المؤلفون: Ola Fjellström, Sibel Akkaya, Hans-Georg Beisel, Per-Olof Eriksson, Karl Erixon, David Gustafsson, Ulrik Jurva, Daiwu Kang, David Karis, Wolfgang Knecht, Viveca Nerme, Ingemar Nilsson, Thomas Olsson, Alma Redzic, Robert Roth, Jenny Sandmark, Anna Tigerström, Linda Öster

المصدر: PLoS ONE, Vol 10, Iss 1, p e0113705 (2015)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4309560?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/1a2cc35337574e84979292e3f9e6ec05

المؤلفون: Chandrali Bhattacharya, Ann-Sofie Sandinge, Ryan A. Bragg, Maria Heijer, Jingjing Yan, Linda C. Andersson, Ulrik Jurva, Marta Pelay-Gimeno, Wouter H.J. Vaes, Rianne A.F. de Ligt, Malin Gränfors, Carl Amilon, Eva-Lotte Lindstedt, Somasekhara R. Menakuru, Pavlo Garkaviy, Lars Weidolf, V. Sashi Gopaul

المصدر: Drug Metabolism and Disposition. 51:451-463

مصطلحات موضوعية: Pharmacology, Pharmaceutical Science

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e32d1617b5bd8c510ddc429b7c85fe93
https://doi.org/10.1124/dmd.122.001100

المؤلفون: Tord Inghardt, Thomas Antonsson, Cecilia Ericsson, Daniel Hovdal, Petra Johannesson, Carina Johansson, Ulrik Jurva, Johan Kajanus, Bengt Kull, Erik Michaëlsson, Anna Pettersen, Tove Sjögren, Henrik Sörensen, Kristina Westerlund, Eva-Lotte Lindstedt

المصدر: Journal of Medicinal Chemistry. 65:11485-11496

مصطلحات موضوعية: Heart Failure, Pyrimidines, Drug Discovery, Animals, Humans, Molecular Medicine, Pyrroles, Stroke Volume, Iodide Peroxidase, Peroxidase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ef1bcb1b44e92cc2a14d39e9d3d4b8
https://doi.org/10.1021/acs.jmedchem.1c02141

المؤلفون: Kurt L. Harris, Raine E.S. Thomson, Yosephine Gumulya, Gabriel Foley, Saskya E. Carrera-Pacheco, Parnayan Syed, Tomasz Janosik, Ann-Sofie Sandinge, Shalini Andersson, Ulrik Jurva, Mikael Bodén, Elizabeth M.J. Gillam

المصدر: Molecular biology and evolution. 39(6)

مصطلحات موضوعية: Mammals, Cytochrome P-450 Enzyme System, Caffeine, Vertebrates, Genetics, Cytochrome P-450 CYP1A1, Animals, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Xenobiotics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6bd20094241284455b5dce4f89f8a0
https://pubmed.ncbi.nlm.nih.gov/35639613

المؤلفون: James J. De Voss, Shalini Andersson, Silja J. Strohmaier, Ulrik Jurva, Elizabeth M. J. Gillam, Jong Min Baek

المصدر: ChemCatChem. 12:1750-1761

مصطلحات موضوعية: chemistry.chemical_classification, biology, 010405 organic chemistry, Organic Chemistry, Cytochrome P450 reductase, Cytochrome P450, Oxidative phosphorylation, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Inorganic Chemistry, Enzyme, chemistry, Biocatalysis, Yield (chemistry), biology.protein, Physical and Theoretical Chemistry, Thermostability

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4e7d3823b489336a8a46a030ba004fa5
https://doi.org/10.1002/cctc.201902235

المؤلفون: Johan Kajanus, Leif Carlsson, Thomas Antonsson, Anna Pettersen, Johan Sundell, Tord Inghardt, Ulrik Jurva

المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1241-1245

مصطلحات موضوعية: Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, CHO Cells, Pharmacology, 01 natural sciences, Biochemistry, Sudden death, Kv1.5 Potassium Channel, Structure-Activity Relationship, Cricetulus, Dogs, Atrial Fibrillation, Drug Discovery, Potassium Channel Blockers, medicine, Animals, Humans, Myocytes, Cardiac, Sinus rhythm, Heart Atria, Molecular Biology, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Effective refractory period, Potassium channel blocker, Atrial fibrillation, Ethylenediamines, medicine.disease, Potassium channel, 0104 chemical sciences, Blockade, Disease Models, Animal, 010404 medicinal & biomolecular chemistry, Heart failure, Molecular Medicine, Rabbits, Anti-Arrhythmia Agents, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed757dd1104a6385cd41b2c629e7f3db
https://doi.org/10.1016/j.bmcl.2019.03.006

المؤلفون: Tord Inghardt, Thomas Antonsson, Cecilia Ericsson, Daniel Hovdal, Petra Johannesson, Carina Johansson, Ulrik Jurva, Johan Kajanus, Bengt Kull, Erik Michaëlsson, Anna Pettersen, Tove Sjögren, Henrik Sörensen, Kristina Westerlund, Eva-Lotte Lindstedt

المصدر: Journal of Medicinal Chemistry. 65:13482-13482

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::762527e04301766c31eec6829fdf10d1
https://doi.org/10.1021/acs.jmedchem.2c01533

المؤلفون: Jeanette E. Stok, Justyna Kulig, Ulrik Jurva, Shan Zheng, Elizabeth M. J. Gillam, Mikael Bodén, Emre M. Isin, Kurt L. Harris, Jong Min Baek, James B. Y. H. Behrendorff, Raine E. S. Thomson, Yosephin Gumulya, James J. De Voss, Shalini Andersson, Luke W. Guddat, Dominic J. B. Hunter, Gerhard Schenk, Xueming Wu, Bin Wu, Shun-Jie Wun

المصدر: Nature Catalysis. 1:878-888

مصطلحات موضوعية: 0301 basic medicine, Ancestral reconstruction, chemistry.chemical_classification, Sequence reconstruction, biology, Chemistry, Process Chemistry and Technology, Vertebrate, Bioengineering, 02 engineering and technology, 021001 nanoscience & nanotechnology, medicine.disease_cause, Biochemistry, Catalysis, 03 medical and health sciences, 030104 developmental biology, Enzyme, Data sequences, Extant taxon, Biocatalysis, biology.animal, medicine, 0210 nano-technology, Escherichia coli

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::80b35f9e22a041706c34dce3cb6a8140
https://doi.org/10.1038/s41929-018-0159-5

المؤلفون: James J. De Voss, Shalini Andersson, Silja J. Strohmaier, Ulrik Jurva, Elizabeth M. J. Gillam

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 48(6)

مصطلحات موضوعية: Metabolite, Chemistry, Pharmaceutical, Pharmaceutical Science, 030226 pharmacology & pharmacy, Redox, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Humans, Enzyme Assays, Pharmacology, biology, CYP3A4, CYP1A2, Cytochrome P450, Recombinant Proteins, Oxygen, chemistry, Biochemistry, Biocatalysis, Cumene hydroperoxide, 030220 oncology & carcinogenesis, biology.protein, Oxidation-Reduction, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e690696f50d720cc5e9f6e65d0f2b283
https://pubmed.ncbi.nlm.nih.gov/32238418

المؤلفون: Ulrik Jurva, Elizabeth M. J. Gillam, Dominic J. B. Hunter, James J. De Voss, Shalini Andersson, Weiliang Huang, Emre M. Isin, Stephlina A. D'Cunha, Raine E. S. Thomson, Martin A. Hayes, Mikael Bodén, Yosephine Gumulya, Katelyn E. Richards, Kurt L. Harris, Jong Min Baek

المصدر: ChemCatChem.

مصطلحات موضوعية: chemistry.chemical_classification, Drug discovery, Organic Chemistry, Mutant, Computational biology, Protein engineering, 010402 general chemistry, Directed evolution, 030226 pharmacology & pharmacy, 01 natural sciences, Catalysis, 0104 chemical sciences, DNA shuffling, Inorganic Chemistry, 03 medical and health sciences, Synthetic biology, 0302 clinical medicine, Enzyme, chemistry, Biocatalysis, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1b20b75a96fdc2acd8b237768e24a48d
https://doi.org/10.1002/cctc.201801644

المؤلفون: Ulrik Jurva, Lars Weidolf

المصدر: TrAC Trends in Analytical Chemistry. 70:92-99

مصطلحات موضوعية: chemistry.chemical_classification, biology, Chemistry, Drug discovery, Metabolite, Cytochrome P450, Analytical Chemistry, chemistry.chemical_compound, Metabolic pathway, Enzyme, Drug development, Biochemistry, Biotransformation, biology.protein, Spectroscopy, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::db7b4c3d965c0c8517909beaa9a94f84
https://doi.org/10.1016/j.trac.2015.04.010

المؤلفون: Katarina Breitholtz, Ulrik Jurva, Lars Weidolf, Malin Darnell, Emre M. Isin

المصدر: Chemical Research in Toxicology. 28:886-896

مصطلحات موضوعية: Stereochemistry, Acylation, Carboxylic acid, Metabolite, Carboxylic Acids, Toxicology, Xenobiotics, chemistry.chemical_compound, Acyl-CoA, Glucuronides, Zomepirac, medicine, Humans, chemistry.chemical_classification, Proteins, General Medicine, Pharmaceutical Preparations, chemistry, Biochemistry, Tienilic acid, Microsomes, Liver, Microsome, Acyl Coenzyme A, Xenobiotic, Oxidation-Reduction, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2872e73a7979df2304aac357c0dfca
https://doi.org/10.1021/tx500514z

المؤلفون: Duncan Armstrong, Eric Wellner, Marcel Geyer, Sebastian Saloman, Reinhold Tacke, Ulrik Jurva

المصدر: ChemMedChem. 10:911-924

مصطلحات موضوعية: Male, Loperamide, Silicon, Stereochemistry, Metabolite, chemistry.chemical_element, Biochemistry, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, Cytochrome P-450 Enzyme System, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Organosilicon Compounds, Enzyme Inhibitors, Rats, Wistar, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, In vitro, Rats, chemistry, Permeability (electromagnetism), Hepatocytes, Microsomes, Liver, Biophysics, Molecular Medicine, Piperidine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c688d0be65bcb97e7ff655ea114bf94f
https://doi.org/10.1002/cmdc.201500040

المؤلفون: Ugo Bussy, Renaud Boisseau, Nicolas Galland, Denis Jacquemin, Ulrik Jurva, Moa Andresen-Bergström, Mohammed Boujtita, Virginie Silvestre

المصدر: Rapid Communications in Mass Spectrometry. 29:456-460

مصطلحات موضوعية: Benzimidazole, Supporting electrolyte, Electrospray ionization, Organic Chemistry, Inorganic chemistry, Side reaction, Lithium acetate, Mass spectrometry, Electrochemistry, Analytical Chemistry, chemistry.chemical_compound, chemistry, Organic chemistry, Ammonium acetate, Spectroscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::12d9985930469eab5df8ae3e1a5a5484
https://doi.org/10.1002/rcm.7122

المؤلفون: Jonas Fägerhag, Christer Westerlund, Graeme R. Robb, Ulrik Jurva, Henriksson Anette Marie Svensson, Peter Bonn, Volker Schnecke, D. Mikael Brink, Michael J. Waring

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:7302-7305

مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Pyrazolopyrimidine, Structure-Activity Relationship, chemistry.chemical_compound, Enzyme activator, Thioether, Glucokinase, Drug Discovery, Glucose homeostasis, Potency, Glycolysis, Molecular Biology, Ligand efficiency, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, High-Throughput Screening Assays, Enzyme Activation, Pyrimidines, chemistry, Pyrazoles, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d272d318a5c8b3861495dc45a411e738
https://doi.org/10.1016/j.bmcl.2012.10.090

المؤلفون: Lars Weidolf, Neal Castagnoli, Ulrik Jurva, Tove Johansson Mali'n

المصدر: Rapid Communications in Mass Spectrometry. 24:1231-1240

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Electrospray ionization, Cyanide, Potassium cyanide, High-performance liquid chromatography, Analytical Chemistry, Adduct, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Animals, Humans, Potassium Cyanide, Chromatography, High Pressure Liquid, Spectroscopy, Chromatography, Organic Chemistry, Iminium, Electrochemical Techniques, Rats, chemistry, Microsomes, Liver, Lactam, Haloperidol, Pyridinium, Oxidation-Reduction, Antipsychotic Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f3a26d6ec46c439076d37ca8ce4b98
https://doi.org/10.1002/rcm.4505

المؤلفون: Ulrik Jurva, Tove Johansson, Friedrich Popp, Lars Weidolf, Reinhold Tacke

المصدر: Drug Metabolism and Disposition. 38:73-83

مصطلحات موضوعية: Male, Stereochemistry, Metabolite, Pharmaceutical Science, behavioral disciplines and activities, chemistry.chemical_compound, Dogs, Tandem Mass Spectrometry, Trifluperidol, medicine, Haloperidol, Animals, Humans, Organosilicon Compounds, Pharmacology, Molecular Structure, Metabolism, Metabolic Detoxication, Phase II, Rats, Models, Chemical, Biochemistry, chemistry, Hepatocytes, Microsomes, Liver, Uridine Diphosphate Glucuronic Acid, Microsome, Female, Metabolic Detoxication, Phase I, Pyridinium, Glucuronide, Drug metabolism, Chromatography, Liquid, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffed367cd3f8bfd449c1a1e2fe053e4b
https://doi.org/10.1124/dmd.109.028449

المؤلفون: Ulrik Jurva, Tove Johansson, Lars Weidolf, Gunnar Grönberg, Collen Masimirembwa

المصدر: Drug Metabolism and Disposition. 37:571-579

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Stereochemistry, Metabolite, Pharmaceutical Science, Tandem mass spectrometry, Mass spectrometry, Aldehyde, Adduct, chemistry.chemical_compound, Cytochrome P-450 CYP1A1, Electrochemistry, Animals, Pharmacology, chemistry.chemical_classification, Molecular Structure, biology, Amodiaquine, Cytochrome P450, Rats, chemistry, Cytochrome P-450 CYP1B1, Microsomes, Liver, biology.protein, Amine gas treating, Aryl Hydrocarbon Hydroxylases, Chromatography, Liquid, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bc1ad6d9766577887b32cdb1c65877
https://doi.org/10.1124/dmd.108.025171

المؤلفون: Steen Honoré Hansen, Kim G. Madsen, Gunnar Grönberg, Ulrik Jurva, Christian Skonberg, Jørgen Olsen

المصدر: Chemical Research in Toxicology. 21:2035-2041

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, medicine.drug_class, Stereochemistry, Toxicology, Rosiglitazone, Troglitazone, chemistry.chemical_compound, Electrochemistry, medicine, Animals, Humans, Moiety, Chromans, Thiazolidinedione, Molecular Structure, Pioglitazone, General Medicine, Glutathione, In vitro, Acetylcysteine, Rats, chemistry, Biochemistry, Microsomes, Liver, Microsome, Chromane, Thiazolidinediones, Oxidation-Reduction, Cysteine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971dcd3e968a526c881cfc7b036930df
https://doi.org/10.1021/tx8002214

المؤلفون: Neal Castagnoli, Philippe Bissel, Ulrik Jurva, Mehdi Ashraf-Khorasani

المصدر: Rapid Communications in Mass Spectrometry. 22:2089-2096

مصطلحات موضوعية: Second pathway, Chemistry, Organic Chemistry, Organic chemistry, Oxidative phosphorylation, 1 methyl 4 phenyl 1, Mass spectrometry, Electrochemistry, Ionization mass, Mass spectrometric, Spectroscopy, Analytical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fb5ecdb8ef692cf4505a640a85ce4423
https://doi.org/10.1002/rcm.3592