Pratik Bhagunde, Parul Patel, Mallika Lala, Kenny Watson, William Copalu, Ming Xu, Pooja Kulkarni, Katherine Young, Matthew L. Rizk

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 10, Pp 748-758 (2019)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2163-8306

URL الوصول: https://doaj.org/article/16930bafa9fd42f6b4ceaac5cf976f1b

المؤلفون: Katherine Young, Pratik Bhagunde, Matthew L. Rizk, Mallika Lala, Kenny Watson, Ming Xu, Pooja Kulkarni, William Copalu, Parul Patel

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 10, Pp 748-758 (2019)
CPT: Pharmacometrics & Systems Pharmacology

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Imipenem, Population, Renal function, Gastroenterology, Models, Biological, Article, Minimum inhibitory concentration, Young Adult, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Dosing, education, Aged, Aged, 80 and over, education.field_of_study, Clinical Trials as Topic, Cilastatin, business.industry, Research, lcsh:RM1-950, Area under the curve, Bacterial Infections, Articles, Middle Aged, Anti-Bacterial Agents, Drug Combinations, Renal Elimination, lcsh:Therapeutics. Pharmacology, Modeling and Simulation, Case-Control Studies, Creatinine, Administration, Intravenous, Female, business, Azabicyclo Compounds, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c749aed133b13b2a9aea9e58cf0414b5
https://doaj.org/article/16930bafa9fd42f6b4ceaac5cf976f1b

المؤلفون: Anthe S. Z, Mats O. Karlsson, Jan H. M. Schellens, William Copalu, Jos H. Beijnen, Alwin D. R. Huitema, M. O. Karlsson, J. H. M. Schellens, W. Copalu

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7f/b0/Invest_New_Drugs_2010_Feb_6_28(1)_61-75.tar.gz

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.7535

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.7535

المؤلفون: Petronella O. Witteveen, Larisa Reyderman, Jantien Wanders, Serena Marchetti, Kenneth Law, Fuping Peng, Jos H. Beijnen, Emile E. Voest, Alwin D. R. Huitema, Jan H.M. Schellens, William Copalu, Lot A. Devriese, Geoff Edwards

المصدر: British Journal of Clinical Pharmacology. 75:507-521

مصطلحات موضوعية: Pharmacology, Eribulin Mesylate, medicine.medical_specialty, business.industry, Cmax, Neutropenia, medicine.disease, Gastroenterology, Metastatic breast cancer, chemistry.chemical_compound, Pharmacokinetics, chemistry, Internal medicine, medicine, Pharmacology (medical), Adverse effect, business, Rifampicin, medicine.drug, Eribulin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8e706dd9c322ac8ae6632dd938f8174c
https://doi.org/10.1111/j.1365-2125.2012.04381.x

المؤلفون: Yves Kibleur, Corinna Tissen, William Copalu, Nathalie Guffon, Joerg Breitkreutz

المصدر: Archives of Disease in Childhood. 97:1081-1085

مصطلحات موضوعية: Adult, Male, Chemistry, Pharmaceutical, Biological Availability, Stimulation, Bioequivalence, Pharmacology, Young Adult, Pharmacokinetics, In vivo, Taste receptor, Humans, Medicine, business.industry, Sodium phenylbutyrate, Middle Aged, Ageusia, Phenylbutyrates, Therapeutic Equivalency, Tolerability, Taste, Anesthesia, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7fc8e1dd263b6f7cf50d15289be9cc
https://doi.org/10.1136/archdischild-2012-302398

المؤلفون: William Copalu, A. Mazur, Jantien Wanders, M Keesen, R. Morrison, D. S. Boss, Jos H. Beijnen, J P O'Brien, Jan H.M. Schellens, Hilary Glen, Thomas J. Evans, B Tait

المصدر: British Journal of Cancer

مصطلحات موضوعية: Adult, Male, Cancer Research, medicine.medical_specialty, Maximum Tolerated Dose, medicine.drug_class, Biology, Tyrosine-kinase inhibitor, Internal medicine, Neoplasms, Protein-Tyrosine Kinases, medicine, Humans, In patient, Protein Kinase Inhibitors, solid tumours, Aged, Aged, 80 and over, Phenylurea Compounds, receptor tyrosine kinase inhibitor, phase I, Middle Aged, Phase i study, Clinical trial, Endocrinology, Oncology, Maximum tolerated dose, dose escalation, Cancer research, Clinical Study, Quinolines, E7080, Female, pharmacokinetics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829756bf3d74dbdd2f3e8f13873b85b4
http://europepmc.org/articles/PMC3349182

المؤلفون: Anthe S. Zandvliet, Alwin D. R. Huitema, William Copalu, Jos H. Beijnen, Jan H.M. Schellens, Mats O. Karlsson

المصدر: Investigational New Drugs

مصطلحات موضوعية: Optimal design, Oncology, medicine.medical_specialty, Phase I trial design, Modeling and simulation, Antineoplastic Agents, Pharmacology, Neutropenia, Pharmacokinetics, Phase I Studies, Internal medicine, Dose escalation, Humans, Medicine, Computer Simulation, Pharmacology (medical), Dose finding, Pharmaceutical sciences, Stage (cooking), Sulfonamides, Models, Statistical, Clinical Trials, Phase I as Topic, Dose-Response Relationship, Drug, business.industry, Clinical study design, medicine.disease, Pharmacodynamics, Drug Design, Toxicity, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c92abed6b82ae098b8d9e3838835f8
https://doi.org/10.1007/s10637-008-9216-2

المؤلفون: Alwin D. R. Huitema, Jos H. Beijnen, Jan H.M. Schellens, William Copalu, Anthe S. Zandvliet

المصدر: Drug Metabolism and Disposition. 34:1041-1046

مصطلحات موضوعية: Erythrocytes, Pharmaceutical Science, Antineoplastic Agents, Plasma protein binding, In Vitro Techniques, Models, Biological, Carbonic anhydrase, Blood plasma, medicine, Humans, Carbon Radioisotopes, Serum Albumin, Carbonic Anhydrases, Whole blood, Pharmacology, Sulfonamides, Clinical Trials, Phase I as Topic, biology, Chemistry, Erythrocyte Membrane, Albumin, Blood proteins, Dissociation constant, Red blood cell, medicine.anatomical_structure, Biochemistry, biology.protein, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae702c7f848c75aa46e97ccd03501fb
https://doi.org/10.1124/dmd.105.008326

المؤلفون: William Copalu, Lot A. Devriese, Larisa Reyderman, Jos H. Beijnen, Marja Mergui-Roelvink, Jantien Wanders, Serena Marchetti, A. Jenner, G. Edwards, F. Peng, Jan H.M. Schellens

المصدر: Investigational new drugs. 31(2)

مصطلحات موضوعية: Eribulin Mesylate, Male, Antifungal Agents, Maximum Tolerated Dose, Nausea, Cmax, Administration, Oral, Pharmacology, chemistry.chemical_compound, Pharmacokinetics, Oral administration, Neoplasms, Medicine, Humans, Pharmacology (medical), Tissue Distribution, Adverse effect, Furans, Infusions, Intravenous, Aged, Dose-Response Relationship, Drug, business.industry, Ketones, Middle Aged, Prognosis, Ketoconazole, Oncology, chemistry, Female, medicine.symptom, business, Eribulin, medicine.drug, Follow-Up Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3aeb4ce8b922ce1b4bc8e1b6b94cbf
https://pubmed.ncbi.nlm.nih.gov/22555773

المؤلفون: Lot A, Devriese, Petronella Els O, Witteveen, Jantien, Wanders, Kenneth, Law, Geoff, Edwards, Larisa, Reyderman, William, Copalu, Fuping, Peng, Serena, Marchetti, Jos H, Beijnen, Alwin D R, Huitema, Emile E, Voest, Jan H M, Schellens

المصدر: British journal of clinical pharmacology. 75(2)

مصطلحات موضوعية: Adult, Male, Administration, Oral, Antimitotic Agents, Ketones, Middle Aged, Microtubules, White People, Asian People, Area Under Curve, Neoplasms, Humans, Drug Interactions, Female, Enzyme Inhibitors, Rifampin, Furans, Aged

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::3aa1230d2d603b3ae6faafff3598c1e3
https://pubmed.ncbi.nlm.nih.gov/22803519

المؤلفون: Anthe S. Zandvliet, A. D. R. Huitema, M.-C. Etienne-Grimaldi, Jan H.M. Schellens, Jos H. Beijnen, G. Milano, William Copalu, W. S. Siegel-Lakhai

المصدر: Clinical pharmacology and therapeutics. 83(6)

مصطلحات موضوعية: Adult, Male, Neutropenia, Pharmacology, Deoxycytidine, Models, Biological, Drug Administration Schedule, Capecitabine, Pharmacokinetics, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Pharmacology (medical), Drug Interactions, CYP2C9, PK/PD models, Aged, Sulfonamides, business.industry, Prodrug, Middle Aged, medicine.disease, NONMEM, Pharmacodynamics, Female, Fluorouracil, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c044ae6d141d41a1999a79dbf56ea977
https://pubmed.ncbi.nlm.nih.gov/17851564

المؤلفون: William Copalu, Anthe S. Zandvliet, Jos H. Beijnen, Jan H.M. Schellens, Alwin D. R. Huitema, Yasuhide Yamada, Tomohide Tamura

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research. 13(10)

مصطلحات موضوعية: Adult, Male, Risk, Cancer Research, Population, Antineoplastic Agents, CYP2C19, Neutropenia, Pharmacology, Biology, Mixed Function Oxygenases, Pharmacokinetics, Neoplasms, medicine, Humans, Allele, education, CYP2C9, Aged, Cytochrome P-450 CYP2C9, Aged, 80 and over, education.field_of_study, Sulfonamides, Polymorphism, Genetic, Genome, Human, Middle Aged, medicine.disease, Cytochrome P-450 CYP2C19, Oncology, Liver, Toxicity, Female, Aryl Hydrocarbon Hydroxylases, Pharmacogenetics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63f8863794205a2ad849a4d78e544dc
https://pubmed.ncbi.nlm.nih.gov/17504998

المؤلفون: William Copalu, Alwin D. R. Huitema, Jos H. Beijnen, Jan H.M. Schellens, Anthe S. Zandvliet

المصدر: Journal of pharmacokinetics and pharmacodynamics. 33(5)

مصطلحات موضوعية: Erythrocytes, Metabolic Clearance Rate, Population, Antineoplastic Agents, Hematocrit, Pharmacology, Models, Biological, White People, Blood cell, Pharmacokinetics, Asian People, Interstitial fluid, Blood plasma, medicine, Humans, Computer Simulation, Tissue Distribution, education, Carbonic Anhydrases, education.field_of_study, Sulfonamides, medicine.diagnostic_test, Clinical Trials, Phase I as Topic, Dose-Response Relationship, Drug, Chemistry, Extracellular Fluid, Blood Proteins, NONMEM, Red blood cell, medicine.anatomical_structure, Biochemistry, Area Under Curve, Multivariate Analysis, Regression Analysis, Algorithms, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a71da5ed0c3d72c005871216fb884c1
https://pubmed.ncbi.nlm.nih.gov/16946998

المؤلفون: Distribution To Human Erythrocytes, Anthe S. Z, William Copalu, Jan H. M. Schellens, Jos H. Beijnen, Alwin D. R, Anthe Zandvliet

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://dmd.aspetjournals.org/content/early/2006/03/24/dmd.105.008326.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.565.5080; http://dmd.aspetjournals.org/content/early/2006/03/24/dmd.105.008326.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.565.5080
http://dmd.aspetjournals.org/content/early/2006/03/24/dmd.105.008326.full.pdf

المؤلفون: Anthe S. Z, Alwin D. R. Huitema, William Copalu, Yasuhide Yamada, Tomohide Tamura, Jos H. Beijnen, Jan H. M. Schellens

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://clincancerres.aacrjournals.org/cgi/reprint/13/10/2970.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.127.8415; http://clincancerres.aacrjournals.org/cgi/reprint/13/10/2970.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.127.8415
http://clincancerres.aacrjournals.org/cgi/reprint/13/10/2970.pdf

المؤلفون: J.H.M. Schellens, J. H. Beijnen, Serena Marchetti, A. Jenner, L. Reyderman, William Copalu, F. Peng, Jantien Wanders, G. Edwards, L. Deviese

المصدر: European Journal of Cancer Supplements. 8:181

مصطلحات موضوعية: Eribulin Mesylate, Cancer Research, Oncology, Pharmacokinetics, business.industry, Medicine, In patient, Ketoconazole, Pharmacology, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a73a884b3b7d3da801e28a8f8ffc4019
https://doi.org/10.1016/s1359-6349(10)72281-3

المؤلفون: Petronella O. Witteveen, E. E. Voest, A. Jenner, Larisa Reyderman, Serena Marchetti, J.H.M. Schellens, Jantien Wanders, Marja Mergui-Roelvink, G. Edwards, William Copalu

المصدر: Journal of Clinical Oncology. 28:2582-2582

مصطلحات موضوعية: Eribulin Mesylate, Cancer Research, medicine.medical_specialty, business.industry, Hepatic impairment, Pharmacology, medicine.disease, Gastroenterology, Metastatic breast cancer, chemistry.chemical_compound, Oncology, chemistry, Mechanism of action, Pharmacokinetics, Internal medicine, medicine, In patient, medicine.symptom, Lung cancer, business, Eribulin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c2ac9b37e482246f82b66b18c9ca350d
https://doi.org/10.1200/jco.2010.28.15_suppl.2582

المؤلفون: Anthe Zandvliet, William Copalu, Alwin Huitema

المصدر: Journal of Pharmacokinetics & Pharmacodynamics; Feb2009, Vol. 36 Issue 1, p39-62, 24p

المؤلفون: Anthe Zandvliet, Jan Schellens, William Copalu, Jos Beijnen, Alwin Huitema

المصدر: Journal of Pharmacokinetics & Pharmacodynamics; Oct2006, Vol. 33 Issue 5, p543-570, 28p