المؤلفون: Evgueni L. Piatnitski, Andrey Konovalov, Leon M. Smith, Daniel L. Milligan, Matthew A. J. Duncton, Sabina Burdzovic-Wizemann, Ki H. Kim, Yaron R. Hadari, Chris Balagtas, Alexander S. Kiselyov, John Columbus, Wai C. Wong, Yong-Jiang Xu, Jacqueline Doody, Sui Ping Lee, Ying Wang, Robin L. Rosler, Yunyu Mao

المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5102-5106

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Thiazepine, Epidermal growth factor receptor, Phosphorylation, Azepine, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Autophosphorylation, Kinase insert domain receptor, Azepines, Vascular Endothelial Growth Factor Receptor-2, Neoplasm Proteins, ErbB Receptors, Diazepine, chemistry, biology.protein, Molecular Medicine, Oxazepine, Heterocyclic Compounds, 3-Ring, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f720430f8a22f885cea8b0d67cf63359
https://doi.org/10.1016/j.bmcl.2006.07.031

المؤلفون: Leon M. Smith, Yong-Jiang Xu, Wai C. Wong, Yunyu Mao, Sabina Burdzovic-Wizeman, Hu Liu, Weitao Pan, Matthew A. J. Duncton

المصدر: Synthetic Communications. 36:347-354

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Magnesium, Stereochemistry, In vivo, Organic Chemistry, Regioselectivity, chemistry.chemical_element, Amine gas treating, Oxazepine, Methylation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7b8a6d99c29eb3647904ea9687e52570
https://doi.org/10.1080/00397910500377479

المؤلفون: Hui-Hsien Chiang, Evgueni L. Piatnitski, Leon M. Smith, Xiaohu Ouyang, James Fleming, Paul Kussie, Yunyu Mao, Jason Gerlak, Vatee Pattaropong, M. Carolina Tuma, Asra Malikzay, Dhanvanthri S. Deevi, Wai C. Wong, Jacqueline Doody, Ki H. Kim, Xiaoling Chen, Sheetal Patel, Hai-Ying He, Marc Labelle, Robin L. Rolser, Daniel L. Milligan, Sui Ping Lee, Yang Yu, Ying Wang, John Kincaid, Alexander S. Kiselyov

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:5154-5159

مصطلحات موضوعية: Cell cycle checkpoint, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, macromolecular substances, Microtubules, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Tumor Cells, Cultured, Humans, Colchicine, Structure–activity relationship, Binding site, Molecular Biology, Molecular Structure, biology, Organic Chemistry, 1,2,4-Triazole, Triazoles, Tubulin Modulators, Tubulin, Epidermoid carcinoma, chemistry, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6565f9e235a9b3bc40e1659b52b776c9
https://doi.org/10.1016/j.bmcl.2005.08.056

المؤلفون: Marc Labelle, Xin Chen, Wai C. Wong, Weitao Pan, Hu Liu, Yong-Jiang Xu

المصدر: Tetrahedron Letters. 46:7523-7526

مصطلحات موضوعية: Scaffold, Chemistry, Organic Chemistry, Drug Discovery, General Medicine, Biochemistry, Reductive amination, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185da24c520499fb3cddb05939fcefd6
https://doi.org/10.1016/j.tetlet.2005.08.161

المؤلفون: Mark G. Bock, Charles Gluchowski, Sriram Tyagarajan, Quanrong Shen, Tsing-Bau Chen, Mohammad R. Marzabadi, Carlos Forray, Dhanapalan Nagarathnam, Wai C. Wong, Stacey O'Malley, Barbara Francis, Dhar T G Murali, Douglas J. Pettibone, Jerry DiSalvo, Roger M. Freidinger, Miao Shou Wu, Raymond S.L. Chang, Bharat Lagu

المصدر: European Journal of Pharmacology. 409:301-312

مصطلحات موضوعية: Male, Tetrahydronaphthalenes, Adrenergic receptor, Stereochemistry, Urinary Bladder, Pyrimidinones, Biology, Phenylephrine, Dogs, Receptors, Adrenergic, alpha-1, Prazosin, medicine, Animals, Humans, Receptor, Adrenergic alpha-Antagonists, Caudal artery, Pharmacology, Hydrobromide, Imidazoles, Prostate, Antagonist, In vitro, Rats, medicine.anatomical_structure, Adrenergic alpha-1 Receptor Antagonists, Adrenergic alpha-Agonists, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9435f2baa4a2313af28f3841b322f801
https://doi.org/10.1016/s0014-2999(00)00854-2

المؤلفون: Carlos Forray, Tsing B. Chen, Raymond S. L. Chang, Stacey O'Malley, Dhanapalan Nagarathnam, George Chiu, Dake Tian, Miao Shou Wu, Wai C. Wong, Bharat Lagu, Richard W. Ransom, Mohammad R. Marzabadi, Kanyin Zhang, Kamlesh P. Vyas, Charles Gluchowski, James Fang, Wanying Sun, Fengqi Zhang

المصدر: Journal of Medicinal Chemistry. 42:4794-4803

مصطلحات موضوعية: Agonist, medicine.drug_class, Stereochemistry, Metabolite, Carboxamide, Phenylpiperazine, Chemical synthesis, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Molecular Medicine, Moiety, Receptor, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c31af145a78e8fe8e37099a3289b08a5
https://doi.org/10.1021/jm990202+

المؤلفون: Robert J. Bendesky, Wai C. Wong, Theodore P. Broten, Fengqi Zhang, Dake Tian, Carlos Forray, James Fang, Sriram Tyagarajan, Dhanapalan Nagarathnam, and Kamlesh P. Vyas, Shou Wu Miao, George Chiu, Mohammad R. Marzabadi, T. G. Murali Dhar, Charles Gluchowski, Kathryn Schneck, Paul J. Kling, Raymond S.L. Chang, Bharat Lagu, Jack Zhang, Wanying Sun, Stacey O'Malley, Tsing B. Chen, Richard W. Ransom, Terry W. Schorn, Charles M. Harrell, John M. Wetzel

المصدر: Journal of Medicinal Chemistry. 42:4764-4777

مصطلحات موضوعية: Male, medicine.drug_class, Drug Evaluation, Preclinical, Nitro compound, Blood Pressure, Carboxamide, Pyrimidinones, In Vitro Techniques, Pharmacology, Binding, Competitive, Chemical synthesis, Rats, Sprague-Dawley, Radioligand Assay, Dogs, Urethra, In vivo, Receptors, Adrenergic, alpha-1, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Receptor, Adrenergic alpha-Antagonists, chemistry.chemical_classification, Prostate, Antagonist, Stereoisomerism, In vitro, Rats, chemistry, Biochemistry, Drug Design, Adrenergic alpha-1 Receptor Antagonists, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a155a502f01c3a2a70aa17db4eda0f
https://doi.org/10.1021/jm990200p

المؤلفون: Miao Shou Wu, Stacey O'Malley, Kamlesh P. Vyas, Paul J. Kling, Raymond S.L. Chang, Wanying Sun, Wai C. Wong, Richard W. Ransom, Kanyin Zhang, John M. Wetzel, Jian Peng, Charles Gluchowski, Theodore P. Broten, Dhanapalan Nagarathnam, Carlos Forray, Fengqi Zhang, Dake Tian, Bharat Lagu, Tsing B. Chen, Mohammad R. Marzabadi

المصدر: Journal of Medicinal Chemistry. 42:4804-4813

مصطلحات موضوعية: Male, medicine.drug_class, Stereochemistry, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Carboxamide, In Vitro Techniques, Binding, Competitive, Chemical synthesis, Structure-Activity Relationship, Dogs, Smooth muscle, Receptors, Adrenergic, alpha-1, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Adrenergic alpha-Antagonists, Chemistry, Prostate, Antagonist, Stereoisomerism, Recombinant Proteins, Rats, Pyrimidines, α1a adrenoceptor, Drug Design, Benzene derivatives, Adrenergic alpha-1 Receptor Antagonists, Molecular Medicine, Enantiomer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644bb1e845f3476e1d3846442d956b07
https://doi.org/10.1021/jm9902032

المؤلفون: Dhanapalan Nagarathnam, Terry W. Schorn, Wai C. Wong, John M. Wetzel, Carlos Forray, Raymond S.L. Chang, William E. Heydorn, George Chiu, Theodore P. Broten, C. Gluchowski, Xingfang Hong, T. A. Branchek, Shou Wu Miao, James Fang, Mohammad R. Marzabadi

المصدر: Journal of Medicinal Chemistry. 41:5320-5333

مصطلحات موضوعية: Male, Dihydropyridines, medicine.medical_specialty, Drug Evaluation, Preclinical, Prostatic Hyperplasia, Nitro compound, Blood Pressure, In Vitro Techniques, Pharmacology, Binding, Competitive, Chemical synthesis, Cell Line, Structure-Activity Relationship, Dogs, Piperidines, Prostate, In vivo, Receptors, Adrenergic, alpha-1, Internal medicine, Drug Discovery, medicine, Animals, Humans, Adrenergic alpha-Antagonists, chemistry.chemical_classification, Chemistry, Dihydropyridine, Antagonist, Muscle, Smooth, Stereoisomerism, Hyperplasia, medicine.disease, Recombinant Proteins, In vitro, Rats, medicine.anatomical_structure, Endocrinology, Adrenergic alpha-1 Receptor Antagonists, Molecular Medicine, Muscle Contraction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2107805a48424aca74e2ba8260056335
https://doi.org/10.1021/jm980506g

المؤلفون: Charles Gluchowski, Dhanapalan Nagarathnam, Wai C. Wong, Carlos Forray, Pierre J.-J. Vaysse, Xingfang Hong, Rui Tang, Shou Wu Miao, Mohammad R. Marzabadi, John M. Wetzel, Theresa Branchek, Herbert Lepor, George Chiu, James Fang, Diana Wang

المصدر: Journal of Medicinal Chemistry. 41:2643-2650

مصطلحات موضوعية: Male, Contraction (grammar), Pyridines, medicine.drug_class, Stereochemistry, Prostatic Hyperplasia, Nitro compound, Carboxamide, In Vitro Techniques, Chemical synthesis, Phenylephrine, Piperidines, Receptors, Adrenergic, alpha-1, Drug Discovery, medicine, Animals, Humans, Adrenergic alpha-Antagonists, Aged, Aged, 80 and over, chemistry.chemical_classification, Calcium channel, Prostate, Antagonist, Dihydropyridine, Brain, Muscle, Smooth, Middle Aged, Rats, chemistry, Molecular Medicine, Calcium Channels, Adrenergic alpha-Agonists, Muscle Contraction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bad3dcef4af073bcdde4b1db5b07bfb
https://doi.org/10.1021/jm980077m

المؤلفون: Matthew A. J. Duncton, Sabina Burdzovic-Wizeman, Alexander S. Kiselyov, Leon M. Smith, Hu Liu, Aaron C. Burns, Wai C. Wong, Yunyu Mao

المصدر: The Journal of Organic Chemistry. 70:9629-9631

مصطلحات موضوعية: Pictet–Spengler reaction, Molecular Structure, biology, Cyclization, Stereochemistry, Chemistry, Organic Chemistry, biology.protein, Azepines, Tyrosine, Chemical synthesis, Catalysis, Receptor tyrosine kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c6d73230c034b5b578b1520f894da6
https://doi.org/10.1021/jo051419g

المؤلفون: Pierre J.-J. Vaysse, Wai C. Wong, Carlos Forray, Diana Wang, Theresa Branchek, Charles Gluchowski

المصدر: Bioorganic & Medicinal Chemistry Letters. 4:2317-2322

مصطلحات موضوعية: α adrenergic receptors, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Rilmenidine, Potassium fluoride, chemistry.chemical_compound, Yield (chemistry), Drug Discovery, medicine, Molecular Medicine, Molecular Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::42b86dbe37d87d66a05c94dd5b5d088f
https://doi.org/10.1016/0960-894x(94)85032-1

المؤلفون: Ove Wiborg, Mathivanan Packiarajan, Mohammad R. Marzabadi, Toni D. Wolinsky, Yalei Lu, Gamini Chandrasena, Hualing Zhong, Kim Andersen, Mary W. Walker, Wai C. Wong, Mahesh N. Desai, Vrej Jubian, Stewart A. Noble

المصدر: Packiarajan, M, Marzabadi, M R, Desai, M, Lu, Y, Noble, S A, Wong, W C, Jubian, V, Chandrasena, G, Wolinsky, T D, Zhong, H, Walker, M W, Wiborg, O & Andersen, K 2011, ' Discovery of Lu AA33810 : a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder ', Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 18, pp. 5436-41 . https://doi.org/10.1016/j.bmcl.2011.06.124

مصطلحات موضوعية: Agonist, medicine.drug_class, Clinical Biochemistry, Rat model, Dose dependence, Drug Evaluation, Preclinical, Pharmaceutical Science, Biological Availability, Pharmacology, Benzothiepins, Biochemistry, Mice, Structure-Activity Relationship, Mild stress, In vivo, Drug Discovery, medicine, Animals, Molecular Biology, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Mood Disorders, Organic Chemistry, Antagonist, Stereoisomerism, Highly selective, Bioavailability, Rats, Receptors, Neuropeptide Y, Disease Models, Animal, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a28a777dee111d70ad35e0c6aa6572
https://pubmed.ncbi.nlm.nih.gov/21782428

المؤلفون: Theresa Branchek, Wai C. Wong, Pierre J.-J. Vaysse, Carlos Forray, Diana Wang, Charles Gluchowski

المصدر: ChemInform. 26

مصطلحات موضوعية: chemistry.chemical_compound, α adrenergic receptors, chemistry, Stereochemistry, Yield (chemistry), medicine, General Medicine, Combinatorial chemistry, Potassium fluoride, Rilmenidine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::10645732b157340a5ca724fc87062576
https://doi.org/10.1002/chin.199517129

المؤلفون: Charles Gluchowski, Wai C. Wong

المصدر: ChemInform. 26

مصطلحات موضوعية: Stereochemistry, Chemistry, medicine, Atipamezole, General Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::87b549850875bcff97b24ff86bb4a917
https://doi.org/10.1002/chin.199531136

المؤلفون: Pierre J.-J. Vaysse, Wanying Sun, Weili Cui, Charles Gluchowski, Theresa Branchek, Yuewen Chen, Wai C. Wong, Carlos Forray

المصدر: ChemInform. 31

مصطلحات موضوعية: Agonist, α2 adrenoceptor, Chemistry, medicine.drug_class, Stereochemistry, α2 adrenoceptor agonist, medicine, General Medicine, Cyclohexylamino oxazoline, Subtype selective, 2-Norbornyl cation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eb6dad808c232598acdf8dff68f613a9
https://doi.org/10.1002/chin.200030109

المؤلفون: Chris Balagtas, Yaron R. Hadari, Matthew A. J. Duncton, Stan Mitelman, Alexander S. Kiselyov, Dan Sherman, Leon M. Smith, Daniel L. Milligan, Paul Kussie, Wai C. Wong, Robin L. Rolster, Reeti Katoch-Rouse, David Surguladze, James R. Tonra, Joel Kawakami, Peter Bohlen, Sheetal Patel, Jacqueline Doody, Eugene L. Piatnitski Chekler, Ying Wang

المصدر: Bioorganicmedicinal chemistry. 17(2)

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Mice, Inbred Strains, Biochemistry, Mice, Growth factor receptor, Piperidines, Oral administration, In vivo, Drug Discovery, Animals, Receptor, Molecular Biology, Vascular Endothelial Growth Factor Receptor-1, biology, Chemistry, Kinase, Organic Chemistry, Kinase insert domain receptor, Isoquinolines, Vascular Endothelial Growth Factor Receptor-2, Enzyme inhibitor, biology.protein, Quinazolines, Molecular Medicine, Phthalazines, Female, Signal transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda1f6a22124c16fa6d6a6398b7c2d5b
https://pubmed.ncbi.nlm.nih.gov/19101155

المؤلفون: Matthew A. J. Duncton, Leon M. Smith, Wai C. Wong, Yunyu Mao, Weitao Pan, Hu Liu, Yong-Jiang Xu, Sabina Burdzovic-Wizeman

المصدر: ChemInform. 37

مصطلحات موضوعية: In vivo, Chemistry, Amine gas treating, General Medicine, Medicinal chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a01f6e985a1d526a7c170e1114cdf571
https://doi.org/10.1002/chin.200623176

المؤلفون: Daniel L. Milligan, Evgueni L. Piatnitski, Leon M. Smith, Matthew A. J. Duncton, Wai C. Wong, Alexander S. Kiselyov, Reeti Katoch-Rouse, Chris Balagtas, Joel Kawakami, Jacqueline Doody

المصدر: ChemInform. 37

مصطلحات موضوعية: chemistry.chemical_classification, Enzyme, chemistry, biology, Biochemistry, Vascular Endothelial Growth Factor Receptor, VEGF receptors, embryonic structures, biology.protein, General Medicine, Inhibitory postsynaptic potential, Tyrosine kinase, Phthalazines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::710e11821a21305ffce2017d1dab3645
https://doi.org/10.1002/chin.200621154

المؤلفون: Leon M. Smith, Hu Liu, Wai C. Wong, Matthew A. J. Duncton, Alexander S. Kiselyov, Yunyu Mao, Aaron C. Burns, Sabina Burdzovic-Wizeman

المصدر: ChemInform. 37

مصطلحات موضوعية: biology, Stereochemistry, Chemistry, biology.protein, General Medicine, Receptor tyrosine kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3fed26c63d16353a5b33b8707e3ba1f1
https://doi.org/10.1002/chin.200613175