المؤلفون: Kulkarni, M, Cameron, LD, Gehman, J, Glaser, VL, Greenwood, M, Islam, G, Lindebaum, D, Mantere, S, Pachidi, S, Petriglieri, G, Rahman, HA, Vaara, E, Van Den Broek, E

مصطلحات موضوعية: 35 Commerce, Management, Tourism and Services, 3507 Strategy, Management and Organisational Behaviour, Networking and Information Technology R&D NITRD, Machine Learning and Artificial Intelligence, Bioengineering, Generic health relevance

الاتاحة: https://dx.doi.org/10.17863/cam.104207
https://www.repository.cam.ac.uk/handle/1810/361259

المؤلفون: Kulkarni, M, Mantere, S, Vaara, E, van den Broek, E, Pachidi, S, Glaser, VL, Gehman, J, Petriglieri, G, Lindebaum, D, Cameron, LD, Rahman, HA, Islam, G, Greenwood, M

Relation: https://ora.ox.ac.uk/objects/uuid:87eaa659-177b-4fc6-9372-5ab78223be03; https://doi.org/10.1177/10564926231219622

الاتاحة: https://doi.org/10.1177/10564926231219622
https://ora.ox.ac.uk/objects/uuid:87eaa659-177b-4fc6-9372-5ab78223be03

المؤلفون: Mavaddat, N, Antoniou, AC, Mooij, TM, Hooning, MJ, Heemskerk-Gerritsen, BA, Nogues, C, Laborde, L, Breysse, E, Stoppa-Lyonnet, D, Gauthier-Villars, M, Buecher, B, Caron, O, Fourme-Mouret, E, Fricker, JP, Lasset, C, Bonadona, V, Berthet, P, Faivre, L, Luporsi, E, Mari, V, Gladieff, L, Gesta, P, Sobol, H, Eisinger, F, Longy, M, Dugast, C, Colas, C, Coupier, I, Pujol, P, Corsini, C, Lortholary, A, Vennin, P, Adenis, C, Nguyen, TD, Delnatte, C, Tinat, J, Tennevet, I, Limacher, JM, Maugard, C, Bignon, YJ, Demange, L, Penet, C, Dreyfus, H, Cohen-Haguenauer, O, Venat-Bouvet, L, Leroux, D, Zattara-Cannoni, H, Fert-Ferrer, S, Bera, O, Ellis, S, Barrowdale, D, Frost, D, Evans, DG, Izatt, L, Adlard, J, Eeles, R, Brewer, C, Tischkowitz, M, Henderson, A, Cook, J, Eccles, D, Hogervorst, FBL, Collee, JM, van Asperen, CJ, Mensenkamp, AR, Ausems, MGEM, Meijers-Heijboer, HEJ, van Engelen, K, Blok, MJ, Oosterwijk, JC, Verloop, J, van den Broek, E, Mourits, MJE, Koppert, LB, Hopper, JL, John, EM, Chung, WK, Andrulis, IL, Daly, MB, Buys, SS, Benitez, J, Caldes, T, Jakubowska, A, Simard, J, Singer, CF, Tan, Y, Olah, E, Navratilova, M, Foretova, L, Gerdes, AM, Roos-Blom, MJ, Van Leeuwen, FE, Arver, B, Olsson, H, Schmutzler, RK, Engel, C, Kast, K, Phillips, KA, Terry, MB, Milne, RL, Goldgar, DE, Rookus, MA, Andrieu, N, Easton, DF

المصدر: Breast cancer research : BCR. 22(1):8

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:143007088

المؤلفون: Bogie, R.M.M., le Clercq, C.M.C., Voorham, Q.J.M., Cordes, M., Sie, D., Rausch, C., van den Broek, E., de Vries, S.D.J., van Grieken, N.C.T., Riedl, R.G., Sastrowijoto, P., Speel, E.J., Vos, R., Winkens, B., van Engeland, M., Ylstra, B., Meijer, G.A., Masclee, A.A.M., Carvalho, B.

المصدر: Bogie , R M M , le Clercq , C M C , Voorham , Q J M , Cordes , M , Sie , D , Rausch , C , van den Broek , E , de Vries , S D J , van Grieken , N C T , Riedl , R G , Sastrowijoto , P , Speel , E J , Vos , R , Winkens , B , van Engeland , M , Ylstra , B , Meijer , G A , Masclee , A A M & Carvalho , B 2022 , ' ....

مصطلحات موضوعية: ISLAND METHYLATOR PHENOTYPE, MICROSATELLITE INSTABILITY, CHROMOSOME INSTABILITY, SERRATED PATHWAY, ADENOMA, RISK, PREVALENCE, MORTALITY, NEOPLASMS, RESECTION

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/4d701de7-e41b-4e4f-b2ea-48f7d01cdad5
https://doi.org/10.1038/s41416-021-01619-z

المؤلفون: Snoek, J.A.A., Nagtegaal, I.D., Siesling, S., van den Broek, E., van Slooten, H.J., Hugen, N.

المساهمون: KWF Kankerbestrijding

المصدر: The Breast ; volume 66, page 178-182 ; ISSN 0960-9776

الاتاحة: http://dx.doi.org/10.1016/j.breast.2022.10.011
https://api.elsevier.com/content/article/PII:S096097762200176X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S096097762200176X?httpAccept=text/plain

المؤلفون: Derks, J., Moonen, L., Hillen, L., van Suylen, R.J., den Bakker, M., von der Thüsen, J., Damhuis, R., Buikhuisen, W.A., van den Broek, E., Maessen, J., Maat, L.P.W.M., van Schil, P.E., Speel, E-J., Dingemans, A-M.C.

المصدر: Annals of Oncology ; volume 33, page S1289 ; ISSN 0923-7534

الاتاحة: http://dx.doi.org/10.1016/j.annonc.2022.07.1713
https://api.elsevier.com/content/article/PII:S0923753422035645?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0923753422035645?httpAccept=text/plain

المؤلفون: Mavaddat, Nasim, Antoniou, Antonis C., Mooij, Thea M., Hooning, Maartje J., Heemskerk-Gerritsen, Bernadette A., Noguès, Catherine, Gauthier-Villars, Marion, Caron, Olivier, Gesta, Paul, Pujol, Pascal, Lortholary, Alain, Barrowdale, Daniel, Frost, Debra, Evans, D. Gareth, Izatt, Louise, Adlard, Julian, Eeles, Ros, Brewer, Carole, Tischkowitz, Marc, Henderson, Alex, Cook, Jackie, Eccles, Diana, van Engelen, Klaartje, Mourits, Marian J. E., Ausems, Margreet G. E. M., Koppert, Linetta B., Hopper, John L., John, Esther M., Chung, Wendy K., Andrulis, Irene L., Daly, Mary B., Buys, Saundra S., Benitez, Javier, Caldes, Trinidad, Jakubowska, Anna, Simard, Jacques, Singer, Christian F., Tan, Yen, Olah, Edith, Navratilova, Marie, Foretova, Lenka, Gerdes, Anne-Marie, Roos-Blom, Marie-José, Van Leeuwen, Flora E., Arver, Brita, Olsson, Håkan, Schmutzler, Rita K., Engel, Christoph, Kast, Karin, Phillips, Kelly-Anne, Terry, Mary Beth, Milne, Roger L., Goldgar, David E., Rookus, Matti A., Andrieu, Nadine, Easton, Douglas F., Laborde, Lilian, Breysse, Emmanuel, Stoppa-Lyonnet, Dominique, Buecher, Bruno, Fourme-Mouret, Emmanuelle, Fricker, Jean-Pierre, Lasset, Christine, Bonadona, Valérie, Berthet, Pascaline, Faivre, Laurence, Luporsi, Elisabeth, Mari, Véronique, Gladieff, Laurence, Sobol, Hagay, Eisinger, François, Longy, Michel, Dugast, Catherine, Colas, Chrystelle, Coupier, Isabelle, Corsini, Carole, Vennin, Philippe, Adenis, Claude, Nguyen, Tan Dat, Delnatte, Capucine, Tinat, Julie, Tennevet, Isabelle, Limacher, Jean-Marc, Maugard, Christine, Bignon, Yves-Jean, Demange, Liliane, Penet, Clotilde, Dreyfus, Hélène, Cohen-Haguenauer, Odile, Venat-Bouvet, Laurence, Leroux, Dominique, Zattara-Cannoni, Hélène, Fert-Ferrer, Sandra, Bera, Odile, Ellis, Steve, Hogervorst, F. B. L., Collée, J. M., van Asperen, C. J., Mensenkamp, A. R., Ausems, M. G. E. M., Meijers-Heijboer, H. E. J., van Engelen, K., Blok, M. J., Oosterwijk, J. C., Verloop, J., van den Broek, E.

مصطلحات موضوعية: Research Article, Breast cancer, BRCA1, BRCA2, Mutation, Risk-reducing salpingo-oophorectomy

وصف الملف: application/zip; application/pdf; text/xml

Relation: https://www.repository.cam.ac.uk/handle/1810/316237

الاتاحة: https://www.repository.cam.ac.uk/handle/1810/316237
https://doi.org/10.17863/CAM.63346

المؤلفون: Mavaddat, Nasim, Antoniou, Antonis C., Mooij, Thea M., Hooning, Maartje J., Heemskerk-Gerritsen, Bernadette A., Noguès, Catherine, Gauthier-Villars, Marion, Caron, Olivier, Gesta, Paul, Pujol, Pascal, Lortholary, Alain, Barrowdale, Daniel, Frost, Debra, Evans, D. Gareth, Izatt, Louise, Adlard, Julian, Eeles, Ros, Brewer, Carole, Tischkowitz, Marc, Henderson, Alex, Cook, Jackie, Eccles, Diana, van Engelen, Klaartje, Mourits, Marian J. E., Ausems, Margreet G. E. M., Koppert, Linetta B., Hopper, John L., John, Esther M., Chung, Wendy K., Andrulis, Irene L., Daly, Mary B., Buys, Saundra S., Benitez, Javier, Caldes, Trinidad, Jakubowska, Anna, Simard, Jacques, Singer, Christian F., Tan, Yen, Olah, Edith, Navratilova, Marie, Foretova, Lenka, Gerdes, Anne-Marie, Roos-Blom, Marie-José, Van Leeuwen, Flora E., Arver, Brita, Olsson, Håkan, Schmutzler, Rita K., Engel, Christoph, Kast, Karin, Phillips, Kelly-Anne, Terry, Mary Beth, Milne, Roger L., Goldgar, David E., Rookus, Matti A., Andrieu, Nadine, Easton, Douglas F., Laborde, Lilian, Breysse, Emmanuel, Stoppa-Lyonnet, Dominique, Buecher, Bruno, Fourme-Mouret, Emmanuelle, Fricker, Jean-Pierre, Lasset, Christine, Bonadona, Valérie, Berthet, Pascaline, Faivre, Laurence, Luporsi, Elisabeth, Mari, Véronique, Gladieff, Laurence, Sobol, Hagay, Eisinger, François, Longy, Michel, Dugast, Catherine, Colas, Chrystelle, Coupier, Isabelle, Corsini, Carole, Vennin, Philippe, Adenis, Claude, Nguyen, Tan Dat, Delnatte, Capucine, Tinat, Julie, Tennevet, Isabelle, Limacher, Jean-Marc, Maugard, Christine, Bignon, Yves-Jean, Demange, Liliane, Penet, Clotilde, Dreyfus, Hélène, Cohen-Haguenauer, Odile, Venat-Bouvet, Laurence, Leroux, Dominique, Zattara-Cannoni, Hélène, Fert-Ferrer, Sandra, Bera, Odile, Ellis, Steve, Hogervorst, F. B. L., Collée, J. M., van Asperen, C. J., Mensenkamp, A. R., Ausems, M. G. E. M., Meijers-Heijboer, H. E. J., van Engelen, K., Blok, M. J., Oosterwijk, J. C., Verloop, J., van den Broek, E.

مصطلحات موضوعية: Research Article, Breast cancer, BRCA1, BRCA2, Mutation, Risk-reducing salpingo-oophorectomy

وصف الملف: application/zip; application/pdf; text/xml

Relation: https://www.repository.cam.ac.uk/handle/1810/306273

الاتاحة: https://doi.org/10.17863/CAM.53353
https://www.repository.cam.ac.uk/handle/1810/306273

المؤلفون: Hermans, B. C.M., Derks, J. L., Groen, H. J.M., Stigt, J. A., Suylen, R. J., Hillen, L. M., van den Broek, E. C., Speel, E. J.M., Dingemans, A. M.C.

المصدر: Hermans , B C M , Derks , J L , Groen , H J M , Stigt , J A , Suylen , R J , Hillen , L M , van den Broek , E C , Speel , E J M & Dingemans , A M C 2019 , ' Large cell neuroendocrine carcinoma with a solitary brain metastasis and low Ki-67 : A unique subtype ' , Endocrine Connections , vol. 8 , no. 12 , pp. 1600-1606 . https://doi.org/10.1530/EC-19-0372

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الاتاحة: https://pure.eur.nl/en/publications/e3369030-245c-4eb8-bfea-38fa13cd2b26
https://doi.org/10.1530/EC-19-0372
https://pure.eur.nl/ws/files/98887393/Large_cell_neuroendocrine_carcinoma_with_a_solitary_brain_metastasis_and_low_Ki-67.pdf
http://www.scopus.com/inward/record.url?scp=85077195921&partnerID=8YFLogxK

المؤلفون: Hermans, B. C. M., Derks, J. L., Thunnissen, E., van Suylen, R. J., den Bakker, M. A., Groen, H. J. M., Smit, E. F., Damhuis, R. A., van den Broek, E. C., Stallinga, C. M., Roemen, G. M., Speel, E. J. M., Dingemans, A. -M. C.

المصدر: PALGA Grp , Hermans , B C M , Derks , J L , Thunnissen , E , van Suylen , R J , den Bakker , M A , Groen , H J M , Smit , E F , Damhuis , R A , van den Broek , E C , Stallinga , C M , Roemen , G M , Speel , E J M & Dingemans , A -M C 2019 , ' Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC) ' , Lung Cancer , ....

مصطلحات موضوعية: Large cell neuroendocrine carcinoma, Lung cancer, PD-L1, CD8, Prognosis, LUNG-CANCER, CHEMOTHERAPY, BLOCKADE

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/66b8ee39-0814-4887-aac4-76b6bc9e43be

الاتاحة: https://hdl.handle.net/11370/66b8ee39-0814-4887-aac4-76b6bc9e43be
https://research.rug.nl/en/publications/66b8ee39-0814-4887-aac4-76b6bc9e43be
https://doi.org/10.1016/j.lungcan.2019.02.022
https://pure.rug.nl/ws/files/92811470/1_s2.0_S0169500219303381_main.pdf

المؤلفون: Hermans, B. C. M., Derks, J. L., Thunnissen, E., van Suylen, R. J., den Bakker, M. A., Groen, H. J. M., Smit, E. F., Damhuis, R. A., van den Broek, E. C., Ruland, A., Speel, E. J. M., Dingemans, A. M. C.

المصدر: PALGA Grp , Hermans , B C M , Derks , J L , Thunnissen , E , van Suylen , R J , den Bakker , M A , Groen , H J M , Smit , E F , Damhuis , R A , van den Broek , E C , Ruland , A , Speel , E J M & Dingemans , A M C 2019 , ' DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile ' , Lung Cancer , vol. 138 , pp. 102-108 . https://doi.org/10.1016/j.lungcan.2019.10.010

مصطلحات موضوعية: Aged, Biomarkers, Tumor/genetics, Carcinoma, Large Cell/genetics, Neuroendocrine/genetics, Female, Humans, Immunohistochemistry, Intracellular Signaling Peptides and Proteins/biosynthesis, Lung Neoplasms/genetics, Male, Membrane Proteins/biosynthesis, Middle Aged, Mutation, Neoplasm Staging, Prognosis, Retrospective Studies

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/9230f217-05d6-4ac8-80cc-5aad7f2cc9d3
https://research.rug.nl/en/publications/9230f217-05d6-4ac8-80cc-5aad7f2cc9d3
https://doi.org/10.1016/j.lungcan.2019.10.010
https://pure.rug.nl/ws/files/111704975/DLL3_expression_in_large_cell_neuroendocrine_carcinoma_LCNEC_and_association_with_molecular_subtypes_and_neuroendocrine_profile_Elsevier_Enhanced_Reader.pdf

المؤلفون: Hermans, B., Derks, J., Gietema, H., Van Den Broek, E., Speel, E., Dingemans, A.M.

المصدر: Journal of Thoracic Oncology ; volume 14, issue 10, page S822 ; ISSN 1556-0864

الاتاحة: http://dx.doi.org/10.1016/j.jtho.2019.08.1768
https://api.elsevier.com/content/article/PII:S1556086419324517?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1556086419324517?httpAccept=text/plain

المؤلفون: Heijboer, F., Derks, J., Rijnsburger, N., Hermans, B., Hillen, L., van den Broek, E., Speel, E-J., Dingemans, A-M.C., Thüsen, J. von der

المصدر: Annals of Oncology ; volume 34, page S1138 ; ISSN 0923-7534

الاتاحة: http://dx.doi.org/10.1016/j.annonc.2023.09.984
https://api.elsevier.com/content/article/PII:S0923753423018203?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0923753423018203?httpAccept=text/plain

المؤلفون: Komor, M.A. (Malgorzata A), Bosch, L.J.W. (Linda), Bounova, G. (Gergana), Bolijn, A.S. (Anne S), Delis-van Diemen, P.M. (Pien M.), Rausch, C. (Christian), Hoogstrate, Y. (Youri), Stubbs, A.P. (Andrew), de Jong, M. (Mark), Jenster, G.W. (Guido), Grieken, N.C.T. (Nicole), Carvalho, B. (Beatriz), Wessels, L. (Lodewyk), Jimenez, C.R. (Connie), Fijneman, R.J.A. (Remond J. A.), Meijer, C.J.L.M. (Chris), Dits, N.F. (Natasja), Böttcher, R. (René), Hiemstra, A.C. (Annemieke C), Ylstra, B. (Bauke), Sie, D.L.S. (Daoud), van den Broek, E. (Evert), van der Meer, D. (David), Pepers, F. (Floor), Caldenhoven, E. (Eric), Janssen, B. (Bart), Workum, W. (W) van, Lieshout, S. (Stef) van, Bangma, C.H. (Chris), Leenders, G.J.H.L. (Geert), Werken, H.J.G. (Harmen) van de

المصدر: Journal of Pathology

مصطلحات موضوعية: adenoma, colon, colorectal cancer, neoplasia, rectum

وصف الملف: application/pdf

Relation: http://repub.eur.nl/pub/110145; urn:hdl:1765/110145

الاتاحة: http://repub.eur.nl/pub/110145
https://doi.org/10.1002/path.5129

المؤلفون: Hermans, B. C.M., Derks, J. L., Thunissen, E., van Suylen, R. J., den Bakker, M. A., Groen, H. J.M., Smit, E. F., Damhuis, R. A., van den Broek, E. C., Palga-Group, P., Stallinga, C. M., Roemen, G. M., Speel, E. J., Dingemans, A. M.C.

المصدر: Hermans , B C M , Derks , J L , Thunissen , E , van Suylen , R J , den Bakker , M A , Groen , H J M , Smit , E F , Damhuis , R A , van den Broek , E C , Palga-Group , P , Stallinga , C M , Roemen , G M , Speel , E J & Dingemans , A M C 2018 , ' Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC) ' , Annals of oncology ....

Relation: https://research.vumc.nl/en/publications/9ada44e6-3f03-42e9-92db-697b1aeceb02

الاتاحة: https://research.vumc.nl/en/publications/9ada44e6-3f03-42e9-92db-697b1aeceb02
https://doi.org/10.1093/annonc/mdy301.007
http://www.scopus.com/inward/record.url?scp=85081531420&partnerID=8YFLogxK

المؤلفون: van den Broek, E.

المصدر: van den Broek , E 2016 , ' Chromosomal breakpoints in colorectal cancer ' , PhD , Vrije Universiteit Amsterdam .

وصف الملف: application/pdf

Relation: urn:ISBN:9789402804294

الاتاحة: https://research.vu.nl/en/publications/f3feab92-0f7a-418b-b666-392505fcb792
https://research.vu.nl/ws/files/42163646/cover.pdf
https://research.vu.nl/ws/files/42163648/title%20page.pdf
https://research.vu.nl/ws/files/42163650/abstract%20dutch.pdf
https://research.vu.nl/ws/files/42163652/abstract%20english.pdf
https://research.vu.nl/ws/files/42163654/table%20of%20contents.pdf
https://research.vu.nl/ws/files/42163656/chapter%201.pdf
https://research.vu.nl/ws/files/42163658/chapter%202.pdf
https://research.vu.nl/ws/files/42163660/chapter%203.pdf
https://research.vu.nl/ws/files/42163662/chapter%204.pdf

المؤلفون: Oikonomopoulou, F., van den Broek, E. A. M., Bristogianni, T., Veer, F. A., Nijsse, R.

المساهمون: Delft University of Technology

المصدر: Glass Structures & Engineering ; volume 2, issue 2, page 183-200 ; ISSN 2363-5142 2363-5150

الاتاحة: http://dx.doi.org/10.1007/s40940-017-0041-x
http://link.springer.com/article/10.1007/s40940-017-0041-x/fulltext.html
http://link.springer.com/content/pdf/10.1007/s40940-017-0041-x.pdf

المؤلفون: Derks, J., Leblay, N., van Suylen, R.J., Thunnissen, E., den Bakker, M.A., Groen, H.J.M., Smit, E., Damhuis, R.A., van den Broek, E., Charbrier, A., Foll, M., McKay, J., Fernandez-Cuesta, L., Speel, E-J., Dingemans, A-M.

المصدر: Annals of Oncology ; volume 28, page v143 ; ISSN 0923-7534

الاتاحة: http://dx.doi.org/10.1093/annonc/mdx368.004
https://api.elsevier.com/content/article/PII:S0923753420378480?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0923753420378480?httpAccept=text/plain
http://academic.oup.com/annonc/article-pdf/28/suppl_5/mdx368.004/19939087/mdx368.004.pdf

المؤلفون: Than, B L N, Linnekamp, J F, Starr, T K, Largaespada, D A, Rod, A, Zhang, Y, Bruner, V, Abrahante, J, Schumann, A, Luczak, T, Niemczyk, A, O'Sullivan, M G, Medema, J P, Fijneman, R J A, Meijer, G A, Van den Broek, E, Hodges, C A, Scott, P M, Vermeulen, L, Cormier, R T

المصدر: Oncogene ; volume 35, issue 32, page 4191-4199 ; ISSN 0950-9232 1476-5594

الاتاحة: http://dx.doi.org/10.1038/onc.2015.483
https://www.nature.com/articles/onc2015483.pdf
https://www.nature.com/articles/onc2015483

المؤلفون: Backus, G.B.C., van den Broek, E., van der Fels, B., Heres, L., Immink, V.M., Knol, E.F., Kornelis, M., Mathur, P.K., van der Peet-Schwering, C., van Riel, J.W., Snoek, H.M, de Smet, A., Tacken, G.M.L., Valeeva, N.I., van Wagenberg, C.P.A.

المصدر: NJAS: Wageningen Journal of Life Sciences ; volume 76, issue 1, page 29-41 ; ISSN 1573-5214 2212-1307

الاتاحة: https://doi.org/10.1016/j.njas.2015.11.002
https://api.elsevier.com/content/article/PII:S157352141530004X?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S157352141530004X?httpAccept=text/xml
https://www.tandfonline.com/doi/pdf/10.1016/j.njas.2015.11.002