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المؤلفون: Alan D. Borthwick, Marie Charbaut, Robert J. Young, Máire A. Convery, Ivan Leo Pinto, Andrew M. Mason, Weston Helen Elisabeth, Matthew Campbell, David W. Brown, Anthony J. Pateman, Henry Anderson Kelly, Derek Pollard, Shah Gita Punjabhai, John R. Toomey, N. Paul King, Stefan Senger, Eric Hortense, Ping Zhou, Hawa Diallo, Nigel S. Watson, Wendy R. Irving, Angela Patikis, Cynthia L. Burns-Kurtis, Savvas Kleanthous, Chuen Chan
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:28-33
مصطلحات موضوعية: Male, Models, Molecular, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Antithrombotic Agent, Tertiary amine, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Coagulation Factor Xa, Pharmaceutical Science, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Anticoagulants, Stereoisomerism, Bridged Bicyclo Compounds, Heterocyclic, Thiophene derivatives, Pyrrolidinones, Rats, Sulfonamide, Enzyme inhibitor, biology.protein, Molecular Medicine, Hydrophobic and Hydrophilic Interactions, Factor Xa Inhibitors
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9Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs
المؤلفون: N. Paul King, Stefan Senger, Matthew Campbell, Henry Anderson Kelly, Máire A. Convery, David W. Brown, Shah Gita Punjabhai, Angela Patikis, Cynthia L. Burns-Kurtis, Savvas Kleanthous, Marie Charbaut, Alan D. Borthwick, Ivan Leo Pinto, Weston Helen Elisabeth, John R. Toomey, Chuen Chan, Chun-wa Chung, Robert J. Young, Nigel S. Watson, Derek Pollard, Andrew M. Mason, Anthony J. Pateman
المصدر: Bioorganicmedicinal chemistry letters. 18(1)
مصطلحات موضوعية: Male, Models, Molecular, Quantitative structure–activity relationship, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Pharmaceutical Science, Biochemistry, Chemical synthesis, Sulfone, Rats, Sprague-Dawley, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Molecular Biology, Sulfonamides, Blood clotting, biology, Chemistry, Organic Chemistry, Anticoagulants, Pyrrolidinones, Rats, Enzyme inhibitor, Drug Design, Lipophilicity, biology.protein, Lactam, Molecular Medicine, Factor Xa Inhibitors
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المؤلفون: Robert J. Young, Alan D. Borthwick, Nigel S. Watson, Weston Helen Elisabeth, Chun-wa Chung, J. Nicole Hamblin, Chuen Chan, Anthony J. Pateman, Savvas Kleanthous, Laiq Chaudry, Shah Gita Punjabhai, David W. Brown, Matthew Campbell, Champa Patel, Máire A. Convery, Stefan Senger, Lisa Johnstone, Angela Patikis, Cynthia L. Burns-Kurtis, Henry Anderson Kelly, Caroline Whitworth, Ping Zhou, John R. Toomey
المصدر: Journal of medicinal chemistry. 50(7)
مصطلحات موضوعية: Male, Models, Molecular, Pyrrolidines, Molecular model, medicine.drug_mechanism_of_action, Stereochemistry, medicine.drug_class, Morpholines, Factor Xa Inhibitor, Carboxamide, Crystallography, X-Ray, Ligands, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Drug Discovery, medicine, Animals, Humans, Binding site, Serum Albumin, Sulfonamides, Bicyclic molecule, biology, Molecular Structure, Chemistry, Anticoagulants, Stereoisomerism, Human serum albumin, Rats, Enzyme inhibitor, Lipophilicity, Factor Xa, biology.protein, Prothrombin Time, Molecular Medicine, Female, medicine.drug, Factor Xa Inhibitors, Protein Binding
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المؤلفون: Matthew Campbell, Ping Zhou, Robert J. Young, Weston Helen Elisabeth, Savvas Kleanthous, David W. Brown, Champa Patel, Satish Dayal, Shah Gita Punjabhai, Alan D. Borthwick, N. Paul King, Cynthia L. Burns-Kurtis, Stefan Senger, Hawa Diallo, Máire A. Convery, Nigel S. Watson, Paul W. Smith, Henry Anderson Kelly, Miriam Crowe, Chuen Chan, Anthony J. Pateman, Jackie E. Mordaunt, Andrew M. Mason
المصدر: Bioorganicmedicinal chemistry letters. 16(23)
مصطلحات موضوعية: Models, Molecular, medicine.drug_mechanism_of_action, Molecular model, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Antithrombin III, Substituent, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Amide, Drug Discovery, Hydrolase, medicine, Pyrroles, Molecular Biology, chemistry.chemical_classification, Alanine, Binding Sites, Molecular Structure, Organic Chemistry, Anticoagulants, Amides, Sulfonamide, chemistry, Drug Design, Lipophilicity, Factor Xa, Molecular Medicine
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المؤلفون: Vipulkumar Kantibhai Patel, Máire A. Convery, J. Nicole Hamblin, Andrew M. Mason, Andrew R. Leach, N. Paul King, Shah Gita Punjabhai, Stefan Senger, Laiq Chaudry, Caroline Whitworth, Rebecca Fenwick, Robert J. Young, Matthew Campbell, Cynthia L. Kurtis, Claudine Haslam, Henry Anderson Kelly, Champa Patel, Weston Helen Elisabeth, Charlotte Jane Mitchell, David W. Brown, Gary R. Manchee, Nigel S. Watson, Chuen Chan
المصدر: Bioorganicmedicinal chemistry letters. 16(14)
مصطلحات موضوعية: Male, medicine.drug_mechanism_of_action, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Antithrombin III, Pharmaceutical Science, Administration, Oral, Biological Availability, Carboxamide, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Pharmacokinetics, Fibrinolytic Agents, Oral administration, Drug Discovery, medicine, Animals, Rats, Wistar, Molecular Biology, Bicyclic molecule, biology, Chemistry, Organic Chemistry, Thrombin, Pyrrolidinones, Rats, Enzyme inhibitor, Lactam, biology.protein, Molecular Medicine