يعرض 1 - 20 نتائج من 331 نتيجة بحث عن '"Vatanen, Tommi"', وقت الاستعلام: 0.57s تنقيح النتائج
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    Academic Journal
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    Academic Journal
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    Academic Journal

    المصدر: Vatanen , T , de Beaufort , C , Marcovecchio , M L , Overbergh , L , Brunak , S , Peakman , M , Mathieu , C & Knip , M 2024 , ' Gut microbiome shifts in people with type 1 diabetes are associated with glycaemic control : an INNODIA study ' , Diabetologia , vol. 67 , no. 9 , pp. 1930-1942 . https://doi.org/10.1007/s00125-024-06192-7

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    Academic Journal

    المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, HUS Children and Adolescents, Children's Hospital, Faculty of Medicine, University of Helsinki, Research Programs Unit, Research Group Knip, Molecular and Integrative Biosciences Research Programme, Helsinki Institute of Life Science HiLIFE, Faculty Common Matters (Faculty of Medicine), Clinicum

    وصف الملف: application/pdf

    Relation: This work was supported by Medicinska underst\u00F6dsf\u00F6reningen Liv och H\u00E4lsa, Finska L\u00E4kares\u00E4llskapet and Pediatric Research Foundation in Finland. Funding: Funding: This work was supported by Medicinska underst\u00F6dsf\u00F6reningen Liv och H\u00E4lsa, Finska L\u00E4kares\u00E4llskapet and Pediatric Research Foundation in Finland. This work was supported by Medicinska underst\u00F6dsf\u00F6reningen Liv och H\u00E4lsa, Finska L\u00E4kares\u00E4llskapet and Pediatric Research Foundation in Finland. The authors thank all the participants, hospitals and personnel of the Finnish Pediatric Diabetes Register.; This work was supported by Medicinska understodsforeningen Liv och Halsa, Finska Lakaresaellskapet and Pediatric Research Foundation in Finland.; http://hdl.handle.net/10138/588703; 85210088098; 001371070400001

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    Academic Journal

    المساهمون: Department of Microbiology, University of Helsinki, Helsinki Institute of Life Science HiLIFE, Helsinki Institute of Sustainability Science (HELSUS), Helsinki One Health (HOH), Viikki Plant Science Centre (ViPS), CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine

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    Relation: Kreuze K and Vatanen T were supported by the Research Council of Finland grants 346950 and 353513.; Kreuze , K , Friman , V P & Vatanen , T 2024 , ' Mobile genetic elements : the hidden puppet masters underlying infant gut microbiome assembly? ' , Microbiome research reports , vol. 3 , no. 4 , 56 . https://doi.org/10.20517/mrr.2024.51; http://hdl.handle.net/10138/588684; 85209812442; 001361273000001

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    Academic Journal
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    Academic Journal

    المساهمون: Lastentautien Tutkimussäätiö, Medicinska Understödsföreningen Liv och Hälsa, Finska Läkaresällskapet

    المصدر: HLA ; volume 104, issue 5 ; ISSN 2059-2302 2059-2310

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    Academic Journal

    المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, Faculty Common Matters (Faculty of Medicine), University of Helsinki, Children's Hospital, Helsinki University Hospital Area, HUS Children and Adolescents, Clinicum

    وصف الملف: application/pdf

    Relation: We thank Tiffany Poon, Luke Besse, and Timothy Arthur for sample and data management and Theresa Reimels for editorial assistance and figure preparation. This work was funded by the National Institutes of Health ( P30 DK043351 to R.J.X.), Juvenile Diabetes Research Foundation ( 2-SRA-2016-247-S-B ), Center for Microbiome Informatics and Therapeutics, and Wallenberg Foundations (to K.S.J.). M.Y. is the Rosalind, Paul and Robin Berlin Faculty Development Chair in Perinatal Research. We thank Tiffany Poon, Luke Besse, and Timothy Arthur for sample and data management and Theresa Reimels for editorial assistance and figure preparation. This work was funded by the National Institutes of Health (P30 DK043351 to R.J.X.), Juvenile Diabetes Research Foundation (2-SRA-2016-247-S-B), Center for Microbiome Informatics and Therapeutics, and Wallenberg Foundations (to K.S.J.). M.Y. is the Rosalind, Paul and Robin Berlin Faculty Development Chair in Perinatal Research. T.V. H.V. M.K. and R.J.X. served as principal investigators. T.V. and K.S.J. analyzed metagenomic data. T.V. K.S.J. J.A.-P. M.S. C.B.C. and D.R.P. analyzed metabolomic data. T.R. analyzed intestinal biomarkers. J.H. analyzed cytokines. T.R. J.H. H.S. S.O. H.H. J.I. S.M.V. and M.K. contributed to collection of stool and blood samples and patient information. M.Y. and C.M.M. collected breast milk samples. T.V. K.S.J. D.R.P. H.V. and R.J.X. drafted the manuscript. All authors discussed the results, critically reviewed the text, and approved the final manuscript. R.J.X. is co-founder of Jnana Therapeutics and Celsius Therapeutics, board director at MoonLake Immunotherapeutics, and consultant to Nestlé; these organizations had no role in the study.; Vatanen , T , Jabbar , K S , Ruohtula , T , Honkanen , J , Avila-Pacheco , J , Siljander , H , Stražar , M , Oikarinen , S , Hyöty , H , Ilonen , J , Mitchell , C M , Yassour , M , Virtanen , S M , Clish , C B , Plichta , D R , Vlamakis , H , Knip , M & Xavier , R J 2022 , ' Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism ' , Cell , vol. 185 , no. 26 , pp. 4921-4936.e15 . https://doi.org/10.1016/j.cell.2022.11.023 , https://doi.org/10.1016/j.cell.2022.11.023; ORCID: /0000-0002-2779-3384/work/128032679; ORCID: /0000-0003-0949-1291/work/128033162; http://hdl.handle.net/10138/569828; b361273f-28e6-4eab-a116-e5c6f415caea; 85144246023; 000910695500001

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    Academic Journal

    المساهمون: Helsinki Institute of Life Science HiLIFE, Faculty Common Matters (Faculty of Medicine), CAMM - Research Program for Clinical and Molecular Metabolism

    وصف الملف: application/pdf

    Relation: Tweedie-Cullen , R Y , Leong , K , Wilson , B C , Derraik , J G B , Albert , B B , Monk , R , Vatanen , T , Creagh , C , Depczynski , M , Edwards , T , Beck , K , Thabrew , H , O'Sullivan , J M & Cutfield , W S 2024 , ' Protocol for the Gut Bugs in Autism Trial : a double-blind randomised placebo-controlled trial of faecal microbiome transfer for the treatment of gastrointestinal symptoms in autistic adolescents and adults ' , BMJ Open , vol. 14 , no. 2 , e074625 . https://doi.org/10.1136/bmjopen-2023-074625; ORCID: /0000-0003-0949-1291/work/155653216; http://hdl.handle.net/10138/573110; c49d9f2f-ad20-4490-8c4b-890ef4255db6; 85185136642; 001184418700016

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    Academic Journal

    المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, University of Helsinki, Faculty Common Matters (Faculty of Medicine)

    وصف الملف: application/pdf

    Relation: Finally, B. longum subsp. infantis and its associated metabolites, such as indolelactate, were positively correlated with two measures of growth (WFL and WFA) in our cohort, thus adding to a growing body of evidence supporting the importance of B. longum subsp. infantis and its metabolites for infant development (Barratt et al., 2022). We found N-acetylglutamate levels in the stool, as well as two microbial pathways involving N-acetylglutamate, to be positively associated with all tested growth measures including LFA. This observation is notable since bacterially produced N-acetyl amino acids enhanced growth in a Drosophila model (Gallo et al., 2021; Martino et al., 2018). A more recent study provided mechanistic insights on how a related compound, N-acetylglutamine, promoted growth in a Drosophila model via down-regulation of a peptidoglycan recognition protein and immune effectors against beneficial microbes, thus providing an intriguing example of host-microbe symbiosis wherein bacterial metabolic products mediate host immune regulation and growth (Gallo et al., 2021; Martino et al., 2018).We would like to thank participants and their families for their involvement in the study. We thank Tiffany Poon, Luke Besse, and Sara Garamszegi for project management of sample processing and data handling. We thank Florence Rochat, Nadine Porta, Anne Bruttin and Solenn Pruvost for technical assistance in obtaining and sequencing bacterial isolates. We also thank the Broad Institute Genomics Platform and Microbial ‘Omics Core for help with sequencing data generation and sample processing. We are grateful to Heather Kang for editorial assistance. Generation of metagenomics and metabolomics data was supported by a grant from Nestle to the Broad Institute (H.V.). Principal investigators, T.V. O.S. H.V. and R.J.X.; metagenomic data analysis, T.V. Q.Y.A. L.S. and D.R.P.; metabolomic data analysis, T.V. Q.Y.A. M.S. A.D. K.P. K.B. C.D. J.A.-P. and C.B.C.; bacterial isolation and genome sequencing and annotation, L.S. S.D. C.N.-B. and O.S.; phylogenetic and functional genomic analyses: T.V. L.S. S.D. C.N.-B. and O.D.-B.; study design, S.A.S. and T.A.; collection of samples and health information, S.A.S. S.Sayed, S.Sultana, and M.R.; manuscript drafting: T.V. Q.Y.A. L.S. C.I.L.R. C.L.B. D.R.P. S.D. O.D.-B. O.S. and R.J.X. All authors discussed the results, critically reviewed the text, and approved the final manuscript. L.S. C.L.B. C.I.L.R. S.D. O.D-B. C.N-B. and O.S. are employees of Société des Produits Nestlé (SPN). R.J.X. is a member of the Scientific Advisory Board at Nestlé, founder of Jnana and Celsius Therapeutics and board member of MoonLake Immunotherapeutics. We filed a patent related to findings described in this study. R.J.X. H.V. T.V. O.S. L.S. S.D. and C.N.-B. are listed as inventors (Bifidobacterium Longum Transitional Microorganisms, Compositions and Uses Thereof, PCT/US2022/035,310). We would like to thank participants and their families for their involvement in the study. We thank Tiffany Poon, Luke Besse, and Sara Garamszegi for project management of sample processing and data handling. We thank Florence Rochat, Nadine Porta, Anne Bruttin and Solenn Pruvost for technical assistance in obtaining and sequencing bacterial isolates. We also thank the Broad Institute Genomics Platform and Microbial ‘Omics Core for help with sequencing data generation and sample processing. We are grateful to Heather Kang for editorial assistance. Generation of metagenomics and metabolomics data was supported by a grant from Nestle to the Broad Institute (H.V.).; Vatanen , T , Ang , Q Y , Siegwald , L , Sarker , S A , Le Roy , C I , Duboux , S , Delannoy-Bruno , O , Ngom-Bru , C , Boulangé , C L , Stražar , M , Avila-Pacheco , J , Deik , A , Pierce , K , Bullock , K , Dennis , C , Sultana , S , Sayed , S , Rahman , M , Ahmed , T , Modesto , M , Mattarelli , P , Clish , C B , Vlamakis , H , Plichta , D R , Sakwinska , O & Xavier , R J 2022 , ' A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning ' , Cell , vol. 185 , no. 23 , pp. 4280-4297.e12 . https://doi.org/10.1016/j.cell.2022.10.011; ORCID: /0000-0003-0949-1291/work/128033163; http://hdl.handle.net/10138/573344; 51bb33c1-fd6c-48ca-bf9d-c4596edd9d6e; 85141522383; 000908351600006

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    Academic Journal
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    Report
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    Academic Journal
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    Academic Journal

    المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, Faculty Common Matters (Faculty of Medicine), Research Programs Unit

    وصف الملف: application/pdf

    Relation: Renall , N , Lawley , B , Vatanen , T , Merz , B , Douwes , J , Corbin , M , Te Morenga , L , Kruger , R , Breier , B H & Tannock , G W 2023 , ' The fecal microbiotas of women of Pacific and New Zealand European ethnicities are characterized by distinctive enterotypes that reflect dietary intakes and fecal water content ' , Gut Microbes , vol. 15 , no. 1 , 2178801 . https://doi.org/10.1080/19490976.2023.2178801; ORCID: /0000-0003-0949-1291/work/131545777; http://hdl.handle.net/10138/356398; c0fa1de1-5536-4042-b235-0354156b3c9b; 000935820200001

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    Academic Journal

    المساهمون: Faculty Common Matters (Faculty of Medicine)

    وصف الملف: application/pdf

    Relation: This study was funded by the Rockfield Trust University of Auckland Grant No. 3714375 and A Better Start National Science Challenge. Dr Chiavaroli was supported (in part) by a European Society for Paediatric Endocrinology Research Fellowship, sponsored by Novo Nordisk A/S; Dr Jayasinghe and Miss Brooke Wilson received a University of Auckland Scholarship; and Dr Albert was supported by Rutherford and Maurice Paykel Research Fellowships.; Leong , K S W , Jayasinghe , T N , Wilson , B C , Derraik , J G B , Albert , B B , Chiavaroli , V , Svirskis , D M , Beck , K L , Conlon , C A , Jiang , Y , Schierding , W , Vatanen , T , Holland , D J , O'Sullivan , J M & Cutfield , W S 2020 , ' Effects of fecal microbiome transfer in adolescents with obesity: the gut bugs randomized controlled trial ' , JAMA Network Open , vol. 3 , no. 12 , 2030415 . https://doi.org/10.1001/jamanetworkopen.2020.30415; Bibtex: leong2020effects; ORCID: /0000-0003-0949-1291/work/127510059; http://hdl.handle.net/10138/352803; cf96bf79-fa2f-4b2b-ab77-f0b8fb32edd9; 000603058300007

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    Academic Journal

    المساهمون: Research Programs Unit, HUS Children and Adolescents, Children's Hospital, CAMM - Research Program for Clinical and Molecular Metabolism, Department of Public Health, Helsinki University Hospital Area, HUS Helsinki and Uusimaa Hospital District, Helsinki Institute of Life Science HiLIFE, Faculty Common Matters (Faculty of Medicine), Research Group Knip, Molecular and Integrative Biosciences Research Programme, Clinicum

    وصف الملف: application/pdf

    Relation: http://hdl.handle.net/10138/357696; 85147807725; 000965097500001