المؤلفون: Stables, J, Green, EK, Sehgal, A, Patkar, OL, Keshvari, S, Taylor, I, Ashcroft, ME, Grabert, K, Wollscheid-Lengeling, E, Szymkowiak, S, McColl, BW, Adamson, A, Humphreys, NE, Mueller, W, Starobova, H, Vetter, I, Shabestari, SK, Blurton-Jones, MM, Summers, KM, Irvine, KM, Pridans, C, Hume, DA

المصدر: Development (Cambridge, England). 149(8)

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:149463830

المؤلفون: Shatunova, S, Aktar, R, Peiris, M, Lee, JYP, Vetter, I, Starobova, H

مصطلحات موضوعية: CIPN pathology, CIPN treatments, chemotherapy-induced dysbiosis, metabolites and neurotransmitters, peripheral mechanisms of CIPN

وصف الملف: 176818 - ?

Relation: Eur J Pharmacol; Svetlana Shatunova, Rubina Aktar, Madusha Peiris, Jia Yu Peppermint Lee, Irina Vetter, Hana Starobova, The Role of the Gut Microbiome in Neuroinflammation and Chemotherapy-Induced Peripheral Neuropathy, European Journal of Pharmacology, 2024, 176818, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2024.176818. (https://www.sciencedirect.com/science/article/pii/S0014299924005077) Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating adverse effects caused by chemotherapy drugs such as paclitaxel, oxaliplatin and vincristine. It is untreatable and often leads to the discontinuation of cancer therapy and a decrease in the quality of life of cancer patients. It is well-established that neuroinflammation and the activation of immune and glial cells are among the major drivers of CIPN. However, these processes are still poorly understood, and while many chemotherapy drugs alone can drive the activation of these cells and consequent neuroinflammation, it remains elusive to what extent the gut microbiome influences these processes. In this review, we focus on the peripheral mechanisms driving CIPN, and we address the bidirectional pathways by which the gut microbiome communicates with the immune and nervous systems. Additionally, we critically evaluate literature addressing how chemotherapy-induced dysbiosis and the consequent imbalance in bacterial products may contribute to the activation of immune and glial cells, both of which drive neuroinflammation and possibly CIPN development, and how we could use this knowledge for the development of effective treatment strategies. Keywords: CIPN pathology; chemotherapy-induced dysbiosis; metabolites and neurotransmitters; peripheral mechanisms of CIPN; CIPN treatments; https://qmro.qmul.ac.uk/xmlui/handle/123456789/98400

الاتاحة: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98400
https://doi.org/10.1016/j.ejphar.2024.176818

المؤلفون: Castro, J., Maddern, J., Chow, C.Y., Tran, P., Vetter, I., King, G.F., Brierley, S.M.

المصدر: http://dx.doi.org/10.1111/jnc.15795.

مصطلحات موضوعية: chronic pelvic pain, Endometriosis, mechanosensitivity, vagina-innervating afferents, visceromotor response, voltage-gated sodium channels

وصف الملف: application/pdf

Relation: http://purl.org/au-research/grants/nhmrc/1181448; http://purl.org/au-research/grants/nhmrc/2008727; http://purl.org/au-research/grants/nhmrc/1136889; http://purl.org/au-research/grants/nhmrc/1162503; http://purl.org/au-research/grants/nhmrc/2014250; http://purl.org/au-research/grants/arc/DP220101269; http://purl.org/au-research/grants/arc/CE200100012; Journal of Neurochemistry, 2023; 1-17; https://hdl.handle.net/2440/137703; Brierley, S.M. [0000-0002-2527-2905]

الاتاحة: https://hdl.handle.net/2440/137703
https://doi.org/10.1111/jnc.15795

المؤلفون: Henriques, ST, Deplazes, E, Lawrence, N, Cheneval, O, Chaousis, S, Inserra, M, Thongyoo, P, King, GF, Mark, AE, Vetter, I, Craik, DJ, Schroeder, CI

مصطلحات موضوعية: 03 Chemical Sciences, 06 Biological Sciences, 11 Medical and Health Sciences, Biochemistry & Molecular Biology, Binding Sites, Humans, Lipid Bilayers, Molecular Dynamics Simulation, NAV1.7 Voltage-Gated Sodium Channel, Nuclear Magnetic Resonance, Biomolecular, Spider Venoms

وصف الملف: Print-Electronic; application/pdf

Relation: J Biol Chem; J Biol Chem, 2016, 291, (33), pp. 17049-17065; http://hdl.handle.net/10453/155517

الاتاحة: http://hdl.handle.net/10453/155517

المؤلفون: Beaufort, N., Ingendahl, L., Merdanovic, M., Schmidt, A., Podlesainski, D., Richter, T., Neumann, T., Kuszner, M., Vetter, I., Stege, P., Burston, S., Filipovic, A., Ruiz-Blanco, Y., Bravo-Rodriguez, K., Mieres-Perez, J., Beuck, C., Uebel, S., Zobawa, M., Schillinger, J., Malik, R., Todorov-Voelgyi, K., Rey, J., Roberti, A., Hagemeier, B., Wefers, B., Mueller, S., Wurst, W., Sanchez-Garcia, E., Zimmermann, A., Hu, X., Clausen, T., Huber, R., Lichtenthaler, S., Schmuck, C., Giese, M., Kaiser, M., Ehrmann, M., Dichgans, M.

المصدر: Nature Communications

Relation: http://hdl.handle.net/21.11116/0000-000F-AAEC-8

الاتاحة: http://hdl.handle.net/21.11116/0000-000F-AAEC-8

المؤلفون: Hu, H., Mawlawi, S. E., Zhao, T., Deuis, J. R., Jami, S., Vetter, I., Lewis, R. J., Cardoso, F. C.

المساهمون: National Health and Medical Research Council

المصدر: Frontiers in Molecular Biosciences ; volume 8 ; ISSN 2296-889X

الاتاحة: http://dx.doi.org/10.3389/fmolb.2021.742457
https://www.frontiersin.org/articles/10.3389/fmolb.2021.742457/full

المؤلفون: Aili, SR, Touchard, A, Hayward, R, Robinson, SD, Pineda, SS, Lalagüe, H, Mrinalini, Vetter, I, Undheim, EAB, Kini, RM, Escoubas, P, Padula, MP, Myers, GSA, Nicholson, GM

مصطلحات موضوعية: 0601 Biochemistry and Cell Biology, 1115 Pharmacology and Pharmaceutical Sciences

وصف الملف: Electronic; application/pdf

Relation: Toxins; Toxins, 2020, 12, (5); http://hdl.handle.net/10453/142196

الاتاحة: http://hdl.handle.net/10453/142196

المؤلفون: Starobova, H., Mueller, A., Allavena, R., Lohman, R. J., Sweet, M. J., Vetter, I.

المساهمون: National Health and Medical Research Council

المصدر: Frontiers in Neuroscience ; volume 13 ; ISSN 1662-453X

الاتاحة: http://dx.doi.org/10.3389/fnins.2019.00653
https://www.frontiersin.org/article/10.3389/fnins.2019.00653/full

المؤلفون: Polley, S., Müschenborn, H., Terbeck, M., De Antoni, A., Vetter, I., Dogterom, M., Musacchio, A., Volkov, V., Huis in´t Veld, P.

المصدر: EMBO Journal

Relation: http://hdl.handle.net/21.11116/0000-000D-2F69-A

الاتاحة: http://hdl.handle.net/21.11116/0000-000D-2F69-A

المؤلفون: Kazandjian, Taline D., Petras, D., Robinson, S. D., van Thiel, J., Greene, Harry W., Arbuckle, K., Barlow, A., Carter, D. A., Wouters, R. M., Whiteley, G., Wagstaff, S. C., Arias, A. S., Albulescu, L.O., Plettenberg Laing, A., Hall, C., Heap, A., Penrhyn-Lowe, S., McCabe, C. V., Ainsworth, S., da Silva, R. R., Dorrestein, P. C., Richardson, M. K., Gutierrez, J. M., Calvete, Juan J., Harrison, R. A., Vetter, I., Undheim, E. A. B., Wuster, W., Casewell, Nicholas R.

المساهمون: German Research Foundation, National Science Foundation (US), Sao Paulo Research Foundation, Leverhulme Trust, Medical Research Council (UK), Australian Research Council, Research Council of Norway, Royal Society (UK), Calvete, Juan J.

Relation: Preprint; Kazandjian, T. D.; Petras, D.; Robinson, S. D.; van Thiel, J.; Greene, H. W.; Arbuckle, K.; Barlow, A.; Carter, D. A.; Wouters, R. M.; Whiteley, G.; Wagstaff, S. C.; Arias, A. S.; Albulescu, L. O.; Plettenberg Laing, A.; Hall, C.; Heap, A.; Penrhyn-Lowe, S.; McCabe, C. V.; Ainsworth, S.; da Silva, R. R.; Dorrestein, P. C.; Richardson, M. K.; Gutierrez, J. M.; Calvete, J. J.; Harrison, R. A.; Vetter, I.; Undheim, E. A. B.; Wuster, W.; Casewell, N. R. Convergent evolution of pain-inducing defensive venom components in spitting cobras. Science 371(6527):386-390 (2021). 10.1126/science.abb9303. http://hdl.handle.net/10261/246347; https://dx.doi.org/10.1101/2020.07.08.192443; Sí; Kazandjian, T.D.; Petras, D.; Robinson, S. D.; van Thiel, J.; Greene, H. W.; Arbuckle, K.; Barlow, A.; Carter, D. A.; Wouters, R. M.; Whiteley, G.; Wagstaff, S. C.; Arias, A. S.; Albulescu, L. O.; Plettenberg Laing, A.; Hall, C.; Heap, A.; Penrhyn-Lowe, S.; McCabe, C. V.; Ainsworth, S.; da Silva, R. R.; Dorrestein, P. C.; Richardson, M. K.; Gutierrez, J. M.; Calvete, Juan J.; Harrison, R. A.; Vetter, I.; Undheim, E. A. B.; Wuster, W.; Casewell, N. R.; 2020; "Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras (Preprint)"; bioRxiv; 10.1101/2020.07.08.192443; http://hdl.handle.net/10261/246322; http://dx.doi.org/10.13039/100000001; http://dx.doi.org/10.13039/501100000923; http://dx.doi.org/10.13039/501100001659; http://dx.doi.org/10.13039/501100000275; http://dx.doi.org/10.13039/501100000265; http://dx.doi.org/10.13039/501100000288

الاتاحة: http://hdl.handle.net/10261/246322
https://doi.org/10.1101/2020.07.08.192443
https://doi.org/10.13039/100000001
https://doi.org/10.13039/501100000923
https://doi.org/10.13039/501100001659
https://doi.org/10.13039/501100000275
https://doi.org/10.13039/501100000265
https://doi.org/10.13039/501100000288

المؤلفون: Walker, A A, Dobson, J, Jin, J, Robinson, S D, Herzig, Volker, Vetter, I, King, G F, Fry, B G

مصطلحات موضوعية: FoR 0601 (Biochemistry and Cell Biology), FoR 1115 (Pharmacology and Pharmaceutical Sciences), venom, peptide, defensin, Asilidae, Diptera, insect venom, Asilidin, inhibitor cystine knot, extra-oral digestion

Relation: usc:30251; URN:ISSN: 2072-6651

الاتاحة: https://doi.org/10.3390/toxins10110456

المؤلفون: Jami, S., Erickson, A., Brierley, S., Vetter, I.

المصدر: http://dx.doi.org/10.3390/toxins10010015.

مصطلحات موضوعية: ASIC, TRP channel, animal venom, pain, pore forming toxin, sodium channel

وصف الملف: application/pdf

Relation: http://purl.org/au-research/grants/nhmrc/1126378; http://purl.org/au-research/grants/nhmrc/1083480; http://purl.org/au-research/grants/nhmrc/1139366; http://purl.org/au-research/grants/nhmrc/1102267; http://purl.org/au-research/grants/nhmrc/1125766; http://purl.org/au-research/grants/nhmrc/1140297; http://purl.org/au-research/grants/arc/FT130101215; Toxins, 2018; 10(1):1-15; http://hdl.handle.net/2440/111810; Brierley, S. [0000-0002-2527-2905]

الاتاحة: http://hdl.handle.net/2440/111810
https://doi.org/10.3390/toxins10010015

المؤلفون: Sousa, S R, Wingerd, J S, Brust, A, Bladen, C, Ragnarsson, L, Herzig, Volker, Deuis, J R, Dutertre, S, Vetter, I, Zamponi, G W, King, G F, Alewood, P F, Lewis, R J

مصطلحات موضوعية: FoR multidisciplinary

Relation: usc:30254; URN:ISSN: 1932-6203

الاتاحة: https://doi.org/10.1371/journal.pone.0182848

المؤلفون: Deuis, J R, Dekan, Z, Wingerd, J S, Smith, J J, Munasinghe, N R, Bhola, R F, Imlach, W L, Herzig, Volker, Armstrong, D A, Rosengren, K J, Bosmans, F, Waxman, S G, Dib-Hajj, S D, Escoubas, P, Minett, M S, Christie, M J, King, G F, Alewood, P F, Lewis, R J, Wood, J N, Vetter, I

مصطلحات موضوعية: FoR multidisciplinary

Relation: usc:30256; URN:ISSN: 2045-2322

الاتاحة: https://doi.org/10.1038/srep40883

المؤلفون: Barry, G, Briggs, JA, Hwang, DW, Nayler, SP, Fortuna, PRJ, Jonkhout, N, Dachet, F, Maag, JLV, Mestdagh, P, Singh, EM, Avesson, L, Kaczorowski, DC, Ozturk, E, Jones, NC, Vetter, I, Arriola-Martinez, L, Hu, J, Franco, GR, Warn, VM, Gong, A, Dinger, ME, Rigo, F, Lipovich, L, Morris, MJ, O'Brien, TJ, Lee, DS, Loeb, JA, Blackshaw, S, Mattick, JS, Wolvetang, EJ

المصدر: urn:ISSN:2045-2322 ; Scientific Reports, 7, 1, 40127

مصطلحات موضوعية: 32 Biomedical and Clinical Sciences, 3209 Neurosciences, Brain Disorders, Stem Cell Research, Stem Cell Research - Induced Pluripotent Stem Cell, Genetics, Neurosciences, Epilepsy, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Neurodegenerative, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Neurological, Animals, Brain, Cells, Cultured, Cortical Excitability, Humans, Kv Channel-Interacting Proteins, Neurons, Pluripotent Stem Cells, Potassium Channels, Voltage-Gated, Protein Binding, RNA, Long Noncoding, Rats, Seizures, Shaker Superfamily of Potassium Channels

وصف الملف: application/pdf

Relation: http://hdl.handle.net/1959.4/unsworks_43781; https://doi.org/10.1038/srep40127

الاتاحة: http://hdl.handle.net/1959.4/unsworks_43781
https://unsworks.unsw.edu.au/bitstreams/c077f3d5-74b2-4b40-9fea-5dd4f5f1fa4a/download
https://doi.org/10.1038/srep40127

المؤلفون: Inserra, M., Israel, M., Caldwell, A., Castro, J., Deuis, J., Harrington, A., Keramidas, A., Garcia-Caraballo, S., Maddern, J., Erickson, A., Grundy, L., Rychkov, G., Zimmermann, K., Lewis, R., Brierley, S., Vetter, I.

المصدر: http://dx.doi.org/10.1038/srep42810.

مصطلحات موضوعية: Ganglia, Spinal, Cells, Cultured, Animals, Humans, Mice, Ciguatoxins, Protein Isoforms, Gene Expression Regulation, Action Potentials, HEK293 Cells, Voltage-Gated Sodium Channels

وصف الملف: application/pdf

Relation: Scientific Reports, 2017; 7(1):42810-1-42810-19; http://hdl.handle.net/2440/105011; Castro, J. [0000-0002-5781-2224]; Harrington, A. [0000-0002-1562-4137]; Grundy, L. [0000-0002-3900-7141]; Rychkov, G. [0000-0002-2788-2977]; Brierley, S. [0000-0002-2527-2905]

الاتاحة: http://hdl.handle.net/2440/105011
https://doi.org/10.1038/srep42810

المؤلفون: Deuis, JR, Dekan, Z, Wingerd, JS, Smith, JJ, Munasinghe, NR, Bhola, RF, Imlach, WL, Herzig, V, Armstrong, DA, Rosengren, KJ, Bosmans, F, Waxman, SG, Dib-Hajj, SD, Escoubas, P, Minett, MS, Christie, MJ, King, GF, Alewood, PF, Lewis, RJ, Wood, JN, Vetter, I

المصدر: Scientific Reports , 7 , Article 40883. (2017)

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/1538505/1/Deuis_Pharmacological%20characterisation%20of%20the%20highly%20NaV17%20selective%20spider%20venom.pdf; https://discovery.ucl.ac.uk/id/eprint/1538505/2/Deuis_Pharmacological%20characterisation%20of%20the%20highly%20NaV17%20selective%20spider%20venom%20SUPPL.pdf; https://discovery.ucl.ac.uk/id/eprint/1538505/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/1538505/1/Deuis_Pharmacological%20characterisation%20of%20the%20highly%20NaV17%20selective%20spider%20venom.pdf
https://discovery.ucl.ac.uk/id/eprint/1538505/2/Deuis_Pharmacological%20characterisation%20of%20the%20highly%20NaV17%20selective%20spider%20venom%20SUPPL.pdf
https://discovery.ucl.ac.uk/id/eprint/1538505/

المؤلفون: Raisch, T., Ciossani, G., d'Amico, E., Cmentowski, V., Carmignani, S., Maffini, S., Merino, F., Wohlgemuth, S., Vetter, I., Raunser, S., Musacchio, A.

المصدر: The EMBO Journal

Relation: info:eu-repo/semantics/altIdentifier/pmid/35373361; http://hdl.handle.net/21.11116/0000-000B-A9DA-1

الاتاحة: http://hdl.handle.net/21.11116/0000-000B-A9DA-1

المؤلفون: Rai, A., Singh, A., Bleimling, N., Posern, G., Vetter, I., Goody, R.

المصدر: Nature Communications

Relation: http://hdl.handle.net/21.11116/0000-000A-C649-5

الاتاحة: http://hdl.handle.net/21.11116/0000-000A-C649-5

المؤلفون: Pesenti, M., Raisch, T., Conti, D., Walstein, K., Hoffmann, I., Vogt, D., Prumbaum, D., Vetter, I., Raunser, S., Musacchio, A.

المصدر: Molecular Cell

Relation: http://hdl.handle.net/21.11116/0000-000A-75FA-9

الاتاحة: http://hdl.handle.net/21.11116/0000-000A-75FA-9