المؤلفون: Baldwin, Alex G., Foley, David W., Collins, Ross, Lee, Hyunah, Jones, D. Heulyn, Wahab, Ben, Waters, Loren, Pedder, Josephine, Paine, Marie, Feng, Gui Jie, Privitera, Lucia, Ashall-Kelly, Alexander, Thomas, Carys, Gillespie, Jason A., Schino, Lauramariú, Belelli, Delia, Rocha, Cecilia, Maussion, Gilles, Krahn, Andrea I., Durcan, Thomas M., Elkins, Jonathan M., Lambert, Jeremy J., Atack, John R., Ward, Simon E.

وصف الملف: application/pdf

Relation: https://orca.cardiff.ac.uk/id/eprint/175044/1/baldwin-et-al-2024-discovery-of-mdi-114215-a-potent-and-selective-limk-inhibitor-to-treat-fragile-x-syndrome.pdf; Baldwin, Alex G. https://orca.cardiff.ac.uk/view/cardiffauthors/A2390986R.html orcid:0000-0002-7126-5220 orcid:0000-0002-7126-5220, Foley, David W. orcid:0000-0001-8449-4754 orcid:0000-0001-8449-4754, Collins, Ross, Lee, Hyunah, Jones, D. Heulyn https://orca.cardiff.ac.uk/view/cardiffauthors/A2399749M.html, Wahab, Ben, Waters, Loren https://orca.cardiff.ac.uk/view/cardiffauthors/A2301525Q.html, Pedder, Josephine, Paine, Marie https://orca.cardiff.ac.uk/view/cardiffauthors/A2472996Q.html, Feng, Gui Jie https://orca.cardiff.ac.uk/view/cardiffauthors/A19907431.html, Privitera, Lucia, Ashall-Kelly, Alexander https://orca.cardiff.ac.uk/view/cardiffauthors/A2405290F.html, Thomas, Carys, Gillespie, Jason A., Schino, Lauramariú https://orca.cardiff.ac.uk/view/cardiffauthors/A2421167L.html, Belelli, Delia, Rocha, Cecilia, Maussion, Gilles, Krahn, Andrea I., Durcan, Thomas M., Elkins, Jonathan M., Lambert, Jeremy J., Atack, John R. https://orca.cardiff.ac.uk/view/cardiffauthors/A2342532W.html orcid:0000-0002-3410-791X orcid:0000-0002-3410-791X and Ward, Simon E. https://orca.cardiff.ac.uk/view/cardiffauthors/A2342916Z.html orcid:0000-0002-8745-8377 orcid:0000-0002-8745-8377 2025. Discovery of MDI-114215: A potent and selective LIMK inhibitor to treat fragile X syndrome. Journal of Medicinal Chemistry 68 (1) , pp. 719-752. 10.1021/acs.jmedchem.4c02694 https://doi.org/10.1021/acs.jmedchem.4c02694 file https://orca.cardiff.ac.uk/id/eprint/175044/1/baldwin-et-al-2024-discovery-of-mdi-114215-a-potent-and-selective-limk-inhibitor-to-treat-fragile-x-syndrome.pdf

الاتاحة: https://orca.cardiff.ac.uk/id/eprint/175044/
https://doi.org/10.1021/acs.jmedchem.4c02694

المؤلفون: Gong, Grace Q., Bilanges, Benoit, Allsop, Ben, Masson, Glenn R., Roberton, Victoria, Askwith, Trevor, Oxenford, Sally, Madsen, Ralitsa R., Conduit, Sarah E., Bellini, Dom, Fitzek, Martina, Collier, Matt, Najam, Osman, He, Zhenhe, Wahab, Ben, McLaughlin, Stephen H., Chan, A. W. Edith, Feierberg, Isabella, Madin, Andrew, Morelli, Daniele, Bhamra, Amandeep, Vinciauskaite, Vanesa, Anderson, Karen E., Surinova, Silvia, Pinotsis, Nikos, Lopez-Guadamillas, Elena, Wilcox, Matthew, Hooper, Alice, Patel, Chandni, Whitehead, Maria A., Bunney, Tom D., Stephens, Len R., Hawkins, Phillip T., Katan, Matilda, Yellon, Derek M., Davidson, Sean M., Smith, David M., Phillips, James B., Angell, Richard, Williams, Roger L., Vanhaesebroeck, Bart

المصدر: Gong , G Q , Bilanges , B , Allsop , B , Masson , G R , Roberton , V , Askwith , T , Oxenford , S , Madsen , R R , Conduit , S E , Bellini , D , Fitzek , M , Collier , M , Najam , O , He , Z , Wahab , B , McLaughlin , S H , Chan , A W E , Feierberg , I , Madin , A , Morelli , D , Bhamra , A , Vinciauskaite , V , Anderson , K E ....

مصطلحات موضوعية: Cell signalling, Drug discovery, Kinases, X-ray crystallography, /dk/atira/pure/subjectarea/asjc/1000, name=General

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/ecb2d398-f5df-47cc-8fd6-537759cc5e07
https://doi.org/10.1038/s41586-023-05972-2
https://discovery.dundee.ac.uk/ws/files/103607439/409738_4_merged_1678279284.pdf
http://www.scopus.com/inward/record.url?scp=85160229754&partnerID=8YFLogxK

المؤلفون: Gong, Grace Q, Bilanges, Benoit, Allsop, Ben, Masson, Glenn R, Roberton, Victoria, Askwith, Trevor, Oxenford, Sally, Madsen, Ralitsa R, Conduit, Sarah E, Bellini, Dom, Fitzek, Martina, Collier, Matt, Najam, Osman, He, Zhenhe, Wahab, Ben, McLaughlin, Stephen H, Chan, AW Edith, Feierberg, Isabella, Madin, Andrew, Morelli, Daniele, Bhamra, Amandeep, Vinciauskaite, Vanesa, Anderson, Karen E, Surinova, Silvia, Pinotsis, Nikos, Lopez-Guadamillas, Elena, Wilcox, Matthew, Hooper, Alice, Patel, Chandni, Whitehead, Maria A, Bunney, Tom D, Stephens, Len R, Hawkins, Phillip T, Katan, Matilda, Yellon, Derek M, Davidson, Sean M, Smith, David M, Phillips, James B, Angell, Richard, Williams, Roger L, Vanhaesebroeck, Bart

المصدر: Nature , 618 pp. 159-168. (2023)

مصطلحات موضوعية: Cell signalling, Drug discovery, Kinases, X-ray crystallography

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10170780/15/Nature_manuscript_RPS.pdf; https://discovery.ucl.ac.uk/id/eprint/10170780/12/SI%20Guide%20with%20tables%20and%20figures_new_upload.pdf; https://discovery.ucl.ac.uk/id/eprint/10170780/8/Supplementary%20Table%201.xlsx; https://discovery.ucl.ac.uk/id/eprint/10170780/2/Supplementary%20Table%204.xls; https://discovery.ucl.ac.uk/id/eprint/10170780/4/Supplementary%20Table%205.xls; https://discovery.ucl.ac.uk/id/eprint/10170780/5/Supplementary%20Table%206.xls; https://discovery.ucl.ac.uk/id/eprint/10170780/11/Supplementary%20Table%207.xlsx; https://discovery.ucl.ac.uk/id/eprint/10170780/6/Supplementary%20Table%208.xlsx; https://discovery.ucl.ac.uk/id/eprint/10170780/7/Supplementary%20Table%209.xlsx; https://discovery.ucl.ac.uk/id/eprint/10170780/9/Suppl%20Video%201_Activation_mechanisms.mp4; https://discovery.ucl.ac.uk/id/eprint/10170780/13/Suppl%20Video%202_A549_WT9_Veh_BYL_Pos18.avi; https://discovery.ucl.ac.uk/id/eprint/10170780/14/Suppl%20Video%203_A549_WT9_1938_BYL_Pos14.avi; https://discovery.ucl.ac.uk/id/eprint/10170780/10/Suppl%20Video%204_A549_KO12_1938_BYL_Pos0.avi; https://discovery.ucl.ac.uk/id/eprint/10170780/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10170780/15/Nature_manuscript_RPS.pdf
https://discovery.ucl.ac.uk/id/eprint/10170780/12/SI%20Guide%20with%20tables%20and%20figures_new_upload.pdf
https://discovery.ucl.ac.uk/id/eprint/10170780/8/Supplementary%20Table%201.xlsx
https://discovery.ucl.ac.uk/id/eprint/10170780/2/Supplementary%20Table%204.xls
https://discovery.ucl.ac.uk/id/eprint/10170780/4/Supplementary%20Table%205.xls
https://discovery.ucl.ac.uk/id/eprint/10170780/5/Supplementary%20Table%206.xls
https://discovery.ucl.ac.uk/id/eprint/10170780/11/Supplementary%20Table%207.xlsx
https://discovery.ucl.ac.uk/id/eprint/10170780/6/Supplementary%20Table%208.xlsx
https://discovery.ucl.ac.uk/id/eprint/10170780/7/Supplementary%20Table%209.xlsx
https://discovery.ucl.ac.uk/id/eprint/10170780/9/Suppl%20Video%201_Activation_mechanisms.mp4

المؤلفون: Wahab, Ben

Thesis Advisors: Watts, Paul

مصطلحات موضوعية: 540, Chemistry

الاتاحة: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669483

المؤلفون: Beswick, Paul, Wahab, Ben, Honey, Mark A., Paradowski, Michael, Jiang, Ke, Lochner, Martin, Murrell-Lagnado, Ruth D., Thompson, Andrew J.

مصطلحات موضوعية: antagonist, agonist, P2X1, P2X4, ligand, screen, ion channel, function, two-electrode voltage clamp, microplate

وصف الملف: application/PDF

Relation: https://www.sciencedirect.com/science/article/pii/S0028390819302345; Beswick, P., Wahab, B., Honey, M. A., Paradowski, M., Jiang, K., Lochner, M., Murrell-Lagnado, R. D. and Thompson, A. J. (2019) A challenge finding P2X1 and P2X4 ligands, Neuropharmacology, 157 (October 2019), DOI:10.1016/j.neuropharm.2019.107674; http://hdl.handle.net/2436/622514; Neuropharmacology

الاتاحة: http://hdl.handle.net/2436/622514
https://doi.org/10.1016/j.neuropharm.2019.107674

المؤلفون: Roe, Mark, Wahab, Ben, Torok, Zsolt, Horvath, Ibolya, Vigh, Laszlo, Prodromou, Chrisostomos

مصطلحات موضوعية: QD0415 Biochemistry, RC0521 Dementia, RM Therapeutics. Pharmacology

وصف الملف: application/pdf

Relation: http://sro.sussex.ac.uk/id/eprint/76485/1/fmolb-05-00051-2.pdf; Roe, Mark, Wahab, Ben, Torok, Zsolt, Horvath, Ibolya, Vigh, Laszlo and Prodromou, Chrisostomos (2018) Dihydropyridines allosterically modulate Hsp90 providing a novel mechanism for heat shock protein co-induction and neuroprotection. Frontiers in Molecular Biosciences, 5 (51). pp. 1-14. ISSN 2296-889X

الاتاحة: http://sro.sussex.ac.uk/id/eprint/76485/
http://sro.sussex.ac.uk/id/eprint/76485/1/fmolb-05-00051-2.pdf
https://doi.org/10.3389/fmolb.2018.00051

المؤلفون: Watts, P, Hooper, J, Wahab, Ben, Wiles, C

Relation: Watts, P, Hooper, J, Wahab, Ben and Wiles, C 2014. The synthesis of isotopically labelled compounds in micro reactors. Presented at: Topical Conference on Applications of Micro-Reactor Engineering 2007, Held at the 2007 AIChE Spring National Meeting, Houston, United States, 22-27 April 2007. -.

الاتاحة: https://orca.cardiff.ac.uk/id/eprint/117484/

المؤلفون: Wahab, Ben, Ellames, George, Passey, Stephen, Watts, Paul

Relation: Wahab, Ben, Ellames, George, Passey, Stephen and Watts, Paul 2010. Synthesis of substituted indoles using continuous flow micro reactors. Tetrahedron 66 (21) , pp. 3861-3865. 10.1016/j.tet.2010.03.005 https://doi.org/10.1016/j.tet.2010.03.005

الاتاحة: https://orca.cardiff.ac.uk/id/eprint/117483/
https://doi.org/10.1016/j.tet.2010.03.005

المؤلفون: Watts, P, Hooper, J, Wahab, Ben, Wiles, C

مصطلحات الفهرس: Conference or Workshop Item, NonPeerReviewed

URL: https://orca.cardiff.ac.uk/id/eprint/117484/
https://orca.cardiff.ac.uk/id/eprint/117484

المؤلفون: Watts, P, Hooper, J, Wahab, Ben, Wiles, C

مصطلحات الفهرس: Conference or Workshop Item, NonPeerReviewed

URL: https://orca.cardiff.ac.uk/id/eprint/117484/
https://orca.cardiff.ac.uk/id/eprint/117484