المؤلفون: Agustin Garcia-Caballero (5167760), Vinicius M. Gadotti (1352526), Md Yousof Ali (1684255), Chris Bladen (1352523), Eder Gambeta (12042056), Jeffrey F. Van Humbeck (11836735), Justin L. MacCallum (2036590), Gerald W. Zamponi (87133)

مصطلحات موضوعية: Biochemistry, Microbiology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, various rodent models, synthetically accessible small, produce false positives, mechanical allodynia induced, induced nocifensive behaviors, compound library screens, complete freund ’, 2 domain iii, deubiquitinase inhibitor wp1130, analgesic properties cav3, 1 also mediated, 2 null mice, 2 calcium channels, part mediated, molecule inhibitor, 2 interface, deubiquitinase usp5, without affecting, vivo experiments, thus confirming, throughput screening

Relation: https://figshare.com/articles/journal_contribution/A_Synthetically_Accessible_Small-Molecule_Inhibitor_of_USP5-Cav3_2_Calcium_Channel_Interactions_with_Analgesic_Properties/19117223

الاتاحة: https://doi.org/10.1021/acschemneuro.1c00765.s001

المؤلفون: Edanur Sen, Krishna P. Kota, Rekha G. Panchal, Sina Bavari, Erkan Kiris

المصدر: Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: Botulinum Neurotoxin, Botulinum Neurotoxin Light Chain Degradation, Botulinum Inhibitors, celastrol, WP1130, PR-619, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.763950/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/5976d6960ae14abe8977a4ec18ca95bf

المؤلفون: Hao Luo, Bo Jing, Yu Xia, Yugen Zhang, Meng Hu, Haiyan Cai, Yin Tong, Li Zhou, Li Yang, Junmei Yang, Hu Lei, Hanzhang Xu, Chuanxu Liu, Yingli Wu

المصدر: Cancer Cell International, Vol 19, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: WP1130, USP24, dCas9-SAM, T-cell acute lymphoblastic leukemia, Mcl-1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12935-019-0773-6; https://doaj.org/toc/1475-2867

URL الوصول: https://doaj.org/article/f0726dd3fc934045a32ccf506e57829c

المؤلفون: Hiroki Akiyama, Yoshihiro Umezawa, Daisuke Watanabe, Keigo Okada, Shinya Ishida, Ayako Nogami, Osamu Miura

المصدر: Cancers; Volume 12; Issue 2; Pages: 406

مصطلحات موضوعية: JAK2-V617F, USP9X, WP1130, ruxolitinib, myeloproliferative neoplasms, BH3 mimetics, oxidative stress

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cancers12020406

الاتاحة: https://doi.org/10.3390/cancers12020406

المؤلفون: Seok Kim, Seon Min Woo, Kyoung-jin Min, Seung Un Seo, Tae-Jin Lee, Peter Kubatka, Dong Eun Kim, Taeg Kyu Kwon

المصدر: Cancers; Volume 11; Issue 3; Pages: 344

مصطلحات موضوعية: WP1130, TRAIL, c-FLIP, DR5, MicroRNA

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cancers11030344

الاتاحة: https://doi.org/10.3390/cancers11030344

المؤلفون: Erkan Kiris, Sina Bavari, Rekha G. Panchal, Edanur Sen, Krishna P. Kota

المساهمون: OpenMETU

المصدر: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: Botulinum Neurotoxin, ubiquitin-proteasomal pathway, RM1-950, Botulinum Inhibitors, Protein degradation, Pharmacology, Deubiquitinating enzyme, chemistry.chemical_compound, Ubiquitin, WP1130, medicine, Pharmacology (medical), Botulism, celastrol, Original Research, Botulinum Neurotoxin Light Chain Degradation, biology, medicine.disease, PR-619, Ubiquitin ligase, chemistry, Proteasome, Celastrol, Ubiquitin-Proteasomal Pathway, biology.protein, Therapeutics. Pharmacology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecc4050e23c706028898646045188c5
https://hdl.handle.net/11511/93301

المؤلفون: Xiang Wang, Jianzhong Shao, Qiuqiang Chen, Zhaohui Dong, Huihui Guo, Ying Bao, Charlie Xiang

المصدر: Oncotarget

مصطلحات موضوعية: 0301 basic medicine, p53, non-small cell lung carcinomas, Lung Neoplasms, Pyridines, medicine.medical_treatment, Cell, cisplatin, Apoptosis, Drug resistance, USP9X, 03 medical and health sciences, Mice, 0302 clinical medicine, WP1130, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, medicine, Animals, Humans, Cyanoacrylates, Cell Proliferation, Cisplatin, Chemotherapy, business.industry, Cell growth, Ubiquitination, Combination chemotherapy, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Cell Transformation, Neoplastic, Oncology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Immunology, Proteolysis, Proteasome inhibitor, Cancer research, Tumor Suppressor Protein p53, business, medicine.drug, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffd852c6d1cd44d82c8f5a0035194da
http://europepmc.org/articles/PMC5564746

المؤلفون: Ayako Nogami, Hiroki Akiyama, Daisuke Watanabe, Yoshihiro Umezawa, Keigo Okada, Shinya Ishida, Osamu Miura

المصدر: Cancers
Cancers, Vol 12, Iss 2, p 406 (2020)
Volume 12
Issue 2

مصطلحات موضوعية: 0301 basic medicine, BH3 mimetics, Cancer Research, Ruxolitinib, DNA damage, ruxolitinib, p38 mitogen-activated protein kinases, USP9X, medicine.disease_cause, lcsh:RC254-282, Article, myeloproliferative neoplasms, 03 medical and health sciences, 0302 clinical medicine, WP1130, hemic and lymphatic diseases, medicine, oxidative stress, Myeloproliferative neoplasm, JAK2-V617F, Kinase, Chemistry, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 030104 developmental biology, Oncology, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, Oxidative stress, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfb366d2331feb62e93c80e1b2e2892
https://pubmed.ncbi.nlm.nih.gov/32050632

المؤلفون: Seung Un Seo, Dong-Eun Kim, Seok Kim, Seon Min Woo, Tae-Jin Lee, Peter Kubatka, Kyoung-jin Min, Taeg Kyu Kwon

المصدر: Cancers, Vol 11, Iss 3, p 344 (2019)
Cancers
Volume 11
Issue 3

مصطلحات موضوعية: Cancer Research, Gene knockdown, c-FLIP, Chemistry, TRAIL, MicroRNA, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Article, USP9X, Oncology, Downregulation and upregulation, Apoptosis, Flip, WP1130, microRNA, Carcinoma, medicine, Cancer research, Ectopic expression, DR5

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f5b5330aee639385812e85f5c1a20e
http://www.mdpi.com/2072-6694/11/3/344

المؤلفون: Yin Tong, Li Yang, Yugen Zhang, Li Zhou, Bo Jing, Ying-Li Wu, Yu Xia, Haiyan Cai, Meng Hu, Hanzhang Xu, Hao Luo, Hu Lei, Junmei Yang, Chuan-Xu Liu

المصدر: Cancer Cell International
Cancer Cell International, Vol 19, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Cancer Research, dCas9-SAM, T cell, USP24, lcsh:RC254-282, Rhodamine 123, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, In vivo, WP1130, Genetics, medicine, lcsh:QH573-671, Progenitor cell, Gene knockdown, lcsh:Cytology, Mcl-1, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cell biology, USP9X, medicine.anatomical_structure, Oncology, chemistry, Apoptosis, 030220 oncology & carcinogenesis, Primary Research, T-cell acute lymphoblastic leukemia

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b261300a67e5f81cde50b3cfac07e8
http://europepmc.org/articles/PMC6415346

المؤلفون: Stefan Drießen (774656), Niklas Berleth (774657), Olena Friesen (774658), Antje S Löffler (9291100), Philip Böhler (774660), Nora Hieke (774661), Fabian Stuhldreier (774662), Christoph Peter (231379), Kay O Schink (9291103), Sebastian W Schultz (9291106), Harald Stenmark (1165), Petter Holland (774664), Anne Simonsen (774665), Sebastian Wesselborg (774666), Björn Stork (774667)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, autophagy, deubiquitinases, ubiquitination, ULK1, WP1130

Relation: https://figshare.com/articles/dataset/Deubiquitinase_inhibition_by_WP1130_leads_to_ULK1_aggregation_and_blockade_of_autophagy/1493010

الاتاحة: https://doi.org/10.6084/m9.figshare.1493010