المؤلفون: Jianhang Huang (3965399), Xinren Wang (8980208), Ruinan Dong (11306941), Xiaoyue Liu (142524), Hongmei Li (51944), Tianyi Zhang (87298), Junyu Xu (620163), Chenhe Liu (8980211), Yanmin Zhang (391964), Shaohua Hou (4914478), Weifang Tang (1478896), Tao Lu (39406), Yadong Chen (621664)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Cancer, Hematology, Chemical Sciences not elsewhere classified, PARP, malignancy, Oral Cyclin-Dependent Kinase Inhibitor, Haematological Malignancies Hematol., inhibitor, compound 37, HM mice xenograft models, CDK, cell cycle progression

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_i_N_i_4-_3-isopropyl-2-methyl_2_i_H_i_indazol-5-yl_pyrimidin-2-yl_-4-_4-methylpiperazin-1-yl_quinazolin-7-amine_as_a_Novel_Potent_and_Oral_Cyclin-Dependent_Kinase_Inhibitor_against_Haematological_Malignancies/15824023

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00271.s004

المؤلفون: Nanxia Zhang (11377866), Weixing Liu (2917547), Zhipeng Dong (2611285), Yunxue Yin (11377869), Jun Luo (120285), Tao Lu (39406), Weifang Tang (1478896), Yue Wang (65477), Yonghu Han (11377872)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, rapid intracellular doxorubicin, modified piperidinepropionic acid, low systemic toxicity, grafting disulfide bond, obtain excellent tme, disulfide bonds packed, smart drug delivery, polymeric micelle system, novel integrated tme, responsive peg -<, responsive polymeric micelles, reduction triggered break, >- pasp -<, peg -<, disulfide bonds, polymeric micelles, polymeric micelle, drug delivery, >- pasp, responsive switches

Relation: https://figshare.com/articles/journal_contribution/An_Integrated_Tumor_Microenvironment_Responsive_Polymeric_Micelle_for_Smart_Drug_Delivery_and_Effective_Drug_Release/16560033

الاتاحة: https://doi.org/10.1021/acs.bioconjchem.1c00385.s001

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661547

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s016

المؤلفون: Jianhang Huang (3965399), Xinren Wang (8980208), Ruinan Dong (11306941), Xiaoyue Liu (142524), Hongmei Li (51944), Tianyi Zhang (87298), Junyu Xu (620163), Chenhe Liu (8980211), Yanmin Zhang (391964), Shaohua Hou (4914478), Weifang Tang (1478896), Tao Lu (39406), Yadong Chen (621664)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Cancer, Hematology, Chemical Sciences not elsewhere classified, PARP, malignancy, Oral Cyclin-Dependent Kinase Inhibitor, Haematological Malignancies Hematol., inhibitor, compound 37, HM mice xenograft models, CDK, cell cycle progression

Relation: https://figshare.com/articles/dataset/Discovery_of_i_N_i_4-_3-isopropyl-2-methyl_2_i_H_i_indazol-5-yl_pyrimidin-2-yl_-4-_4-methylpiperazin-1-yl_quinazolin-7-amine_as_a_Novel_Potent_and_Oral_Cyclin-Dependent_Kinase_Inhibitor_against_Haematological_Malignancies/15824005

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00271.s003

المؤلفون: Jianhang Huang (3965399), Xinren Wang (8980208), Ruinan Dong (11306941), Xiaoyue Liu (142524), Hongmei Li (51944), Tianyi Zhang (87298), Junyu Xu (620163), Chenhe Liu (8980211), Yanmin Zhang (391964), Shaohua Hou (4914478), Weifang Tang (1478896), Tao Lu (39406), Yadong Chen (621664)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Cancer, Hematology, Chemical Sciences not elsewhere classified, PARP, malignancy, Oral Cyclin-Dependent Kinase Inhibitor, Haematological Malignancies Hematol., inhibitor, compound 37, HM mice xenograft models, CDK, cell cycle progression

Relation: https://figshare.com/articles/dataset/Discovery_of_i_N_i_4-_3-isopropyl-2-methyl_2_i_H_i_indazol-5-yl_pyrimidin-2-yl_-4-_4-methylpiperazin-1-yl_quinazolin-7-amine_as_a_Novel_Potent_and_Oral_Cyclin-Dependent_Kinase_Inhibitor_against_Haematological_Malignancies/15823984

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00271.s001

المؤلفون: Jianhang Huang (3965399), Xinren Wang (8980208), Ruinan Dong (11306941), Xiaoyue Liu (142524), Hongmei Li (51944), Tianyi Zhang (87298), Junyu Xu (620163), Chenhe Liu (8980211), Yanmin Zhang (391964), Shaohua Hou (4914478), Weifang Tang (1478896), Tao Lu (39406), Yadong Chen (621664)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Cancer, Hematology, Chemical Sciences not elsewhere classified, PARP, malignancy, Oral Cyclin-Dependent Kinase Inhibitor, Haematological Malignancies Hematol., inhibitor, compound 37, HM mice xenograft models, CDK, cell cycle progression

Relation: https://figshare.com/articles/dataset/Discovery_of_i_N_i_4-_3-isopropyl-2-methyl_2_i_H_i_indazol-5-yl_pyrimidin-2-yl_-4-_4-methylpiperazin-1-yl_quinazolin-7-amine_as_a_Novel_Potent_and_Oral_Cyclin-Dependent_Kinase_Inhibitor_against_Haematological_Malignancies/15823987

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00271.s002

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661502

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s001

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661505

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s002

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661508

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s003

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661511

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s004

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661514

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s005

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661517

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s006

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661523

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s008

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661520

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s007

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661526

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s009

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661529

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s010

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661532

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s011

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661535

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s012

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661538

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s013

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661541

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s014