المؤلفون: Bertolini, Anna, Bloks, Vincent W, Wilmink, Marijn, Bos, Eline, Eilers, Roos, Prins, Sake, van de Peppel, Ivo P, Thomas, Rachel, de Bruin, Alain, Verkade, Henkjan, Jonker, Johan W

المصدر: Bertolini , A , Bloks , V W , Wilmink , M , Bos , E , Eilers , R , Prins , S , van de Peppel , I P , Thomas , R , de Bruin , A , Verkade , H & Jonker , J W 2024 , ' Treatment of intestinal and liver features in cystic fibrosis mice by the osmotic laxative polyethylene glycol ' , Journal of Cystic Fibrosis , vol. 23 , no. 3 , pp. 461-473 . https://doi.org/10.1016/j.jcf.2023.09.015

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/c3b2355c-bce9-4b52-b09c-b98aac500cc7
https://research.rug.nl/en/publications/c3b2355c-bce9-4b52-b09c-b98aac500cc7
https://doi.org/10.1016/j.jcf.2023.09.015
https://pure.rug.nl/ws/files/1086364794/1-s2.0-S1569199323009190-main.pdf

المؤلفون: van de Peppel, Ivo P., Demirdas, Serwet, Özcan, Behiye

المصدر: van de Peppel , I P , Demirdas , S & Özcan , B 2023 , ' Commentary : The mutations and clinical variability in maternally inherited diabetes and deafness: an analysis of 161 patients ' , Frontiers in Endocrinology , vol. 14 , 1205862 . https://doi.org/10.3389/fendo.2023.1205862

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الاتاحة: https://pure.eur.nl/en/publications/c4a1dcf6-11dc-480c-9c0d-fb712d226643
https://doi.org/10.3389/fendo.2023.1205862
https://pure.eur.nl/ws/files/99024896/fendo-14-1205862.pdf
http://www.scopus.com/inward/record.url?scp=85162879587&partnerID=8YFLogxK

المؤلفون: Verzijl, Cristy R C, van de Peppel, Ivo P, Eilers, Roos E, Bloks, Vincent W, Wolters, Justina C, Koehorst, Martijn, Kloosterhuis, Niels J, Havinga, Rick, Jalving, Mathilde, Struik, Dicky, Jonker, Johan W

المصدر: Verzijl , C R C , van de Peppel , I P , Eilers , R E , Bloks , V W , Wolters , J C , Koehorst , M , Kloosterhuis , N J , Havinga , R , Jalving , M , Struik , D & Jonker , J W 2023 , ' Pharmacological inhibition of MEK1/2 signaling disrupts bile acid metabolism through loss of Shp and enhanced Cyp7a1 expression ' , Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie , vol. 159 , 114270 . https://doi.org/10.1016/j.biopha.2023.114270

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/da97b802-ab06-4ef4-b713-b0365658ee90
https://research.rug.nl/en/publications/da97b802-ab06-4ef4-b713-b0365658ee90
https://doi.org/10.1016/j.biopha.2023.114270
https://pure.rug.nl/ws/files/563366740/1_s2.0_S0753332223000586_main.pdf

المؤلفون: Grefhorst, Aldo, van de Peppel, Ivo P, Larsen, Lars E, Jonker, Johan W, Holleboom, Adriaan G

المصدر: Grefhorst , A , van de Peppel , I P , Larsen , L E , Jonker , J W & Holleboom , A G 2021 , ' The Role of Lipophagy in the Development and Treatment of Non-Alcoholic Fatty Liver Disease ' , Frontiers in endocrinology , vol. 11 , 601627 . https://doi.org/10.3389/fendo.2020.601627

مصطلحات موضوعية: non-alcoholic fatty liver disease, lipophagy, lipid droplet, autophagy, lipid homeostasis

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/4a454aae-5c1e-4f2b-887b-beb215045a90
https://research.rug.nl/en/publications/4a454aae-5c1e-4f2b-887b-beb215045a90
https://doi.org/10.3389/fendo.2020.601627
https://pure.rug.nl/ws/files/160451491/fendo_11_601627.pdf

المؤلفون: Blankestijn, Maaike, van de Peppel, Ivo P, Dvorak, Ales, Capkova, Nikola, Vitek, Libor, Jonker, Johan W, Verkade, Henkjan J

المصدر: Blankestijn , M , van de Peppel , I P , Dvorak , A , Capkova , N , Vitek , L , Jonker , J W & Verkade , H J 2021 , ' Induction of fecal cholesterol excretion is not effective for the treatment of hyperbilirubinemia in Gunn rats ' , Pediatric Research , vol. 89 , pp. 510–517 . https://doi.org/10.1038/s41390-020-0926-2

مصطلحات موضوعية: X-RECEPTOR ACTIVATION, UNCONJUGATED HYPERBILIRUBINEMIA, INTESTINAL EXCRETION, ORLISTAT TREATMENT, BILIRUBIN, LIVER, TRANSPORT, IDENTIFICATION, DISPOSITION, ABSORPTION

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/31cd14e2-f5c7-40b0-a238-0c1261276cc2
https://research.rug.nl/en/publications/31cd14e2-f5c7-40b0-a238-0c1261276cc2
https://doi.org/10.1038/s41390-020-0926-2
https://pure.rug.nl/ws/files/202669222/s41390_020_0926_2.pdf

المؤلفون: Wu, Hoi W., Van de Peppel, Ivo P., Rutten, Julie W., Jukema, J. Wouter, Aten, Emmelien, Jazet, Ingrid M., Koopmann, Tamara T., Barge-Schaapveld, Daniela Q. C. M., Ajmone Marsan, Nina

المصدر: Journal of Cardiovascular Development & Disease (JCDD); Mar2024, Vol. 11 Issue 3, p86, 8p

المؤلفون: van de Peppel, Ivo P, Rao, Anuradha, Dommerholt, Marleen B, Bongiovanni, Laura, Thomas, Rachel, de Bruin, Alain, Karpen, Saul J, Dawson, Paul A, Verkade, Henkjan J, Jonker, Johan W

المساهمون: Pathobiologie, dPB RMSC, Dep Biomolecular Health Sciences

مصطلحات موضوعية: bile acid, enterohepatic circulation, fat absorption, obesity, steatosis

وصف الملف: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/409362

الاتاحة: https://dspace.library.uu.nl/handle/1874/409362

المؤلفون: Bertolini, Anna, van de Peppel, Ivo P, Bodewes, Frank A J A, Moshage, Han, Fantin, Alberto, Farinati, Fabio, Fiorotto, Romina, Jonker, Johan W, Strazzabosco, Mario, Verkade, Henkjan J, Peserico, Giulia

المصدر: Bertolini , A , van de Peppel , I P , Bodewes , F A J A , Moshage , H , Fantin , A , Farinati , F , Fiorotto , R , Jonker , J W , Strazzabosco , M , Verkade , H J & Peserico , G 2020 , ' Abnormal Liver Function Tests in Patients WithCOVID-19 : Relevance and Potential Pathogenesis ' , Hepatology , vol. 72 , no. 5 . https://doi.org/10.1002/hep.31480

مصطلحات موضوعية: COVID-19, CORONAVIRUS, PNEUMONIA, MANIFESTATIONS, DYSFUNCTION, INFECTION, FEATURES, INJURY, WUHAN, CHINA

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/11a5e4d3-3884-47c0-bc6d-2b19ba9d9f14
https://research.rug.nl/en/publications/11a5e4d3-3884-47c0-bc6d-2b19ba9d9f14
https://doi.org/10.1002/hep.31480
https://pure.rug.nl/ws/files/130034228/Abnormal_liver_function_tests_in_COVID_.pdf

المؤلفون: Rao, Anuradha, van de Peppel, Ivo P., Gumber, Sanjeev, Karpen, Saul J., Dawson, Paul A.

المصدر: Rao , A , van de Peppel , I P , Gumber , S , Karpen , S J & Dawson , P A 2020 , ' Attenuation of the Hepatoprotective Effects of Ileal Apical Sodium Dependent Bile Acid Transporter (ASBT) Inhibition in Choline-Deficient L-Amino Acid-Defined (CDAA) Diet-Fed Mice ' , Frontiers in Medicine , vol. 7 , 60 . https://doi.org/10.3389/fmed.2020.00060

مصطلحات موضوعية: liver, triglyceride, fibrosis, fat absorption, cholesterol, FATTY LIVER-DISEASE, ENTEROHEPATIC CIRCULATION, GUT MICROBIOTA, METABOLISM, ABSORPTION, PHOSPHATIDYLCHOLINE, STEATOHEPATITIS, IMPACT, EXPRESSION

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/5859159e-e6ed-48cc-bfdc-a86660606ece
https://research.rug.nl/en/publications/5859159e-e6ed-48cc-bfdc-a86660606ece
https://doi.org/10.3389/fmed.2020.00060
https://pure.rug.nl/ws/files/133312691/_SICI_1097_0045_19980301_34_4_292_AID_PROS7_3.0.CO_2_J.pdf

المؤلفون: Verzijl, Cristy R C, Van De Peppel, Ivo P, Struik, Dicky, Jonker, Johan W

المصدر: Verzijl , C R C , Van De Peppel , I P , Struik , D & Jonker , J W 2020 , ' Pegbelfermin (BMS-986036) : an investigational PEGylated fibroblast growth factor 21 analogue for the treatment of nonalcoholic steatohepatitis ' , Expert opinion on investigational drugs , vol. 29 , no. 2 , pp. 1-9 . https://doi.org/10.1080/13543784.2020.1708898

مصطلحات موضوعية: Pegbelfermin, FGF21, NAFLD, NASH, FATTY LIVER-DISEASE, BODY-WEIGHT, CONFERS SUSCEPTIBILITY, BARIATRIC SURGERY, REDUCES FEATURES, BETA-KLOTHO, MOUSE MODEL, PATHOGENESIS, ASSOCIATION

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/a8747d25-31f5-42ba-a5d5-37e9fdbc6066
https://research.rug.nl/en/publications/a8747d25-31f5-42ba-a5d5-37e9fdbc6066
https://doi.org/10.1080/13543784.2020.1708898
https://pure.rug.nl/ws/files/111582414/Pegbelfermin_BMS_986036_an_investigational_PEGylated_fibroblast_growth_factor_21_analogue_for_the_treatment_of_nonalcoholic_steatohepatitis.pdf

المؤلفون: van de Peppel, Ivo P, Verkade, Henkjan J, Jonker, Johan W

المصدر: van de Peppel , I P , Verkade , H J & Jonker , J W 2020 , ' Metabolic consequences of ileal interruption of the enterohepatic circulation of bile acids ' , American Journal of Physiology. Gastrointestinal and Liver Physiology , vol. 319 , no. 5 , pp. G619-G625 . https://doi.org/10.1152/ajpgi.00308.2020

مصطلحات موضوعية: ASBT, bile acids, enterohepatic circulation, FXR

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/3c91acfa-970a-4400-a7a0-d844911fa26c
https://research.rug.nl/en/publications/3c91acfa-970a-4400-a7a0-d844911fa26c
https://doi.org/10.1152/ajpgi.00308.2020
https://pure.rug.nl/ws/files/167294451/Metabolic_consequences_of_ileal_interruption_of_the_enterohepatic_circulation_of_bile_acids.pdf

المؤلفون: van de Peppel, Ivo P, Bertolini, Anna, van Dijk, Theo H, Groen, Albert K, Jonker, Johan W, Verkade, Henkjan J

المصدر: van de Peppel , I P , Bertolini , A , van Dijk , T H , Groen , A K , Jonker , J W & Verkade , H J 2019 , ' Efficient reabsorption of transintestinally excreted cholesterol is a strong determinant for cholesterol disposal in mice[S] ' , Journal of Lipid Research , vol. 60 , no. 9 , pp. 1562-1572 . https://doi.org/10.1194/jlr.M094607

مصطلحات موضوعية: ASBT inhibition, intestinal cholesterol absorption, transintestinal cholesterol excretion, ezetimibe, BILE-ACID TRANSPORT, LIVER-X-RECEPTOR, NEUTRAL STEROL EXCRETION, REDUCES ATHEROSCLEROSIS, PLASMA-CHOLESTEROL, ABSORPTION, METABOLISM, INHIBITION, MICE

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/fabe643b-ba46-4c13-9b93-fc735ff26263
https://research.rug.nl/en/publications/fabe643b-ba46-4c13-9b93-fc735ff26263
https://doi.org/10.1194/jlr.M094607
https://pure.rug.nl/ws/files/94519137/Efficient_reabsorption_of_transintestinally_excreted_cholesterol_is_a_strong_determinant_for_cholesterol_disposal_in_mice.pdf
https://pure.rug.nl/ws/files/97541265/Efficient_reabsorption_of_transintestinally_excreted.pdf

المؤلفون: Bertolini, Anna, van de Peppel, Ivo P., Doktorova-Demmin, Marcela, Bodewes, Frank A. J. A., de Jonge, Hugo, Bijvelds, Marcel, Verkade, Henkjan J., Jonker, Johan W.

المصدر: Bertolini , A , van de Peppel , I P , Doktorova-Demmin , M , Bodewes , F A J A , de Jonge , H , Bijvelds , M , Verkade , H J & Jonker , J W 2019 , ' Defective FXR-FGF15 signaling and bile acid homeostasis in cystic fibrosis mice can be restored by the laxative polyethylene glycol ' , American Journal of Physiology. Gastrointestinal and Liver Physiology , vol. 316 , no. 3 , pp. G404-G411 . https://doi.org/10.1152/ajpgi.00188.2018

مصطلحات موضوعية: bile acids, cystic fibrosis, FGF15, FXR, polyethylene glycol, GUT MICROBIOTA, FAT-ABSORPTION, INTESTINE, FGF19

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/e446459d-2599-4ab6-b324-4cb053103c23

الاتاحة: https://hdl.handle.net/11370/e446459d-2599-4ab6-b324-4cb053103c23
https://research.rug.nl/en/publications/e446459d-2599-4ab6-b324-4cb053103c23
https://doi.org/10.1152/ajpgi.00188.2018
https://pure.rug.nl/ws/files/74451054/Defective_FXR_FGF15_signaling_and_bile_acid_homeostasis_in_cystic_fibrosis_mice_can_be_restored_by_the_laxative_polyethylene_glycol.pdf

المؤلفون: van de Peppel, Ivo P, Doktorova, Marcela, Berkers, Gitte, de Jonge, Hugo R, Houwen, Roderick H J, Verkade, Henkjan J, Jonker, Johan W, Bodewes, Frank A J A

المصدر: van de Peppel , I P , Doktorova , M , Berkers , G , de Jonge , H R , Houwen , R H J , Verkade , H J , Jonker , J W & Bodewes , F A J A 2019 , ' IVACAFTOR restores FGF19 regulated bile acid homeostasis in cystic fibrosis patients with an S1251N or a G551D gating mutation ' , Journal of Cystic Fibrosis , vol. 18 , no. 2 , pp. 286-293 . https://doi.org/10.1016/j.jcf.2018.09.001

مصطلحات موضوعية: Enterohepatic circulation, FXR, FGF15, FGF19, Bile acid metabolism, G551D mutation, S125N mutation, Ivacaftor, IRRITABLE-BOWEL-SYNDROME, DIURNAL-VARIATION, POTENTIATOR, EFFICACY, CFTR, 7-ALPHA-HYDROXY-4-CHOLESTEN-3-ONE, ACTIVATION, SAFETY, FGF21, ASSAY

Relation: https://research.rug.nl/en/publications/1474aa8c-54a0-4a91-a372-1e2ce262adff

الاتاحة: https://hdl.handle.net/11370/1474aa8c-54a0-4a91-a372-1e2ce262adff
https://research.rug.nl/en/publications/1474aa8c-54a0-4a91-a372-1e2ce262adff
https://doi.org/10.1016/j.jcf.2018.09.001

المؤلفون: van de Peppel, Ivo P, Bodewes, Frank A J A, Verkade, Henkjan J, Jonker, Johan W

المصدر: van de Peppel , I P , Bodewes , F A J A , Verkade , H J & Jonker , J W 2019 , ' Bile acid homeostasis in gastrointestinal and metabolic complications of cystic fibrosis ' , Journal of Cystic Fibrosis , vol. 18 , no. 3 , pp. 313-320 . https://doi.org/10.1016/j.jcf.2018.08.009

مصطلحات موضوعية: Cystic fibrosis, Bile acids, Metabolism, Intestine, Liver, FARNESOID-X-RECEPTOR, TRANSMEMBRANE CONDUCTANCE REGULATOR, BETA-MURICHOLIC ACID, GROWTH-FACTOR 15, URSODEOXYCHOLIC ACID, GUT MICROBIOTA, LIVER-DISEASE, SUPPLEMENTATION IMPROVES, INTESTINAL-OBSTRUCTION, HEPATOBILIARY DISEASE

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/e1afc849-a084-44e0-8fa8-43cffe11458c
https://research.rug.nl/en/publications/e1afc849-a084-44e0-8fa8-43cffe11458c
https://doi.org/10.1016/j.jcf.2018.08.009
https://pure.rug.nl/ws/files/84985146/1_s2.0_S1569199318307574_main.pdf

المؤلفون: van de Peppel, Ivo P, Bertolini, Anna, Jonker, Johan W, Bodewes, Frank A J A, Verkade, Henkjan J

المصدر: van de Peppel , I P , Bertolini , A , Jonker , J W , Bodewes , F A J A & Verkade , H J 2017 , ' Diagnosis, follow-up and treatment of cystic fibrosis-related liver disease ' , Current Opinion in Pulmonary Medicine , vol. 23 , no. 6 , pp. 562-569 . https://doi.org/10.1097/MCP.0000000000000428

مصطلحات موضوعية: cystic fibrosis-related liver disease, diagnosis, treatment, ursodeoxycholic acid, TRANSMEMBRANE CONDUCTANCE REGULATOR, PLACEBO-CONTROLLED TRIAL, TRANSIENT ELASTOGRAPHY, OBETICHOLIC ACID, G551D MUTATION, IVACAFTOR, CHILDREN, CFTR, TRANSPLANTATION

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/5cc842c6-e920-4048-9a90-907ce112b4ef

الاتاحة: https://hdl.handle.net/11370/5cc842c6-e920-4048-9a90-907ce112b4ef
https://research.rug.nl/en/publications/5cc842c6-e920-4048-9a90-907ce112b4ef
https://doi.org/10.1097/MCP.0000000000000428
https://pure.rug.nl/ws/files/48387422/00063198_900000000_99268.pdf

المؤلفون: van de Peppel, Ivo P., Demirdas, Serwet, Özcan, Behiye

المصدر: Frontiers in Endocrinology; 2023, p01-03, 3p

مصطلحات موضوعية: DEAFNESS, DIABETES, MEDICAL genetics

المؤلفون: van de Peppel, Ivo P., Rao, Anuradha, Dommerholt, Marleen B., Bongiovanni, Laura, Thomas, Rachel, de Bruin, Alain, Karpen, Saul J., Dawson, Paul A., Verkade, Henkjan J., Jonker, Johan W.

المصدر: Molecular Nutrition & Food Research ; volume 64, issue 24 ; ISSN 1613-4125 1613-4133

الاتاحة: http://dx.doi.org/10.1002/mnfr.202070055
https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.202070055

المؤلفون: Bertolini, Anna, van de Peppel, Ivo P., Bodewes, Frank A.J.A., Moshage, Han, Fantin, Alberto, Farinati, Fabio, Fiorotto, Romina, Jonker, Johan W., Strazzabosco, Mario, Verkade, Henkjan J., Peserico, Giulia

المصدر: Hepatology (Baltimore, Md.)

مصطلحات موضوعية: Male, Pneumonia, Viral, Review Article, Comorbidity, Risk Assessment, Sensitivity and Specificity, Severity of Illness Index, AST, LFTs, SARS-CoV-2, cholangiocyte, liver enzymes, SARS‐CoV‐2, Liver Function Tests, Prevalence, Humans, Aspartate Aminotransferases, Review Articles, Pandemics, Liver Diseases, COVID-19, Prognosis, Hospitalization, Liver, Female, Coronavirus Infections

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dc5fbb41421098d4336fb4951cb2310e
http://hdl.handle.net/11577/3350928

المؤلفون: Pathobiologie, dPB RMSC, Dep Biomolecular Health Sciences, van de Peppel, Ivo P, Rao, Anuradha, Dommerholt, Marleen B, Bongiovanni, Laura, Thomas, Rachel, de Bruin, Alain, Karpen, Saul J, Dawson, Paul A, Verkade, Henkjan J, Jonker, Johan W

URL: https://doi.org/10.1002/mnfr.202000750
http://hdl.handle.net/1874/409362
1613-4125
Molecular Nutrition & Food Research
64
24
2000750