المؤلفون: Gregory L. Adams (3383210), Parul S. Pall (11863965), Steven M. Grauer (2296078), Xiaoping Zhou (453164), Jeanine E. Ballard (2413057), Marissa Vavrek (2432575), Richard L. Kraus (2245585), Pierre Morissette (1370229), Nianyu Li (127232), Stefania Colarusso (2238346), Elisabetta Bianchi (427005), Anandan Palani (1930282), Rebecca Klein (310566), Christopher T. John (3106674), Deping Wang (1992346), Matthew Tudor (281359), Andrew F. Nolting (2547085), Mirlinda Biba (2451073), Timothy Nowak (11863968), Alexey A. Makarov (1862065), Mikhail Reibarkh (39479), Alexei V. Buevich (1433287), Wendy Zhong (106968), Erik L. Regalado (534558), Xiao Wang (19312), Qi Gao (133189), Aurash Shahripour (1570807), Yuping Zhu (802053), Daniele de Simone (11863971), Tommaso Frattarelli (11863974), Nicolo’ Maria Pasquini (11863977), Paola Magotti (2005273), Roberto Iaccarino (11863980), Yuxing Li (263516), Kelli Solly (11863983), Keun-Joong Lee (2243086), Weixun Wang (2057191), Feifei Chen (283821), Haoyu Zeng (9047556), Jixin Wang (2292100), Hilary Regan (11863986), Rupesh P. Amin (9623430), Christopher P. Regan (2307325), Christopher S. Burgey (2397964), Darrell A. Henze (1779955), Chengzao Sun (475137), David M. Tellers (1308345)

مصطلحات موضوعية: Biochemistry, Medicine, Neuroscience, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, safely display systemic, pharmacologically relevant levels, new designs achieve, v , vivo <, vitro <, thermal stimuli, structural modeling, often toxic, article describes

Relation: https://figshare.com/articles/journal_contribution/Development_of_ProTx-II_Analogues_as_Highly_Selective_Peptide_Blockers_of_Na_sub_v_sub_1_7_for_the_Treatment_of_Pain/17315796

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01570.s001

المؤلفون: Gregory L. Adams (3383210), Parul S. Pall (11863965), Steven M. Grauer (2296078), Xiaoping Zhou (453164), Jeanine E. Ballard (2413057), Marissa Vavrek (2432575), Richard L. Kraus (2245585), Pierre Morissette (1370229), Nianyu Li (127232), Stefania Colarusso (2238346), Elisabetta Bianchi (427005), Anandan Palani (1930282), Rebecca Klein (310566), Christopher T. John (3106674), Deping Wang (1992346), Matthew Tudor (281359), Andrew F. Nolting (2547085), Mirlinda Biba (2451073), Timothy Nowak (11863968), Alexey A. Makarov (1862065), Mikhail Reibarkh (39479), Alexei V. Buevich (1433287), Wendy Zhong (106968), Erik L. Regalado (534558), Xiao Wang (19312), Qi Gao (133189), Aurash Shahripour (1570807), Yuping Zhu (802053), Daniele de Simone (11863971), Tommaso Frattarelli (11863974), Nicolo’ Maria Pasquini (11863977), Paola Magotti (2005273), Roberto Iaccarino (11863980), Yuxing Li (263516), Kelli Solly (11863983), Keun-Joong Lee (2243086), Weixun Wang (2057191), Feifei Chen (283821), Haoyu Zeng (9047556), Jixin Wang (2292100), Hilary Regan (11863986), Rupesh P. Amin (9623430), Christopher P. Regan (2307325), Christopher S. Burgey (2397964), Darrell A. Henze (1779955), Chengzao Sun (475137), David M. Tellers (1308345)

مصطلحات موضوعية: Biochemistry, Medicine, Neuroscience, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, safely display systemic, pharmacologically relevant levels, new designs achieve, v , vivo <, vitro <, thermal stimuli, structural modeling, often toxic, article describes

Relation: https://figshare.com/articles/dataset/Development_of_ProTx-II_Analogues_as_Highly_Selective_Peptide_Blockers_of_Na_sub_v_sub_1_7_for_the_Treatment_of_Pain/17315817

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01570.s004

المؤلفون: Gregory L. Adams (3383210), Parul S. Pall (11863965), Steven M. Grauer (2296078), Xiaoping Zhou (453164), Jeanine E. Ballard (2413057), Marissa Vavrek (2432575), Richard L. Kraus (2245585), Pierre Morissette (1370229), Nianyu Li (127232), Stefania Colarusso (2238346), Elisabetta Bianchi (427005), Anandan Palani (1930282), Rebecca Klein (310566), Christopher T. John (3106674), Deping Wang (1992346), Matthew Tudor (281359), Andrew F. Nolting (2547085), Mirlinda Biba (2451073), Timothy Nowak (11863968), Alexey A. Makarov (1862065), Mikhail Reibarkh (39479), Alexei V. Buevich (1433287), Wendy Zhong (106968), Erik L. Regalado (534558), Xiao Wang (19312), Qi Gao (133189), Aurash Shahripour (1570807), Yuping Zhu (802053), Daniele de Simone (11863971), Tommaso Frattarelli (11863974), Nicolo’ Maria Pasquini (11863977), Paola Magotti (2005273), Roberto Iaccarino (11863980), Yuxing Li (263516), Kelli Solly (11863983), Keun-Joong Lee (2243086), Weixun Wang (2057191), Feifei Chen (283821), Haoyu Zeng (9047556), Jixin Wang (2292100), Hilary Regan (11863986), Rupesh P. Amin (9623430), Christopher P. Regan (2307325), Christopher S. Burgey (2397964), Darrell A. Henze (1779955), Chengzao Sun (475137), David M. Tellers (1308345)

مصطلحات موضوعية: Biochemistry, Medicine, Neuroscience, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, safely display systemic, pharmacologically relevant levels, new designs achieve, v , vivo <, vitro <, thermal stimuli, structural modeling, often toxic, article describes

Relation: https://figshare.com/articles/dataset/Development_of_ProTx-II_Analogues_as_Highly_Selective_Peptide_Blockers_of_Na_sub_v_sub_1_7_for_the_Treatment_of_Pain/17315811

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01570.s003

المؤلفون: Gregory L. Adams (3383210), Parul S. Pall (11863965), Steven M. Grauer (2296078), Xiaoping Zhou (453164), Jeanine E. Ballard (2413057), Marissa Vavrek (2432575), Richard L. Kraus (2245585), Pierre Morissette (1370229), Nianyu Li (127232), Stefania Colarusso (2238346), Elisabetta Bianchi (427005), Anandan Palani (1930282), Rebecca Klein (310566), Christopher T. John (3106674), Deping Wang (1992346), Matthew Tudor (281359), Andrew F. Nolting (2547085), Mirlinda Biba (2451073), Timothy Nowak (11863968), Alexey A. Makarov (1862065), Mikhail Reibarkh (39479), Alexei V. Buevich (1433287), Wendy Zhong (106968), Erik L. Regalado (534558), Xiao Wang (19312), Qi Gao (133189), Aurash Shahripour (1570807), Yuping Zhu (802053), Daniele de Simone (11863971), Tommaso Frattarelli (11863974), Nicolo’ Maria Pasquini (11863977), Paola Magotti (2005273), Roberto Iaccarino (11863980), Yuxing Li (263516), Kelli Solly (11863983), Keun-Joong Lee (2243086), Weixun Wang (2057191), Feifei Chen (283821), Haoyu Zeng (9047556), Jixin Wang (2292100), Hilary Regan (11863986), Rupesh P. Amin (9623430), Christopher P. Regan (2307325), Christopher S. Burgey (2397964), Darrell A. Henze (1779955), Chengzao Sun (475137), David M. Tellers (1308345)

مصطلحات موضوعية: Biochemistry, Medicine, Neuroscience, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, safely display systemic, pharmacologically relevant levels, new designs achieve, v , vivo <, vitro <, thermal stimuli, structural modeling, often toxic, article describes

Relation: https://figshare.com/articles/dataset/Development_of_ProTx-II_Analogues_as_Highly_Selective_Peptide_Blockers_of_Na_sub_v_sub_1_7_for_the_Treatment_of_Pain/17315805

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01570.s002

المؤلفون: Thomas J. Tucker (3019827), Mark W. Embrey (3010674), Candice Alleyne (3355139), Rupesh P. Amin (9623430), Alan Bass (1648318), Bhavana Bhatt (9623433), Elisabetta Bianchi (427005), Danila Branca (9623436), Tjerk Bueters (2055823), Nicole Buist (1436656), Sookhee N. Ha (2218750), Mike Hafey (11608688), Huaibing He (2454631), John Higgins (26776), Douglas G. Johns (1445989), Angela D. Kerekes (2276686), Kenneth A. Koeplinger (1811914), Jeffrey T. Kuethe (1437001), Nianyu Li (127232), BethAnn Murphy (11608691), Peter Orth (2026309), Scott Salowe (4237612), Aurash Shahripour (1570807), Rodger Tracy (9623448), Weixun Wang (2057191), Chengwei Wu (8275014), Yusheng Xiong (298240), Hratch J. Zokian (9623454), Harold B. Wood (1665394), Abbas Walji (8038067)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, parenterally dosed antibodies, overall profiles favorable, orally bioavailable next, maintain therapeutic levels, kexin type 9, demonstrated target engagement, daily oral lipid, coronary artery disease, clinically validated target, generation lead structures, 44 , clinically approved, potential development, optimized molecules, multiparameter optimization, molecules represent, lowering agents, key regulator, highly potent, first report

Relation: https://figshare.com/articles/journal_contribution/A_Series_of_Novel_Highly_Potent_and_Orally_Bioavailable_Next-Generation_Tricyclic_Peptide_PCSK9_Inhibitors/16879247

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01599.s001

المؤلفون: Thomas J. Tucker (3019827), Mark W. Embrey (3010674), Candice Alleyne (3355139), Rupesh P. Amin (9623430), Alan Bass (1648318), Bhavana Bhatt (9623433), Elisabetta Bianchi (427005), Danila Branca (9623436), Tjerk Bueters (2055823), Nicole Buist (1436656), Sookhee N. Ha (2218750), Mike Hafey (11608688), Huaibing He (2454631), John Higgins (26776), Douglas G. Johns (1445989), Angela D. Kerekes (2276686), Kenneth A. Koeplinger (1811914), Jeffrey T. Kuethe (1437001), Nianyu Li (127232), BethAnn Murphy (11608691), Peter Orth (2026309), Scott Salowe (4237612), Aurash Shahripour (1570807), Rodger Tracy (9623448), Weixun Wang (2057191), Chengwei Wu (8275014), Yusheng Xiong (298240), Hratch J. Zokian (9623454), Harold B. Wood (1665394), Abbas Walji (8038067)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, parenterally dosed antibodies, overall profiles favorable, orally bioavailable next, maintain therapeutic levels, kexin type 9, demonstrated target engagement, daily oral lipid, coronary artery disease, clinically validated target, generation lead structures, 44 , clinically approved, potential development, optimized molecules, multiparameter optimization, molecules represent, lowering agents, key regulator, highly potent, first report

Relation: https://figshare.com/articles/dataset/A_Series_of_Novel_Highly_Potent_and_Orally_Bioavailable_Next-Generation_Tricyclic_Peptide_PCSK9_Inhibitors/16879250

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01599.s002

المؤلفون: Thomas J. Tucker (3019827), Mark W. Embrey (3010674), Candice Alleyne (3355139), Rupesh P. Amin (9623430), Alan Bass (1648318), Bhavana Bhatt (9623433), Elisabetta Bianchi (427005), Danila Branca (9623436), Tjerk Bueters (2055823), Nicole Buist (1436656), Sookhee N. Ha (2218750), Mike Hafey (11608688), Huaibing He (2454631), John Higgins (26776), Douglas G. Johns (1445989), Angela D. Kerekes (2276686), Kenneth A. Koeplinger (1811914), Jeffrey T. Kuethe (1437001), Nianyu Li (127232), BethAnn Murphy (11608691), Peter Orth (2026309), Scott Salowe (4237612), Aurash Shahripour (1570807), Rodger Tracy (9623448), Weixun Wang (2057191), Chengwei Wu (8275014), Yusheng Xiong (298240), Hratch J. Zokian (9623454), Harold B. Wood (1665394), Abbas Walji (8038067)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, parenterally dosed antibodies, overall profiles favorable, orally bioavailable next, maintain therapeutic levels, kexin type 9, demonstrated target engagement, daily oral lipid, coronary artery disease, clinically validated target, generation lead structures, 44 , clinically approved, potential development, optimized molecules, multiparameter optimization, molecules represent, lowering agents, key regulator, highly potent, first report

Relation: https://figshare.com/articles/dataset/A_Series_of_Novel_Highly_Potent_and_Orally_Bioavailable_Next-Generation_Tricyclic_Peptide_PCSK9_Inhibitors/16879253

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01599.s003

المؤلفون: Thomas J. Tucker (3019827), Mark W. Embrey (3010674), Candice Alleyne (3355139), Rupesh P. Amin (9623430), Alan Bass (1648318), Bhavana Bhatt (9623433), Elisabetta Bianchi (427005), Danila Branca (9623436), Tjerk Bueters (2055823), Nicole Buist (1436656), Sookhee N. Ha (2218750), Mike Hafey (11608688), Huaibing He (2454631), John Higgins (26776), Douglas G. Johns (1445989), Angela D. Kerekes (2276686), Kenneth A. Koeplinger (1811914), Jeffrey T. Kuethe (1437001), Nianyu Li (127232), BethAnn Murphy (11608691), Peter Orth (2026309), Scott Salowe (4237612), Aurash Shahripour (1570807), Rodger Tracy (9623448), Weixun Wang (2057191), Chengwei Wu (8275014), Yusheng Xiong (298240), Hratch J. Zokian (9623454), Harold B. Wood (1665394), Abbas Walji (8038067)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, parenterally dosed antibodies, overall profiles favorable, orally bioavailable next, maintain therapeutic levels, kexin type 9, demonstrated target engagement, daily oral lipid, coronary artery disease, clinically validated target, generation lead structures, 44 , clinically approved, potential development, optimized molecules, multiparameter optimization, molecules represent, lowering agents, key regulator, highly potent, first report

Relation: https://figshare.com/articles/dataset/A_Series_of_Novel_Highly_Potent_and_Orally_Bioavailable_Next-Generation_Tricyclic_Peptide_PCSK9_Inhibitors/16879256

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01599.s004