المؤلفون: Steve S. Gernhardt, Kathryn A. Welch, Jennifer L. Liras, Cheryl Li, Michelle A. Salafia, Haojing Rong, Cheng Chang, Patrick Robert Verhoest, Kari R. Fonseca, Tristan S. Maurer, Christine A. Strick, Laura E. Zawadzke, Jamison B. Tuttle, Brian M. Campbell, Aarti Sawant-Basak, Weldon Horner, Amy B. Dounay

المصدر: Molecular pharmacology. 94(2)

مصطلحات موضوعية: 0301 basic medicine, Drug, Male, media_common.quotation_subject, Central nervous system, Pharmacology, Kynurenic Acid, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Kynurenic acid, In vivo, Tandem Mass Spectrometry, medicine, Animals, Humans, Enzyme Inhibitors, Brain function, Cells, Cultured, Transaminases, media_common, chemistry.chemical_classification, Brain Chemistry, biology, Brain, Kynurenine aminotransferase II, Rats, Macaca fascicularis, 030104 developmental biology, Enzyme, medicine.anatomical_structure, chemistry, Molecular Medicine, Pyrazoles, Female, biology.gene, 030217 neurology & neurosurgery, Kynurenine, Chromatography, Liquid, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf47151ea884653446a1868b8f4bbe1
https://pubmed.ncbi.nlm.nih.gov/29853495

المؤلفون: Amy B. Dounay, Kari R. Fonseca, Graham V. Williams, Christine A. Strick, Douglas S. Chapin, Mihály Hajós, Amanda L. Abbott, Damon Young, William E. Hoffmann, Dina McGinnis, Weldon Horner, Tamás Kiss, Brooke M. Roberts, Rouba Kozak, Victor Guanowsky, Patricia A. Seymour, Brian M. Campbell, Stacy A. Castner

المصدر: Journal of Neuroscience. 34:10592-10602

مصطلحات موضوعية: Male, Allosteric modulator, Kynurenic Acid, Hippocampus, Rats, Sprague-Dawley, chemistry.chemical_compound, Cognition, Kynurenic acid, medicine, Animals, Humans, Attention, Rats, Long-Evans, Enzyme Inhibitors, Wakefulness, Maze Learning, Amphetamine, Neurons, biology, General Neuroscience, Antagonist, Glutamate receptor, Brain, Kynurenine aminotransferase II, Articles, medicine.disease, Macaca mulatta, Rats, Memory, Short-Term, chemistry, Schizophrenia, Evoked Potentials, Auditory, Pyrazoles, NMDA receptor, Female, biology.gene, Psychology, Neuroscience, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a6047a2dd863fcfb3f794b280e2b69
https://doi.org/10.1523/jneurosci.1107-14.2014

المؤلفون: Brian Rago, Vinod D. Parikh, Bruce M. Bechle, Somraj Ghosh, Edelweiss Evrard, Brian M. Campbell, Christine A. Strick, Jamison B. Tuttle, Xinmin Gan, Amy B. Dounay, Kari R. Fonseca, Laura E. Zawadzke, Larry C. James, Jayvardhan Pandit, Michelle A. Salafia, Ji-Young Kim, Laura A. McAllister, Patrick Robert Verhoest, Weldon Horner, Cheng Chang, Marie Anderson

المصدر: ACS Medicinal Chemistry Letters. 4:37-40

مصطلحات موضوعية: chemistry.chemical_classification, Hydroxamic acid, Stereochemistry, Organic Chemistry, Biology, Aryl hydrocarbon receptor, Biochemistry, chemistry.chemical_compound, Kynurenic acid, Enzyme, chemistry, Drug Discovery, biology.protein, Potency, Structure based, Transferase, Kynurenine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92127bdf5d5f958d781a03a20a82086
https://doi.org/10.1021/ml300237v

المؤلفون: Kari R. Fonseca, Rong Suobao, Bruce M. Bechle, Xinmin Gan, Michelle Marie Claffey, Amy B. Dounay, Jayvardhan Pandit, Edelweiss Evrard, Jamison B. Tuttle, Laura E. Zawadzke, Christine A. Strick, Brian M. Campbell, Katherine Schuyten, Artem G. Evdokimov, Vinod D. Parikh, Marie Anderson, Somraj Ghosh, Matthew R. Reese, James J. Valentine, Hong Wang, Patrick Robert Verhoest, Weldon Horner, Ji-Young Kim, Vanessa Paradis, Laura A. McAllister, Matthew Merrill Hayward, Michelle A. Salafia

المصدر: ACS Medicinal Chemistry Letters. 3:187-192

مصطلحات موضوعية: Hydroxamic acid, biology, Chemistry, Organic Chemistry, Active site, Kynurenine aminotransferase II, Biochemistry, Cofactor, chemistry.chemical_compound, Kynurenic acid, Pharmacokinetics, In vivo, Drug Discovery, biology.protein, biology.gene, Pyridoxal phosphate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcbfbd5f6721faf10267dd4dae396be
https://doi.org/10.1021/ml200204m

المؤلفون: Laura McDowell, Sarah M. Osgood, Shari L. DeNinno, Hans Rollema, Chris L. Shaffer, Robert J. Mather, Brenda R. Ellerbrock, Jotham Wadsworth Coe, Theresa Tritto, Rouba Kozak, Jen Sadlier, Raymond S. Hurst, Weldon Horner, Roxanne R Gorczyca, Mary C. MacDougall, F. David Tingley, Mark J. Majchrzak, Lei Zhang, Alka Shrikhande, John A. Lowe, Scot Richard Mente, Karen M. Ward, David E. Johnson

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4749-4752

مصطلحات موضوعية: Agonist, Bicyclic molecule, Chemistry, Stereochemistry, medicine.drug_class, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, In vitro, Nicotinic agonist, In vivo, Drug Discovery, medicine, Molecular Medicine, Receptor, Molecular Biology, Acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7c382b229004850d41226ee3e512105a
https://doi.org/10.1016/j.bmcl.2010.06.142

المؤلفون: David E. Johnson, Rouba Kozak, Mark J. Majchrzak, Mihály Hajós, Kathryn E. Williams, William E. Hoffmann, Hans Rollema, Patricia A. Seymour, Doug S. Chapin, Stafford McLean, Victor Guanowsky, Weldon Horner, Jody Freeman

المصدر: Biochemical Pharmacology. 78:813-824

مصطلحات موضوعية: Male, Reflex, Startle, Alcohol Drinking, media_common.quotation_subject, medicine.medical_treatment, Context (language use), Receptors, Nicotinic, Pharmacology, Hippocampus, Biochemistry, Partial agonist, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, Cognition, Reward, Quinoxalines, Animals, Humans, Medicine, Attention, Nicotinic Agonists, Rats, Wistar, Varenicline, media_common, Cerebral Cortex, Neurotransmitter Agents, Depression, business.industry, Addiction, Recognition, Psychology, Tobacco Use Disorder, Benzazepines, Startle reaction, Rats, Drug Partial Agonism, Mice, Inbred C57BL, Affect, Mood, Nicotinic agonist, chemistry, Smoking cessation, business, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc35e34c456e3d48f7c746cdd4c74149
https://doi.org/10.1016/j.bcp.2009.05.033

المؤلفون: Aarti Sawant-Basak, Emily Miller, Michelle Vanase-Frawley, Mihály Hajós, Laura McDowell, David M. Rubitski, Kim Jonelle Stutzman-Engwall, Roxanne R Gorczyca, Weldon Horner, Katherine Fisher, Elaine E. Tseng, David E. Johnson, Sarah Grimwood, Elena M. Drummond, Chester J. Siok, Robin T. Nelson

المصدر: The Journal of pharmacology and experimental therapeutics. 341(3)

مصطلحات موضوعية: Male, medicine.medical_specialty, Microdialysis, Serotonin, Pyridones, Prefrontal Cortex, Thiophenes, Hippocampal formation, Pharmacology, Biology, Hippocampus, Rats, Sprague-Dawley, chemistry.chemical_compound, Serotonin 5-HT4 Receptor Agonists, Tandem Mass Spectrometry, Internal medicine, medicine, Animals, Humans, Receptor, Prefrontal cortex, Chromatography, High Pressure Liquid, Benzofurans, Prucalopride, Electroencephalography, Acetylcholine, Rats, Endocrinology, chemistry, Area Under Curve, Molecular Medicine, Receptors, Serotonin, 5-HT4, Histamine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e004fc131fe86d44da7998100426a1d2
https://pubmed.ncbi.nlm.nih.gov/22408061

المؤلفون: John A, Lowe, Shari L, DeNinno, Jotham W, Coe, Lei, Zhang, Scot, Mente, Raymond S, Hurst, Robert J, Mather, Karen M, Ward, Alka, Shrikhande, Hans, Rollema, David E, Johnson, Weldon, Horner, Roxanne, Gorczyca, F David, Tingley, Rouba, Kozak, Mark J, Majchrzak, Theresa, Tritto, Jen, Sadlier, Chris L, Shaffer, Brenda, Ellerbrock, Sarah M, Osgood, Mary C, MacDougall, Laura L, McDowell

المصدر: Bioorganicmedicinal chemistry letters. 20(16)

مصطلحات موضوعية: Structure-Activity Relationship, Sulfonamides, Nicotinic Agonists, Receptors, Nicotinic, Azabicyclo Compounds

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e3e0aeafc79a23cb6f1cb38b8c61e6b9
https://pubmed.ncbi.nlm.nih.gov/20663668

المؤلفون: Frederick R. Nelson, Elaine E. Tseng, Weldon Horner, Karthik Venkatakrishnan, Hans Rollema, Irina V. Kaplan, Jonathan L. French, Megan A. Gibbs

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 35(8)

مصطلحات موضوعية: Central Nervous System, Male, medicine.medical_specialty, Microdialysis, ATP Binding Cassette Transporter, Subfamily B, Indoles, Central nervous system, Pharmaceutical Science, Mice, Inbred Strains, Biology, Pharmacology, Cell Line, Rats, Sprague-Dawley, Mice, Cerebrospinal fluid, Dogs, Pharmacokinetics, Internal medicine, medicine, Distribution (pharmacology), Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, GABA-A Receptor Agonists, Receptor, Active metabolite, P-glycoprotein, Cerebrospinal Fluid, Brain Chemistry, Mice, Knockout, Brain, Biological Transport, Extracellular Fluid, Receptors, GABA-A, Rats, Endocrinology, medicine.anatomical_structure, Area Under Curve, biology.protein, ATP-Binding Cassette Transporters

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c753c7e1ad2c9062bcc17f03f60b3a
https://pubmed.ncbi.nlm.nih.gov/17470526

المؤلفون: Weldon Horner, David E. Johnson, Hans Rollema, Anne W. Schmidt

المصدر: European journal of pharmacology. 558(1-3)

مصطلحات موضوعية: Male, Microdialysis, medicine.medical_treatment, Prefrontal Cortex, Pharmacology, Atomoxetine Hydrochloride, Histamine Release, Rats, Sprague-Dawley, chemistry.chemical_compound, Norepinephrine, Dopamine, mental disorders, medicine, Animals, Prefrontal cortex, Propylamines, Methylphenidate, Atomoxetine, Rats, Stimulant, chemistry, Attention Deficit Disorder with Hyperactivity, Psychology, Neuroscience, Histamine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5a6052b8cd2184da1acce581ccf845
https://pubmed.ncbi.nlm.nih.gov/17198700