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المؤلفون: Stefan Gerhardt, Richard A. Pauptit, Jason Breed, Kevin J. Embrey, Jon Read, David Timms, Wendy S. VanScyoc, Geoffrey A. Holdgate, Alun Bermingham, Douglas Campbell, Alexander L. Breeze, Richard A. Norman, Walter H.J. Ward, Jane E. Sullivan
المصدر: Biochemistry. 44:16475-16490
مصطلحات موضوعية: Models, Molecular, Purine, biology, Protein Conformation, Stereochemistry, p38 mitogen-activated protein kinases, MAP Kinase Kinase 6, p38 Mitogen-Activated Protein Kinases, Biochemistry, Recombinant Proteins, Enzyme Activation, chemistry.chemical_compound, A-site, chemistry, Mitogen-activated protein kinase, biology.protein, Humans, Transferase, Moiety, Phosphorylation, Enzyme Inhibitors, Selectivity, Nuclear Magnetic Resonance, Biomolecular, Protein Binding
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2
المؤلفون: Walter H.J. Ward, Geoffrey A. Holdgate
المصدر: Drug Discovery Today. 10:1543-1550
مصطلحات موضوعية: Pharmacology, Protein Denaturation, Drug discovery, Chemistry, Proteins, Drug design, Thermodynamics, Calorimetry, Characterization (materials science), Pharmaceutical technology, Drug Design, Drug Discovery, Instrumentation (computer programming), Protein Binding
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3
المصدر: Journal of the Chemical Society, Perkin Transactions 1. :1709-1715
مصطلحات موضوعية: Serine, chemistry.chemical_classification, Hydrolysis, Chromatography, Enzyme, Chemistry, Phosphopeptide, Phosphatase, Substrate (chemistry), Peptide, Threonine
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4
المؤلفون: Walter H.J. Ward
المصدر: Protein Engineering Design and Selection. 24:65-67
مصطلحات موضوعية: Knowledge management, Drug Industry, Mechanism (biology), business.industry, Drug discovery, Bioengineering, Biochemistry, Enzymes, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Laboratories, business, Molecular Biology, Biotechnology, Pharmaceutical industry
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5
المؤلفون: Peter N. Cook, Christine Heys, Eric J. Culbert, Vivien Jacobs, Patrick Ple, Frederic Henri Jung, Trevor J. Franklin, William P. Morris, Walter H.J. Ward
المصدر: Biochemical Pharmacology. 58:867-876
مصطلحات موضوعية: Pharmacology, biology, Biochemistry, Mycophenolic acid, Xanthosine monophosphate, chemistry.chemical_compound, Non-competitive inhibition, chemistry, IMP dehydrogenase, Enzyme inhibitor, medicine, biology.protein, Inosine-5′-monophosphate dehydrogenase, Uncompetitive inhibitor, Inosine, medicine.drug
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6
المؤلفون: Gina Rosenbrock, Simon A. Weston, Ian W. F. Taylor, Richard A. Pauptit, Peter T. Barth, Alan Tunnicliffe, Geoffrey A. Holdgate, Walter H.J. Ward, David Timms
المصدر: Biochemistry. 36:9663-9673
مصطلحات موضوعية: Crystallography, Protein structure, Chemistry, Mutant protein, Hydrogen bond, Mutant, medicine, Molecule, Biochemistry, DNA gyrase, Novobiocin, Entropy (order and disorder), medicine.drug
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7
المصدر: Protein & Peptide Letters. 3:415-422
مصطلحات موضوعية: Structural Biology, General Medicine, Biochemistry
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8
المؤلفون: Pauline A. Girdwood, Susan Freeman, Robert G. Davidson, Geoffrey A. Holdgate, Brown George Robert, Walter H.J. Ward, M.Allan Eakin, Fergus McTaggart, Keith Blakeney Mallion
المصدر: Biochemical Pharmacology. 51:1489-1501
مصطلحات موضوعية: Quinuclidines, Stereochemistry, Kinetics, Farnesyl pyrophosphate, Sensitivity and Specificity, Biochemistry, Squalene, chemistry.chemical_compound, Animals, Humans, Enzyme Inhibitors, Pharmacology, Farnesyl-diphosphate farnesyltransferase, Binding Sites, Dose-Response Relationship, Drug, biology, Chemistry, Substrate (chemistry), Callithrix, Rats, Farnesyl-Diphosphate Farnesyltransferase, Enzyme inhibitor, Microsomes, Liver, Microsome, biology.protein, Quinuclidine
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9
المؤلفون: Geoffrey A. Holdgate, Walter H.J. Ward, D. Huw Davies, Anthony M. Slater, Peter N. Cook, Leslie R'. Green
المصدر: Biochemical Pharmacology. 48:659-666
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, biology, Stereochemistry, Kinase, Biochemistry, chemistry.chemical_compound, Enzyme, chemistry, Enzyme inhibitor, Epidermal growth factor, biology.protein, Quinazoline, Enzyme kinetics, Ternary complex, Tyrosine kinase
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10
المؤلفون: Robin D. Whittaker, Geoffrey A. Holdgate, Vivien Jacobs, M. Fennell, Laurent Francois Andre Hennequin, Judith A. Hargreaves, Brigitte Boyer, Alun Bermingham, Tim P. Green, Jon Curwen, Walter H.J. Ward, Allen Jack Mcqueen, Paul Elvin, Robert W. Wilkinson, Gerard Costello, Patrick Ple, Neil O. Carragher, D. Mark Hickinson, Barry R. Davies, Armelle Logie
المصدر: Green, T P, Fennell, M, Whittaker, R, Curwen, J, Jacobs, V, Allen, J, Logie, A, Hargreaves, J, Hickinson, D M, Wilkinson, R W, Elvin, P, Boyer, B, Carragher, N, Plé, P A, Bermingham, A, Holdgate, G A, Ward, W H J, Hennequin, L F, Davies, B R & Costello, G F 2009, ' Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530 ', Molecular Oncology, vol. 3, no. 3, pp. 248-261 . https://doi.org/10.1016/j.molonc.2009.01.002
مصطلحات موضوعية: Cancer Research, Transplantation, Heterologous, Administration, Oral, Mice, Nude, Antineoplastic Agents, Pharmacology, Metastasis, Mice, Rats, Nude, Clinical Trials, Phase II as Topic, In vivo, Cell Movement, Cell Line, Tumor, Genetics, medicine, Animals, Humans, Neoplasm Invasiveness, Benzodioxoles, Phosphorylation, Protein Kinase Inhibitors, Paxillin, Cell Proliferation, biology, Cell migration, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, In vitro, Neoplasm Proteins, Rats, Transplantation, src-Family Kinases, Oncology, Urinary Bladder Neoplasms, Tumor progression, Focal Adhesion Kinase 1, Papers, biology.protein, NIH 3T3 Cells, Quinazolines, Molecular Medicine, Neoplasm Transplantation, Proto-oncogene tyrosine-protein kinase Src
وصف الملف: application/pdf
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11
المؤلفون: Walter H.J. Ward, David Robert Brittain, Peter N. Cook, Donald J. Mirrlees, Tuffin David Patrick, Ralph Howe, Frank Carey, Preston John
المصدر: Biochemical Pharmacology. 42:2115-2123
مصطلحات موضوعية: Stereochemistry, Glucuronate, Kidney, Biochemistry, Nitroparaffins, chemistry.chemical_compound, Non-competitive inhibition, Aldehyde Reductase, medicine, Animals, Sulfones, Pharmacology, Aldose reductase, Binding Sites, biology, Aldose reductase inhibitor, Kinetics, chemistry, Enzyme inhibitor, biology.protein, Cattle, Sorbitol, Uncompetitive inhibitor, medicine.drug
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12
المؤلفون: Donald J. Mirrlees, Christopher M. Sennitt, Anthony Dingle, Walter H.J. Ward, Helen Ross, Tuffin David Patrick, David Timms
المصدر: Biochemical Pharmacology. 39:337-346
مصطلحات موضوعية: Glucuronate, Stereochemistry, Glucuronates, Kidney, Biochemistry, Substrate Specificity, chemistry.chemical_compound, Non-competitive inhibition, Glucuronic Acid, Aldehyde Reductase, Lens, Crystalline, medicine, Animals, Pharmacology, chemistry.chemical_classification, Aldose reductase, Dose-Response Relationship, Drug, biology, Isoenzymes, Pyridazines, Kinetics, Glucose, Enzyme, chemistry, Mechanism of action, Enzyme inhibitor, Hyperglycemia, biology.protein, Phthalazines, Cattle, Sorbitol, medicine.symptom, Software, Protein Binding, Sugar Alcohol Dehydrogenases
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13
المؤلفون: Geoff Holdgate, Stewart L. Fisher, Walter H.J. Ward
المصدر: Biocalorimetry 2: Applications of Calorimetry in the Biological Sciences
مصطلحات موضوعية: Enthalpy–entropy compensation, Drug discovery, Chemistry, Thermodynamics, Isothermal titration calorimetry
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14
المؤلفون: David A. Roberts, Walter H.J. Ward
المصدر: Medicinal Chemistry: Principles and Practice ISBN: 9780854046317
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15
المؤلفون: Geoffrey A. Holdgate, Walter H.J. Ward
مصطلحات موضوعية: Crystallography, Protein structure, Titration curve, Chemistry, Stereochemistry, Ligand, Enthalpy, Isothermal titration calorimetry, Titration, Calorimetry, Target protein
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16
المؤلفون: Wright W. Nichols, Ian W. F. Taylor, Roger Camble, David Timms, Geoffrey A. Holdgate, Walter H.J. Ward, Siân Rowsell, Richard A. Pauptit, Clayton Edward, Anil Mistry, David A. Jude, Jeremy G. Colls, Carolyn J. Britton, Neil James Hales, Estelle McLean, Claire A. Minshull
المصدر: Biochemistry. 38(38)
مصطلحات موضوعية: Enoyl-acyl carrier protein reductase, Reductase, Crystallography, X-Ray, Biochemistry, Binding, Competitive, Catalysis, Mass Spectrometry, chemistry.chemical_compound, Structure-Activity Relationship, Oxidoreductase, Fatty Acid Synthase, Type II, Enzyme Inhibitors, Antibacterial agent, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Escherichia coli Proteins, NAD, Enoyl-(Acyl-Carrier-Protein) Reductase (NADH), Triclosan, Acyl carrier protein, Kinetics, Enzyme, chemistry, Models, Chemical, biology.protein, Anti-Infective Agents, Local, Chromatography, Gel, NAD+ kinase, Crystallization, Oxidoreductases
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17
المؤلفون: Fergus McTaggart, Graham J. Smith, Robert G. Davidson, Susan Freeman, Keith Blakeney Mallion, Walter H.J. Ward, Geoffrey A. Holdgate, Donald J. Mirrlees, Brown George Robert
المصدر: Biochemical pharmacology. 51(11)
مصطلحات موضوعية: Quinuclidines, Stereochemistry, Farnesyl pyrophosphate, Mevalonic Acid, Tritium, Biochemistry, Sensitivity and Specificity, chemistry.chemical_compound, Squalene, Dolichol, Animals, Enzyme Inhibitors, Pharmacology, Farnesyl-diphosphate farnesyltransferase, biology, Cholesterol, Rats, Inbred Strains, Farnesol, Rats, Kinetics, Farnesyl-Diphosphate Farnesyltransferase, chemistry, Liver, Enzyme inhibitor, biology.protein, Female, Mevalonate pathway
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المؤلفون: Peter N. Cook, Donald J. Mirrlees, Walter H.J. Ward, Ralph Howe, Frank Carey, Tuffin David Patrick, J. Mark Petrash, Christopher M. Sennitt, Preston John, David Robert Brittain
المصدر: Biochemical pharmacology. 49(8)
مصطلحات موضوعية: Glucuronate, Stereochemistry, Kidney, Biochemistry, chemistry.chemical_compound, Non-competitive inhibition, Aldehyde Reductase, Lens, Crystalline, medicine, Animals, Humans, Sulfones, Pharmacology, Aldose reductase, Dose-Response Relationship, Drug, Methylglyoxal, Pyruvaldehyde, Aldose reductase inhibitor, Recombinant Proteins, Kinetics, Glucose, chemistry, Sorbitol, Acetanilides, Cattle, Uncompetitive inhibitor, NADP, medicine.drug
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المؤلفون: Donald J. Mirrlees, Tuffin David Patrick, Ralph Howe, Peter N. Cook, Walter H.J. Ward, David Robert Brittain, Frank Carey, Preston John
المصدر: Advances in Experimental Medicine and Biology ISBN: 9781461362593
مصطلحات موضوعية: chemistry.chemical_classification, Aldose reductase, Non-competitive inhibition, chemistry, Stereochemistry, medicine, Enzyme kinetics, Steady state (chemistry), Uncompetitive inhibitor, Aldehyde, Aldose reductase inhibitor, Aldehyde Reductase, medicine.drug
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المؤلفون: Walter H.J. Ward, Ann L. Jackman, R. Kimbell
المصدر: Biochemical pharmacology. 43(9)
مصطلحات موضوعية: Stereochemistry, Thiophenes, Biochemistry, Thymidylate synthase, chemistry.chemical_compound, Mice, medicine, Quinazoline, Tumor Cells, Cultured, Animals, Leukemia L1210, Tetrahydrofolates, Pharmacology, chemistry.chemical_classification, Binding Sites, biology, Biological activity, Glutamic acid, Thymidylate Synthase, Kinetics, Enzyme, chemistry, Mechanism of action, Enzyme inhibitor, biology.protein, Quinazolines, L1210 cells, medicine.symptom, Cell Division