المؤلفون: Tambe, Mahesh, Unterberger, Sarah, Kriegbaum, Mette C., Vänttinen, Ida, Olgac, Ezgi June, Vähä-Koskela, Markus, Kontro, Mika, Wennerberg, Krister, Heckman, Caroline A.

المصدر: Tambe , M , Unterberger , S , Kriegbaum , M C , Vänttinen , I , Olgac , E J , Vähä-Koskela , M , Kontro , M , Wennerberg , K & Heckman , C A 2024 , ' Venetoclax triggers sublethal apoptotic signaling in venetoclax-resistant acute myeloid leukemia cells and induces vulnerability to PARP inhibition and azacitidine ' , Cell Death and Disease , vol. 15 , no. 10 , 750 . https://doi.org/10.1038/s41419-024-07140-4

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/venetoclax-triggers-sublethal-apoptotic-signaling-in-venetoclaxresistant-acute-myeloid-leukemia-cells-and-induces-vulnerability-to-parp-inhibition-and-azacitidine(fc08121e-948b-4905-8963-b47db29c68d0).html
https://doi.org/10.1038/s41419-024-07140-4
https://curis.ku.dk/ws/files/410169106/s41419_024_07140_4.pdf

المؤلفون: Avenel, Inès C.N., Ewald, Jesper D., Ariey-Bonnet, Jérémy, Kristensen, Ida H., Petterson, Stine A., Thesbjerg, Martin N., Burton, Mark, Thomassen, Mads, Wennerberg, Krister, Michaelsen, Signe R., Kristensen, Bjarne W.

المصدر: Avenel , I C N , Ewald , J D , Ariey-Bonnet , J , Kristensen , I H , Petterson , S A , Thesbjerg , M N , Burton , M , Thomassen , M , Wennerberg , K , Michaelsen , S R & Kristensen , B W 2024 , ' GDNF/GFRA1 signaling contributes to chemo- and radioresistance in glioblastoma ' , Scientific Reports , vol. 14 , no. 1 , 17639 . https://doi.org/10.1038/s41598-024-68626-x

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/gdnfgfra1-signaling-contributes-to-chemo-and-radioresistance-in-glioblastoma(f0555591-63b1-4266-a87e-4359d85f01d5).html
https://doi.org/10.1038/s41598-024-68626-x
https://curis.ku.dk/ws/files/401617987/s41598_024_68626_x.pdf

المؤلفون: Ianevski, Aleksandr, Nader, Kristen, Driva, Kyriaki, Senkowski, Wojciech, Bulanova, Daria, Moyano-Galceran, Lidia, Ruokoranta, Tanja, Kuusanmäki, Heikki, Ikonen, Nemo, Sergeev, Philipp, Vähä-Koskela, Markus, Giri, Anil K., Vähärautio, Anna, Kontro, Mika, Porkka, Kimmo, Pitkänen, Esa, Heckman, Caroline A., Wennerberg, Krister, Aittokallio, Tero

المصدر: Ianevski , A , Nader , K , Driva , K , Senkowski , W , Bulanova , D , Moyano-Galceran , L , Ruokoranta , T , Kuusanmäki , H , Ikonen , N , Sergeev , P , Vähä-Koskela , M , Giri , A K , Vähärautio , A , Kontro , M , Porkka , K , Pitkänen , E , Heckman , C A , Wennerberg , K & Aittokallio , T 2024 , ' Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones ' , Nature Communications , vol. 15 , ....

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/singlecell-transcriptomes-identify-patienttailored-therapies-for-selective-coinhibition-of-cancer-clones(8ea9e10e-5c69-43fe-b849-465233a6e4ae).html
https://doi.org/10.1038/s41467-024-52980-5
https://curis.ku.dk/ws/files/410165536/s41467_024_52980_5.pdf

المؤلفون: Adnan Awad, Shady, Dufva, Olli, Klievink, Jay, Karjalainen, Ella, Ianevski, Aleksandr, Pietarinen, Paavo, Kim, Daehong, Potdar, Swapnil, Wolf, Maija, Lotfi, Kourosh, Aittokallio, Tero, Wennerberg, Krister, Porkka, Kimmo, Mustjoki, Satu

المساهمون: TRIMM - Translational Immunology Research Program, Department of Clinical Chemistry and Hematology, HUS Comprehensive Cancer Center, Hematologian yksikkö, University of Helsinki, Digital Precision Cancer Medicine (iCAN), Department of Oncology, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Computational Systems Medicine, Medicum, Helsinki Institute for Information Technology, Tero Aittokallio / Principal Investigator, Bioinformatics, Clinicum

مصطلحات موضوعية: BCR::ABL1-independent resistance, CML, CRISPR-Cas9 screening, drug combination, drug repurposing, drug screening, KCTD5, progenitor, stem cell, TKI, Biomedicine, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: This work was supported by the Academy of Finland (grant nos. 292605 , 287224 , 310507 , 313267 , and 326238 ); a Finnish special governmental subsidy for health sciences, research, and training; the Signe and Ane Gyllenberg Foundation; the Finnish Cancer Institute; the Nordic Cancer Union; the Helsinki Institute of Life Science; Cancer Foundation Finland; the Relander Foundation; the EUTOS project for CML 2022; a Pfizer investigator initiated research grant; the European Union\u2019s Horizon Europe Research & Innovation Programme (REMEDi4ALL project, grant agreement no. 101057442 ); the Cancer Society of Finland; and the Sigrid Jus\u00E9lius Foundation . The FIMM-HTB unit is supported by the University of Helsinki , HiLIFE , and Biocenter Finland .; Adnan Awad , S , Dufva , O , Klievink , J , Karjalainen , E , Ianevski , A , Pietarinen , P , Kim , D , Potdar , S , Wolf , M , Lotfi , K , Aittokallio , T , Wennerberg , K , Porkka , K & Mustjoki , S 2024 , ' Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia ' , Cell Reports Medicine , vol. 5 , no. 5 , 101521 . https://doi.org/10.1016/j.xcrm.2024.101521; ORCID: /0000-0002-7780-482X/work/167512377; ORCID: /0000-0002-0816-8241/work/167513135; ORCID: /0000-0003-4112-5902/work/167513683; ORCID: /0000-0002-1253-8946/work/167513801; ORCID: /0000-0002-0886-9769/work/167514805; ORCID: /0000-0002-2778-6918/work/167517884; http://hdl.handle.net/10138/585585; 337c68cc-2b11-44ac-94b7-64072220e331; 85192488855; 001301443700001

الاتاحة: http://hdl.handle.net/10138/585585

المؤلفون: Kuusanmäki, Heikki, Dufva, Olli, Vähä-Koskela, Markus, Leppä, Aino-Maija, Huuhtanen, Jani, Vänttinen, Ida, Nygren, Petra, Klievink, Jay, Bouhlal, Jonas, Pölönen, Petri, Zhang, Qi, Adnan-Awad, Shady, Mancebo-Pérez, Cristina, Saad, Joseph, Miettinen, Juho, Javarappa, Komal K., Aakko, Sofia, Ruokoranta, Tanja, Eldfors, Samuli, Heinäniemi, Merja, Theilgaard-Mönch, Kim, Wartiovaara-Kautto, Ulla, Keränen, Mikko, Porkka, Kimmo, Konopleva, Marina, Wennerberg, Krister, Kontro, Mika, Heckman, Caroline A., Mustjoki, Satu

المساهمون: Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, TRIMM - Translational Immunology Research Program, Department of Clinical Chemistry and Hematology, HUS Comprehensive Cancer Center, Department of Oncology, Digital Precision Cancer Medicine (iCAN), Medicum, Hematologian yksikkö, Research Programs Unit, Clinicum, Faculty Common Matters (Faculty of Medicine), Department of Medicine, Krister Wennerberg / Principal Investigator

مصطلحات موضوعية: Acute megakaryoblastic leukemia, Acute megakaryocytic leukemia, Cancer, Cell-death, Erythropoietin, Expression, Gene, Inhibitor, Transcription factor, World-health-organization, Cancers

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10138/571955; 85147217903; 000969347500001

الاتاحة: http://hdl.handle.net/10138/571955

المؤلفون: Bulanova, Daria, Akimov, Yevhen, Senkowski, Wojciech, Oikkonen, Jaana, Gall-Mas, Laura, Timonen, Sanna, Elmadani, Manar, Hynninen, Johanna, Hautaniemi, Sampsa, Aittokallio, Tero, Wennerberg, Krister

المصدر: Bulanova , D , Akimov , Y , Senkowski , W , Oikkonen , J , Gall-Mas , L , Timonen , S , Elmadani , M , Hynninen , J , Hautaniemi , S , Aittokallio , T & Wennerberg , K 2024 , ' A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells ' , Science Advances , vol. 10 , no. 21 , eadj1564 . https://doi.org/10.1126/sciadv.adj1564

وصف الملف: application/pdf

الاتاحة: https://curis.ku.dk/portal/da/publications/a-synthetic-lethal-dependency-on-casein-kinase-2-in-response-to-replicationperturbing-therapeutics-in-rb1deficient-cancer-cells(d2111454-7fee-4e63-8dcc-70ad6cbcf007).html
https://doi.org/10.1126/sciadv.adj1564
https://curis.ku.dk/ws/files/395024330/sciadv.adj1564.pdf

المؤلفون: Ayuda Duran, Pilar, Hermansen, Johanne Uthus, Giliberto, Mariaserena, Yin, Yanping, Hanes, Robert, Gordon, Sandra, Kuusanmäki, Heikki, Brodersen, Andrea M, Andersen, Aram Nikolai, Tasken, Kjetil, Wennerberg, Krister, Enserink, Jorrit, Skånland, Sigrid S

المصدر: 2058-7716.

Relation: NFR/328827; NFR/294916; SKGJ/Grant 19, Jebsen Ctr. B cell malignancies; HSØ/2015031; NFR/262652; EC/H2020/847912; NFR/322898; KF/182524; KF/208012; HSØ/2019096; OTHER/Danish Cancer Society grant no. R223-A13071; HSØ/2018012; Ayuda Duran, Pilar Hermansen, Johanne Uthus Giliberto, Mariaserena Yin, Yanping Hanes, Robert Gordon, Sandra Kuusanmäki, Heikki Brodersen, Andrea M Andersen, Aram Nikolai Tasken, Kjetil Wennerberg, Krister Enserink, Jorrit Skånland, Sigrid S . Standardized assays to monitor drug sensitivity in hematologic cancers. Cell death discovery. 2023, 9(1); http://hdl.handle.net/10852/107295; 2198814; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell death discovery&rft.volume=9&rft.spage=&rft.date=2023; Cell death discovery; https://doi.org/10.1038/s41420-023-01722-5

الاتاحة: http://hdl.handle.net/10852/107295
https://doi.org/10.1038/s41420-023-01722-5

المؤلفون: Potdar, Swapnil, Ianevski, Filipp, Ianevski, Aleksandr, Tanoli, Ziaurrehman, Wennerberg, Krister, Seashore-Ludlow, Brinton, Kallioniemi, Olli, Ostling, Paivi, Aittokallio, Tero Antero, Saarela, Jani

المصدر: 0305-1048.

Relation: Potdar, Swapnil Ianevski, Filipp Ianevski, Aleksandr Tanoli, Ziaurrehman Wennerberg, Krister Seashore-Ludlow, Brinton Kallioniemi, Olli Ostling, Paivi Aittokallio, Tero Antero Saarela, Jani . Breeze 2.0: An interactive web-tool for visual analysis and comparison of drug response data. Nucleic Acids Research (NAR). 2023, 51(W1), W57-W61; http://hdl.handle.net/10852/105870; 2171048; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nucleic Acids Research (NAR)&rft.volume=51&rft.spage=W57&rft.date=2023; Nucleic Acids Research (NAR); 51; W1; W57; W61; https://doi.org/10.1093/nar/gkad390

الاتاحة: http://hdl.handle.net/10852/105870
https://doi.org/10.1093/nar/gkad390

المؤلفون: Denisova, Oxana V., Merisaari, Joni, Huhtaniemi, Riikka, Qiao, Xi, Yetukuri, Laxman, Jumppanen, Mikael, Kaur, Amanpreet, Paakkonen, Mirva, von Schantz-Fant, Carina, Ohlmeyer, Michael, Wennerberg, Krister, Kauko, Otto, Koch, Raphael, Aittokallio, Tero, Taipale, Mikko, Westermarck, Jukka

المساهمون: Institute for Molecular Medicine Finland, Krister Wennerberg / Principal Investigator, Tero Aittokallio / Principal Investigator

مصطلحات موضوعية: Akt, Pdk, Pp2a, Apoptosis, Glioblastoma, Mitochondria, Cancers

وصف الملف: application/pdf

Relation: We kindly thank Dr William Leenders (Radboud University Medical Center, the Netherlands) for E98-Fluc-mCherry cells, Professor Pirjo Laakkonen (University of Helsinki, Finland) for U87MG and U251MG cell lines, HIFko astrocytes, and patient-derived GSCs, BT3-CD133+ and BT12, and Professor Johanna Ivaska (Turku Bioscience, Finland) for human fibroblasts and useful comments on the manuscript. Authors acknowledge the Biocenter Finland infrastructure, especially Turku Proteomics Facility, Turku Bioimaging, and Genome Editing Core at Turku Bioscience Centre, Turku Center for Disease Modelling at the University of Turku. Personal acknowledgements to Dr Nikhil Gupta for help with the nucleofection technique; MSc William Eccleshall and MSc Mung Kwan Long for help with Seahorse experiments; Dr Kari Kurppa for expert help with Incucyte experiments and for helpful discussions; Taina Kalevo-Mattila for excellent technical support, as well as the entire Turku Bioscience personnel for excellent working environment. This work was supported by Sigrid Juselius Foundation (JW), K. Albin Johanssons Foundation (JW), Finnish Cancer Foundation (180157, JW), Finnish Cultural Foundation Central Fund (00160159, OVD), Finnish Cultural Foundation Varsinais-Suomi Regional Fund (85191366, OVD), AAMU Pediatric Cancer Foundation (201900013, OVD), Turku Doctoral Programme of Molecular Medicine (JM), and Academy of Finland (TA).; http://hdl.handle.net/10138/565591; 85165625743; 001036606100001

الاتاحة: http://hdl.handle.net/10138/565591

المؤلفون: Potdar, Swapnil, Ianevski, Filipp, Ianevski, Aleksandr, Tanoli, Ziaurrehman, Wennerberg, Krister, Seashore-Ludlow, Brinton, Kallioniemi, Olli, Östling, Päivi, Aittokallio, Tero, Saarela, Jani

المساهمون: Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Computational Systems Medicine, Divisions of Faculty of Pharmacy, Helsinki Institute for Information Technology, Tero Aittokallio / Principal Investigator, Bioinformatics, Research Programs Unit

مصطلحات موضوعية: Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10138/563604; 85163938249; 000985764300001

الاتاحة: http://hdl.handle.net/10138/563604

المؤلفون: Senkowski, Wojciech, Gall-Mas, Laura, Falco, Matias Marin, Li, Yilin, Lavikka, Kari, Kriegbaum, Mette C., Oikkonen, Jaana, Bulanova, Daria, Pietras, Elin J., Vossgrone, Karolin, Chen, Yan-Jun, Erkan, Erdogan Pekcan, Dai, Jun, Lundgren, Anastasia, Hog, Mia Kristine Gronning, Larsen, Ida Marie, Lamminen, Tarja, Kaipio, Katja, Huvila, Jutta, Virtanen, Anni, Engelholm, Lars, Christiansen, Pernille, Santoni-Rugiu, Eric, Huhtinen, Kaisa, Carpen, Olli, Hynninen, Johanna, Hautaniemi, Sampsa, Vähärautio, Anna, Wennerberg, Krister

المساهمون: Research Program in Systems Oncology, Research Programs Unit, Clinicum, ATG - Applied Tumor Genomics, HUSLAB, Department of Pathology, Medicum, Precision Cancer Pathology, Olli Mikael Carpen / Principal Investigator, Sampsa Hautaniemi / Principal Investigator, Faculty Common Matters (Faculty of Medicine), Organismal and Evolutionary Biology Research Programme, Krister Wennerberg / Principal Investigator

مصطلحات موضوعية: Cell sensitivity, Stem-cell, In-vitro, Expression, Disease, Identification, Challenges, Dependence, Signatures, Framework, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: Senkowski , W , Gall-Mas , L , Falco , M M , Li , Y , Lavikka , K , Kriegbaum , M C , Oikkonen , J , Bulanova , D , Pietras , E J , Vossgrone , K , Chen , Y-J , Erkan , E P , Dai , J , Lundgren , A , Hog , M K G , Larsen , I M , Lamminen , T , Kaipio , K , Huvila , J , Virtanen , A , Engelholm , L , Christiansen , P , Santoni-Rugiu , E , Huhtinen , K , Carpen , O , Hynninen , J , Hautaniemi , S , Vähärautio , A & Wennerberg , K 2023 , ' A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids ' , Developmental Cell , vol. 58 , no. 12 , pp. 1106-+ . https://doi.org/10.1016/j.devcel.2023.04.012; ORCID: /0000-0003-4721-3954/work/140312937; ORCID: /0000-0002-7749-2694/work/140313658; ORCID: /0000-0002-7467-8434/work/140318318; ORCID: /0000-0002-6813-0050/work/140318596; ORCID: /0000-0001-9685-5246/work/140318666; http://hdl.handle.net/10138/563842; f26f9d3b-cae3-4716-b99f-00f01b30a49d; 001026015200001

الاتاحة: http://hdl.handle.net/10138/563842

المؤلفون: Talwelkar, Sarang S., Lähdeniemi, Iris A. K., Mäyränpää, Mikko I., Hemmes, Annabrita, Linnavirta, Nora, Räsänen, Jari, Knuuttila, Aija, Wennerberg, Krister, Verschuren, Emmy

المساهمون: Lung Cancer Model Systems, Institute for Molecular Medicine Finland, Research Group Verschuren Emmy, HUSLAB, Department of Pathology, HUS Heart and Lung Center, III kirurgian klinikka, HUS Comprehensive Cancer Center, Department of Medicine, Clinicum, Keuhkosairauksien yksikkö, Krister Wennerberg / Principal Investigator

مصطلحات موضوعية: Surgery, anesthesiology, intensive care, radiology

وصف الملف: application/pdf

Relation: Talwelkar , S S , Lähdeniemi , I A K , Mäyränpää , M I , Hemmes , A , Linnavirta , N , Räsänen , J , Knuuttila , A , Wennerberg , K & Verschuren , E 2022 , ' Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics ' , STAR protocols , vol. 3 , no. 4 , 101720 . https://doi.org/10.1016/j.xpro.2022.101720; ORCID: /0000-0002-0877-9640/work/130151777; ORCID: /0000-0001-5771-9129/work/130152305; ORCID: /0009-0005-5051-9331/work/157594301; http://hdl.handle.net/10138/355292; 38fc7f70-f82b-483c-ab91-19ec1760a316; 001059380200005

الاتاحة: http://hdl.handle.net/10138/355292

المؤلفون: Ayuda-Durán, Pilar, Hermansen, Johanne U., Giliberto, Mariaserena, Yin, Yanping, Hanes, Robert, Gordon, Sandra, Kuusanmäki, Heikki, Brodersen, Andrea M., Andersen, Aram N., Taskén, Kjetil, Wennerberg, Krister, Enserink, Jorrit M., Skånland, Sigrid S.

المساهمون: Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE

مصطلحات موضوعية: Biochemistry, cell and molecular biology, Multiple-myeloma, In-vitro, Tumor, Inhibitors, Culture, Cells

وصف الملف: application/pdf

Relation: We thank the High-Throughput Chemical Biology Screening Platform at Centre for Molecular Medicine Norway (NCMM), University of Oslo; the High Throughput Biomedicine Unit at Institute for Molecular Medicine Finland (FIMM), University of Finland; and DK-OPENSCREEN, Lyngby, Denmark for assistance with drug sensitivity screens. This work was supported by the Research Council of Norway (262652) under the frames of ERA PerMed (CLL-CLUE: 322898) and Digital Life Norway (PINpOINT: 294916), the European Union’s Horizon 2020 research and innovation programme (RESCUER: 847912), the South-Eastern Norway Regional Health Authority (2015031, 2018012 and 2019096), the Norwegian Cancer Society (182524 and 208012), Stiftelsen Kristian Gerhard Jebsen (Grant 19), the Norwegian Center for Clinical Research (MATRIX: Research Council of Norway and the Norwegian Cancer Society joint grant 328827), and the Danish Research Center for Precision Medicine in Blood Cancers (Danish Cancer Society grant no. R223-A13071).; Ayuda-Durán , P , Hermansen , J U , Giliberto , M , Yin , Y , Hanes , R , Gordon , S , Kuusanmäki , H , Brodersen , A M , Andersen , A N , Taskén , K , Wennerberg , K , Enserink , J M & Skånland , S S 2023 , ' Standardized assays to monitor drug sensitivity in hematologic cancers ' , Cell death discovery , vol. 9 , no. 1 , 435 . https://doi.org/10.1038/s41420-023-01722-5; http://hdl.handle.net/10138/568851; 458d2f55-701c-4464-861f-c04b43aa8287; 85178234764; 001112740700005

الاتاحة: http://hdl.handle.net/10138/568851

المؤلفون: Kuusanmaki, Heikki, Kytölä, Sari, Vänttinen, Ida, Ruokoranta, Tanja, Ranta, Amanda, Huuhtanen, Jani, Suvela, Minna, Parsons, Alun, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E. L., Koskela, Sirpa, Räty, Riikka, Itälä-Remes, Maija, Västrik, Imre, Dufva, Olli, Siitonen, Sanna, Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A., Ettala, Pia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Kontro, Mika

المساهمون: Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, HUS Comprehensive Cancer Center, Hematologian yksikkö, Department of Clinical Chemistry and Hematology, HUSLAB, Clinicum, Department of Oncology, Department of Medicine

مصطلحات موضوعية: Intensive chemotherapy, Personalized therapy, Patient samples, Azacitidine, Resistance, Cancers

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10138/564635; 85164232369; 001032976400012

الاتاحة: http://hdl.handle.net/10138/564635

المؤلفون: Chen, Yingjia, He, Liye, Ianevski, Aleksandr, Ayuda Duran, Pilar, Potdar, Swapnil, Saarela, Jani, Miettinen, Juho J., Kytölä, Sari, Miettinen, Susanna, Manninen, Mikko, Heckman, Caroline A., Enserink, Jorrit, Wennerberg, Krister, Aittokallio, Tero Antero

المصدر: 1754-2189.

Relation: NFR/262652; NFR/261936; NFR/314811; NFR/294916; EC/H2020/847912; EC/H2020/101057442; EC/H2020/ERA PerMed JAKSTAT-TARGET; EC/H2020/CLL-CLUE; Chen, Yingjia He, Liye Ianevski, Aleksandr Ayuda Duran, Pilar Potdar, Swapnil Saarela, Jani Miettinen, Juho J. Kytölä, Sari Miettinen, Susanna Manninen, Mikko Heckman, Caroline A. Enserink, Jorrit Wennerberg, Krister Aittokallio, Tero Antero . Robust scoring of selective drug responses for patient-tailored therapy selection. Nature Protocols. 2023, 1-30; http://hdl.handle.net/10852/110067; 2212983; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Protocols&rft.volume=&rft.spage=1&rft.date=2023; Nature Protocols; 19; 60; 82; https://doi.org/10.1038/s41596-023-00903-x

الاتاحة: http://hdl.handle.net/10852/110067
https://doi.org/10.1038/s41596-023-00903-x

المؤلفون: Denisova, Oxana V., Merisaari, Joni, Huhtaniemi, Riikka, Qiao, Xi, Yetukuri, Laxman, Jumppanen, Mikael, Kaur, Amanpreet, Pääkkönen, Mirva, von Schantz-Fant, Сarina, Ohlmeyer, Michael, Wennerberg, Krister, Kauko, Otto, Koch, Raphael, Aittokallio, Tero Antero, Taipale, Mikko, Westermarck, Jukka

المصدر: 1574-7891.

Relation: Denisova, Oxana V. Merisaari, Joni Huhtaniemi, Riikka Qiao, Xi Yetukuri, Laxman Jumppanen, Mikael Kaur, Amanpreet Pääkkönen, Mirva von Schantz-Fant, Сarina Ohlmeyer, Michael Wennerberg, Krister Kauko, Otto Koch, Raphael Aittokallio, Tero Antero Taipale, Mikko Westermarck, Jukka . PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells. Molecular Oncology. 2023, 17(9), 1803-1820; http://hdl.handle.net/10852/106531; 2177533; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular Oncology&rft.volume=17&rft.spage=1803&rft.date=2023; Molecular Oncology; 17; 1803; 1820; https://doi.org/10.1002/1878-0261.13488

الاتاحة: http://hdl.handle.net/10852/106531
https://doi.org/10.1002/1878-0261.13488

المؤلفون: Benada, Jan, Bulanova, Daria, Azzoni, Violette, Petrosius, Valdemaras, Ghazanfar, Saba, Wennerberg, Krister, Sørensen, Claus Storgaard

المصدر: Benada , J , Bulanova , D , Azzoni , V , Petrosius , V , Ghazanfar , S , Wennerberg , K & Sørensen , C S 2023 , ' Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma ' , NAR Cancer , vol. 5 , no. 3 , zcad029 . https://doi.org/10.1093/narcan/zcad029

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

Relation: https://orbit.dtu.dk/en/publications/e56196eb-391b-4150-9466-9d9b8439727f

الاتاحة: https://orbit.dtu.dk/en/publications/e56196eb-391b-4150-9466-9d9b8439727f
https://doi.org/10.1093/narcan/zcad029
https://backend.orbit.dtu.dk/ws/files/326523828/zcad029.pdf

المؤلفون: Talwelkar, Sarang S., Mayranpaa, Mikko I., Schuler, Julia, Linnavirta, Nora, Hemmes, Annabrita, Adinolfi, Simone, Kankainen, Matti, Sommergruber, Wolfgang, Levonen, Anna-Liisa, Rasanen, Jari, Knuuttila, Aija, Verschuren, Emmy W., Wennerberg, Krister

المصدر: Talwelkar , S S , Mayranpaa , M I , Schuler , J , Linnavirta , N , Hemmes , A , Adinolfi , S , Kankainen , M , Sommergruber , W , Levonen , A-L , Rasanen , J , Knuuttila , A , Verschuren , E W & Wennerberg , K 2023 , ' PI3Kβ inhibition enhances ALK-inhibitor sensitivity in ALK -rearranged lung cancer ' , Molecular Oncology , vol. 17 , no. 5 , pp. 747-764 . https://doi.org/10.1002/1878-0261.13342

مصطلحات موضوعية: ALK-rearranged lung cancer, combination treatment, drug resistance, EGFR, EML4-ALK, NSCLC, patient-derived cells, PI3K beta, CRIZOTINIB, RESISTANCE, P110-BETA, COMBINATION, MUTATION, AZD8186, BREAST, GROWTH, GENE

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/pi3k-inhibition-enhances-alkinhibitor-sensitivity-in-alkrearranged-lung-cancer(b2670bc5-99d6-4a05-a26f-eb8561d2e5c7).html
https://doi.org/10.1002/1878-0261.13342
https://curis.ku.dk/ws/files/346255138/Molecular_Oncology_2022_Talwelkar_PI3K_inhibition_enhances_ALK_inhibitor_sensitivity_in_ALK_rearranged_lung_cancer.pdf

المؤلفون: Kuusanmäki, Heikki, Dufva, Olli, Vähä-Koskela, Markus, Leppä, Aino Maija, Huuhtanen, Jani, Vänttinen, Ida, Nygren, Petra, Klievink, Jay, Bouhlal, Jonas, Pölönen, Petri, Zhang, Qi, Adnan-Awad, Shady, Mancebo-Pérez, Cristina, Saad, Joseph, Miettinen, Juho, Javarappa, Komal K., Aakko, Sofia, Ruokoranta, Tanja, Eldfors, Samuli, Heinäniemi, Merja, Theilgaard-Mönch, Kim, Wartiovaara-Kautto, Ulla, Keränen, Mikko, Porkka, Kimmo, Konopleva, Marina, Wennerberg, Krister, Kontro, Mika, Heckman, Caroline A., Mustjoki, Satu

المساهمون: Department of Computer Science, Aalto-yliopisto, Aalto University

وصف الملف: 1610-1625; application/pdf

Relation: BLOOD; Volume 141, issue 13; PURE LINK: http://www.scopus.com/inward/record.url?scp=85147217903&partnerID=8YFLogxK; PURE FILEURL: https://research.aalto.fi/files/104907863/SCI_Kuusanm_ki_etal_Blood_2023.pdf; https://aaltodoc.aalto.fi/handle/123456789/120373

الاتاحة: https://aaltodoc.aalto.fi/handle/123456789/120373
https://doi.org/10.1182/blood.2021011094

المؤلفون: Gönen, Mehmet, Weir, Barbara A, Cowley, Glenn S, Vazquez, Francisca, Guan, Yuanfang, Jaiswal, Alok, Karasuyama, Masayuki, Uzunangelov, Vladislav, Wang, Tao, Tsherniak, Aviad, Howell, Sara, Marbach, Daniel, Hoff, Bruce, Norman, Thea C, Airola, Antti, Bivol, Adrian, Bunte, Kerstin, Carlin, Daniel, Chopra, Sahil, Deran, Alden, Ellrott, Kyle, Gopalacharyulu, Peddinti, Graim, Kiley, Kaski, Samuel, Khan, Suleiman A, Newton, Yulia, Ng, Sam, Pahikkala, Tapio, Paull, Evan, Sokolov, Artem, Tang, Hao, Tang, Jing, Wennerberg, Krister, Xie, Yang, Zhan, Xiaowei, Zhu, Fan, Community, Broad-DREAM, Afsari, Bahman, Aittokallio, Tero, Boehm, Jesse S, Chang, Yu-Chuan, Chen, Tenghui, Chong, Zechen, Elmarakeby, Haitham, Fertig, Elana J, Gonçalves, Emanuel, Gong, Pinghua, Hafemeister, Christoph, Hahn, William C, Heath, Lenwood, Kędziorski, Łukasz, Khemka, Niraj, King, Erh-kan, Lauria, Mario, Liu, Mark, Machado, Daniel, Mamitsuka, Hiroshi, Margolin, Adam A, Mazurkiewicz, Mateusz, Menden, Michael P, Migacz, Szymon, Nie, Zhi, Praveen, Paurush, Priami, Corrado, Rizzetto, Simone, Rocha, Miguel, Root, David E, Rudd, Cameron, Rudnicki, Witold R, Saez-Rodriguez, Julio, Song, Lei, Stolovitzky, Gustavo, Stuart, Joshua M, Sun, Duanchen, Szalai, Bence

المصدر: Cell Systems. 5(5)

مصطلحات موضوعية: Biological Sciences, Genetics, Cancer, Biotechnology, Algorithms, Cell Line, Tumor, Gene Expression, Genes, Essential, Genomics, Humans, RNA, Small Interfering, Broad-DREAM Community, cancer genomics, community challenge, crowdsourcing, functional screen, machine learning, oncogene, Biochemistry and Cell Biology, Biochemistry and cell biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8d96f0j7
https://escholarship.org/content/qt8d96f0j7/qt8d96f0j7.pdf