المؤلفون: Kelly Slocum, Jianmei Fan, Michael Dore, Palermo Mark G, Zhan Deng, Bakary-Barry Toure, Jorge Garcia-Fortanet, Dyuti Majumdar, Martin F. Hentemann, Nick Keen, Suzanne Zhu, Christopher Towler, Michael Shultz, William R. Sellers, Simon Mathieu, Denise Grunenfelder, Robert Koenig, Douglas C. Bauer, Shumei Liu, Jay Larrow, Victoriano Tamez, David Dunstan, Andreea Argintaru, Timothy Michael Ramsey, Zhouliang Chen, Gang Liu, Ying-Nan Chen, Rukundo Ntaganda, Bing Yu, Joanna Slisz, Hongyun Wang, Pascal D. Fortin, Christopher Sean Straub, Ji-Hu Zhang, Ping Wang, Laura R. LaBonte, Mitsunori Kato, Matthew J. Meyer, Fan Yang, Patrick James Sarver, Samuel B. Ho, Brant Firestone, Rajesh Karki, John F. Reilly, Troy Smith, Ho Man Chan, Cary Fridrich, John William Giraldes, Julie Boisclair, Chen Christine Hiu-Tung, Meir Glick, Zhao B. Kang, Morvarid Mohseni, Lawrence Blas Perez, Michael G. Acker, Sarah Williams, Matthew J. LaMarche, Martin Sendzik, Michelle Fodor, Huia-Xiang Hao, Peter Fekkes, Minying Pu, Travis Stams, Stanley Spence, Andriana Jouk

المصدر: Journal of medicinal chemistry. 63(22)

مصطلحات موضوعية: Drug, Programmed cell death, media_common.quotation_subject, Allosteric regulation, Antineoplastic Agents, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Pharmacology, 01 natural sciences, 03 medical and health sciences, Mice, Dogs, Allosteric Regulation, In vivo, Neoplasms, Drug Discovery, medicine, Tumor Cells, Cultured, Animals, Humans, Enzyme Inhibitors, Gene, 030304 developmental biology, media_common, 0303 health sciences, Chemistry, Cancer, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, Rats, PTPN11, 010404 medicinal & biomolecular chemistry, Macaca fascicularis, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345804676325a445ebbb9ef600ced79a
https://pubmed.ncbi.nlm.nih.gov/32910655

المؤلفون: Victoriano Tamez, Brant Firestone, Michelle Fodor, Martin Sendzik, Michael G. Acker, Stan Spence, Matthew J. LaMarche, Mitsunori Kato, Chen Liu, Christopher Towler, Ping Wang, Ho Man Chan, Eric McNeill, Shumei Liu, Morvarid Mohseni, Sarah Williams, Zhouliang Chen, Gang Liu, Bing Yu, Robert Koenig, Huaixiang Hao, Ying-Nan Chen, Murphy Hentemann, Ritesh Bhanudasji Tichkule, Hongyun Wang, Jorge Garcia Fortanet, Laura R. LaBonte, Jeffrey T. Bagdanoff, Travis Stams, Patrick James Sarver

المصدر: Journal of Medicinal Chemistry. 62:1793-1802

مصطلحات موضوعية: Male, Programmed cell death, Allosteric regulation, Administration, Oral, Aminopyridines, Antineoplastic Agents, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Pyrimidinones, Protein tyrosine phosphatase, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, Allosteric Regulation, Pharmacokinetics, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Potency, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, Molecular Structure, Bicyclic molecule, Chemistry, Xenograft Model Antitumor Assays, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Lipophilic efficiency, Chemical diversity, Molecular Medicine, Female, Allosteric Site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24d74ccebe527aac56b75855102ac3c
https://doi.org/10.1021/acs.jmedchem.8b01726

المؤلفون: Christopher Towler, Andriana Jouk, Murphy Hentemann, Matthew J. LaMarche, Bing Yu, Jorge Garcia Fortanet, Michelle Fodor, Hongyun Wang, Sarah Williams, Morvarid Mohseni, Shumei Liu, Huaixiang Hao, Ritesh Bhanudasji Tichkule, Ying-Nan Chen, Chen Liu, Ping Wang, Patrick James Sarver, Stan Spence, Laura R. LaBonte, Jeffrey T. Bagdanoff, Brant Firestone, Michael Shultz, Martin Sendzik, Eric McNeill, Zhouliang Chen, Gang Liu, Victoriano Tamez, Robert Koenig, Michael G. Acker, Ho Man Chan, Travis Stams, Mitsunori Kato

المصدر: Journal of medicinal chemistry. 62(7)

مصطلحات موضوعية: Text mining, business.industry, Chemistry, Drug Discovery, Molecular Medicine, Pharmacology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385537f7a24ba5be8ef7298e05ce98f5
https://pubmed.ncbi.nlm.nih.gov/30688459

المؤلفون: Alex Aycinena, Yu Ding, Audry Kauffmann, Tatiana Zavorotinskaya, Amy Lambert, John L. Langowski, Julie Chan, Cornelia Bellamacina, Robert Lowell Simmons, Yumin Dai, Min Y. Chen, Christine Fritsch, Gordana Atallah, Elaine Ginn, Victoriano Tamez, Matthew Burger, Kristine Muller, Richard Zang, Paul Feucht, Joseph Castillo, Estelle Pfister, K. Gary Vanasse, Mika Lindvall, Pablo Garcia, Michelle Mathur, Wooseok Han, Gisele Nishiguchi, Jocelyn Holash, Yingyun Wang, Kay Huh, Zhang Yanchen, Steve Basham, Jiong Lan

المصدر: Journal of Medicinal Chemistry. 58:8373-8386

مصطلحات موضوعية: Chemistry, Kinase, Myeloid leukemia, Cancer, medicine.disease, Virology, In vitro, Clinical trial, Leukemia, In vivo, hemic and lymphatic diseases, Drug Discovery, medicine, Cancer research, Molecular Medicine, Multiple myeloma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3fbae38e8687d6cf1c7760d3d1539a2b
https://doi.org/10.1021/acs.jmedchem.5b01275

المؤلفون: Yan Lou, Sharadha Subramanian, Yingyun Wang, Lifeng Wan, John Tellew, Laura Tandeske, Benjamin R. Taft, Kalyani Gampa, Jacob R. Haling, Gisele Nishiguchi, Lina Setti, Alice Rico, Sylvia Ma, Payman Amiri, Mallika Singh, Huw Tanner, Brent A. Appleton, Robert J. Aversa, Sepideh Vaziri, Shenlin Huang, Johanna M. Jansen, Anne Van Abbema, Jing Yuan, Vesselina G. Cooke, Hanne Merritt, Aaron Smith, Wenlin Shao, Valery Polyakov, Fei Feng, Savithri Ramurthy, Matthew Burger, Mulugeta Mamo, Lesley A. Mathews Griner, Vijay Sethuraman, Victoriano Tamez, Michael Patrick Dillon, Emma Lees, Ina Dix, Paul A. Barsanti, Richard Zang, Darrin Stuart, Mohammad Hekmat-Nejad

المصدر: Journal of medicinal chemistry. 60(12)

مصطلحات موضوعية: 0301 basic medicine, Proto-Oncogene Proteins B-raf, Mutant, Antineoplastic Agents, medicine.disease_cause, Crystallography, X-Ray, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 0302 clinical medicine, 2,2'-Dipyridyl, Dogs, Drug Stability, Neoplasms, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, c-Raf, Molecular Targeted Therapy, Benzamide, Chemistry, Kinase, Drug discovery, Small molecule, Xenograft Model Antitumor Assays, Rats, 030104 developmental biology, Biochemistry, 030220 oncology & carcinogenesis, Drug Design, Benzamides, ras Proteins, Molecular Medicine, raf Kinases, KRAS

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2623e531b4911ee04267b3f1e132c67
https://pubmed.ncbi.nlm.nih.gov/28557458

المؤلفون: Cornelia Bellamacina, Gordana Atallah, Gisele Nishiguchi, Victoriano Tamez, Yumin Dai, Jiong Lan, Pablo Garcia, Mika Lindvall, Paul Feucht, Wooseok Han, Matthew Burger, Kent Wong, Tatiana Zavorotinskaya

المصدر: Bioorganicmedicinal chemistry letters. 26(9)

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Serine, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Downregulation and upregulation, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Drug Discovery, medicine, Structure–activity relationship, Threonine, Molecular Biology, Protein Kinase Inhibitors, Chemistry, Kinase, Organic Chemistry, Amides, 030104 developmental biology, 030220 oncology & carcinogenesis, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f950c64b01f379325235713e8896168
https://pubmed.ncbi.nlm.nih.gov/26995528

المؤلفون: Matthew T, Burger, Gisele, Nishiguchi, Wooseok, Han, Jiong, Lan, Robert, Simmons, Gordana, Atallah, Yu, Ding, Victoriano, Tamez, Yanchen, Zhang, Michelle, Mathur, Kristine, Muller, Cornelia, Bellamacina, Mika K, Lindvall, Richard, Zang, Kay, Huh, Paul, Feucht, Tatiana, Zavorotinskaya, Yumin, Dai, Steve, Basham, Julie, Chan, Elaine, Ginn, Alex, Aycinena, Jocelyn, Holash, Joseph, Castillo, John L, Langowski, Yingyun, Wang, Min Y, Chen, Amy, Lambert, Christine, Fritsch, Audry, Kauffmann, Estelle, Pfister, K Gary, Vanasse, Pablo D, Garcia

المصدر: Journal of medicinal chemistry. 58(21)

مصطلحات موضوعية: Models, Molecular, Leukemia, Myeloid, Acute, Mice, Halogenation, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Proto-Oncogene Proteins, Animals, Humans, Protein Serine-Threonine Kinases, Picolinic Acids, Amides, Protein Kinase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::520e2275f65794da2b12343a31ae7d5e
https://pubmed.ncbi.nlm.nih.gov/26505898

المؤلفون: Robert Erik Plata, Victoriano Tamez, John A. Grosso, Venkatapuram A. Palaniswamy, Apurba Bhattacharya, Nitinchandra D. Patel, Michael Peddicord, Sankara Cherukuri

المصدر: Tetrahedron Letters. 47:5481-5484

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Organic Chemistry, Drug Discovery, Organic chemistry, One-Step, General Medicine, Solvent effects, Condensation reaction, Biochemistry, Combinatorial chemistry, Pyrrole derivatives, Pyrrole

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d38ec18e8d7349c59b2822f42b541d
https://doi.org/10.1016/j.tetlet.2006.05.167

المؤلفون: Victor Suarez, Jiejun Wu, Apurba Bhattacharya, Victoriano Tamez

المصدر: Tetrahedron Letters. 47:3221-3223

مصطلحات موضوعية: In situ, chemistry.chemical_compound, Chemistry, Regeneration (biology), Organic Chemistry, Drug Discovery, Organic chemistry, Thioacetic acid, Biochemistry, Environmentally friendly, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b3b0b99d54fb0318c8b10915db43e7e1
https://doi.org/10.1016/j.tetlet.2006.03.057

المؤلفون: Victoriano Tamez, Kay Huh, John L. Langowski, Tatiana Zavorotinskaya, Min Y. Chen, Gisele Nishiguchi, Matthew Burger, Zhang Yanchen, Jocelyn Holash, Cornelia Bellamacina, Pablo Garcia, Kristine Muller, Michelle Mathur, Wooseok Han, Jiong Lan, Joseph Castillo, Christopher McBride, Paul Feucht, Mika Lindval, Yu Ding, Yumin Dai, Gordana Atallah, Elizabeth L. Beans, Yingyun Wang

مصطلحات موضوعية: Myeloid, Kinase, Organic Chemistry, Myeloid leukemia, PIM1, Biology, medicine.disease, Biochemistry, Virology, In vitro, Lymphoma, Haematopoiesis, medicine.anatomical_structure, In vivo, hemic and lymphatic diseases, Drug Discovery, medicine, Cancer research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944da92389832ca637e9d382159688c5
https://europepmc.org/articles/PMC4027555/

المؤلفون: Narayan G. Bhat, Laura Garcia, Victoriano Tamez

المصدر: Tetrahedron Letters. 44:7175-7177

مصطلحات موضوعية: chemistry.chemical_classification, Organic Chemistry, General Medicine, Medicinal chemistry, Biochemistry, chemistry.chemical_compound, chemistry, Bromide, Intramolecular force, Drug Discovery, Nucleophilic substitution, Organic chemistry, Moiety, Hydrogen peroxide, Sodium acetate, Alkyl, Tetrahydrofuran

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335d74ebdc37af563b2c6fc85647339f
https://doi.org/10.1016/s0040-4039(03)01841-0

المؤلفون: Matthew T. Burger, Gisele Nishiguchi, Wooseok Han, Jiong Lan, Robert Simmons, Gordana Atallah, Yu Ding, Victoriano Tamez, Yanchen Zhang, Michelle Mathur, Kristine Muller, Cornelia Bellamacina, MikaK. Lindvall, Richard Zang, Kay Huh, Paul Feucht, Tatiana Zavorotinskaya, Yumin Dai, Steve Basham, Julie Chan

المصدر: Journal of Medicinal Chemistry; Nov2015, Vol. 58 Issue 21, p8373-8386, 14p