المؤلفون: Mendoza-Munoz, Pamela L., Gavande, Navnath S., VanderVere-Carozza, Pamela S., Pawelczak, Katherine S., Dynlacht, Joseph R., Garrett, Joy E., Turchi, John J.

المساهمون: Medicine, School of Medicine

المصدر: PMC

مصطلحات موضوعية: DNA-dependent protein kinase (DNA-PK), DNA damage response (DDR), Non-homologous end joining (NHEJ), Double-strand break (DSB)

وصف الملف: application/pdf

Relation: NAR Cancer; Mendoza-Munoz PL, Gavande NS, VanderVere-Carozza PS, et al. Ku-DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks. NAR Cancer. 2023;5(1):zcad003. Published 2023 Feb 6. doi:10.1093/narcan/zcad003; https://hdl.handle.net/1805/36635

الاتاحة: https://hdl.handle.net/1805/36635

المؤلفون: Mendoza-Munoz, Pamela L, Gavande, Navnath S, VanderVere-Carozza, Pamela S, Pawelczak, Katherine S, Dynlacht, Joseph R, Garrett, Joy E, Turchi, John J

المساهمون: National Institutes of Health, Tom and Julie Wood Family Foundation

المصدر: NAR Cancer ; volume 5, issue 1 ; ISSN 2632-8674

الاتاحة: http://dx.doi.org/10.1093/narcan/zcad003
https://academic.oup.com/narcancer/article-pdf/5/1/zcad003/57074463/zcad003.pdf

المؤلفون: VanderVere-Carozza, Pamela S., Gavande, Navnath S., Jalal, Shadia I., Pollok, Karen E., Ekinci, Elmira, Heyza, Joshua, Patrick, Steve M., Masters, Andi, Turchi, John J., Pawelczak, Katherine S.

المساهمون: Medicine, School of Medicine

المصدر: PMC

مصطلحات موضوعية: DNA damage response, DNA repair, Cancer, DNA repair inhibitors, Replication protein A, Replication stress response

وصف الملف: application/pdf

Relation: Frontiers in Oncology; VanderVere-Carozza PS, Gavande NS, Jalal SI, et al. In Vivo Targeting Replication Protein A for Cancer Therapy. Front Oncol. 2022;12:826655. Published 2022 Feb 18. doi:10.3389/fonc.2022.826655; https://hdl.handle.net/1805/33353

الاتاحة: https://hdl.handle.net/1805/33353

المؤلفون: Kelm, Jeremy M., Samarbakhsh, Amirreza, Pillai, Athira, VanderVere-Carozza, Pamela S., Aruri, Hariprasad, Pandey, Deepti S., Pawelczak, Katherine S., Turchi, John J., Gavande, Navnath S.

المساهمون: Medicine, School of Medicine

المصدر: PMC

مصطلحات موضوعية: DNA repair, DNA damage response, Non-PIKKs inhibitors, Homology directed repair, Single-strand annealing

وصف الملف: application/pdf

Relation: Frontiers in Oncology; Kelm JM, Samarbakhsh A, Pillai A, et al. Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair. Front Oncol. 2022;12:850883. Published 2022 Apr 6. doi:10.3389/fonc.2022.850883; https://hdl.handle.net/1805/33647

الاتاحة: https://hdl.handle.net/1805/33647

المؤلفون: Par, Sui, Vaides, Sofia, VanderVere-Carozza, Pamela S., Pawelczak, Katherine S., Stewart, Jason, Turchi, John J.

المساهمون: Medicine, School of Medicine

المصدر: PMC

مصطلحات موضوعية: DNA binding, DNA damage response, DNA repair, DNA replication, OB-fold, Cancer therapy, Drug development, Genome stability, Single-stranded DNA

وصف الملف: application/pdf

Relation: Cancers; Par S, Vaides S, VanderVere-Carozza PS, Pawelczak KS, Stewart J, Turchi JJ. OB-Folds and Genome Maintenance: Targeting Protein-DNA Interactions for Cancer Therapy. Cancers (Basel). 2021;13(13):3346. Published 2021 Jul 3. doi:10.3390/cancers13133346; https://hdl.handle.net/1805/31013

الاتاحة: https://hdl.handle.net/1805/31013

المؤلفون: Cong, Ke, Peng, Min, Kousholt, Arne Nedergaard, Lee, Wei Ting C., Lee, Silviana, Nayak, Sumeet, Krais, John, VanderVere-Carozza, Pamela S., Pawelczak, Katherine S., Calvo, Jennifer, Panzarino, Nicholas J., Turchi, John J., Johnson, Neil, Jonkers, Jos, Rothenberg, Eli, Cantor, Sharon B.

المصدر: Molecular Cell ; volume 81, issue 15, page 3227 ; ISSN 1097-2765

الاتاحة: https://doi.org/10.1016/j.molcel.2021.07.015
https://api.elsevier.com/content/article/PII:S1097276521005840?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1097276521005840?httpAccept=text/plain

المؤلفون: Gavande, Navnath S, VanderVere-Carozza, Pamela S, Pawelczak, Katherine S, Mendoza-Munoz, Pamela, Vernon, Tyler L, Hanakahi, Leslyn A, Summerlin, Matthew, Dynlacht, Joseph R, Farmer, Annabelle H, Sears, Catherine R, Nasrallah, Nawar Al, Garrett, Joy, Turchi, John J

المساهمون: Medicine, School of Medicine

المصدر: Publisher

مصطلحات موضوعية: protein kinase, DNA-PK, anti-cancer therapeutics

وصف الملف: application/pdf

Relation: Nucleic Acids Research; Gavande, N. S., VanderVere-Carozza, P. S., Pawelczak, K. S., Mendoza-Munoz, P., Vernon, T. L., Hanakahi, L. A., Summerlin, M., Dynlacht, J. R., Farmer, A. H., Sears, C. R., Nasrallah, N. A., Garrett, J., & Turchi, J. J. (2020). Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku–DNA interaction. Nucleic Acids Research, 48(20), 11536–11550. https://doi.org/10.1093/nar/gkaa934; 0305-1048, 1362-4962; https://hdl.handle.net/1805/27306

الاتاحة: https://hdl.handle.net/1805/27306

المؤلفون: Gavande, Navnath S., VanderVere-Carozza, Pamela S., Hinshaw, Hilary D., Jalal, Shadia I., Sears, Catherine R., Pawelczak, Katherine S., Turchi, John J.

المساهمون: Department of Medicine, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Antineoplastic Agents, therapeutic use, DNA, drug effects, DNA Breaks, Double-Stranded, DNA Repair, Neoplasms, drug therapy

وصف الملف: application/pdf

Relation: Pharmacology & Therapeutics; Gavande, N. S., VanderVere-Carozza, P. S., Hinshaw, H. D., Jalal, S. I., Sears, C. R., Pawelczak, K. S., & Turchi, J. J. (2016). DNA repair targeted therapy: the past or future of cancer treatment? Pharmacology & Therapeutics, 160, 65–83. http://doi.org/10.1016/j.pharmthera.2016.02.003; https://hdl.handle.net/1805/14282

الاتاحة: https://hdl.handle.net/1805/14282

المؤلفون: Turchi, John J., VanderVere-Carozza, Pamela S.

المصدر: Methods in Molecular Biology ; DNA Repair ; page 217-221 ; ISSN 1064-3745 1940-6029 ; ISBN 9781493994991 9781493995004

الاتاحة: http://dx.doi.org/10.1007/978-1-4939-9500-4_13
http://link.springer.com/content/pdf/10.1007/978-1-4939-9500-4_13

المؤلفون: Gavande, Navnath S., VanderVere-Carozza, Pamela S., Pawelczak, Katherine S., Vernon, Tyler L., Jordan, Matthew R., Turchi, John J.

المساهمون: Medicine, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Replication protein A, DNA damage and repair, Reversible inhibitors, SAR, Medicinal chemistry

وصف الملف: application/pdf

Relation: ACS Medicinal Chemistry Letter; Gavande NS, VanderVere-Carozza PS, Pawelczak KS, Vernon TL, Jordan MR, Turchi JJ. Structure-Guided Optimization of Replication Protein A (RPA)-DNA Interaction Inhibitors. ACS Med Chem Lett. 2020;11(6):1118-1124. Published 2020 Jan 2. doi:10.1021/acsmedchemlett.9b00440; https://hdl.handle.net/1805/30696

الاتاحة: https://hdl.handle.net/1805/30696

المؤلفون: Sriramkumar, Shruthi, Matthews, Timothy D., Ghobashi, Ahmed H., Miller, Samuel A., VanderVere-Carozza, Pamela S., Pawelczak, Katherine S., Nephew, Kenneth P., Turchi, John J., O’Hagan, Heather M.

المساهمون: Biochemistry and Molecular Biology, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Ovarian cancer, DNA damage and repair, RING1A, Cisplatin, RPA, Ubiquitination of H2A

وصف الملف: application/pdf

Relation: Molecular Cancer Research; Sriramkumar S, Matthews TD, Ghobashi AH, et al. Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer. Mol Cancer Res. 2020;18(11):1699-1710. doi:10.1158/1541-7786.MCR-20-0396; https://hdl.handle.net/1805/30120

الاتاحة: https://hdl.handle.net/1805/30120

المؤلفون: Alaoui-Jamali, Moulay A., Berdis, Anthony J., Bijian, Krikor, Bindra, Ranjit S., Borgmann, Kerstin, Choi, Jung-Suk, Christmann, Markus, D’Arcangelo, Manolo, Dasari, Anvesh, Deans, Andrew J., Dikomey, Ekkehard, Drew, Yvette, Fishel, Melissa L., Gavande, Navnath S., Köcher, Sabrina, Kaina, Bernd, Kelley, Mark R., Kriegs, Malte, Mansour, Wael, Martin, Sarah A., Murfuni, Ivana, O’Rourke, Julienne J., Parplys, Ann-Christin, Pawelczak, Katherine S., Plummer, Ruth, Poletto, Mattia, Powell, Simon N., Rass, Ulrich, Rieckmann, Thorsten, Rothkamm, Kai, Setton, Jeremy, Shariati, Behzad, Tell, Gianluca, Turchi, John J., VanderVere-Carozza, Pamela S., Vascotto, Carlo, Vasko, Michael R., Wurzba, Sabrina D., Zanville, Noah

المصدر: DNA Repair in Cancer Therapy ; page xiii-xv

الاتاحة: http://dx.doi.org/10.1016/b978-0-12-803582-5.00019-x
https://api.elsevier.com/content/article/PII:B978012803582500019X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:B978012803582500019X?httpAccept=text/plain

المؤلفون: Pawelczak, Katherine S., Gavande, Navnath S., VanderVere-Carozza, Pamela S., Turchi, John J.

المصدر: ACS Chemical Biology ; volume 13, issue 2, page 389-396 ; ISSN 1554-8929 1554-8937

الاتاحة: http://dx.doi.org/10.1021/acschembio.7b00777
https://pubs.acs.org/doi/pdf/10.1021/acschembio.7b00777

المؤلفون: Pawelczak, Katherine S., Gavande, Navnath S., VanderVere-Carozza, Pamela S., Turchi, John J.

المصدر: ACS Chemical Biology; 20240101, Issue: Preprints